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Synaptic aging disrupts synaptic morphology and function in cerebellar Purkinje cells

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Neural Regeneration Research 2018年第6期13卷 1019-1025页

作者： Wen-Juan Fan Ming-Chao Yan Lai Wang Yi-Zheng Sun Jin-bo deng Jie-Xin deng Institute of Neurobiology School of Life Science Henan University

Synapses are key structures in neural networks,and are involved in learning and memory in the central nervous *** synaptogenesis and synaptic aging is important in understanding neural development and neural degeneration in diseases such as Alzheimer disease and Parkinson’s *** previous study found that synaptogenesis and synaptic maturation were harmonized with brain development and ***,synaptic damage and loss in the aging cerebellum are not well *** study was designed to investigate the occurrence of synaptic aging in the cerebellum by observing the ultrastructural changes of dendritic spines and synapses in cerebellar Purkinje cells of aging ***,Di I diolistic assays,and transmission electron microscopy were used to visualize the morphological characteristics of synaptic buttons,dendritic spines and synapses of Purkinje cells in mice at various *** synaptic aging in the cerebellum,dendritic spines and synaptic buttons were lost,and the synaptic ultrastructure was altered,including a reduction in the number of synaptic vesicles and mitochondria in presynaptic termini and smaller thin specialized zones in pre-and post-synaptic *** findings confirm that synaptic morphology and function is disrupted in aging synapses,which may be an important pathological cause of neurodegenerative diseases.

关键词： nerve regeneration aging cerebellum degenerative disease dendritic spine nerve regeneration mice neurodegenerative diseases Purkinje cells synapse synaptogenesis synaptic ultrastructure neural regeneration

Effect of fatigue load on the bending tribo-corrosion-fatigue behaviors between the main cable wires

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Friction 2024年第7期12卷 1512-1531页

作者： bo WANG Dagang WANG Jihong YE Liang TANG Hailang CHONG Wei XU Xinxin ZHANG Jianhao CHEN Haiyan deng Jie ZHANG Guowen YAO Magd Abdel WAHAB School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Xuzhou Key Laboratory for Fire Safety of Engineering Structures China University of Mining and TechnologyXuzhou 221116China National Wire Rope Quality Inspection Center Nantong Product Quality Supervision and Inspection InstituteNantong 226011China Jiangsu Langshan Wire Rope Co. Ltd.Nantong 226003China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityZwijnaarde B-9052Belgium

The main cable bent around the saddle of the suspension bridge is subjected to the wind,the vehicle,the bridge’s own weight and the corrosive *** coupling of the three loads and the environments causes the friction,the corrosion,and the fatigue(tribo-corrosion-fatigue)among the wires inside the main *** this paper,a wire bending tribo-corrosion-fatigue test rig was designed and *** effect of fatigue load on the bending friction behaviors between the cable wires in ultrapure water and 3.5%NaCl solution was *** tribological properties and electrochemical corrosion behaviors under different fatigue loading ranges were *** tribo-corrosion-fatigue interaction between the cable wires was quantitatively characterized,and the mechanism of the interaction was *** results demonstrate that the increasing fatigue load exacerbates the coupling damage of the cable wires attributed to the enhanced *** findings carry theoretical importance when assessing the main cable’s deterioration and the load-bearing safety of a suspension bridge.

关键词： bending tribo-corrosion-fatigue interaction parallel steel wires fatigue load

SIMULATION　CALCULATION　FOR　CHEMICAL　SPECIATION　OF　LEAD　BY　FEEDBACK　NEURAL　NETWORK

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Chinese Chemical Letters 1996年第3期7卷 265-266页

作者： Hua MO bo deng(Department of Chemistry, Tsinghua University, Beijing, 100084.) Department of Chemistry Tsinghua University Beijing 100084

The chemical speciations of Ph2+ in the aqueous solution can becalculated using a Feedback Neural Network. The effects of CO3(2-), random errorand temperature on the simulation results were discussed. The results show... 详细信息

关键词： LEAD OF SPECIATION FEEDBACK CALCULATION BY

High-density triple-phase contact points for enhanced photocatalytic CO_(2) reduction to methanol

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Chinese Chemical Letters 2024年第2期35卷 252-256页

作者： Hanwen Jian Kaiming deng Tongyu Wang Chengxi Huang Fang Wu Hailing Huo bo Ouyang Xuan Liu Jingjing Ma Erjun Kan Ang Li MIIT Key Laboratory of Semiconductor Microstructure and Quantum Sensing School of ScienceNanjing University of Science and TechnologyNanjing 210094China College of Information Science and Technology Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021China

The efficiency of photocatalytic CO_(2) reduction reaction(PCRR)is restricted by the low solubility and mobility of CO_(2) in water,poor CO_(2) adsorption capacity of catalyst,and competition with hydrogen evolution reaction(HER).Recently,hydrophobic modification of the catalyst surface has been proposed as a potential solution to induce the formation of triple-phase contact points(TPCPs)of CO_(2)(gas phase),H_(2) O(liquid phase),and catalysts(solid phase)near the surface of the catalyst,enabling direct delivery of highly concentrated CO_(2) molecules to the active reaction sites,resulting in higher CO_(2) and lower H+surface *** TPCPs thus act as the ideal reaction points with enhanced PCRR and suppressed ***,the initial synthesis of triple-phase photocatalysts tends to possess a lower bulk density of TPCPs due to the simple structure leading to limited active points and CO_(2) adsorption ***,based on constructing a hydrophobic hierarchical porous TiO_(2)(o-HPT)with interconnected macropores and mesopores structure,we have significantly increased the density of TPCPs in a unit volume of the *** with hydrophobic macroporous TiO_(2)(o-MacPT)or mesoporous TiO_(2)(o-MesPT),the o-HPT with increased TPCP density leads to enhanced photoactivity,enabling a high methanol production rate with 1111.5μmol g^(−1) h^(−1) from *** results emphasize the significance of high-density TPCPs design and propose a potential path for developing efficient PCRR systems.

关键词： Photocatalysis CO_(2)reduction reaction Photocatalyst Triple-phase contact points Methanol

Nanoscratching and mechanical behaviors of high-entropy alloys with different phase constituents

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Journal of Iron and Steel Research(International) 2019年第11期26卷 1240-1248页

作者： Jiang-li Ning Yun-li Feng Xu-dong Li Qi-bo deng Yong-jiang Huang College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina Tianjin Key Laboratory of Advanced Functional Porous Materials Institute for New Energy Materials and Low-Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina

High-entropy alloys(HEAs)exhibit unique microstructural features and properties in nanoscale and atomic scale because of their multi-element alloy *** nanoscratching behaviors of three HEAs with different phase constituents,relative to the microstructure and mechanical properties of the HEAs,were *** typical phase constituents were selected:face-centered cubic(FCC)structure,body-centered cubic(BCC)structure,and a dual-phase structure containing both FCC and BCC *** the fact that the FCC alloy has the highest ductility and strain hardening capability,it exhibited inferior scratch resistance due to the over-softening of *** to the brittle failure mode,the BCC alloy hardly exhibited desirable scratch resistance despite its highest *** contrast,the nanostructured dual-phase alloy exhibited the best scratch resistance because of its good combination of strength and ductility,as well as the ductile failure *** research suggests that the HEA with structure comprising nanoscale hard and soft phases is desirable for nanoscratch resistance,and possesses appropriate hardness for industrial applications.

关键词： High-entropy alloy Nanoscratch Mechanical property Microstructure-Failure mode

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城市轨道交通差异化票价和补贴优化

交通运输系统工程与信息 2022年第5期22卷 26-36页

作者：汪晴邓连波许景南京邮电大学现代邮政学院南京210003 中南大学交通运输工程学院长沙410075

为研究不同群体,即一般群体和特殊群体(老年人、残疾人、学生)的票价方案和补贴问题,本文考虑不同群体的差异性,以各群体的票价折扣率和列车开行间隔为决策变量,构建基于群体差异化的运营补贴优化模型,以社会福利最大化为目标,优化各群... 详细信息

为研究不同群体,即一般群体和特殊群体(老年人、残疾人、学生)的票价方案和补贴问题,本文考虑不同群体的差异性,以各群体的票价折扣率和列车开行间隔为决策变量,构建基于群体差异化的运营补贴优化模型,以社会福利最大化为目标,优化各群体的票价折扣率、企业的服务水平及政府的补贴额度,确保各群体获得合适的补贴,实现公共交通出行的公平性。综合考虑城市轨道交通运输能力约束、政府财政约束及不同群体票价折扣率约束,设计了基于模拟退火算法的求解算法。以长沙地铁2号线为例,分析比较不同群体的票价折扣率,提出基于列车运行计划的福利票价方案。研究结果表明,一般群体不享受折扣,残疾人4折优惠,老年人2折优惠及学生6折优惠,交通特殊群体的出行比分别提升了1.06%,2.86%及1.94%。政府在实施补贴政策时,可以通过不同群体的票价福利措施和企业的服务水平确定补贴额度。

关键词：城市交通票价折扣率模拟退火算法交通群体社会福利开行间隔

Age-specific differences in the association between prediabetes and cardiovascular diseases in China:A national cross-sectional study

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World Journal of Diabetes 2024年第2期15卷 240-250页

作者： Shuo Xie Li-Ping Yu Fei Chen Yao Wang Rui-Fen deng Xue-Lian Zhang bo Zhang Department of Endocrinology Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is *** is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among *** develop a focused screening plan and treatment for Chinese adults with prediabetes,it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on *** To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in *** The cross-sectional study involved a total of 46239 participants from June 2007 through May 2008.A thorough evaluation was *** with prediabetes were categorized into two groups based on *** atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 *** forest was established in both age *** Additive exPlanation method prioritized the importance of features from the perspective of assessment *** In total,6948 people were diagnosed with prediabetes in this *** prediabetes,prevalences of CVD were 5(0.29%)in the younger group and 148(2.85%)in the older ***,11.11%of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the Prediction for ASCVD Risk in China equation in ten *** the younger age group,the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle,whereas in the older age group,resident status was more closely *** The susceptibility to CVD is age-specific in newly diagnosed *** is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.

关键词： Age Cardiovascular diseases Prediabetes Risk factors Differences

Effect of Surface Mechanical Attrition Treatment on Corrosion Behavior of 316 Stainless Steel

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Journal of Iron and Steel Research(International) 2009年第2期16卷 68-72页

作者： HAO Yun-wei deng bo ZHONG Cheng JIANG Yi-ming LI Jin Department of Materials Science Fudan University Shanghai 200433 China

The nanocrystalline microstructure of the surface of 316 stainless steel （316SS） induced by surface mechanical attrition treatment （SMAT） was determined by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. The technique of hydrogen embrittlement was first used to obtain the information of the brittleness cleavage plane. The effects of SMAT and the following annealing process on the corrosion behavior of 316SS were investiga- ted by potentiodynamic polarization curves and potentiostatic critical pitting temperature measurements. The results demonstrated that the nanoerystalline layer with an average grain size of 19 nm was produced. However, there were lots of cracks on the surface, which led to the degradation in the corrosion resistance of 316SS after SMAT. Never- theless, after annealing treatment, the corrosion resistance of the nanocrystalline surface had been improved greatly. The higher the annealing temperature, the better was the corrosion resistance.

关键词： surface mechanical attrition treatment nanocrystalline corrosion heat treatment

Wnt gene expression in adult porcine longissimus dorsi and its association with muscle fiber type,energy metabolism,and meat quality

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Journal of Integrative Agriculture 2017年第1期16卷 144-150页

作者： MEN Xiao-ming deng bo TAO Xin QI Ke-ke XU Zi-wei Institute of Animal Husbandry and Veterinary Science Zhejiang Academy of Agricultural Science Hangzhou 310021 P.R. China

This study investigated the expression profiles of Writ genes in adult porcine Iongissimus dorsi （LD） from different porcine genotypes and their associations with meat quality. The results showed that Wnt5a gene expression level was the highest in Jinhua （JHP） pigs, followed by Zhongbai （ZBP）, DurocxZhongbai （DZB）, and Duroc×Yorkshire×Landrace （DYL） pigs, with significant differences between ZBP, DZB, and DYL （P〈0.05）. This genotypic order was reversed for Wnt7a, Wnt10b, and Wnt11 expression, with JHP and DYL having the lowest and highest expressive levels, respectively. Wnt5a expression was negatively correlated with pH,5 min and ApH （P〈0.01）, some glycolytic markers （P〈0.05）, and positively correlated with meat color （a＊）, shear force （SF） value （P〈0.05）, myosion heavy chain （MyHC） I mRNA proportion （P〈0.01）, turnover ratio of creatine phosphate （CP）, and creatine kinase （CK） activity （P〈0.05）. Opposite correlations were observed for Writ2, Wnt7a, Wnt10b, and Wnt11. These results revealed that Wnt5a, Wnt7a, Wnt10b, and Wnt11 gene expressions in adult porcine muscle contributed to differences between porcine genotypes and affected pork quality. Wnt5a gene expression could be beneficial for the formation of high quality pork by regulating muscle fiber types and postmortem energy metabolism.

关键词： pigs meat quality Wnt genes muscle-fiber type energy metabolism