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Ethnopharmacological Potentials of Warburgia ugandensis on Antimicrobial Activities

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Chinese Journal of Integrative Medicine 2021年第8期27卷 633-640页

作者： denis Okello Youngmin Kang Korean Convergence Medicine Major University of Science and TechnologyDaejeonRepublic of Korea Gombe Secondary School P.O.Box 192Butambala/MpigiUganda Herbal Medicine Research Division Korea Institute of Oriental MedicineDaejeon34054Republic of Korea

Warburgia ugandensis(***)is known by various names,including the East African greenheart,pepper bark tree,and Ugandan greenheart,and has a rich history of extensive use in the treatment of a host of human diseases in many African *** review is based on the botany and ethnopharmacological potentials of *** for the treatment of pneumonia,asthma,malaria,candidiasis,skin infections,human immunodeficiency virus opportunistic infections,diarrhea,and measles given the common use in the management of these *** from *** have strong antimicrobial activities against a broad spectrum of pathogens mainly because of the presence of abundant terpenoids,drimane,and coloratane type sesquditerpenoids amongst which are ugandensial,warburganal,mukaadial,and other secondary metabolites,such as tannins,flavonoids,saponins,steroids,and *** group of compounds gives the plant a high therapeutic *** on the review,there is a need for identification and isolation of the highly therapeutic phytochemical constituents and a drive for more preclinical and clinical trials to validate the safety and efficacy of the *** gives basis for the potential development of new therapeutic drugs from the plant.

关键词： Ethnopharmacological potential Warburgia ugandensis greenheart pharmacological activity review

围术期神经肌肉阻滞的管理:欧洲麻醉和重症监护学会临床指南

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中华麻醉学杂志 2024年第6期44卷 641-656页

作者： Thomas Fuchs-Buder Carolina S.Romero Heidrun Lewald Massimo Lamperti Arash Afshari Ana-Marjia Hristovska denis Schmartz Jochen Hinkelbein Dan Longrois Maria Popp Hans Dde Boer Massimiliano Sorbello Radmilo Jankovic Peter Kranke 法国南锡大学医学院附属医院麻醉学、重症监护与围术期医学科法国南锡54000 巴伦西亚大学综合医院麻醉与重症监护科西班牙巴伦西亚46014 慕尼黑工业大学麻醉学与重症监护科德国慕尼黑80333 克利夫兰阿布扎比诊所麻醉学研究所阿联酋阿布扎比31250 哥本哈根大学医院小儿和产科麻醉科丹麦哥本哈根2100 哥本哈根大学医院麻醉学与重症监护科丹麦赫维德2650 布鲁塞尔自由大学Erasme医院麻醉科比利时布鲁塞尔1070 科隆大学医院麻醉学与重症监护科德国科隆50937 巴黎大学附属比查特克劳德伯纳德医院麻醉学与重症监护医学科法国巴黎75018 维尔茨堡大学医院麻醉学、危重病医学、急诊医学和疼痛医学科德国维尔茨堡97080 格罗宁根大学医院麻醉学、疼痛医学与程序性镇静与镇痛科荷兰格罗宁根9713 GZ 卡坦尼亚大学医院麻醉与重症监护科意大利卡坦尼亚95123 尼什大学医学院尼什临床中心麻醉学与重症治疗科塞尔维亚尼什18000

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(Europea... 详细信息

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(European Society of Anaesthesiology and Intensive Care,ESAIC)首次发布围术期神经肌肉阻滞管理临床指南,旨在为临床医生提供最佳医疗管理的循证建议,以提高围术期患者安全。本指南主要聚焦在3个临床问题:肌松药是否有助于成人气管插管?神经肌肉阻滞深度是否影响腹部手术患者的预后?肌松药残留阻滞的诊断和治疗策略有哪些?根据PICO原则(患者、干预、对照、结局;patient,intervention,comparator,outcome;PICO)构建临床问题并进行文献检索。初始纳入的临床研究为24 000篇,采用逐步筛选策略,最终临床研究88篇纳入指南分析。应用GRADE方法学(Grading of Recommendations,Assessment,Development and Evaluation,GRADE)对结局指标证据、质量等级进行评价。运用两轮德尔菲法收集专家组建议并形成统一推荐:R1推荐应用肌松药辅助气管插管(1A)。R2推荐应用肌松药以减少气管插管导致的咽部和(或)喉部损伤(1C)。R3推荐在快速顺序诱导插管(rapid sequence induction intubation,RSII)时使用短效肌松药,例如琥珀胆碱1 mg/kg或罗库溴铵0.9~1.2 mg/kg(1B)。R4推荐在需要改善外科手术条件时,加深神经肌肉阻滞深度(1B)。R5尚无足够的证据推荐深度神经肌肉阻滞可减轻术后疼痛或降低围术期并发症的发生率(2C)。R6推荐在拇内收肌处刺激尺神经,定量监测神经肌肉阻滞深度以排除肌松药残留阻滞(1B)。R7推荐应用舒更葡糖钠逆转甾体类肌松药(罗库溴铵、维库溴铵)诱导的深、中及浅度神经肌肉阻滞(1A)。R8推荐在使用新斯的明前,TOFr自行恢复至>0.2,并继续定量监测神经肌肉功能,直至TOFr超过0.9(1C)。

关键词：神经肌肉阻滞神经肌肉功能肌松药临床指南罗库溴铵琥珀胆碱外科手术定量监测

Complete Hydatidiform Mole at Menopause: A Case Report from Panzi Hospital, Bukavu, Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1010-1017页

作者： Julien Bwama De-Joseph Kakisingi Mibi Nsenga Bin Musa Jeff Andrea Mbozi Déborah Kambonesa Salire Dieudonné Kakusu Christine Amisi Tina Aroni Toto Tchass Chasinga Baharanyi denis Mukwege Mukengere Olivier Nyakio Ngeleza Department of Gynaecology-Obstetrics Faculty of Medicine and Community Health Evangelical University in Africa Bukavu Democratic Republic of Congo Gynaecology-Obstetrics Department Panzi General Referral Hospital Bukavu Democratic Republic of Congo Saint Vincent Hospital Bukavu Democratic Republic of Congo Medical Imaging Department Panzi General Referral Hospital Bukavu Democratic Republic of Congo Anatomopathology Department Panzi General Referral Hospital Bukavu Democratic Republic of Congo Panzi Foundation Bukavu Democratic Republic of Congo Department of Gynaecology-Obstetrics Faculty of Medicine Official University of Bukavu Bukavu Democratic Republic of Congo Department of Gynaecology-Obstetrics Faculty of Medicine University of Kindu Kindu Democratic Republic of Congo

Gestational trophoblastic disease is an abnormal proliferation of trophoblastic tissue during pregnancy. It occurs in women of childbearing age, although a few cases have also been observed in post-menopausal women, although it is extremely rare in the latter. Here we describe a rare case of complete hydatidiform mole in a 56-year-old female patient who presented with genital bleeding combined with nausea and vomiting and a gravid uterus 16 cm in height. The ultrasound findings and the increase in serum β-HCG to 182566.00 mIU/ml suggested a diagnosis of complete hydatidiform mole. Given the post-menopausal state and the future risk of post-molar gestational trophoblastic neoplasia, we opted for total hysterectomy without preservation of the adnexa via a transabdominal approach, followed by antimitotic treatment with methotrexate. The uterus measured 18.45 cm × 11.18 cm with intra cavitary vesicles. Microscopic examination showed chorionic villi of variable size and shape, most of which were dilated and oedematous, associated with trophoblastic cell proliferation and haemorrhage suggestive of complete benign hydatidiform mole. Follow-up showed a consistent decrease in serum β-HCG levels and no evidence of residual disease. A suspicion of gestational trophoblastic disease should be borne in mind when evaluating a patient with peri- or post-menopausal bleeding to avoid delay in diagnosis and treatment.

关键词： Complete Hydatidiform Mole Menopause β-HCG Panzi Bukavu DRC

Macro-or microencapsulation of pig islets to cure type 1 diabetes

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World Journal of Gastroenterology 2012年第47期18卷 6885-6893页

作者： denis Dufrane Pierre Gianello Department of Health Sciences Institute for Experimental and ClinicalExperimental Surgery and TransplantationCatholic University of LouvainB-1200 BrusselsBelgium

Although allogeneic islet transplantation can successfully cure type 1 diabetes,it has limited *** example,organs are in short supply;several human pancreas donors are often needed to treat one diabetic recipient;the intrahepatic site may not be the most appropriate site for islet implantation;and immunosuppressive regimens,which are associated with side effects,are often required to prolong survival of the islet *** alternative source of insulinproducing cells would therefore be of major *** represent a possible alternative source of beta *** of pig islets may appear difficult because of the immunologic species barrier,but pig islets have been shown to function in primates for at least 6 mo with clinically incompatible ***,a bioartificial pancreas made of encapsulated pig islets may resolve issues associated with islet *** several groups have shown that encapsulated pig islets are functional in small-animal models,less is known about the use of bioartificial pancreases in large-animal *** this review,we summarize current knowledge of encapsulated pig islets,to determine obstacles to implantation in humans and possible solutions to overcome these obstacles.

关键词： Cell transplantation Diabetes mellitus type 1 Islets of Langerhans Porcine Xenografts

Statistical Estimation of the Shannon Entropy

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Acta Mathematica Sinica,English Series 2019年第1期35卷 17-46页

作者： Alexander BULINSKI denis DIMITROV Steklov Mathematical Institute of Russian Academy of Sciences and Department of Mathematics and Mechanics Lomonosov Moscow State UniversityMoscow 119234Russia

The behavior of the Kozachenko–Leonenko estimates for the(differential) Shannon entropy is studied when the number of i.i.d. vector-valued observations tends to infinity. The asymptotic unbiasedness and L^2-consistency of the estimates are established. The conditions employed involve the analogues of the Hardy–Littlewood maximal function. It is shown that the results are valid in particular for the entropy estimation of any nondegenerate Gaussian vector.

关键词： Shannon differential entropy Kozachenko-Leonenko estimates Hardy-Littlewood maxi-mal function analogues asymptotic unbiasedness and L^2-consistency Gaussian vectors

Action observation as a tool for neurorehabilitation to moderate motor deficits and aphasia following stroke

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Neural Regeneration Research 2012年第26期7卷 2063-2074页

作者： denis Ertelt Ferdinand Binkofski Center for Clinical Trials University of Luebeck University Hospital Schleswig-Holstein-Campus Luebeck Cognitive Neurology Department of NeurologyRWTH Aachen University Hospital

The mirror neuron system consists of a set of brain areas capable of matching action observation with action execution. One core feature of the mirror neuron system is the activation of motor areas by action observation alone. This unique capacity of the mirror neuron system to match action perception and action execution stimulated the idea that mirror neuron system plays a crucial role in the understanding of the content of observed actions and may participate in procedural learning. These features bear a high potential for neurorehabilitation of motor deficits and of aphasia following stroke. Since the first articles exploring this principle were published, a growing number of follow-up studies have been conducted in the last decade. Though, the combination of action observation with practice of the observed actions seems to constitute the most powerful approach. In the present review, we present the existing studies analyzing the effects of this neurorehabJlitative approach in clinical settings especially in the rehabilitation of stroke associated motor deficits and give a perspective on the ongoing trials by our research group. The data obtained up to date showed significant positive effect of action observation on recovery of motor functions of the upper limbs even in the chronic state after stroke, indicating that our approach might become a new standardized add-on feature of modern neurorehabilitative treatment schemes.

关键词： mirror neuron system motor system procedural learning stroke neurorehabilitation aphasia paresis motor deficits aphasic deficits stroke

Vespa velutina nest distribution at a local scale： An 8-year survey of the invasive honeybee predator

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Insect Science 2017年第4期24卷 663-674页

作者： Karine Monceau denis Thiery INRA UMR 1065 Sante et Agroecologie du Vignoble Bordeaux Sciences Agro ISVV F-33883 Villenave d'Omon Cedex France

Vespa velutina is an invasive species that was observed for the first time in France and Europe in 2004, which rapidly threatened domestic honeybees with active predation. For the first time in this study, we analyzed the distribution of V. velutina nests at a local scale to understand the pattern of nesting, and in 8 years of monitoring, a total of 528 nests were surveyed. With the exception of 2 years, the nests of V. velutina were randomly distributed within the monitored area, which suggested that intraspecific competition for nesting sites and/or food was unlikely. When the data for all years were combined, an aggregated distribution of nests at the seafront in the vicinity of the oyster farm and sportfishing activities was observed. This distribution suggested that seafood, attractive to vespids, might provide a valuable alternative food source that favored colony development. We also tested the effect of spring queen trapping of V. velutina on the distribution of nests in 2014, which was the year with the greatest number of colonies within the area; the position of the traps did not influence the distribution of the nests. For the first time, this study showed that （i） intraspecific competition was unlikely to be a mechanism for population regulation, （ii） some areas were more likely favored for hornet nests, and （iii） spring queen wasp trapping was inefficient as a method to limit the distribution of the V. velutina population.

关键词： intraspecific competition nesting habits spring queen trapping yellow-legged hornet

Turned Trochoidal Disturbance on a Liquid Jet Surface

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Chinese Journal of Mechanical Engineering 2014年第4期27卷 846-852页

作者： SADIK Shalom KIRZHNER Felix KRAMARENKO denis Department of Mechanical Engineering ORT Braude College Division of Environmental Water and Agricultural Engineering Faculty of Civil and Environmental EngineeringTechnion-IIT Haifa 32000 Israel Biotechnology Engineering ORT Braude College

This paper shows that a turned trochoidal function disturbance may lead to peripheral drops production. The resulting model is used to describe that a turned trochoidal disturbance leads to peripheral drops production on the liquid jet surface without the necessity for superimposed disturbances. The trochoid is a non-unique parametric function. Only non-unique parametric functions disturbances may lead to peripheral drops production. The trochoidal function disturbance is decomposed to Fourier series. Every Fourier element receives an amplification factor in accordance to the Rayleigh inviscid jet model. Peripheral drops are received on the jet surface. The paper shows that all trochoidal disturbance functions, prolate cycloid, cycloid and curtate cycloid have a capability of peripheral drops producing. A limited capability of peripheral drops production is introduced for the trochoidal curtate cycloid. Produced drops size are reduced for increasing the jet velocity and wave number. Smaller drops are also received by transition from the prolate cycloid to curtate cycloid disturbance.

关键词： drops liquid jet trochoidal function

The peculiar case of the “double-humped” super-luminous supernova SN 2006oz

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Research in Astronomy and Astrophysics 2013年第10期13卷 1202-1206页

作者： Rachid Ouyed denis Leahy Department of Physics and Astronomy University of Calgary 2500 University Drive NWCalgaryAlberta T2N 1N4 Canada

SN 2006oz is a super-luminous supernova with a mysterious bright precursor that has resisted explanation in standard ***,such a precursor has been predicted in the dual-shock quark nova model of super-luminous supernovae–the precursor is the supernova event while the main light curve of the super-luminous supernova is powered by the Quark-Nova（explosive transition of the neutron star to a quark star）.As the supernova is fading,the Quark-Nova re-energizes the supernova ejecta,producing a＂double-humped＂light *** show that the quark nova model successfully reproduces the observed light curve of SN 2006oz.

关键词： supernovae:general supernovae:individual(SN 2006oz