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Systems Microbiology and Biomanufacturing 2023年第2期3卷 312-327页

作者： debanjan mitra Pradeep K.Das Mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

The current scenario of COVID-19 makes us to think about the devastating diseases that kill so many people every *** of viral proteins contributes many things that are utterly useful in the evolution of therapeutic drugs and *** this study,sequence and structure of fusion glycoproteins and major surface glycoproteins of respiratory syncytial virus(RSV)were analysed to reveal the stability and transmission *** A has the highest abundance of aromatic *** Kyte–Doolittle scale indicates the hydrophilic nature of RSV A protein which leads to the higher transmission rate of this ***-protein interactions such as carbonyl interactions,cation-pi,and salt bridges were shown to be greater in RSV A compared to RSV B,which might lead to improved *** study discovered the presence of a network aromatic–sulphur interaction in viral *** of ligand binding pocket of RSV proteins indicated that drugs are performing better on RSV B than RSV *** was also shown that increasing the number of tunnels in RSV A proteins boosts catalytic *** study will be helpful in drug discovery and vaccine development.

关键词： Respiratory syncytial virus Stability Intra-protein interactions Tunnels Drug discovery

Cold adaptation strategy of psychrophilic bacteria:an in-silico analysis of isocitrate dehydrogenase

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Systems Microbiology and Biomanufacturing 2021年第4期1卷 483-493页

作者： debanjan mitra Pradeep Kr.Das Mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

Non-specific electrostatics is crucial for structure and stability;recently,it has been argued that psychrophilic proteins may also utilize specific electrostatic *** psychrophilic proteins increase the number of salt bridges for cold adaptation?Are there any changes that occur in their sequence,which helps them to adapt in an extreme environment?Do intra-protein interactions affect their stability?Is there any special type of intra-protein interaction present in psychrophilic protein structure?This study will give all those ***(n~100)and structures of psychrophilic isocitrate dehydrogenase and mesophilic isocitrate dehydrogenase extracted from *** had been analyzed in BLOCK and non-BLOCK *** sequences of psychrophiles and mesophiles create two separate *** number of charged and uncharged polar residues is very much high in psychrophilic *** formation of long network aromatic-aromatic interactions and network aromatic-sulfur interactions are very crucial for psychrophilic protein *** of these types of interactions is also a novelty of this *** mutation of charged residues with high-energy contributions affects the protein *** study will help in protein engineering.

关键词： Cold adaptation Aromatic-aromatic interactions Aromatic-sulfur interactions Non-covalent interactions Mutation

Intra-protein interactions of SARS-CoV-2 and SARS:a bioinformatic analysis for plausible explanation regarding stability,divergency,and severity

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 653-664页

作者： debanjan mitra Aditya K.Pal Pradeep Kr.Das Mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

The current nightmare for the whole world is *** occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China,was first reported on December 30,***-CoV first disclosed in 2002 but had not outspread *** 18 years,in 2020,it reemerged and outspread worldwide as SARS-CoV-2(COVID-19),as the most dangerous virus-creating disease in the *** it possible to create a favorable evolution within the short time(18 years)?If possible,then what are those properties or factors that are changed in SARS-CoV-2 to make it undefeated?What are the fundamental differences between SARS-CoV-2 and SARS?The study is one of the initiatives to find out all those ***,four types of protein sequences from SARS-CoV-2 and SARS were retrieved from the database to study their physicochemical and structural *** showed that charged residues are playing a pivotal role in SARS-CoV-2 evolution and contribute to the helix *** formation of the cyclic salt bridge and other intra-protein interactions specially network aromatic-aromatic interaction also play the crucial role in *** comparative study will help to understand the evolution from SARS to SARS-CoV-2 and helpful in protein engineering.

关键词： COVID-19 Evolution Cyclic salt bridge Intra-protein interactions Protein engineering

Easy-to-fabricate high efficiency silicon nanowires solar cell modified by CdTe and zinc tetraphenyl porphyrin nanostructures

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Journal of Energy Chemistry 2021年第12期30卷 484-497,I0012页

作者： debanjan Maity Saurabh Kumar Pathak Melepurath Deepa Department of Chemistry Indian Institute of Technology HyderabadKandiSangareddyTelangana 502284India

Liquid junction solar cell(LJSC) with vertically silicon nanowires(SiNWs) as the primary photosensitizer,co-sensitized with luminescent and narrow gap CdTe nanoparticles,and cuboidal microstructures of zinc tetraphenyl porphyrin(ZnTPP) dye offers broad and intense visible light absorption that translates into a maximum power conversion efficiency(PCE) of 9.09%,when combined with a polymeric gel of a I_(2)/I^(-)redox couple as the hole transport material and a counter electrode(CE) of poly(3,4-ethyelenedioxythio phene) doped with imide ions(PEDOT-N(CF_(3) SO_(2))_(2)),under 1 sun *** p-type CdTe efficiently scavenges holes from SiNWs and simultaneously allows the passage of photoexcited electrons from ZnTPP to SiNWs via electrical conduction thus imparting an enhanced solar cell *** also supresses back electron transfer effectively,as is inferred from a ~68% enhancement in PCE compared to SiNWs *** of the CE entailed the evaluation of the effect of dopant anion:imide versus dicyanamide in PEDOT,and revealed that the presence of macro-cracks in the polymer surface,a deeper work function,and a lower electrical conductance are the shortcomings of the dicyanamide doped PEDOT and reduce the overall PCE,compared to *** study brings out how by judicious choice of photoanode and CE components,efficient,stable and easy-to-assemble LJSCs can be developed.

关键词： Silicon Nanowires Porphyrin Solar cell Hole transfer

Study of pressure surge during priming phase of start transient in an initially unprimed pump-fed liquid rocket engine

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Propulsion and Power Research 2022年第3期11卷 353-375页

作者： debanjan Das P.Padmanabhan Systems Reliability Group ISRO Propulsion ComplexIndian Space Research OrganisationTirunelveli(Mahendragiri)Tamil Nadu627133India

In this paper, transient phenomenon during start up process of a pump fed liquidrocket engine is investigated through numerical simulation. The engine studied in this workis designed such that engine systems are not wetted with propellant until the engine is com-manded to start. This is achieved by positioning the valves for propellant admission at the inter-face of test stand/flight stage and the engine. To evaluate engine performance during starttransient for such systems, unsteady flow simulation was conducted using Method of Charac-teristics and equations for priming. The same has been reported in this work. The results indi-cated a brief period of abrupt pressure rise at pump upstream after opening of the propellantadmission valves, during the process of priming of engine systems at valve *** peak pressure obtained was significantly higher than the propellant tank pressure as wellas the steady state pump suction pressure. The transitory pressure rise was found to occurdue to flow resistance at impeller inlet caused by formation of a forced vortex for orientingthe flow through impeller blades during off design transient regime. The maximum pressureat pump upstream, as computed from start transient simulation, was used as a design inputfor pump inlet feed lines. The engine was realized and subsequently qualified in a ground test facility. Hot test data obtained for pressure and flow rate during transient regime were found tobe in good agreement with the simulation results.

关键词： Method of Characteristics Priming analysis Liquid rocket engines Start transient Off design pump losses

Role of self-help groups on socioeconomic development and the achievement of Sustainable Development Goals(SDGs)among rural women in Cooch Behar District,India

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Regional Sustainability 2024年第2期5卷 63-74页

作者： debanjan BASAK Indrajit Roy CHOWDHURY Department of Geography and Applied Geography University of North BengalSiliguri734013India

This study examines the transformative role of self-help groups(SHGs)in the socioeconomic development of rural women in Cooch Behar District,India,and their contribution toward achieving Sustainable Development Goals(SDGs)of the United *** this study,we explored the effect of SHGs on rural women by specifically addressing SDGs,such as no poverty(SDG 1),zero hunger(SDG 2),good health and well-being(SDG 3),quality education(SDG 4),and gender equality(SDG 5).Given this issue,a cross-sectional survey and comparison analyses are needed to assess the socioeconomic development of rural women and their awareness level before and after the participation of rural women in *** survey conducted as part of this study was divided into three sections,namely,demographic characteristics,socioeconomic development,and awareness level,with each focusing on different aspects.A group of 400 individuals who were part of SHGs completed the questionnaire survey *** results showed that the participation of rural women in SHGs significantly improved their socioeconomic development and awareness level,as supported by both mean values and t test *** in SHGs and microcredit programs were the major elements that boosted the socioeconomic development of rural women,which also achieves SDGs 1,2,3,4,and *** study revealed that participation in SHGs and related financial services significantly aided rural women in economically disadvantaged communities in accumulating savings and initiating entrepreneurial ***,participation in SHGs was instrumental in enhancing the self-confidence,self-efficacy,and overall self-esteem of rural ***,doing so enabled them to move more freely for work and other activities and to make family and common decisions.

关键词： Self-help groups Rural women Socioeconomic development Sustainable Development Goals(SDGs) Microcredit India

Correlating mode-I fracture toughness and mechanical properties of heat-treated crystalline rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第1期10卷 91-101页

作者： Mayukh Talukdar debanjan Guha Roy T.N.Singh Indian Institute of Technology Bombay PowaiMumbai400076India IITB-Monash Research Academy Indian Institute of Technology BombayPowaiMumbai400076India

For the effect of thermal treatment on the mode-I fracture toughness(FT), three crystalline rocks(two basalts and one tonalite) were experimentally investigated. Semi-circular bend specimens of the rocks were prepared following the method suggested by the International Society for Rock Mechanics(ISRM)and were treated at various temperatures ranging from room temperature(25 ℃) to 600 ℃. Mode-I FT was correlated with tensile strength(TS), ultrasonic velocities, and Young’s modulus(YM). Additionally,petrographic and X-ray diffraction analyses were carried out to find the chemical changes resulting from the heat treatment. Further, scanning electron microscopy(SEM) was conducted to observe the micro structural changes when subjected to high temperatures. These experiments demonstrate that heat treatment has a strong negative impact on the FT and mechanical properties of the rocks. From room temperature to 600 ℃, mode-I FT values of massive basalt, giant plagioclase basalt, and tonalite were reduced by nearly 52%, 68%, and 64%, respectively. Also, at all temperature levels, FT and mechanical properties are found to be exponentially correlated. However, the exact nature of the relationship mainly depends on rock type. Besides, TS was found to be a better indicator of degradation degree than the mode-I FT. SEM images show that micro crack density and structural disintegration of the mineral grains increase with temperature. These physical changes confirm the observed reduction in the stiffness of heat-treated crystalline rocks.

关键词： Fracture toughness(FT) Tensile strength(TS) Ultrasonic velocity Young's modulus(YM) Crystalline rocks

Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and hydrophilic drugs

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Frontiers of Chemical Science and Engineering 2014年第4期8卷 498-510页

作者： Juichen YANG Hong CHEN Yuan YUAN debanjan SARKAR Jie ZHENG Department of Chemical and Biomolecular Engineering The University of Akron Akron OH 44325 USA Department of Biomedical Engineering University at Buffalol State University of New York Buffalo NY 14260 USA Department of Chemical and Biological Engineering University at Buffalo State University of New York Buffalo NY 14260 USA

Design of biocompatible and biodegradable polymer systems for sustained and controlled release of bioactive agents is critical for numerous biomedical applications. Here, we designed, synthesized, and char- acterized four polyurethane carrier systems for controlled release of model drugs. These polyurethanes are biocom- patible and biodegradable because they consist of biocompatible poly（ethylene glycol） or poly（caprolactone diol） as soft segment, linear aliphatic hexamethylene diisocyanate or symmetrical aliphatic cyclic dicyclohex- ylmethane-4,4＇-diisocyanate as hard segment, and biode- gradable urethane linkage. They were characterized with Fourier transform infrared spectroscopy, atomic force microscope, and differential scanning calorimetry, whereas their degradation behaviors were investigated in both phosphate buffered saline and enzymatic solutions. By tuning polyurethane segments, different release profiles of hydrophobic and hydrophilic drugs were obtained in the absence and presence of enzymes. Such difference in release profiles was attributed to a complex interplay among structure, hydrophobicity, and degradability of polyurethanes, the size and hydrophobicity of drugs, and drug-polymer interactions. Different drug-polyurethane combinations modulated the distribution and location of the drugs in polymer matrix, thus inducing different drug release mechanisms. Our results highlight an important role of segmental structure of the polyurethane as an engineering tool to control drug release.

关键词： polyurethanes controlled release drug delivery phase structure degradation

Observation of Resistive Switching Memory by Reducing Device Size in a New Cr/CrO_x/TiO_x/TiN Structure

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Nano-Micro Letters 2015年第4期7卷 392-399页

作者： debanjan Jana Subhranu Samanta Sourav Roy Yu Feng Lin Siddheswar Maikap Thin Film Nano Tech. Lab. Department of Electronic Engineering Chang Gung University

The resistive switching memory characteristics of 100 randomly measured devices were observed by reducing device size in a Cr/Cr Ox/Ti Ox/Ti N structure for the first *** electron microscope image confirmed a viahole size of 0.4 lm.A 3-nm-thick amorphous Ti Oxwith 4-nm-thick polycrystalline Cr Oxlayer was observed.A small 0.4-lm device shows reversible resistive switching at a current compliance of 300 l A as compared to other larger size devices(1–8 lm)owing to reduction of leakage current through the Ti *** device-to-device uniformity with a yield of[85%has been clarified by weibull distribution owing to higher slope/shape *** switching mechanism is based on oxygen vacancy migration from the Cr Oxlayer and filament formation/rupture in the Ti *** read pulse endurance of[105cycles,good data retention of 6 h,and a program/erase speed of 1 ls pulse width have been obtained.

关键词： CrOx TiOx Resistive switching memory Slope/shape factor Device size

Deletion of IFT20 in early stage T lymphocyte differentiation inhibits the development of col agen-induced arthritis

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Bone Research 2014年第4期2卷 241-251页

作者： Xue Yuan Lee Ann Garrett-Sinha debanjan Sarkar Shuying Yang Department of Oral Biology School of Dental MedicineUniversity at BuffaloThe State University of New YorkBuffaloNY 14214USA Department of Biochemistry School of Medicine and Biomedical SciencesUniversity at BuffaloThe State University of New YorkBuffaloNY 14203USA Laboratory for Biomaterials and Regenerative Therapeutics Department of Biomedical EngineeringUniversity at BuffaloThe State University of New YorkBuffaloNY 14260-2050USA Developmental Genomics Group New York State Center of Excellence in Bioinformatics and Life SciencesUniversity at BuffaloThe State University of New YorkBuffaloNY 14203USA

IFT20 is the smallest member of the intraflagellar transport protein（IFT） complex B. It is involved in cilia formation. Studies of IFT20 have been confined to ciliated cells. Recently, IFT20 was found to be also expressed in non-ciliated T cells and have functions in immune synapse formation and signaling in vitro. However, how IFT20 regulates T-cell development and activation in vivo is still unknown. We deleted the IFT20 gene in early and later stages of T-cell development by crossing IFT20flox/flox（IFT20f/f） mice with Lck-Cre and CD4-Cre transgenic mice, and investigated the role of IFT20 in T-cell maturation and in the development of T cell-mediated collagen-induced arthritis（CIA）. We found that both Lck-Cre/IFT20f/f and CD4-Cre/IFT20f/f mice were indistinguishable from their wild-type littermates in body size, as well as in the morphology and weight of the spleen and thymus. However, the number of CD4- and CD8-positive cells was significantly lower in thymus and spleen in Lck-Cre/IFT20f/f mice. Meanwhile, the incidence and severity of CIA symptoms were significantly decreased, and inflammation in the paw was significantly inhibited in Lck-Cre/IFT20f/f mice compared to Lck-Cre/IFT201/1littermates. Deletion IFT20 in more mature T cells of CD4-Cre/IFT20f/f mice had only mild effects on the development of T cells and CIA. The expression of IL-1b, IL-6 and TGF-b1 were significantly downregulated in the paw of Lck-Cre/IFT20f/f mice, but just slight decreased in CD4-Cre/IFT20f/f mice. These results demonstrate that deletion of IFT20 in the early stage of T-cell development inhibited CIA development through regulating T-cell development and the expression of critical cytokines.

关键词： T cells transgenic mice body size in vitro