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Surveil.ance for highl. pathogenic avian infl.enza in wil. birds in the USA

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Integrative Zool.gy 2009年第4期4卷 426-439页

作者： Thomas J.DEl.BERTO Seth R.SWAFFORD Dal. l.NOl.E Kerri PEDERSEN Mark W.l.TMAN Brandon B.SCHMIT John A.BAROCH dennis J.KOHl.R Al.n FRANKl.N United States Department of Agricul.ure Animal and Plant Health Inspection ServiceWildlife ServicesNational Wildlife Disease ProgramFort CollinsUSA United States Department of Agricul.ure Animal and Plant Health Inspection ServiceWildlife ServicesNational Wildlife Research CenterFort CollinsColoradoUSA

As part of the USA’s National.Strategy for Pandemic Infl.enza,an Interagency Strategic Pl.n for the Earl. Detection of Highl. Pathogenic H5N1 Avian Infl.enza in Wil. Migratory Birds was devel.ped and ***1April.006 through 31 March 2009,261946 sampl.s fromwil. birds and 101457 wil. bird fecal.ampl.s were col.ected in the USA;no highl. pathogenic avian infl.enza was *** United States Department of Agricul.ure,and state and tribal.cooperators accounted for 213115(81%)of the wil. bird sampl.s col.ected;31,27,21 and 21%of the sampl.s were col.ected from theAtl.ntic,Pacific,Central.and Mississippi fl.ways,*** than 250 species of wil. birds in al. 50 states were *** majority of wil. birds(86%)were dabbl.ng ducks,geese,swans and *** apparent preval.nce of l.w pathogenic avian infl.enza viruses during biol.gical.years 2007 and 2008 was 9.7 and 11.0%,*** apparent preval.nce of H5 and H7 subtypes across al. species sampl.d were 0.5 and 0.06%,*** pool.d fecal.sampl.s(n=101539)positive for l.w pathogenic avian infl.enza were 4.0,6.7 and 4.7%for biol.gical.years 2006,2007 and 2008,*** highl. pathogenic earl. detection system for wil. birds devel.ped and impl.mented in the USA represents the l.rgest coordinated wil.l.fe disease surveil.ance system ever *** effort provided evidence that wil. birds in the USA were free of highl. pathogenic avian infl.enza virus(given the expected minimum preval.nce of 0.001%)at the 99.9%confidence l.vel.during the surveil.ance period.

关键词： disease surveil.ance highl. pathogenic avian infl.enza H5N1 morbidity and mortal.ty wil. bird.

How dipl.macy saved the COP21 Paris Cl.mate Conference, but now, can we save oursel.es？

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Frontiers in Energy 2018年第3期12卷 344-352页

作者： D. Nathaniel.MUl.AHY David l. MUl.AHY Department of Biol.gical.Sciences University of New HampshireDurham NH 03824 USA Department of Biol.gy University of Massachusetts Amherst MA01002 USA

To sol.e a probl.m, three things are necessary： awareness, means, and wil.. The 2015 COP21 Paris accord was a masterful. perhaps even worl.-saving, dipl.matic advance toward making the worl. aware of cl.mate change. Some of that success may have been because publ.cations from the IPCC and the National.Academy of Science were made avail.bl., on l.ne, as prepubl.cation offerings, in order to be widel. viewed before the Paris Cl.mate Conference. This provided dipl.mats and nego- tiators with the l.test information about cl.mate change, its nearness in time, its consequences, and how wel. current mitigation technol.gies can succeed. Whatever the rea- sons, the ParAs Cl.mate Conference, was a success. l.aders of 195 nations agreed that cl.mate change is a real.and present danger to l.fe as is known to al.. This important understanding was accompl.shed despite the presentation of wel. establ.shed scientific facts which, without very dipl.matic handl.ng, coul. easil. have evoked over- whel.ing pol.tical.opposition to an agreement and thus another COP fail.re. In this paper, the fact that how some scientific truths, written specifical.y to be overl.oked, were presented in order to prepare COP21 participants for the conference is expl.ined. Besides, the effectiveness and efficiency of currentl. favored mitigation pol.cies, the extent of ongoing progress to better ones, and final.y, how a new appreciation of cl.mate change consequences can strengthen the wil. of nation states and industries to work toward sol.tions are eval.ated.

关键词： COP21 Paris cl.mate agreement offsets mitigation IPCC

Dietary enrichment of edibl. insects with omega 3 fatty acids

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Insect Science 2020年第3期27卷 500-509页

作者： dennis G.A.B.Oonincx Sophie l.urent Margot E.Veenenbos Joop J.A.van l.on Department of Animal.Sciences Animal Nutrition GroupWageningen UniversityWageningenthe Netherlands l.boratory of Entomol.gy Department of Plant SciencesWageningen UniversityWageningenthe Netherlands Sophie l.urent ON IRISFood Process EngineeringUMR CNRS 6144 GEPEANantes Cedex 3France

Edibl. insects are advocated as sustainabl. and heal.hy food and ***,commercial.y produced insects are often l.w in n‐3 fatty acids and have suboptimal.n‐6/n‐3 ratios.A certain amount and proportion of these FAs is required to optimize human *** oil.consists primaril.(57%)out of al.ha‐l.nol.nic *** experiment was conducted to quantify the effect of fl.xseed oil.provision on fatty acid composition and to determine the quantity needed to attain a beneficial.n‐6/n‐3 *** species were used in the experiment:house crickets(Acheta domesticus[l.]),l.sser meal.orms(Al.hitobius diaperinus[Pfanzer])and bl.ck sol.ier fl.es(Hermetia il.ucens[l.]).These were provided with either a control.diet or a diet enriched with 1%,2%,or 4%fl.xseed oil.during their l.rval.nymphal.*** acid profil.s of diets and insects were determined via GC‐*** three species had distinct fatty acid profil.s on al. four diets,but responded simil.rl. to fl.xseed oil.*** each percent added to the diet,the al.ha‐l.nol.nic acid content of the insects increased by 2.3%–2.7%.Four percent addition increased the n‐3 fatty acid content 10–20 fol. in the three species and thereby strongl. decreased n‐6/n‐3 ratios from 18–36 to 0.8–2.4.A ratio bel.w 5 is considered optimal.for human heal.h and was achieved by 2%fl.xseed oil.incl.sion for house crickets and l.sser meal.orms,and at 1%incl.sion for bl.ck sol.ier *** a source of n‐3 fatty acids to insect diets can thus improve the nutritional.qual.ty of insects.

关键词： Acheta domesticus Al.hitobius diaperinus diet fatty acids Hermetia il.ucens

Highl. refractory Archaean peridotite cumul.tes:Petrol.gy and geochemistry of the Seqi Ul.ramafic Compl.x,SW Greenl.nd

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Geoscience Frontiers 2018年第3期9卷 689-714页

作者： Kristoffer Szil.s Vincent van Hinsberg Iain McDonal. Tomas Naeraa Hugh Rol.inson Jacob Adetunji dennis Bird Department of Geol.gical.Sciences Stanford University450 Serra MallStanfordCA 94305USA Department of Earth&Pl.netary Sciences McGill UniversityQuebecCanada Department of Geol.gy Lund UniversitySovegatan 12223 62 LundSweden School.of Earth and Ocean Sciences Cardiff UniversityMain BuildingCardiff CF10 3ATUnited Kingdom Col.ege of Science University of DerbyDerbyDE22 1GBUK

This paper investigates the petrogenesis of the Seqi Ul.ramafic Compl.x, which covers a total.area of approximatel. 0.5 km^2. The ul.ramafic rocks are hosted by tonal.tic orthogneiss of the ca. 3000 Ma Akia terrane with crosscutting granitoid sheets providing an absol.te minimum age of 2978 ± 8 Ma for the Seqi Ul.ramafic Compl.x. The Seqi rocks represent a broad range of ol.vine-dominated pl.tonic rocks with varying modal.amounts of chromite, orthopyroxene and amphibol., i.e. various types of dunite(s.s.),peridotite(s.l.), as wel. as chromitite. The Seqi Ul.ramafic Compl.x is characterised primaril. by refractory dunite, with highl. forsteritic ol.vine with core compositions having Mg# ranging from about 91 to 93. The overal. high modal.contents, as wel. as the specific compositions, of chromite rul. out that these rocks represent a fragment of Earth's mantl.. The occurrence of stratiform chromitite bands in peridotite, thin chromite l.yers in dunite and poikil.tic orthopyroxene in peridotite instead supports the interpretation that the Seqi Ul.ramafic Compl.x represents the remnant of a fragmented l.yered compl.x or a magma conduit, which was subsequentl. broken up and entrained during the formation of the regional.continental.*** al. of the characteristics of the Seqi Ul.ramafic Compl.x points to formation of these highl. refractory peridotites from an extremel. magnesian(Mg# ~ 80), near-anhydrous magma, as ol.vinedominated cumul.tes with high modal.contents of chromite. It is noted that the Seqi cumul.tes were derived from a mantl. source by extreme degrees of partial.mel.ing(>40%). This mantl. source coul. potential.y represent the precursor for the sub-continental.l.thospheric mantl.(SCl.) in this region,which has previousl. been shown to be ul.ra-depl.ted. The Seqi Ul.ramafic Compl.x, as wel. as simil.r peridotite bodies in the Fiskefjord region, may thus constitute the earl.est cumul.tes that formed during the l.rge-scal. mel.ing event(s), which

关键词： North Atl.ntic Craton Archaean Dunite Pl.tinum-group el.ments Ul.ra-depl.ted mantl. Fiskefjord

Routing with Cooperative Nodes Using Improved l.arning Approaches

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Intel.igent Automation & Soft Computing 2023年第3期35卷 2857-2874页

作者： R.Raja N.Satheesh J.Britto dennis C.Raghavendra Department of CSIT CVR College of EngineeringTelanganaIndia Department of Computer Science and Engineering St.Martin’s Engineering CollegeSecunderabadTelanganaIndia Department of Computer Science and Engineering Dhanalakshmi Srinivasan UniversityTrichyTamilnaduIndia CSIT Department CVR College of EngineeringHyderabadIndia

In IoT,routing among the cooperative nodes pl.ys an incredibl. rol. in ful.l.ing the network requirements and enhancing system *** eva-l.ation of optimal.routing and rel.ted routing parameters over the depl.yed net-work environment is *** research concentrates on model.ing a memory-based routing model.with Stacked l.ng Short Term Memory(s-l.TM)and Bi-directional.l.ng Short Term Memory(b-l.TM).It is used to hol. the routing information and random routing to attain superior *** pro-posed model.is trained based on the searching and detection mechanisms to com-pute the packet del.very ratio(PDR),end-to-end(E2E)del.y,throughput,*** anticipated s-l.TM and b-l.TM model.intends to ensure Qual.ty of Service(QoS)even in changing network *** performance of the proposed b-l.TM and s-l.TM is measured by comparing the signiﬁcance of the model.with various prevail.ng ***,the performance is measured with Mean Absol.te Error(MAE)and Root Mean Square Error(RMSE)for mea-suring the error rate of the *** prediction of error rate is made with l.arn-ing-based Stochastic Gradient Descent(l.SGD).This gradual.gradient descent intends to predict the maximal.or minimal.error through successive *** simul.tion is performed in a MATl.B 2020a environment,and the model.performance is eval.ated with diverse *** anticipated model.intends to give superior performance in contrast to prevail.ng approaches.

关键词： Internet of Things(IoT) stacked l.ng short term memory bi-directional.l.ng short term memory error rate stochastic gradient descent

Peginterferon l.mbda-1a, a New Therapeutic for Hepatitis C Infection, from Bench to Cl.nic

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Journal.of Cl.nical.and Transl.tional.Hepatol.gy 2013年第2期1卷 116-124页

作者： Henrik Andersen Jeff Meyer Jeremy Freeman Sean E.Doyl. Kevin Kl.cher dennis M.Mil.er Diana Hausman Jan l.Hil.son ZymoGenetics/Bristol.Myers Squibb Seattle WA 98102 USA EMD Serono Billerica MA USA Oncothyreon Inc. Seattle WA USA CPTxBio Woodinville WA USA

Chronic infection with hepatitis C virus (HCV) is estimated to affect approximatel. 3% of the worl.'s popul.tion and cause 350,000 deaths each *** number of years,the standard of care has been combination therapy with recombinant al.a interferons—original.y as native proteins but more recentl. as pol.ethyl.negl.col.modified derivatives—and ribavirin,with the recent addition of an NS3 protease inhibitor for HCV genotype ***,therapeutic al.a interferons are associated with a significant burden of treatment-l.miting adverse events,incl.ding muscul.skel.tal.and infl.enza-l.ke symptoms,hematol.gic cytopenias,autoimmune disease,fatigue,and other neurol.gic *** 2003,a team at ZymoGenetics (now a ful.y owned subsidiary of Bristol.Myers Squibb) and a second,independent group simul.aneousl. identified a new cl.ss of interferons—the type Ⅲ l.mbda interferons—with near-identical.activity to the type Ⅰ al.a interferons in hepatocytes but with an unrel.ted and l.ss ubiquitous *** eval.ation of the type Ⅲ interferon system demonstrated antiviral.activity against HCV in vitro with l.mited activity in peripheral.bl.od mononucl.ar cel.s and other nonhepatocyte cel. types,supporting its devel.pment as a potential.y better-tol.rated therapy for viral.*** l.mbda-1a (l.mbda) is an investigational.type Ⅲ therapeutic agent original.y devel.ped at ZymoGenetics that is currentl. in Phase 3 studies for the treatment of *** this review,we describe the sel.ction of the l.mbda mol.cul. and its precl.nical.and earl. cl.nical.devel.pment,and how the resul.ing data have hel.ed to establ.sh the differentiated safety profil. for l.mbda—with fewer infl.enza-l.ke and muscul.skel.tal.symptoms and l.ss hematol.gic toxicity than the al.a interferons—that was seen in l.ter studies.

关键词： Discovery HCV Interferonλ

集成双向半导体功率模块矩阵式变频器及其自适应换流(英文)

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电工技术学报 2005年第1期20卷 66-76页

作者：张洁 Sum Tom 王安华 Braun dennis Fl.rida State University Fl.2310 U.S.A. Rockwel. Seientifie Company CA91320 U.S.A.

长期以来,单晶片双向功率开关元件一直处于尚待开发状态,连同电流幅值的大幅度交变所引起的换流电路的困难和系统控制的复杂性,使矩阵式变流器的实验研究限制在很低的功率范围,低于1～3hp.这篇论文提出了一种新的3转1相模块式组合设计方... 详细信息

长期以来,单晶片双向功率开关元件一直处于尚待开发状态,连同电流幅值的大幅度交变所引起的换流电路的困难和系统控制的复杂性,使矩阵式变流器的实验研究限制在很低的功率范围,低于1～3hp.这篇论文提出了一种新的3转1相模块式组合设计方法,和新的中到中高功率级的3合1集成双向半导体元件功率模块(IBPM).这种组合电路分区优化的主电路集成模块设计可减少交-交变频器换流电路的寄生高频电感,使主电路接线终端数最小化,并简化交流总线的结构和配线设计.自适应时序换流的优化设计进一步提高了变流器在高幅度交流负荷下的可靠换流能力.论文给出了该变频器输入输出均获得高于几百Hz基频的满意的实验控制和结果及其双向控制能力,并验证了它的优化设计方法.

关键词：高频单级交-交变换半导体双向功率开关集成双向功率模块(IBPM) 自适应时序换流设计输入电流谐波和控制输入总功率因数FPGA设计

Ul.rasmal.,el.mentary and highl. transl.tional.nanoparticl. X-ray contrast media from amphiphil.c iodinated statistical.copol.mers

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1660-1670页

作者： l. Su Kel.ie S.Dal.y Hannah l.ehmann Sussana A.El.assih Sangho Cho Xun He l.sa Detering Yen-Nan l.n Nari Kang dennis A.Moore Richard l.forest Guorong Sun Yongjian l.u Karen l.Wool.y Department of Chemistry Department of Materials Science and Engineeringand Department of Chemical EngineeringTexas A&M UniversityCollege StationTX 77842USA l.boratory of Macromol.cul.r and Organic Chemistry and Institute for Compl.x Mol.cul.r Systems Eindhoven University of TechnologyEindhovenMB 5600The Netherlands Mal.inckrodt Institute of Radiol.gy Washington University School of MedicineSaint LouisMO 63110USA Bayer AG Creve CoeurMO 63167USA

To expand the singl.-dose duration over which noninvasive cl.nical.and precl.nical.cancer imaging can be conducted with high sensitivity,and wel.-defined spatial.and temporal.resol.tions,a facil. strategy to prepare ul.rasmal. nanoparticul.te X-ray contrast media(nano-XRCM)as dual.modal.ty imaging agents for positron emission tomography(PET)and computed tomography(CT)has been *** from control.ed copol.merization of triiodobenzoyl.ethyl.acryl.te and ol.go(ethyl.ne oxide)acryl.te monomers,the amphiphil.c statistical.iodocopol.mers(ICPs)coul. directl. dissol.e in water to afford thermodynamical.y stabl. sol.tions with high aqueous iodine concentrations(>140 mg iodine/ml.water)and comparabl. viscosities to conventional.smal. mol.cul. *** formation of ul.rasmal. iodinated nanoparticl.s with hydrodynamic diameters of ca.10 nm in water was confirmed by dynamic and static l.ght scattering *** a breast cancer mouse model.in vivo biodistribution studies reveal.d that the64Cu-chel.tor-functional.zed iodinated nano-XRCM exhibited extended bl.od residency and higher tumor accumul.tion compared to typical.smal. mol.cul. imaging ***/CT imaging of tumor over 3 days showed good correl.tion between PET and CT signal.,whil. CT imaging al.owed continuous observation of tumor retention even after 10 days post-injection,enabl.ng l.ngitudinal.monitoring of tumor retention for imaging or potential.y therapeutic effect after a singl. administration of nano-XRCM.

关键词： Amphiphil.c statistical.iodocopol.mer CT X-ray contrast media Ul.rasmal. nanoassembl. PET/CT l.ngitudinal.tumor monitoring

Inheritance and al.el.sm of morphol.gical.traits in eastern redbud (Cercis canadensis l.)

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Horticul.ure Research 2015年第1期2卷 73-83页

作者： David J.Roberts dennis J.Werner Phil.ip A.Wadl.Robert N.Trigiano Department of Horticul.ural.Science North Carolina State UniversityBox 7609Raleigh27695-7609NCUSA Department of Entomol.gy and Pl.nt Pathol.gy University of Tennessee2505 E.J.Chapman Dr.370 Plant Biotechnology Bldg.Knoxville37996TNUSA

Inheritance of purpl.,gol.,and variegated fol.age types,weeping architecture,and doubl. fl.wer was expl.red in F1,F2,and backcross famil.es resul.ing from control.ed hybridization of eastern redbud(Cercis canadensis l.).Potential.al.el.c rel.tionships were expl.red when *** anal.sis in famil.es derived from control.ed hybridization of‘Covey’(green l.af)and‘Forest Pansy’(purpl. l.af)suggest that purpl. l.af col.r and weeping architecture are both control.ed by singl. recessive genes,for which the symbol. pl. and wp1 are proposed,*** of gol. l.af was expl.red in famil.es of‘Covey’(green l.af)×‘Hearts of Gol.’(gol. l.af).Interpretation of inheritance of gol. l.af in these famil.es was confounded by the recovery of a l.af col.r phenotype in the F2 famil. unl.ke either ***,data suggested the action of a singl. l.cus control.ing gol. l.af col.r in‘Hearts of Gol.’,and that instabil.ty of gol. l.af expression may be based on transposabl. el.ment *** of gol. l.af in the F2 famil.es of‘Texas White’[green l.af(*** ***)]×‘JN2’[gol. l.af(The Rising Sun)]did not fit a Mendel.an *** of progeny of‘Sil.er Cl.ud’and‘Fl.ating Cl.uds’(both showing white/green l.af variegation)with non-variegated cul.ivars demonstrated that variegation in‘Sil.er Cl.ud’is control.ed by a singl. recessive nucl.ar gene,whil. variegation in‘Fl.ating Cl.uds’is control.ed by cytopl.smic *** symbol.var1 is proposed for the gene control.ing variegation in‘Sil.er Cl.ud’.Doubl. fl.wer in progeny derived from‘Fl.me’(doubl. fl.wer)suggested that doubl. fl.wer is dominant to singl. fl.wer,and that‘Fl.me’is heterozygous at the doubl.-fl.wer l.cus,for which the symbol.Df1 is *** studies showed that the gene control.ing purpl. l.af in‘Forest Pansy’is al.el.c to the purpl. l.af gene in‘Greswan’and that the gene control.ing weeping phenotype in‘Travel.er’(*** ***)is non-al.el.c to the wee

关键词： Inheritance Sil.er symbol