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Splenic injuries secondary to colonoscopy:Rare but serious complication

World Journal of Gastrointestinal Surgery 2020年第2期12卷 55-67页

作者： Waqas Ullah Mamoon Ur Rashid Asif Mehmood Yousaf Zafar Ishtiaq Hussain deepika sarvepalli Muhammad Khalid Hasan Department of Internal Medicine Abington HospitalAbingtonPA 19001United States Department of Internal Medicine Advent Health HospitalOrlandoFL 32804United States Department of Internal Medicine Geisinger Medical CenterDanvillePA 17822United States Department of Internal Medicine UMKC5100 Rockhill RdKansas CityMO 64110United States Department of Gastroenterology Cleveland ClinicWestonFL 33331United States Department of Gastroenterology Advent Health HospitalOrlandoFL 32804United States

BACKGROUND Colonoscopy is a safe and routine diagnostic and therapeutic procedure for evaluation of large bowel *** common procedure related complications include bleeding and perforation but rarely a splenic *** To investigate the reason for colonoscopy,presentation of patient with spleen injury,types of injury,diagnosis,management and outcomes of patients METHODS A structured search on four databases was done and 45 articles with 68 patients were *** reason for colonoscopy,presentation of patient with spleen injury,types of injury,diagnosis,management and outcomes of patients were identified and analyzed using *** The mean age of the patients was 62.7 years with 64%*** two percent had a complete splenic rupture with colonoscopy while 63%had subcapsular hematoma,spleen laceration and spleen *** most common reason for colonoscopy was screening(46%)followed by diagnostic colonoscopy(28%).Eighty seven percent of patients presented with abdominal *** with spleen rupture mostly required splenectomy(47%),while minor spleen hematomas and lacerations were managed conservatively(38%).Six percent of the patients were managed with proximal splenic artery splenic embolization and 4%were managed with laparoscopic *** overall mortality was 10%while 77%had complete *** reason of colonoscopy against presentation specifically,abdominal pain showed no statistical significance P=*** indication of colonoscopy had no significant impact on incidence of splenic injury(P=0.89).Majority of the patients(47%)were managed with splenectomy while the rest were managed conservatively(P=0.04).This association was moderately strong at a cramer’s V test(0.34).The Fisher exact test showed a higher mortality with spleen rupture(P=0.028).CONCLUSION Spleen rupture due to colonoscopy is a significant concern and is associated with high *** management of the patients can be individualized based on clinical pre

关键词： Colonoscopy Spleen Splenic rupture Systematic review Splenic injuries

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Alcohol associated liver disease and bariatric surgery:Current perspectives and future directions

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 650-657页

作者： Katherine M Cooper Alessandro Colletta Nicholas Hebda deepika Devuni Department of Medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Bariatric surgery is a routinely performed procedure and is associated with a reduction in all-cause mortality in patients with ***,bariatric sur-gery has also been linked to increased alcohol use with up to 30%of these patients developing alcohol use disorder(AUD).The mechanism of AUD after bariatric surgery is multifactorial and includes anatomic,metabolic,and neurohumoral changes associated with post-surgical *** patients are at increased risk of alcohol associated liver disease and,in some cases,require liver *** this article,we provide a scoping review of epidemiology,patho-physiology,and clinical outcomes of alcohol-related health conditions after bariatric surgery.

关键词： Obesity medicine Alcohol use disorder Roux-en-Y gastric bypass Vertical sleeve gastrectomy Liver transplant Simultaneous liver transplant and bariatric surgery

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A hierarchical clustering approach for colorectal cancer molecular subtypes identification from gene expression data

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Intelligent Medicine 2024年第1期4卷 43-51页

作者： Shivangi Raghav Aastha Suri deepika Kumar Aakansha Aakansha Muskan Rathore Sudipta Roy Department of Computer Science&Engineering Bharati Vidyapeeth’s College of EngineeringNew DelhiIndia Artificial Intelligence&Data Science Jio InstituteNavi Mumbai410206India

Background Colorectal cancer(CRC)is the second leading cause of cancer fatalities and the third most common human *** molecular subgroups of CRC and treating patients accordingly could result in better therapeutic success compared with treating all CRC patients *** have highlighted the significance of CRC as a major cause of mortality worldwide and the potential benefits of identifying molecular subtypes to tailor treatment strategies and improve patient *** This study proposed an unsupervised learning approach using hierarchical clustering and feature selection to identify molecular subtypes and compares its performance with that of conventional *** proposed model contained gene expression data from CRC patients obtained from Kaggle and used dimension reduction techniques followed by Z-score-based outlier *** hierarchy clustering was used to identify molecular subtypes,with a P-value-based approach for feature *** performance of the model was evaluated using various classifiers including multilayer perceptron(MLP).Results The proposed methodology outperformed conventional methods,with the MLP classifier achieving the highest accuracy of 89%after feature *** model successfully identified molecular subtypes of CRC and differentiated between different subtypes based on their gene expression *** This method could aid in developing tailored therapeutic strategies for CRC patients,although there is a need for further validation and evaluation of its clinical significance.

关键词： Machine learning Colorectal cancer Feature selection Classification Clustering

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A Case Report of Pulmonary Alveolar Proteinosis with Associated Opportunistic Infection of Pneumocystis jirovecii and Molluscum Contagiosum

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Journal of Forensic Science and Medicine 2024年第1期10卷 68-71页

作者： Sapna Patel deepika Gurumurthy Smitha Rani Sheela Devi Department of Pathology JSSAHERMysoreKarnatakaIndia2Department of Forensic MedicineJSSAHERMysoreKarnatakaIndia

Pulmonary alveolar proteinosis(PAP)is an idiopathic rare diffuse pulmonary disease,first described in 1958 by Rosen et *** estimated prevalence is about 1 in 3.7-6.9×10^(6) with a male:female ratio of 1:1-2:*** of the patient’s age ranges between 20 and 50 *** on microscopy is characterized by the presence of massive insoluble,amorphous,phospholipid-rich protein deposits in the bronchial and alveolar *** patients with acquired PAP present with cough and exertional *** has been studied that there is increased risk of superinfection in PAP with opportunistic organisms like pneumocystis and vice *** diagnosis of Pneumocystis jirovecii pneumonia rests on the demonstration of the organism within the alveoli by special stains like Grocott Methenamine Silver *** contagiosum(MC)is a common superficial skin infection caused by the *** is characterized by painless papules commonly seen in children and immunocompromised ***,we present a 34-year-old female who had complaints of severe difficulty in breathing and was brought dead to our *** external examination,she had multiple warts over chest,abdomen,and over *** examination was *** of kidney,lung,and skin biopsy of genital warts sent for histopathological examination revealed acute tubular necrosis,*** with PAP,and MC respectively.

关键词： Bronchoalveolar lavage molluscum contagiosum Pneumocystis jirovecii pulmonary alveolar proteinosis

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Characterization of tumors of jaw:Additive value of contrast enhancement and dual-energy computed tomography

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World Journal of Radiology 2024年第4期16卷 82-93页

作者： Deepak Justine Viswanathan Ashu Seith Bhalla Smita Manchanda Ajoy Roychoudhury deepika Mishra Asit Ranjan Mridha Department of Radiodiagnosis and Interventional Radiology All India Institute of Medical SciencesNew Delhi 110029India Department of Oral and Maxillofacial Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Oral Pathology and Microbiology All India Institute of Medical SciencesNew Delhi 110029India Department of Pathology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

BACKGROUND Currently,the differentiation of jaw tumors is mainly based on the lesion’s morphology rather than the enhancement characteristics,which are important in the differentiation of neoplasms across the *** is a paucity of literature on the enhancement characteristics of jaw *** is mainly because,even though computed tomography(CT)is used to evaluate these lesions,they are often imaged without intravenous *** study hypothesised that the enhancement characteristics of the solid component of jaw tumors can aid in the differentiation of these lesions in addition to their morphology by dual-energy CT,therefore improving the ability to differentiate between various *** To evaluate the role of contrast enhancement and dual-energy quantitative parameters in CT in the differentiation of jaw *** Fifty-seven patients with jaw tumors underwent contrast-enhanced dual-energy *** analysis of the tumor,including the enhancing solid component,was done,followed by quantitative analysis of iodine concentration(IC),water concentration(WC),HU,and normalized *** study population was divided into four subgroups based on histopathological analysis-central giant cell granuloma(CGCG),ameloblastoma,odontogenic keratocyst(OKC),and other jaw tumors.A one-way ANOVA test for parametric variables and the Kruskal-Wallis test for nonparametric variables were *** significant differences were found,a series of independent t-tests or Mann-Whitney U tests were *** Ameloblastoma was the most common pathology(n=20),followed by CGCG(n=11)and *** showed a higher mean concentration of all quantitative parameters than ameloblastomas(P<0.05).An IC threshold of 31.35×100μg/cm^(3) had the maximum sensitivity(81.8%)and specificity(65%).Between ameloblastomas and OKC,the former showed a higher mean concentration of all quantitative parameters(P<0.001),however when comparing unilocular ameloblastomas with OKCs,the latter showed

关键词： Jaw neoplasms Ameloblastomas Dual-energy computed tomography Iodine quantification Mandibular neoplasms Maxillary neoplasms

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Diversity and species composition of microbiota associated with dengue mosquito breeding habitats:A cross-sectional study from selected areas in Udapalatha MOH division,Sri Lanka

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Asian Pacific Journal of Tropical Medicine 2023年第8期16卷 363-370页

作者： Yashoda Kumari deepika Amarasinghe Koshila Ranasinghe Department of Zoology and Environmental Management Faculty of ScienceUniversity of KelaniyaDalugamaKelaniya GQ 11600Sri Lanka

Objective:To determine the diversity of microbiota associated with different breeding habitats of dengue vector mosquitoes Aedes(Ae.)aegypti and *** and to identify any parasitic,epibiont,pathogenic,competitive or predatory ***:Sampling was performed from a variety of breeding habitats using dipping,pipetting and siphoning *** in water samples were preserved using Rose Bengal solution and Lugol's iodine,and were *** samples of microbiota were kept under laboratory conditions to observe any pathogenic or parasitic microbiota interacting with ***:A total of eleven microbiota species(Canthocamptus staphylinus,Canthocamptus microstaphylinus,Parastenocaris brevipes,Lepadella ovalis,Lepadella patella,Rotatoria rotatoria,Rotatoria macrura,Asplanchna brightwelli,Trichocerca rattus,Euglena variabilis,and Flagilaria capucina)belonging to four(4)phyla(Arthropoda,Rotifera,Euglenozoa,and Ochrophyta)and 8 microbiota species belonged to four phyla(Arthropoda,Rotifera,Euglenozoa,and Ochrophyta)were identified from *** and *** breeding habitats *** was a higher percentage(54.54%)of larval habitats positive for the secondary vector *** than through the primary vector *** in the Gampola urban area indicating higher possibility of transmitting the dengue virus through the secondary ***,no pathogenic or parasitic ciliates on mosquito larvae were encountered in the present *** findings may be due to sampling maingly from temporary container-type breeding ***:The relative distribution of microbiota associated with mosquito species differed significantly among *** and *** overall findings of this study could help in implementing novel eco-friendly vector-control strategies in the study area.

关键词： Aedes Biological Mosquito-control Vectors

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Remote Sensing Image Retrieval Based on 3D-Local Ternary Pattern(LTP)Features and Non-subsampled Shearlet Transform(NSST)Domain Statistical Features

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 137-164页

作者： Hilly Gohain Baruah Vijay Kumar Nath deepika Hazarika Department of Electronics and Communication Engineering Tezpur UniversityAssam784028India

With the increasing popularity of high-resolution remote sensing images,the remote sensing image retrieval(RSIR)has always been a topic of major issue.A combined,global non-subsampled shearlet transform(NSST)-domain statistical features(NSSTds)and local three dimensional local ternary pattern(3D-LTP)features,is proposed for high-resolution remote sensing *** model the NSST image coefficients of detail subbands using 2-state laplacian mixture(LM)distribution and its three parameters are estimated using Expectation-Maximization(EM)*** also calculate the statistical parameters such as subband kurtosis and skewness from detail subbands along with mean and standard deviation calculated from approximation subband,and concatenate all of them with the 2-state LM parameters to describe the global features of the *** various properties of NSST such as multiscale,localization and flexible directional sensitivity make it a suitable choice to provide an effective approximation of an *** order to extract the dense local features,a new 3D-LTP is proposed where dimension reduction is performed via selection of‘uniform’*** 3D-LTP is calculated from spatial RGB planes of the input *** proposed inter-channel 3D-LTP not only exploits the local texture information but the color information is captured ***,a fused feature representation(NSSTds-3DLTP)is proposed using new global(NSSTds)and local(3D-LTP)features to enhance the discriminativeness of *** retrieval performance of proposed NSSTds-3DLTP features are tested on three challenging remote sensing image datasets such as WHU-RS19,Aerial Image Dataset(AID)and PatternNet in terms of mean average precision(MAP),average normalized modified retrieval rank(ANMRR)and precision-recall(P-R)*** experimental results are encouraging and the NSSTds-3DLTP features leads to superior retrieval performance compared to many well known existing descriptors such as Gabor RGB,Granulometry,loc

关键词： Remote sensing image retrieval laplacian mixture model local ternary pattern statistical modeling,KS test,texture,global features

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Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1186-1195页

作者： Na Wang deepika Singh Qiong Wu Department of Ophthalmology Shaanxi Eye HospitalXi’an People’s Hospital(Xi’an Fourth Hospital)Affiliated People’s Hospital of Northwest UniversityXi’an 710004Shaanxi ProvinceChina Department of Pharmaceutical Sciences Sam Higginbottom University of AgricultureTechnology and SciencesPrayagraj 211007India

AIM:To investigate the aldose reductase(AR)inhibition capacity of astragalin(AST)against streptozoticin-induced diabetic cataracts(DCs)in ***:Ex vivo investigations were conducted by treating the lens of a goat placed for 72h in artificial aqueous humor(AAH)of pH 7.8 at room temperature with cataract-causing substance(55 mmol/L of galactose)and in vivo studies were performed on rats via induction with *** was administered at different dose levels and scrutinize for DC ***:In diabetic rats,AST improved the body weight,blood insulin,and glucose as well as the levels of galactitol in a dose-dependent way,other biochemical parameters *** mediators and cytokines,and also suppress AR *** level of the antioxidant parameters such as superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)activity were also altered on a diabetic lens after the administration of the ***:AST protects against lens opacification to avoid cataracts and polyols formation,indicating that it could be used as a potential therapeutic agent for diabetes.

关键词： astragalin diabetic cataract lens opacification aldose reductase rats

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Spatio-temporal variation of trace elements distributed over surface water of Upper Ganga River Basin in Western Himalayan Region

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Journal of Mountain Science 2023年第1期20卷 145-162页

作者： deepika DIMRI Ambika KUMAR DeepakKumar MISHRA Archana SHARMA Doon University Dehradun248012India Bhagalpur National College Bhagalpur812007India

The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream *** metals flowed with river water can lead to serious impact on ecological system and human ***,the documentation on trace elements of Himalayan rivers is inadequately *** current study deals with the spatial and temporal variability of the major and trace elements of Ganga river water in epirhithron,metarhithron and hyporhithron zone belonging to Himalayan *** samples from nineteen monitoring locations were collected in pre-monsoon(May-June),monsoon(AugustSeptember)and post-monsoon(December)seasons and subjected to be assessed for 20 elements(Ag,Al,Ba,Cd,Ca,Cr,Cu,Fe,Ga,K,Mn,Mg,Na,Ni,Pb,Sr,Th,U,Zn,and Zr)using ICP-OES(Inductively Coupled Plasma-Optical Emission Spectrometer).Different water pollution indexes such as HPI(Heavy Metal Pollution Index),MI(Metal Index)and PI(Pollution Index)were used to describe current water quality status at each monitoring station under particular classified ecological *** studied stations in hyporhithron zone had the value of Metal Index(MI>1),indicating threshold of ***,the highest values of HPI in hyporhithron zone correspond to poor water quality *** with poor water quality were also found to be contaminated as per the Pollution Index(PI),exhibiting high concentrations for element(Fe).However,the epirhithron and metarhithron zone in Himalayan segment showed excellent water quality mainly contributed from natural *** Analysis(CA)and Principal Component Analysis(PCA)were applied to identify the main influential sources for Ganga river water *** Kriging interpolation method was also applied to prepare spatial distribution map of computed indexes(HPI,MI,and PI).With the help of index of local Moran’s I(LMI),identified spatial clusters and spatial outliers revealed the elevated concentration of most elements in hyporhithr

关键词： Trace elements Spatial variation Temporal variation Surface water Ganga River Basin ICP-OES

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Recent updates on the biological basis of heterogeneity in bone marrow stromal cells/ skeletal stem cells

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Biomaterials Translational 2022年第1期3卷 3-16页

作者： deepika Arora Pamela Gehron Robey National Institute of Dental and Craniofacial Research National Institutes of HealthDepartment of Health and Human ServicesBethesdaMDUSA Biosystems and Biomaterials Division National Institute of Standards and TechnologyDepartment of CommerceGaithersburgMDUSA Department of Biotechnology School of Biological Engineering&Life SciencesShobhit Institute of Engineering&Technology(Deemed-to-be-University)MeerutIndia

Based on studies over the last several decades,the self-renewing skeletal lineages derived from bone marrow stroma could be an ideal source for skeletal tissue ***,the markers for osteogenic precursors;i.e.,bone marrow-derived skeletal stem cells(SSCs),in association with other cells of the marrow stroma(bone marrow stromal cells,BMSCs)and their heterogeneous nature both in vivo and in vitro remain to be *** review aims to highlight:i)the importance of distinguishing BMSCs/SSCs from other“mesenchymal stem/stromal cells”,and ii)factors that are responsible for their heterogeneity,and how these factors impact on the differentiation potential of SSCs towards *** prospective role of SSC enrichment,their expansion and its impact on SSC phenotype is *** has also been given to emerging single cell RNA sequencing approaches in scrutinizing the unique population of SSCs within the BMSC population,along with their committed *** the factors involved in heterogeneity may help researchers to improvise their strategies to isolate,characterize and adopt best culture practices and source identification to develop standard operating protocols for developing reproducible stem cells ***,more scientific understanding of the molecular basis of heterogeneity is warranted that may be obtained from the robust high-throughput functional transcriptomics of single cells or clonal populations.

关键词： bone marrow stromal cells clonal analysis heterogeneity single cell analysis skeletal stem cells

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