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Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions

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International Journal of Oral Science 2013年第3期5卷 130-140页

作者： Carol L Fischer Katherine S Walters David R Drake deborah v dawson Derek R Blanchette Kim A Brogden Philip W Wertz Dows Institute for Dental Research College of Dentistry The University of Iowa Central Microscopy Research Facility College of Dentistry The University of Iowa Department of Endodontics College of Dentistry The University of Iowa Department of Pediatric Dentistry College of Dentistry The University of Iowa Department of Periodontics College of Dentistry The University of Iowa Department of Oral Pathology Radiology & Medicine College of Dentistry The University of Iowa

Oral mucosal and salivary lipids exhibit potent antimicrobial activity for a variety of Gram-positive and Gram-negative bacteria;however,little is known about their spectrum of antimicrobial activity or mechanisms of action against oral *** this study,we examine the activity of two fatty acids and three sphingoid bases against Porphyromonas gingivalis,an important colonizer of the oral cavity implicated in *** inhibitory concentrations,minimal bactericidal concentrations,and kill kinetics revealed variable,but potent,activity of oral mucosal and salivary lipids against ***,indicating that lipid structure may be an important determinant in lipid mechanisms of activity against bacteria,although specific components of bacterial membranes are also likely *** micrographs showed ultrastructural damage induced by sapienic acid and phytosphingosine and confirmed disruption of the bacterial plasma *** information,coupled with the association of treatment lipids with *** lipids revealed via thin layer chromatography,suggests that the plasma membrane is a likely target of lipid antibacterial *** a combination of two-dimensional in-gel electrophoresis and Western blot followed by mass spectroscopy and N-terminus degradation sequencing we also show that treatment with sapienic acid induces upregulation of a set of proteins comprising a unique *** stress response,including proteins important in fatty acid biosynthesis,metabolism and energy production,protein processing,cell adhesion and *** or therapeutic lipid treatments may be beneficial for intervention of infection by supplementing the natural immune function of endogenous lipids on mucosal surfaces.

关键词： antimicrobial lipid fatty acid Porphyromonasgingivalis sphingoid base sphingolipid ultrastructure

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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(vEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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Effects of pyrethroid and organophosphate insecticides on reared black soldier fly larvae(Hermetia illucens)

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Insect Science 2024年第3期31卷 817-834页

作者： Nathan Meijer Lisa Zoet Theo de Rijk Paul Zomer deborah Rjkers H.J.van der Fels-Klerx Joop J.A.van Loon Wageningen Food Safety Research(WFSR) Part of Wageningen University and ResearchWageningenThe Netherlands Bestico B.v. Industrieweg 6Berkel en RodenrjsThe Netherlands Plant Sciences Group Laboratory of EntomologyWageningen UniversityWageningenTheNetherlands

Black soldier fly larvae(Hermetia illucens)receive growing interest as a potential alternative animal feed *** insects may be exposed to insecticide residues in the rearing *** study aimed to investigate the effects of six different pyrethroid and organophosphate insecticides on this insect species'*** toxicity of two"model"substances for each of these classes(cypermethrin;pirimiphosmethyl)was quantified,with and without the synergist piperonyl butoxide(PBO).Critical effect doses corresponding to 10%yield(CED10)for cypermethrin(0.4 mg/kg)and pirimiphos-methyl(4.8 mg/kg)were *** addition of PBO to cypermethrin enhanced its relative potency with a factor *** data were compared against the relative toxicity of two analogue substances in each class(permethrin,deltamethrin;chlorpyrifosmethyl,malathion).Results suggest that exposure to concentrations complying with legal limits can cause significant reductions in *** to multiple substances at lower concentrations resulted in negative additive and synergistic *** the tested substances,deltamethrin was most toxic,causing 94%yield at 0.5 mg/*** results suggested that transfer of tested substances to the larval biomass was substance-and concentration-specific,but appeared to be correlated to reduced yields and the presence of *** of organophosphates was overall low(very low limits in insect biomass(~0.01 mg/kg),high transfer may result in *** is recommended that rearing companies implement lower contractual thresholds,and that policymakers consider adjusting legally allowed maximum residue levels in insect feed.

关键词： feed insects pesticides rearing substrate

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A randomized,fellow eye,comparison of keratometry,aberrometry,tear film,axial length and the anterior chamber depth after eye rubbing in non-keratoconic eyes

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Eye and vision 2017年第1期4卷 106-113页

作者： Jordan v.Chervenkoff Elizabeth Hawkes Gabriela Ortiz deborah Horney Mayank A.Nanavaty Sussex Eye Hospital Brighton&Sussex University Hospitals NHS TrustEastern RoadBrighton BN25BFUK

Background:To investigate the effect of eye rubbing on keratometry(K),aberrometry,tear film break-up-time(TFBUT)and anterior chamber depth(ACD).Methods:volunteers without any corneal pathology or dry eyes were randomised to rubbing in one eye and the fellow-eye was *** rubbing was performed for 2 *** outcomes studied were anterior and posterior K *** outcomes were changes in TFBUT,axial length(AL)&ACD,K changes in various zones,asphericity and *** and post rubbing K,aberrometry,ACD and TFBUT were assessed in a predetermined *** relationship of the above parameters to axial length(AL)was also *** was analysed using vector ***:Pre versus post rubbing,anterior flatter K further flattened(42.51±1.52 D vs.42.36±1.53 D,p=0.003)and the changes to J0 vector in central cornea(−0.16±0.26 D vs.-0.27±0.33 D,p=0.038)suggested change to against-the-rule(ATR)*** was significant change in Z^(+2)_(2) polynomial following *** found a positive correlation between axial length and change in posterior K(r=0.335,p=0.020).The TFBUT reduced following eye rubbing(15.3 s vs.13.9 s,p=0.0001).There was a positive correlation between AL and increase in ACD post rubbing(r=0.300,p=0.038).There was a positive correlation between ACD and change in mean posterior K(r=0.305,p=0.035).Conclusions:In healthy eyes,following eye rubbing,there is a significant change in TFBUT and central anterior K changes towards ATR *** eyes had more changes in posterior K and ***,eyes with deeper ACD showed more steepness of posterior K.

关键词： Eye rubbing Ectasia Tear film break up time Astigmatism Aberrations

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Direct LED writing of submicron resist patterns： Towards the fabrication of individually-addressable InGaN sub-micron stripe-shaped LED arrays

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Nano Research 2014年第12期7卷 1849-1860页

作者： Zheng Gong Benoit Guilhabert Zhitao Chen Martin D. dawson Institute of Photonics University of Strathclyde Wolfson Centre 106 Rottenrow Glasgow G40NW UK Guangdong General Research Institute for Industrial Technology 363 Changxin Road Tianhe District Guangzhou 510650 China

Submicron stripe-shaped InGaN light-emitting diode （LED） arrays with individually addressable capabilities are demonstrated. The critical submicron- stripe metallic electrodes, which define the emission pattern, are formed by direct LED writing in a mask-free manner. The individually addressable submicron-stripe LEDs show excellent performance in terms of their electrical characteristics （with typical turn-on voltage of 3 v, operational stability and power output up to 28 ~W at 3 mA）. Unlike conventional broad-sized LEDs, the efficiency droop of the submicron-stripe LED is significantly suppressed--in fact, there is no efficiency droop for current densities up to 100 A/cm^2. Furthermore, the submicron-stripe LED shows a lower temperature-dependent shift of the emission wavelength. The lateral emission width is increased with increasing injection current, resulting in a wider lateral emission size than the metallic submicron-stripe electrode. The underlying physics of these phenomena are analysed. Such submicron-stripe LED arrays open up promising applications in nanophotonics and bio-sensing.

关键词： direct writing light-emitting diodes electroluminescence efficiency droop mask-free lithography

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The incorporation of emotion-regulation skills into couple-and family-based treatments for post-traumatic stress disorder

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Military Medical Research 2017年第4期4卷 218-228页

作者： deborah A.Perlick Frederic J.Sautter Julia J.Becker-Cretu Danielle Schultz Savannah C.Grier Alexander v.Libin Manon Maitland Schladen Shirley M.Glynn JJPeters Department of veterans Affairs Medical Center and vISN2 South Mental Illness Research Education and Clinical Center130 West Kingsbridge RdBronxNY 10468USA Department of Psychiatry Icahn School of Medicine at Mount Sinai1 Gustave L.Levy PINew YorkNY 10029USA Southeast Louisiana veterans Health Care System 1601 Perdido StNew OrleansLA 70112USA Tulane University School of Medicine 1430 Tulane AveNew OrleansLA 70112USA Research and Development Washington DC VA Medical Center50 Irving St NWWashingtonDC 20422USA. Georgetown University Medical Center 3800 Reservoir Rd NWWashingtonDC 20007USA vA Greater Los Angeles Healthcare System 11301 Wilshire BlvdLos AngelesCA 90073USA David Geffen School of Medicine UCLA10833 LeConte Ave#12138Los AngelesCA 90095USA

Post-traumatic stress disorder(PTSD) is a disabling, potentially chronic disorder that is characterized by re-experience and hyperarousal symptoms as well as the avoidance of trauma-related stimuli. The distress experienced by many veterans of the vietnam War and their partners prompted a strong interest in developing conjoint interventions that could both alleviate the core symptoms of PTSD and strengthen family bonds. We review the evolution of and evidence base for conjoint PTSD treatments from the vietnam era through the post-911 era. Our review is particularly focused on the use of treatment strategies that are designed to address the emotions that are generated by the core symptoms of the disorder to reduce their adverse impact on veterans, their partners and the relationship. We present a rationale and evidence to support the direct incorporation of emotion-regulation skills training into conjoint interventions for PTSD. We begin by reviewing emerging evidence suggesting that high levels of emotion dysregulation are characteristic of and predict the severity of both PTSD symptoms and the level of interpersonal/marital difficulties reported by veterans with PTSD and their family members. In doing so, we present a compelling rationale for the inclusion of formal skills training in emotional regulation in couple–/family-based PTSD treatments. We further argue that increased exposure to trauma-related memories and emotions in treatments based on learning theory requires veterans and their partners to learn to manage the uncomfortable emotions that they previously avoided. Conjoint treatments that were developed in the last 30 years all acknowledge the importance of emotions in PTSD but vary widely in their relative emphasis on helping participants to acquire strategies to modulate them compared to other therapeutic tasks such as learning about the disorder or disclosing the trauma to a loved one. We conclude our review by describing two recent innovative treatmen

关键词： couples family post-traumatic stress disorder emotional regulation

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COURT ***

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The World of Chinese 2015年第4期 34-35页

作者： DAvID dawson

In August of 201 1,one of the country’s most influential bodies,the Commission for Political and Legal Affairs of the Communist Party of China,named and shamed 13 judicial officials in what was the third round of cor... 详细信息

关键词： COURT v.GOvERNMENT

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The Yin and Yang of the protein corona on the delivery journey of nanoparticles

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Nano Research 2023年第1期16卷 715-734页

作者： Yi-Feng Wang Yaxin Zhou JiaBei Sun Xiaotong Wang Yaru Jia Kun Ge Yan Yan Kenneth A.dawson Shutao Guo Jinchao Zhang Xing-Jie Liang Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapythe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Chinese Academy of Sciences(CAS)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China China National Institute of Food and Drug Control Beijing 100061China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding 071002China Centre for BioNano Interactions School of ChemistrySchool of Biomolecular and Biomedical ScienceUniversity College DublinDublin D04V1W8Ireland

Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled ***,tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in *** challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological ***,once the nanoparticles are injected into the blood,a protein corona will inevitably form on the *** protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate ***,it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery *** this review,we first summarize the fundamental impact of the protein corona on the delivery journey of ***,we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in ***,we highlight what we need to do as a next step towards better understanding and exploitation of the protein *** hope these insights into the“Yin and Yang”effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles.

关键词： protein corona nanoparticles biological identity drug delivery bio-nano interaction

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SuperSAGE digital expression analysis of differential growth rate in a European sea bass population

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Aquaculture and Fisheries 2019年第1期4卷 17-26页

作者： Bruno Louro Rute S.T.Martins Patricia I.S.Pinto Richard Reinhardt Dirk-Jan de Koning Adelino v.M.Canario deborah M.Power CCMAR-Centre of Marine Sciences University of AlgarveCampus de GambelasFaro 8005-139Portugal Max Planck Genome Centre Carl-von-Linne-Weg 10Köln 50829Germany The Roslin Institute and R(D)SvS University of EdinburghEaster BushMidlothian EH259RGScotland UK Department of Animal Breeding and Genetics Swedish University of Agricultural SciencesBox 7023Uppsala 75007Sweden

One of the goals of the aquaculture industry is to understand and control growth associated traits through selective *** the present study the molecular basis of growth heterogeneity in the European sea bass(Dicentrarchus labrax)was *** establish growth heterogeneity in a group of hatchery bred sea bass individuals were tagged and their specific growth rates(SGR)determined at monthly *** expression in the brain,liver and white muscle from fish with the most divergent sustained SGR(6 individuals of the first and last quartile)was assessed using SuperSAGE(Serial Analysis Gene Expression)combined with next generation SOLiD4 sequencing.A total of approx.11 million edited tags(26 bp),on average 2 million tags per SAGE library,that represented 47.071 unique transcripts were *** of transcripts in fish with high and low SGR yielded 344,698 and 601 differently expressed tags(0.01%false discovery rate and 4-fold change)in brain,liver and muscle,*** tags were mapped onto the sea bass genome and approximately one third of the tags could be assigned to annotated *** enrichment analysis revealed in liver,muscle and brain intricate gene expression changes in endocrine regulatory pathways involved in growth,metabolic and the stress axis,underlying divergent SGR in sea bass.

关键词： European sea bass Specific growth rate Gene expression SuperSAGE Pathways

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Musculoskeletal Conditions in Persons Living with HIv/AIDS:A Scoping Review

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Current Medical Science 2022年第1期42卷 17-25页

作者： Louise Schade Berg James JYoung deborah Kopansky-Giles Stefan Eberspaecher Geoff Outerbridge Eric LHurwitz Jan Hartvigsen Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark Department of Research Canadian Memorial Chiropractic CollegeToronto M2H3 J1Canada Department of Family&Community Medicine University of TorontoMG51V7Canada Department of Orthopedic Surgery Princess Marina HospitalGaborone 8WVF+7H3Botswana World Spine Care Canadian Memorial Chiropractic CollegeToronto M2H 3J1Canada Office of Public Health Studies University of Hawaii at ManoaHonolulu 96822USA Chiropractic Knowledge Hub Odense 5230Denmark

Objective:Globally 37.9 million people are living with HIv/AIDS,and with mortality rates declining,there is an increasing focus on comorbidities including musculoskeletal(MSK)***,the aim of this scoping review was to generate and summarize an overview of the existing scientific literature dealing with MSK complaints in people living with HIv/AIDS(PLWHAs).Methods:This scoping review followed the five-stage methodological framework proposed by Arksey and O'Malley.

关键词： musculoskeletal conditions HIv AIDS

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