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食窦魏斯氏菌协同植物乳杆菌改善四川泡菜风味

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食品科学 2020年第14期41卷 102-108页

作者：张楠笛祝林许琴向文良西华大学食品与生物工程学院四川成都610039

探索食窦魏斯氏菌协同植物乳杆菌(协同发酵)对四川泡菜风味的影响,研究发酵过程中乳酸菌菌落总数、pH值及乳酸、乙酸、苹果酸、柠檬酸的变化;采用顶空固相微萃取结合气相色谱-质谱法,分析四川泡菜产品中挥发性物质成分及含量,并对产品... 详细信息

探索食窦魏斯氏菌协同植物乳杆菌(协同发酵)对四川泡菜风味的影响,研究发酵过程中乳酸菌菌落总数、pH值及乳酸、乙酸、苹果酸、柠檬酸的变化;采用顶空固相微萃取结合气相色谱-质谱法,分析四川泡菜产品中挥发性物质成分及含量,并对产品感官品质进行评价。结果表明:协同发酵能够快速提升发酵前期(0~4 d)泡菜体系中乳酸菌、乳酸和乙酸的含量,改善泡菜产品发酵风味,提升产品品质。发酵第1天,协同发酵组中乳酸菌菌落总数达到8.52(lg(CFU/mL)),比植物乳杆菌组增加了0.85(lg(CFU/mL));发酵第3天,协同发酵组中乳酸质量浓度达10.9 g/L,比植物乳杆菌组增加了5.5 g/L;发酵结束后,协同发酵泡菜产品的感官优于植物乳杆菌发酵泡菜产品。挥发性物质分析表明,协同发酵组中挥发性物质达27种,比植物乳杆菌组新增7种挥发性物质;挥发性物质总量为6.096 mg/L,显著高于植物乳杆菌组(3.188 mg/L)。因此,食窦魏斯氏菌能够较好协同植物乳杆菌发酵四川泡菜,改善产品风味,表现了较好的潜在应用价值。

关键词：四川泡菜食窦魏斯氏菌植物乳杆菌协同发酵风味

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利用改进的图像修复的联合帧间差错隐藏算法

计算机辅助设计与图形学学报 2016年第2期28卷 280-287页

作者：侯宇马然李攀攀安平史楠迪上海大学通信与信息工程学院上海200072 新型显示技术及应用集成教育部重点实验室上海200072

针对图像修补的不足和视频帧间编码的特点,提出利用改进的图像修复的帧间差错隐藏联合算法.根据丢失宏块的周围宏块的运动相关性和正确接收情况对丢失宏块进行运动性和可用性判断,如果丢失宏块属于静止宏块且可用性不为零,则采用改进的... 详细信息

针对图像修补的不足和视频帧间编码的特点,提出利用改进的图像修复的帧间差错隐藏联合算法.根据丢失宏块的周围宏块的运动相关性和正确接收情况对丢失宏块进行运动性和可用性判断,如果丢失宏块属于静止宏块且可用性不为零,则采用改进的图像修补隐藏帧间差错,否则采用外边界匹配准则进行差错隐藏;并在图像修补中对置信度、等照度和修复方向等方面进行了改进.该算法既发挥了图像修复对纹理丰富区域的修复优势,也克服了图像修补对运动区域的隐藏效果不好的缺陷.实验结果表明,该算法可以带来主观和客观质量上的提高,并且明显克服了外边界匹配算法带来的视频抖动.

关键词：图像修补差错隐藏外边界匹配准则

Secondary Plant Metabolites of Natural Product Origin—<i>Strongylodon macrobotrys</i>as Pitting Corrosion Inhibitors of Steel around Heavy Salt Deposits in Gabu, Nigeria

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Journal of Materials Science and Chemical Engineering 2020年第5期8卷 38-60页

作者： Benedict U. Ugi Victoria M. Bassey Mbang E. Obeten Stephen A. Adalikwu Desmond O. nandi Department of Pure & Applied Chemistry University of Calabar Calabar Nigeria Department of Chemistry Cross River State University of Technology Calabar Nigeria Department of Chemistry Cross River State College of Education Akamkpa Nigeria

Investigation into the Inhibition of pitting corrosion in mild steel around heavy salt deposits by some selected secondary plant metabolites—alkaloid extract (AESML), saponin extract (SESML and flavonoid extract (FESML) of natural product origin—Strongylodon macrobotrys was successfully completed with the aid of electrochemical impedance spectroscopy, potentiodynamic polarization, gravimetric and gasometric experimentation. The research proved that the selected secondary plant metabolites were excellent inhibitors of mild steel in the salt water environment as inhibition efficiency was recorded at 99.2%, 92.6% and 84.7% for AESML, SESML and FESML. The inhibitors showed higher inhibition at lower temperature due to frequent scale redeposition from agitation in temperature rise and loss in collision of the molecules. The potentiodynamic polarization result confirmed the reduction in the loss of electrons at the anode by the inhibitors that would have trigger oxidation reaction that causes the anode to corrode. Charge transfer resistance reflected the maximum inhibition efficiency obtained for mild steel at maximum concentration and the decrease in double layer capacitance is due to the decrease of the area where electrolyte is present due to the formation of inhibitor film. Thermodynamic investigation shows that the inhibitor has the potential of increasing the energy of the intermediate, reducing both the number of collisions, and number of particles that have enough energy to react and also number of corrosion reaction particles with the correct orientation. The adsorption isotherm consideration shows physical adsorption mechanism with binding constant increasing with increasing temperature.

关键词： Keywords Corrosion Electrochemistry Polarization Adsorption Strongylodon macrobotrys Gasometric

Novel Hemorrhagic Risk Score in Elderly Patients with Coronary Artery Disease and Gastrointestinal Malignant Tumor Comorbidity:A 10-year Clinical Inpatient Data Analysis from 2 Medical Centers

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Cardiology Discovery 2021年第3期1卷 163-172页

作者： nandi Bao Wanling Wang Huitao Wu Yabin Wang Hebin Che Wenwen Meng Jiaxin Miao Dong Han Fan Yin National Clinical Research Center for Geriatric Diseases The Second Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Medical School of Chinese People's Liberation Army General Hospital Beijing 100853China National Engineering Laboratory for Medical Big Data Application Technology The First Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Department of Oncology The Second Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China

Objective:Older patients with comorbidity,such as coronary heart disease(CHD)and malignant gastrointestinal tumors,are at a high risk of bleeding ***,risk prediction models based on risk factor assessment remain *** study aimed to establish an individualized bleeding risk assessment system based on the analysis of 10-year inpatient clinical big ***:Total clinical data of 56,819 patients with CHD and 25,988 patients with malignant digestive tract tumors(admitted from January 2008 to December 2017)were retrospectively collected at the First and Second Medical Centers of Chinese People's Liberation Army General *** them,1307 patients with CHD and malignant digestive tract tumors were screened as the derivation *** dependent variable was the occurrence of major clinical bleeding *** statistics and hypothesis tests of differences were performed for independent variables according to the occurrence of *** Tree,eXtreme Gradient Boosting(XGBoost),logistic regression,and random forest models were used for *** accuracy,sensitivity,specificity,and area under the receiver operating characteristic curve(AUC-ROC)were applied as the criteria for evaluating and verifying model *** evaluate this developed model,another cohort comprising 454 patients(admitted from January 2018 to December 2019)was prospectively enrolled as the validation cohort based on the same inclusion and exclusion ***:Among the 64 variables with<50%missing values,the recursive feature elimination method with a random forest model was used to screen the selected *** highest accuracy was obtained following the selection of 10 scalars,and the final model was constructed *** demonstrated the best performance *** AUC-ROC of this model was 0.981,with an accuracy,sensitivity,and specificity of 0.939,0.950,and 0.927,*** the validation cohort,the AUC-ROC,accurac

关键词： Coronary disease Gastrointestinal cancers Bleeding Multivariate analysis Risk factors Machine learning

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耐热赖氨酸氨肽酶的原核表达及特性表征

食品与生物技术学报 2019年第12期38卷 110-115页

作者：黄浩周楠迪田亚平江南大学生物工程学院江苏无锡214122 江南大学工业生物技术教育部重点实验室江苏无锡214122

铜绿假单胞菌NJ-814(Pseudomonas aeruginosa NJ-814)所产氨肽酶具有良好的热稳定性。克隆出该氨肽酶编码基因(lap),测序得知该基因长度为1461 bp,编码486个氨基酸。将lap与表达载体pET-42a(+)连接构建重组基因pET-42a-lap,重组基因转... 详细信息

铜绿假单胞菌NJ-814(Pseudomonas aeruginosa NJ-814)所产氨肽酶具有良好的热稳定性。克隆出该氨肽酶编码基因(lap),测序得知该基因长度为1461 bp,编码486个氨基酸。将lap与表达载体pET-42a(+)连接构建重组基因pET-42a-lap,重组基因转化进入原核表达宿主*** BL21(DE3)构建重组菌BLAP,BLAP在16℃低温诱导下成功表达出重组氨肽酶。通过镍柱(Ni-NTA)亲和层析对重组酶进行分离纯化,得到电泳纯的重组酶酶液,纯化倍数和回收率分别为4.7和83.5%。考察该重组氨肽酶的酶学特性,发现该酶的最适pH为8.3,在pH 6.5~9.5之间具有较好的稳定性;最适反应温度为80℃,经过70℃热处理1 h仍能保留60%以上的酶活性;底物特异性研究表明该重组酶能够水解Arg-pNA、Leu-pNA和Lys-pNA,对Lys-pNA的水解能力分别是其他2种的6.6倍和2.4倍,通过酶动力学分析证实了该酶对赖氨酸底物具有最强的亲和力,与野生菌所产的酶一致属于一种赖氨酸氨肽酶。

关键词：赖氨酸氨肽酶热稳定性原核表达酶学特性

Effect of Hydro-ethanolic (1:1) Extract of Stephania Hernandifolia and Achyranthes Aspera in Composite Manner on Testicular Activity in Male Albino Rat:A Dose Dependent Analysis

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Journal of Reproduction and Contraception 2012年第4期23卷 209-221页

作者： Daniel Paul Kazi Monjur Ali Debidas Ghosh Dilip K.nandi Hanéne Chenni Mohamed M.Trabelsi Department of Bio-Medical Laboratory Science & Management (UGC Innovative Programme Funded Department under Xth-5 years plan) Vidyasagar University Department of Physiology Raja N.L. Khan Women's College Laboratory of Histology and Embryology Faculty of Medicine

Objective To investigate the effect of hydro-ethanolic extraet of Stephania hernandifolia leaves and Aehyranthes aspera roots in composite manner at the ratio of 1：3 on testicular activity in male rats. Methods Rats were divided into 4 groups with 8 animals in each group. The control （group A） received 0. 5 ml of olive oil/100 g body weight orally, other three groups were treated with said extract orally at a dose of 0.4 mg/g （group B） or 0.8 mg/g （group C） or 1.6 mg/g body weight （group D） respectively for 28 d. On 29th day of experiment, the animals were sacrificed. Sperm concentrations in cauda epididymis and biochemical markers like testicular cholesterol, androgenic key enzyme activity, plasma testosterone level seminal fructose level, glutamate oxaloacetate transaminase （GOT） and glutamate pyruvate transaminase （GPT） activities and serum triglyceride levels were measured following standard methods. ResuIts Extract treated animals in all doses resulted in a significant （P〈O. 05）decrease in sperm concentration, testicular androgenic key enzyme activity, plasma testosterone and seminal vesicle fructose levels along with an increase in testieular cholesterol level Animals treated at a dose of O. 8 mg/g body weight showed more promising result without causing any metabolic toxicity compared with other doses. Histological study also supported the biochemical results. The minimum but most effective dose i.e. 0.8 mg/g body weight had an inhibitory effect on implantation focused here by mating *** The composite efficacy as male contraceptive extract of S. hernandifolia and A. aspera has a potent that may provide clues to the pharmaceutical industries for male contraceptive development

关键词： Achyranthes aspera Stephania hernandifolia testosterone seminiferous tubule

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跨文化情景下组织试错学习机理研究

管理科学 2016年第2期29卷 29-41页

作者：宁烨刘南荻王姗姗东北大学工商管理学院沈阳110169

试错学习是企业全球化经营时应对文化冲突不可缺少的革新过程,已有研究对企业试错学习过程和机理尚缺乏深入探讨和明确阐释,尤其是针对跨文化情景下的研究较少。以美国医药行业著名跨国企业H公司作为研究对象,运用扎根理论方法,借助定... 详细信息

试错学习是企业全球化经营时应对文化冲突不可缺少的革新过程,已有研究对企业试错学习过程和机理尚缺乏深入探讨和明确阐释,尤其是针对跨文化情景下的研究较少。以美国医药行业著名跨国企业H公司作为研究对象,运用扎根理论方法,借助定性分析软件NVivo 8.0对访谈和二手所得资料进行分析,探究跨文化情景下组织试错学习的影响因素及机理模型。借助开放性编码、主轴编码和选择性编码分析得出试错学习的7个主要影响因素,包括跨文化学习能力、跨文化制度设计、稳定的跨文化经营、团队领导者素质、跨文化试错学习氛围、母公司的支持和跨文化适应性;选用著名跨国制药企业M公司案例进行理论饱和度检验,得到另一个影响因素即企业研发能力;据此构建试错学习过程模型。研究结果表明,试错学习是一个循环往复的过程,可分为失败分析、试验开展和措施生效3个阶段;通过进一步分析各阶段的主要影响因素,构建跨文化情景下组织试错学习的机理模型。研究结论旨在为跨文化经营的企业有针对性地提升试错学习效率提供理论支持。

关键词：试错学习跨文化情景影响因素扎根理论组织学习

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中华内科杂志 2022年第5期61卷 594-597页

作者：包楠迪李婷婷解放军总医院第六医学中心心血管病医学部北京100853 解放军总医院第二医学中心消化内科国家老年疾病临床医学研究中心肾脏疾病国家重点实验室北京100853

代谢相关脂肪性肝病(MAFLD)包括非酒精性脂肪肝和非酒精性脂肪性肝炎,其病理特点包括肝脏脂肪变性、肝细胞损伤和炎症反应等。钠-葡萄糖共转运蛋白-2(SGLT2)抑制剂是一种新型抗糖尿病药物,可通过增加尿葡萄糖排泄改善患者血糖水平。目... 详细信息

代谢相关脂肪性肝病(MAFLD)包括非酒精性脂肪肝和非酒精性脂肪性肝炎,其病理特点包括肝脏脂肪变性、肝细胞损伤和炎症反应等。钠-葡萄糖共转运蛋白-2(SGLT2)抑制剂是一种新型抗糖尿病药物,可通过增加尿葡萄糖排泄改善患者血糖水平。目前已有相关研究发现SGLT2抑制剂可能通过多种作用机制影响MAFLD的病理生理过程。本文就SGLT2抑制剂在治疗MAFLD中的应用及可能的作用机制予以综述。

关键词：钠-葡萄糖共转运蛋白-2抑制剂代谢相关脂肪性肝病糖尿病,2型肥胖

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中国循证医学杂志 2005年第9期5卷 725-727页

作者： Paul Chinnock nandi Siegfried Mike Clarke 杜亮 Cochrane创伤组牛津大学英国Cochrane中心

尽管循证医学的推广仍然存在一些阻力，但循证卫生保健已被广为接受和采纳。卫生保健干预措施有效性的系统评价是循证卫生保健的力量之源；关于应怎样制作系统评价和它们能起什么作用的著述颇丰。如果系统评价在发达国家的应用收效良好... 详细信息

尽管循证医学的推广仍然存在一些阻力，但循证卫生保健已被广为接受和采纳。卫生保健干预措施有效性的系统评价是循证卫生保健的力量之源；关于应怎样制作系统评价和它们能起什么作用的著述颇丰。如果系统评价在发达国家的应用收效良好（我们认为的确如此），那么它们在发展中国家甚至会更有用。无论在何种情况下提供和接受卫生保健，都需要了解哪种干预有效，哪种无效，以及哪种可能有害。在卫生问题极其严重，资源匮乏到承受不起丝毫浪费时，这就尤为重要。[第一段]

关键词：卫生保健循证医学系统评价发展中国家