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CXC chemokines and chemokine receptors in gastric cancer: From basic findings towards therapeutic targeting

World journal of Gastroenterology 2014年第7期20卷 1681-1693页

作者： Hyo Jin Lee Ik-Chan Song Hwan-Jung Yun deog-yeon jo Samyong Kim Division of Hematology/Oncology Department of Internal MedicineSchool of Medicine Chungnam National University and Chungnam National University HospitalDaejeon 301-721South Korea Cancer Research Institute Chungnam National UniversityDaejeon 301-721South Korea Division of Hematology/Oncology Department of Internal MedicineChungnam National University HospitalDaejeon 301-721South Korea

Gastric cancer is the fourth most common cancer,and the second-highest cause of cancer-related deaths *** extensive research to identify novel diagnostic and therapeutic agents,patients with advanced gastric cancer suffer from a poor quality of life and poor prognosis,and treatment is dependent mainly on conventional cytotoxic *** improve the quality of life and survival of gastric cancer patients,a better understanding of the underlying molecular pathologies,and their application towards the development of novel targeted therapies,is urgently *** are a group of small proteins associated with cytoskeletal rearrangements,the directional migration of several cell types during development and physiology,and the host immune response via interactions with G-protein coupled *** is also growing evidence to suggest that chemokines not only play a role in the immune system,but are also involved in the development and progression of *** gastric cancer,CXC chemokines and chemokine receptors regulate the trafficking of cells in and out of the tumor *** chemokines and their receptors can also directly influence tumorigenesis by modulating tumor transformation,survival,growth,invasion and metastasis,as well as indirectly by regulating angiogenesis,and tumor-leukocyte *** this review,we will focus on the roles of CXC chemokines and their receptors in the development,progression,and metastasis of gastric tumors,and discuss their therapeutic potential for gastric cancer.

关键词： Chemokine Chemokine receptor Gastric neoplasm Therapeutic target

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Stem and Progenitor Cell Expansionin Co-culture of Mobilized CD34^+ Cells and Osteopetrotic Mouse Stroma

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生物医学工程学杂志 2005年第S1期22卷 155-157页

作者： Na LI Pierre Feugier deog-yeon jo Jae Hung Shieh Karen L.Mac Kenzie JF Lesesve V Latger-Cannard D Bensoussan Ronald G Crystal Shahin Rafii JF Stoltz Malcolm A.S.Moore Unitéde Thérapie Cellulaire et Banque de Tissus et UMR CNRS 7563 CHU et Facultéde Médecine de NancyFrance James Ewing Laboratory of Developmental Hematopoiesis Memorial Sloan-Kettering Cancer CenterNew YorkNY 10021USA Hématologie Clinique NancyFrance Hématologie Biologique NancyFrance Division of Hematology-Oncology Weill Medical College of Cornell University-New York Presbyterian HospitalNew YorkNY 10021USA Institute of Genetic Medicine and Division of Pulmonary and Critical Care Medicine Weill Medical College of Cornell University-New York Presbyterian HospitalNew YorkNY 10021USA

1 IntroductionCulture systems capable of expanding and/or maintaining hematopoietic stem cells will not only facilitate our understanding of stem cell biology, but also broaden clinical applications. Among various in vitro hematopoietic culture systems, co-cultures of marrow or CD34+ cells with an adherent stromal layer that can produce cytokines and extracellular matrix components most effectively supports long-term hematopoiesis ( LTC ), mimicking the bone marrow micro-environment.

关键词： CD Cells and Osteopetrotic Mouse Stroma Stem and Progenitor Cell Expansionin Co-culture of Mobilized CD34

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Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface

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Food Science and Human Wellness 2024年第3期13卷 1556-1566页

作者： Pianpian Yan Ramachandran Chelliah Kyoung Hee jo Xiuqin Chen Akanksha Tyagi Hyeon yeong jo Fazle Elahi Nam Chan Woo Min Seung Wook deog Hwan Oh Department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National UniversityChuncheon 24341South Korea Kangwon Institute ofInclusive Technology(KIIT) Kangwon National UniversityChuncheon 24341South Korea Saveetha School of Engineering (SIMATS)UniversitySriperumbudur 600124India Seoulin Bioscience Company Seongnam-si 13488South Korea

Slightly acidic electrolyzed water(SAEW)has proven to be an efficient and novel sanitizer in food and agriculture *** study assessed the efficacy of SAEW(30 mg/L)at 40℃on the inactivation of foodbome pathogens and detachment of multi-resistant Staphylococcus aureus(MRSA)*** underlying mechanism of MRS A biofilm under heated SAEW at 40℃treatment on metabolic profiles was *** results showed that the heated SAEW at 40℃significantly effectively against foodbome pathogens of 1.96-7.56(lg(CFU/g))reduction in pork,chicken,spinach,and *** heated SAEW at 40℃treatment significantly reduced MRS A biofilm cells by 2.41(lg(CFU/cm^(2))).The synergistic effect of SAEW treatment showed intense anti-biofilm activity in decreasing cell density and impairing biofilm cell *** metabolic response of MRSA biofilms,treated by SAEW at 40℃,revealed the alterations of intracellular metabolites,including amino acids,organic acid,fatty acid,and ***,signaling pathways involved in amino acid metabolism,energy metabolism,nucleotide synthesis,carbohydrate metabolites,and lipid biosynthesis were functionally disrupted by the SAEW at 40℃*** per our knowledge,this is the first research to uncover the potential mechanism of heated SAEW treatment against MRSA biofilm on food contact surface.

关键词： Multi-resistant Staphylococcus aureus Metabolic profile SAEW Biofilm Hurdle technology Electrode material

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Investigations of an Air Starting Motor of Marine Medium-Speed Diesel Engine with Numerical Analyses

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journal of Thermal Science 2010年第2期19卷 148-153页

作者： yeon Won Lee Yoon Hwan Choi deog Hee Doh Division of Mechanical Eng. Pukyong National Univ.San 100 Division of Mechanical and Information Eng.

The marine medium-speed diesel engines are started by two methods;one is the electric motors,and the other air starting *** though air starting motor is dependent of the engine types and sizes,it has been widely used in this area due to its simplicity,convenience and *** purpose of this paper is to give the designing parameters in order to make a proper "Air Starting Motor" using *** aerodynamic approaches were given to understand the internal flow characteristics of the air starting *** addition,we have carried out the investigation of effects of tip *** the calculations the tip clearance of air starting motor has been varied between 0,2.8,4.3 and 5.7% of blade *** results of computation are the tip clearance increased to 2.8%,the torque decreased 24%,and there was no more large changes when the clearances increased to 4.3% and 5.7%.

关键词： Medium-Speed Diesel Engine Air Starting Motor CFD Tip Clearance Influences

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Temperature Distribution and Thermal Stresses in Various Conditions of Moving Heating Source during Line Heating Process

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journal of Thermal Science 2012年第1期21卷 82-87页

作者： Yoon Hwan Choi yeon Won Lee Kwang Choi deog Hee Doh Kyoung joon Kim Department of Mechanical and Automotive Engineering Pukyong National University Steel Structure Research Division Research Institute of Industrial Science & Technology Division of Mechanical and information Engineering Korea Maritime University

Line heating method is widely used to manufacture curved surfaces in ship building. The main factors governing the quality of the manufactured products are the moving velocity of the heating source, heating strength, and heating ways. In this study, the temperature distributions of the heated plate were investigated with the condition that the line heating process was automatic. The temperature variations were also investigated with the changes of those three variables. The numerical results showed that the peak temperature decreased as the moving velocity of the heating source increased. It also revealed that the peak temperatures changed linearly with the changes of the heating source.

关键词： Moving heat source Line heating Thermal stress Residual deformation Conductive heat transfer

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Analysis of the Sloshing Flows of a LNG Cargo Tank

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journal of Thermal Science 2011年第5期20卷 442-448页

作者： deog Hee Doh Hyo Je jo Byeong Rog Shin Min Cheol Ryu Yoon Sik Hwang Division of Mechanical and Information Eng. Korea Maritime University Division of Naval Architecture and Ocean Systems Eng. Korea Maritime University Department of Mechanical Engineering Changwon National University Fluid Dynamics R&D Team DSMEGeoje-siKorea

The sloshing flows in a LNG cargo tank model （1/50 scale） of a ship are measured by an embedded pano- ramicPIV system. The measurement system consists of a Nd-Yag laser（120mJ, 15Hz）, two cameras（lk x lk） and a host computer. Four experimental cases were tested for the tank model, in which swaying motions are made by a 6 DOF-motion platform. The amplitudes of swaying are 9.76mm and 29.29mm, and the swaying frequencies are 0.633Hz and 0.828Hz. The measurement regions are the vertical plane 50ram away from the front wall of the tank where a pump tower is installed. It was verified that the flow patterns of the sloshing are similar to each other when the swaying amplitudes are similar.

关键词： Sloshing Model Ship Cargo Tank Embedded Panoramic PIV Swaying Motion

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Effects of dietary high dose DHA omega-3 supplement in dry eye with meibomian gland dysfunction

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International journal of Ophthalmology(English edition) 2021年第11期14卷 1700-1706页

作者： yeon Ji jo jong Soo Lee Department of Ophthalmology Pusan National University School of Medicine&Medical Research Institute of Pusan National University HospitalBusan 49241Republic of Korea

AIM:To evaluate the clinical efficacy of dietary supplement of high dose DHA omega-3 in dry eye with meibomian gland dysfunction(MGD).METHODS:Prospective randomized double-masked,placebo-controlled clinical trial was conducted in mild to moderate dry eye patients with *** have no history of taking any dietary omega-3 supplements before 3 *** were divided into two groups:24 patients in the omega-3 group and 26 patients in the placebo *** omega-3 group received two capsules of Easyeye Dry?,total containing 600 mg of EPA and 1640 mg of DHA,while the placebo group received two capsules containing 3000 mg of olive *** patients take two pills once a *** examination of MGD scores,tear break-up time(TBUT),corneal staining test(NEI),strip meniscometry(SM tube),and ocular surface disease index(OSDI)scores were performed at baseline,after 4 and 8 ***:A total of 50 patients were *** were no differences in baseline characteristics between the two groups,such as age,sex,and other ocular examination *** TBUT,NEI,and OSDI scores significantly improved after 4 and 8 wk in both *** after 8 wk TBUT(6.00±1.62 s vs 5.08±1.28 s,P=0.034)and MGD score(7.2±1.8 vs 8.1±2.6,P=0.033)in the omega-3 group was more significantly improved than that of the placebo ***:Dry eye with the MGD patient,a high dose of DHA omega-3 dietary supplement can improve TBUT and MGD score after 8 wk,effective in stabilizing the tear film.

关键词： DHA dietary supplement dry eye disease meibomian gland dysfunction

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Performance Analyses for a Cyclone Type Filter

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journal of Thermal Science 2015年第3期24卷 290-294页

作者： Hyoung-June Kim Masahiro Takei Hyun Jin Lee yeon Won Lee Yoon Hwan Choi deog-Hee Doh School of Mechanical Engineering Artificial Science Division Chiba University Division of Mech. and Energy Systems Eng. Korea Maritime University Dept. of Mechanical and Automotive Engineering Pukyong National University

Flow characteristics inside a cyclone filter were investigated by the use of computational fluid dynamics(CFD). For computations, SST model was adopted. Parametric study was carried out considering the filtering performance. Revolution speeds were changed from 100 to 550 with 50 increments. A skirt is the driving source for cyclone operation. The influence of several design factors, such as the skirt length, the skirt gap and the return length to filtering performance was investigated under the particle diameter 100μm of debris material(Al, s.g.=2.7). The filtering performance was also investigated with the skirt length 28 mm changing the debris diameters from 1μm to 50μm. The flow rate of the working fluid was maintained at 0.55kg/s. It has been verified that the most influential factors to the filtering efficiencies was the skirt gap between the cyclone generator and the cyclone vessel.

关键词： CFD cyclone filter design factors filtering performances

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Clinical efficacy of 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

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International journal of Ophthalmology(English edition) 2022年第12期15卷 1924-1931页

作者： yeon Ji jo Ji Eun Lee jong Soo Lee Efficacy of nano-cyclosporine to DES with MGD 1 Department of Ophthalmology Pusan National University School of Medicine&Medical Research InstitutePusan National University HospitalPusan 49241Republic of Korea Department of Ophthalmology Pusan National University School of Medicine&Medical Research CenterYangsan Pusan National University HospitalYangsan 626-770Republic of Korea

AIM:To evaluate the clinical efficacy of topical 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome(DES)with meibomian gland dysfunction(MGD).METHODS:This prospective study included 64 patients with DES and MGD who were randomly assigned to three groups:Group 1(n=24,conventional cyclosporine),Group 2(n=21,nano-emulsion cyclosporine),and Group 3(n=19,control).Lid margin telangiectasia(LMT),meibomian gland secretion(MGS),conjunctival injection(CI),corneal staining(CS),tear break-up time(TBUT),Schirmer test I(STI),Ocular Surface Disease Index(OSDI),and lipid layer thickness(LLT)was evaluated at 4,8,and 12wk of ***:In Group 3(control),LMT,CS,and CI improved after 8wk,MGS,TBUT after 12wk of *** Group 1(conventional cyclosporine),LMT,MGS,and TBUT improved significantly after 4wk,whereas CS,CI,STI,and LLT improved significantly after 8wk,and OSDI at *** Group 2(nano-cyclosporine),LMT,MGS,CS,CI,TBUT,and OSDI significantly improved after 4wk,and STI after ***,LLT was significantly higher than other groups after ***:Cyclosporine and nano-cyclosporine shows significant improvement in DES with MGD than the control *** contrast,the nano-cyclosporine group shows more statistically improved CI and CS at 4wk,especially LLT at 4,8,and 12wk compared to the conventional cyclosporine group.

关键词： anti-inflammatory treatment cyclosporine dry eye disease meibomian gland dysfunction

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Comparative outcomes of the pathogen in cultured jones tubes used in lacrimal bypass surgery according to follow up periods

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国际眼科杂志:英文版 2023年第10期16卷 1623-1629页

作者： Bo Hyun Park Hui Kyung Kim yeon Ji jo jong Soo Lee Department of Ophthalmology Pusan National University School of Medicine&Medical Research Institute of Pusan National University HospitalPusan 49241Republic of Korea

AIM:To evaluate the pathogens in cultured jones tubes used in lacrimal bypass surgery according to the postoperative periods and to obtain data for the prevention of infection of functional lacrimal stent ***:Totally 71 patients(81 eyes)who underwent the removal of jones tubes were enrolled in *** the removed jones tubes were cultured for bacterial and fungal identification and tested for bacterial antibiotic *** results were analyzed according to the duration of the inserted jones tube after lacrimal bypass ***:Of the 81 eyes,bacteria were isolated from 69 eyes(85.2%)and fungi from 6 eyes(7.4%).Among 69 eyes,40.6% showed Staphylococcus aureus(***),11.6% were Pseudomonas aeruginosa(***).Gram-positive bacteria were isolated more than Gramnegative bacteria,but Gram-negative bacteria showed a higher incidence in the jones tube implanted for over 10y(P=0.035).The antibiotic sensitivity test showed that 46.4% of *** were resistant to *** terms of antibiotics commonly used in ocular clinical practice,vancomycin was sensitive to *** and Streptococcus pneumoniae(***),amikacin responded to *** and Proteus mirabilis(***).Trimethoprim/sulfamethoxazole(TMP/SMX)was all sensitive to ***,*** and *** except ***:*** is the most commonly found organism in the jones tube after lacrimal bypass surgery,and 46.4% of them are methicillin-resistant ***(MRSA),sensitive to ***,*** responded with amikacin is dominantly detected in the jones tubes implanted for more than 10y.

关键词： jones tube lacrimal bypass surgery Pseudomonas aeruginosa Proteus mirabilis Staphylococcus aureus

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