Synaptic aging disrupts synaptic morphology and function in cerebellar Purkinje cells

作     者：Wen-Juan Fan Ming-Chao Yan Lai Wang Yi-Zheng Sun Jin-Bo Deng Jie-Xin Deng 

作者机构：Institute of Neurobiology School of Life Science Henan University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第6期

页      面：1019-1025页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by the Science and Technology Projects of Henan Province of China,No.172102310001 the Biology Advantage Discipline Fund of Henan Province of China 

主　　题：nerve regeneration aging cerebellum degenerative disease dendritic spine nerve regeneration mice neurodegenerative diseases Purkinje cells synapse synaptogenesis synaptic ultrastructure neural regeneration 

摘      要：Synapses are key structures in neural networks,and are involved in learning and memory in the central nervous *** synaptogenesis and synaptic aging is important in understanding neural development and neural degeneration in diseases such as Alzheimer disease and Parkinson’s *** previous study found that synaptogenesis and synaptic maturation were harmonized with brain development and ***,synaptic damage and loss in the aging cerebellum are not well *** study was designed to investigate the occurrence of synaptic aging in the cerebellum by observing the ultrastructural changes of dendritic spines and synapses in cerebellar Purkinje cells of aging ***,Di I diolistic assays,and transmission electron microscopy were used to visualize the morphological characteristics of synaptic buttons,dendritic spines and synapses of Purkinje cells in mice at various *** synaptic aging in the cerebellum,dendritic spines and synaptic buttons were lost,and the synaptic ultrastructure was altered,including a reduction in the number of synaptic vesicles and mitochondria in presynaptic termini and smaller thin specialized zones in pre-and post-synaptic *** findings confirm that synaptic morphology and function is disrupted in aging synapses,which may be an important pathological cause of neurodegenerative diseases.