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Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats

World Journal of Gastroenterology 2016年第25期22卷 5761-5768页

作者： Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira debora cristina damasceno Jose Ricardo Arruda Miranda Sao Paulo State University BotucatuSP 18618-970Brazil Instituto de Ciencias Biologicas e da Saude Federal University of Mato GrossoBarra do GarcasMT 78600-000Brazil Universidade Estadual de Ciencias da Saude de Alagoas MaceioAL 57010-300Brazil Sao Paulo University Ribeirao PretoSP 14049-900Brazil

AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying.

关键词： Reproductive physiological process Sex hormones Gastrointestinal motility Magnetic fields Gastric emptying

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Metabolic Syndrome: Consensus and Controversy: State of the Art

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Open Journal of Endocrine and Metabolic Diseases 2015年第9期5卷 124-130页

作者： Hamilton dos Prazeres Tavares Rafael Bottaro Gelaleti Fernanda Picolo Suelma Beatriz Marques Prata Tavares Gabriela Marini Joelcio Francisco Abbade debora cristina damasceno Meirelles dos Santos Paulo Adao de Campos Iracema de matos Paranhos Calderon Marilza Vieira Cunha Rudge Department of Gynecology and Obstetrics Botucatu Medical School UNESP—Universidade Estadual Paulista Botucatu Brazil Department of Gynecology and Obstetrics of the Municipal Hospital of Huambo Huambo Angola University of Sacred Heart (USC) Bauru Brazil Departament of Gynecology and Obstetric in Medical School Agostinho Neto University Luanda Angola

Metabolic syndrome is an epidemic that affects more and more people, increasing the probability of suffering metabolic and cardiovascular diseases in the short, medium or long term depending on the severity. The purpose of this article is to review the metabolic syndrome, assessing consensus, controversy and prevalence. The methodology was the preparation of a literature review on various health care databases, which were from 43 articles published from 2010 to 2015, in the general population. SM rate ranges from 0% to 90% depending on genders, ages and regions. There is still lack of consensus on cutoffs of diagnostic criteria. Thus, it is concluded that the prevalence of metabolic syndrome is being increased, urging the need for early diagnosis and treatment to promote the health of the global population.

关键词： Metabolic Syndrome X Prevalence Consensus

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Hepatitis A:Epidemiology and prevention in developing countries

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World Journal of Hepatology 2012年第3期4卷 68-73页

作者： Elisabetta Franco cristina Meleleo Laura Serino debora Sorbara Laura Zaratti Department of Public HealthUniversity Tor Vergata Specialization School for Hygiene and Preventive Medicine University Tor Vergata

Hepatitis A is the most common form of acute viral hepatitis in the *** geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socioeconomic *** anti-hepatitis A virus(HAV)seroprevalence rate is presently decreasing in many parts of the world,but in less developed regions and in several developing countries,HAV infection is still very common in the first years of life and seroprev-alence rates approach 100%.In areas of intermediate endemicity,the delay in the exposure to the virus has generated a huge number of susceptible adolescents and adults and significantly increased the average age at *** the severity of disease increases with age,this has led to outbreaks of hepatitis *** factors contribute to the decline of the infection rate,including rising socioeconomic levels,increased access to clean water and the availability of a hepatitis A vaccine that was developed in the *** populations with a high proportion of susceptible adults,implementing vaccination programs may be *** this report,we review available epidemiological data and implementation of vaccination strategies,particularly focusing on developing countries.

关键词： Hepatitis A Developing countries Endemic-ity Seroprevalence Vaccine

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Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino cristina Russo Anna Longo Carmelina Daniela Anfuso Gabriella Lupo debora Lo Furno Rosario Giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine

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Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population

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World Journal of Gastroenterology 2009年第12期15卷 1465-1471页

作者： Hivana Patricia Melo Barbosa Luisa Caricio Martins Sidney Emanuel Batista dos Santos Samia Demachki Mnica Baraúna Assumpo Charliana damasceno Arago Tereza cristina de Oliveira Corvelo Laboratory of Immunogenetics Federal University of Pará66075-110BelémBrazil Nucleus of Tropical Medicine Federal University of Pará66055-240BelémBrazil Laboratory of Human and Medical Genetics Federal University of Pará66075-110BelémBrazil Department of Pathology Joo de Barros Barreto Universitary HospitalFederal University of Pará66073-000BelémBrazil Department of Endoscopy Joo de Barros Barreto Universitary HospitalFederal University of Pará66073-000BelémBrazil

AIM:To study the association between Interleukin-1(IL-1)and tumor necrosis factor(TNF)-αpolymorphisms,infection by Helicobacter pylori(H pylori)and the development of gastrointestinal ***:Genomic DNA was extracted from the peripheral blood of 177 patients with various gastrointestinal diseases and from 100 healthy *** polymorphisms in IL-1βand TNF-αgenes were analyzed using the polymerase chain reactionrestriction fragment length polymorphism method(PCRRFLP)and those from IL-1RN with *** presence of infection due to H pylori and the presence of the CagA toxin were detected by *** histopathological parameters in the gastric biopsies of the patients were according to the Sydney ***:A comparison of the frequencies of the different polymorphisms studied among the patients and the control group demonstrated that the allele IL1RN*2 was more frequent among patients with gastric ulcers and *** of the allele ILRN*2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinoma,as well as a higher degree of inflammation and neutrophilic activity in the gastric ***:Our results indicate a positive association between IL-1RN gene polymorphism and infection by positive H pylori CagA strains and the development of gastric ulcers and adenocarcinoma.

关键词：白细胞介素1 多态性分析法肿瘤坏死因子幽门螺杆菌 PCRRFLP 幽门螺旋杆菌组织病理学参数 RN基因多态性

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Genetic Diversity of Uropathogenic Escherichia coli Isolated from Human T Lymphotropic Virus Type I (HTLV-I) Infected Individuals

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Advances in Infectious Diseases 2016年第4期6卷 163-173页

作者： Andréia Santos Silva Elizabeth de Souza Neves Maria cristina Lourenç o Márcia dos Santos Guimarã es debora Ribeiro de Souza Santos Adriana Hamond Regua-Mangia Escola Nacional de Saúde Pública Sergio Arouca Funda&ccedil ã o Oswaldo Cruz Rio de Janeiro Brazil Instituto Nacional de Infectologia Funda&ccedil ã o Oswaldo Cruz Rio de Janeiro Brazil Instituto Nacional de Controle de Qualidade em Saúde Funda&ccedil ã o Oswaldo Cruz Rio de Janeiro Brazil

Urinary tract infection (UTI) is a frequent pathology among HTLV-I+ individuals being capable of severely compromising the kidneys and bladder. Molecular characteristics of uropathogenic Escherichia coli (UPEC) from HTLV-I+ infected individuals are unknown. UPEC isolates from HTVL-I+ individuals, with and without clinical symptoms of myelopathy, were submitted to genetic typing seeking to infer bacterial diversity and potential virulence. 71 bacterial isolates were characterized according to random amplified polymorphic DNA and phylotypes. Phylotyping classified E. coli into four phylogenetic groups: A (18.3%), B1 (16.9%), B2 (39.4%), and D (25.3%) and 8 phylotypes according to the presence of the genetic sequences chuA, yjaA and the DNA fragment TSPE4.C2: ﹣﹣﹣ (5.6%) and ﹣+﹣ (12.6%) in phylogroup A, ﹣﹣+ (7.0%) and ﹣++ (9.8%) in B1, +++ (32.3%) and ++﹣ (7.0%) in B2, +﹣﹣ (15.4%) and +﹣+ (9.8%) in D. The B2 phylogroup was the most prevalent among HTLV﹣ associated myelopathy and asymptomatic individuals. RAPD-PCR typing revealed a high degree of bacterial polymorphism indicating a non-clonal origin. Genotypes were not found to be distributed according to clinical status or epidemiological features. Our results lead us to suggest that the neurological impairment in HTLV-I+ individuals can be a risk factor for urinary infections due E. coli which are caused by distinct bacterial lineages.

关键词： Uropathogenic Escherichia coli Genetic Diversity Phylotype HTLV-I+

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Metabolic Syndrome and Pregnancy, Its Prevalence, Obstetrical and Newborns Complications

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Open Journal of Obstetrics and Gynecology 2015年第11期5卷 618-625页

作者： Hamilton dos Prazeres Tavares Mariana Alvarez Arantes Suelma Beatriz Marques Prata Tavares Joelcio Francisco Abbade D. C. D. Meirelles dosDébora cristina damasceno Meirelles dos Santos Iracema de Mattos Paranhos Calderon Marilza Vieira Cunha Rudge PhD Student in Gynecology Obstetrics and Mastology at the Botucatu Medical School Unesp Paulista State University Botucatu SP Brazil Medical Specialist in Gynaecology and Obstetrics and Boss of Department of Gynecology and Obstetrics of the Municipal Hospital of Huambo Huambo Angola Assistant Professor of Obstetrics Botucatu Medical School Unesp Paulista State University Botucatu SP Brazil PhD Department of Gynecology and Obstetrics Laboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School Unesp Paulista State University Botucatu SP Brazil Full Professor of Obstetrics in Botucatu Medical School Unesp Paulista State University Botucatu SP Brazil

Background: The metabolic syndrome affects more and more global people. Although it shows increasing prevalence in general population, the syndrome affects more women than men, what makes its risk of being developed during pregnancy period. Also, possible perinatal adverse effects are always lurking. Objective: the objective was demonstrated what’s new in literature on metabolic syndrome and pregnancy. Methods: A literature review was performed to extract the articles published on metabolic syndrome and pregnancy, its prevalence, obstetrical complications and its perinatal adverse effects. This review was conducted by online researching in PubMed, Lilacs, Medline, Embase, Scopus, Medscape, Libertas Academica and CINAHL database, Science database and also by researches in books. 27 selected articles on metabolic syndrome after this research were all published between 1988 and 2015. Results: Among those 27 articles and two books studied, SM rate in obstetric population ranged from 3% to 42% depending on the previously manifested components of the syndrome, age and region. Women with previously manifested components showed more adverse perinatal effects. Conclusion: Women with pregestational DM or SM and SM develop more during pregnancy, obstetric complications and adverse perinatal outcomes.

关键词： Metabolic Syndrome Pregnancy Adverse Perinatal Outcomes

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Subacute Cutaneous Lupus Erythematosus in Older Man: Case Report

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Journal of Biosciences and Medicines 2017年第10期5卷 25-33页

作者： debora Trindade Martins Thiago Sande Miguel Nayrton Kalys Cruz dos Anjos Sebastiao Celio Horta Coelho Filho Vinicius Moreira Paladino Bruna Sande Miguel Vinicius Sande Miguel Daniel Almeida da Costa Livia cristina de Melo Pino The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects mainly women, presents several clinical manifestations and has no known exact cause. The skin is one of the organs that can be affected, with subacute cutaneous lupus erythematosus (SCLE) being one of the classifications according to cutaneous lupus erythematosus lesions. SCLE is commonly found in young to middle age women and carries characteristics related to sun exposure. In this report, there is a rare case of a male and elderly patient that presents SCLE subgroup initially asymptomatic, with subsequent appearance of macular skin lesions and vitiligo appearance. This is an important case to alert health professionals that the disease can manifest itself and open its clinical profile even in patients of sex and unusual ages.

关键词： Autoimmune-Disease Skin Man Lupus

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Secondary Syphilis in Man: Prozone Effect

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Journal of Biosciences and Medicines 2018年第2期6卷 1-8页

作者： Nayrton Kalys Cruz dos Anjos Daniel Almeida da Costa Thiago Sande Miguel Livia cristina de Melo Pino Sebastiao Celio Horta Coelho Filho debora Trindade Martins Vinicius Sande Miguel Bruna Sande Miguel Fernando Antonio Galvao Pereira Jr Vinicius Moreira Paladino Faculdade de Medicina de Valenca Rio de JaneiroBrazil Universidade Unigranrio Rio de JaneiroBrazil

Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be made through a direct investigation of the etiologic agent or non-treponemal (VDRL) and treponemal (FTA-Abs) serological tests. False-negative results are rare. Objectives: The present report presents a rare case of a man with a secondary syphilis syndrome who was initially undiagnosed due to the prozone effect, since he presented VDRL in low titers, and was later confirmed with a new diluted serum sample and VDRL and FTA-Abs, which were positive. Conclusion: A close look should be given to patients who, although the clinical condition is compatible, complementary exams may not be, and clinical cases should be carefully evaluated so that the patient is not treated late.

关键词： Secondary Syphilis Prozone Effect Treponema pallidum

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Can the detection of IgA anti-Mycoplasma pneumoniae added to IgM increase diagnostic accuracy in patients with infections of the lower respiratory airways?

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World Journal of Clinical Infectious Diseases 2016年第4期6卷 67-72页

作者： Massimo De Paschale Teresa Cerulli debora Cagnin Alessia Paganini Maria Teresa Manco Luisa Belvisi cristina Morazzoni Laura Marinoni Carlo Agrappi Paola Mirri Pierangelo Clerici Microbiology Unit ASST-Ovest Milanese Hospital of Legnano

AIM To evaluate the increase in diagnostic yield, by using IgA in addition to IgM, instead of IgM alone, in relation to the age of the *** The study considered 1067 blood samples from patients with clinical signs of lower respiratory tract infections, tested for anti-Mycoplasma IgG, IgM and IgA *** The increase in diagnostic yield with IgA, compared to IgM detection alone was of 3.5% with statistically significant differences between age groups(0.8% for those equal/under 50 years of age and 4.3% for those over 50).CONCLUSION Our findings demonstrate that IgA detection lead to a twofold increase in the number of diagnoses among the older age groups, but it did not result in relevant increase among the younger age groups.

关键词： Community-acquired infections Diagnostic yield Elderly patients IgA Mycoplasma pneumoniae

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