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Imaging the initial condition of heavy-ion collisions and nuclear structure across the nuclide chart

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Nuclear Science and Techniques 2024年第12期35卷 438-454页

作者： Jiangyong Jia Giuliano Giacalone Benjamin Bally James Daniel Brandenburg Ulrich Heinz Shengli Huang dean lee Yen‑Jie lee Constantin Loizides Wei Li Matthew Luzum Govert Nijs Jacquelyn Noronha‑Hostler Mateusz Ploskon Wilke van der Schee Bjoern Schenke Chun Shen Vittorio Somà Anthony Timmins Zhangbu Xu You Zhou Stony Brook University Stony BrookNY 11794USA Brookhaven National Laboratory UptonNY 11973USA CERN CH‑1211 Geneve 23Switzerland IRFU CEAUniversitéParis-Saclay91191 Gif‑sur‑YvetteFrance The Ohio State University ColumbusOH 43210‑1117USA Michigan State University East LansingMI 48824USA Massachusetts Institute of Technology CambridgeMA 02139USA Rice University HoustonTX 77005USA Instituto de Física Universidade de São PauloR.do Matão 1371São Paulo 05508‑090Brazil University of Illinois at Urbana-Champaign ChampaignIL 61801USA Lawrence Berkeley National Laboratory BerkeleyCA 94720USA Wayne State University DetroitMI 48201USA RIKEN BNL Research Center Brookhaven National LaboratoryUptonNY 11973USA University of Houston HoustonTX 77204USA Physics Department Kent State UniversityKentOH 44242USA Niels Bohr Institute University of CopenhagenBlegdamsvej 172100 CopenhagenDenmark

High-energy nuclear collisions encompass three key stages:the structure of the colliding nuclei,informed by low-energy nuclear physics,the initial condition,leading to the formation of quark-gluon plasma(QGP),and the hydrodynamic expansion and hadronization of the QGP,leading to fnal-state hadron distributions that are observed *** advances in both experimental and theoretical methods have ushered in a precision era of heavy-ion collisions,enabling an increasingly accurate understanding of these ***,most approaches involve simultaneously determining both QGP properties and initial conditions from a single collision system,creating complexity due to the coupled contributions of these stages to the fnal-state *** avoid this,we propose leveraging established knowledge of low-energy nuclear structures and hydrodynamic observables to independently constrain the QGP's initial *** conducting comparative studies of collisions involving isobar-like nuclei—species with similar mass numbers but diferent ground-state geometries—we can disentangle the initial condition's impacts from the QGP *** approach not only refnes our understanding of the initial stages of the collisions but also turns high-energy nuclear experiments into a precision tool for imaging nuclear structures,ofering insights that complement traditional low-energy *** for carrying out such comparative experiments at the Large Hadron Collider and other facilities could signifcantly advance both highenergy and low-energy nuclear ***,this approach has implications for the future electron-ion *** the possibilities are extensive,we focus on selected proposals that could beneft both the high-energy and low-energy nuclear physics *** prepared as input for the long-range plan of *** physics,this white paper refects the status as of September 2022,with a brief update on developments sinc

关键词： Nuclear structure Heavy-ion collisions Collective behavior Quark-gluon plasma

Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population

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Science China(Life Sciences) 2019年第2期62卷 153-164页

作者： Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao dean-Yao lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province Sichuan Provincial People's Hospital School of MedicineUniversity of Electronic Science and Technology of China Institute of Chengdu Biology Sichuan Translational Medicine Hospital Chinese Academy of Sciences Department of Ophthalmology Visual Science Eye and ENT Hospital Shanghai Medical School Fudan University Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Department of Ophthalmology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital

Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders.

关键词： intraocular pressure glaucoma genome-wide association study

Whole exome sequencing identifies mutations of multiple genes in a Chinese cohort of 95 sporadic probands with presumptive retinitis pigmentosa

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Journal of Bio-X Research 2018年第3期1卷 132-139页

作者： Lulin Huang Jialiang Yang Shiyao Xu Yao Mao dean Yao lee Jiyun Yang Chao Qu Yang Li Zhenglin Yang The Key Laboratory for Human Disease Gene Study Chengdu Institute of Biology Sichuan Translational Medicine Research Hospital Chinese Academy of SciencesChengduSichuan Province Department of Ophthalmology Sichuan Academy of Medical Science and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijingChina

Retinitis pigmentosa(RP),a major cause of inherited blindness worldwide,is highly *** study aimed to identify mutations in a Chinese cohort of sporadic probands with presumptive *** exome sequencing represents a considerable advancement in the identification of mutations associated with Mendelian diseases,such as *** this study,whole exome sequencing analysis was performed in a Chinese cohort of 95 sporadic probands who were initially diagnosed with RP,in order to identify disease *** detected variations were confirmed by direct Sanger sequencing,and potential pathogenicity was assessed by predictions of the mutations’*** overall mutation rate of presumptive RP genes for this cohort was 30.5%(n=29 of 95 probands).Forty-four mutations were identified in 19 RP genes,among which 40 mutations were *** probands carried mutations in autosomal dominant genes(38.0%),16 probands carried mutations in autosomal recessive genes(55.2%),and 2 probands carried mutations in X-linked genes(6.9%).Twenty-eight mutations in 18 genes linked to other retinal diseases in 23 probands were also ***,mutations were detected in 52 probands(54.7%).The recurrent and novel mutations reported here will expand potential understanding of the pathogenesis of RP and other retinal diseases.

关键词： gene mutation mutation proband retinitis pigmentosa whole exome sequencing

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还挣扎在文件泥淖中吗?

职场 2013年第1期 42-42页

作者： dean lee

花费宝贵的时间找东西实在是让工作变得很无趣，也会给你带来很多压力。采用这些简单的关于文件归档整理的技巧，建立一套适合自己的文件归档系统，应用于生活之中将让你生活更轻松。

关键词：文件归档挣扎归档整理生活

儿童神经母细胞瘤自然杀伤细胞扩增和激活的免疫治疗研究

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维普期刊数据库

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儿童神经母细胞瘤自然杀伤细胞扩增和激活的免疫治疗研究

Hurricane disturbances, tree diversity, and succession in North Carolina Piedmont forests, USA

2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者：刘茵 Hong-Wei Wu Michael A. Sheard Richard Sposto Robert C. Seeger Laurence J.N. Cooper dean A. lee Division of Hematology/Oncology and Saban Research Institute Children’s Hospital Los Angeles Keck School of Medicine University of Southern California 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 Department of Preventive Medicine Keck School of Medicine University of Southern California Division of Pediatrics MD Anderson Cancer Center University of Texas

目的自然杀伤细胞(NK细胞)及抗肿瘤细胞膜受体可应用于一系列肿瘤的免疫治疗。本研究旨在探讨体外扩增高危神经母细胞瘤(NB)患儿外周血获得大量高肿瘤细胞杀伤能力NK细胞的方法,NK细胞杀伤肿瘤细胞过程中释放的细胞因子和趋化因子,以及... 详细信息

目的自然杀伤细胞(NK细胞)及抗肿瘤细胞膜受体可应用于一系列肿瘤的免疫治疗。本研究旨在探讨体外扩增高危神经母细胞瘤(NB)患儿外周血获得大量高肿瘤细胞杀伤能力NK细胞的方法,NK细胞杀伤肿瘤细胞过程中释放的细胞因子和趋化因子,以及小鼠体内NK细胞杀伤NB肿瘤细胞的能力。方法K562

关键词：儿童神经母细胞瘤杀伤能力细胞扩增免疫治疗

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Journal of Forestry Research 2019年第1期30卷 219-231页

作者： Weimin Xi Robert K.Peet Michael T.lee dean L.Urban Department of Biology University of North Carolina at Chapel Hill Department of Biological and Health Sciences Texas A & M University-Kingsville The Nicholas School of the Environment Duke University

Windthrow plays a critical role in maintaining species diversity in temperate forests. Do large-scale strong wind events(i.e., tropical cyclones, including hurricanes,typhoons and severe cyclonic storms) increase tree diversity in severely damaged forest areas? Do hurricanes(tropical cyclones that occurs in the Atlantic Ocean and northeastern Pacific Ocean) lead to altered relative abundance of shade-tolerant and shade-intolerant species? Did historic hurricanes alter the succession trajectory of the damaged forests? We used nearly 70-year tree demographic data to assess the effects of two major hurricanes on woody species diversity in Piedmont forests, North Carolina, USA. Species richness(S) and Shannon–Wiener's diversity index(H') were used to evaluate the changes in tree diversity. The changes in composition were assessed with Nonmetric Multidimensional Scaling. The pre-hurricane successional phase can strongly influence both the damage severity and subsequent responses. Although there is often an immediate drop in diversity following a hurricane, understory tree diversity quickly increases to levels that exceed those prior to the disturbance. This leads to an increase in diversity in stands that were substantially damaged. Hurricanes significantly decrease the dominance of shade-intolerant canopy species while increasing preestablished, more shade-tolerant species. We conclude that large, and infrequent hurricanes help to maintain local tree diversity, but also accelerate the increase in dominance of understory species such as red maple and beech.

关键词： Wind disturbance Tree species diversity Plant succession Disturbance-diversity relationship Piedmont forests

Public Exposure to U.S. Commercial Nuclear Power Plants Induced Disasters

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International Journal of Disaster Risk Science 2015年第3期6卷 238-249页

作者： dean Kyne Department of Sociology and Anthropology The University of Texas Rio Grande Valley

This study explores the potential risks associated with the 65 U.S.-based commercial nuclear power plants and the distribution of those risks among the populations of both their respective host communities and of the communities located in outlying areas. First, it starts by examining the racial/ethnic composition of the host community populations, as well as the disparities in socioeconomic status that exist, if any, between the host communities and communities located in outlying ***, it utilizes two independent-sample T tests to identify any differences in the sociodemographic compositions of the two areas. Third, it explores regional demographic trends by looking at the percent change in demographic variables in the host communities and communities located in outlying areas in 1990–2000 and2000–2010. Findings reveal that during the past two decades more people were exposed to the risks as population living in the host communities increased.

关键词： Exposure to nuclear power disasters Host communities Nuclear disasters U.S. commercial nuclear power plants

Sustainability in Data and Food

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Data Intelligence 2019年第1期1卷 43-57页

作者： dean Allemang Working Ontologist LLC.55 W Livingston AvenueColumbusOH 43215USA

As the world population continues to increase,world food production is not keeping *** means that to continue to feed the world,we will need to optimize the production and utilization of food around the *** of a process on a global scale requires massive *** is no exception,but also brings its own unique issues,based on how wide spread agricultural data are,and the wide variety of data that is relevant to optimization of food production and *** suggests that we need a global data ecosystem for agriculture and *** an ecosystem already exists to some extent,made up of data sets,metadata sets and even search engines that help to locate and utilize data sets.A key concept behind this is sustainability-how do we sustain our data sets,so that we can sustain our production and distribution of food?In order to make this vision a reality,we need to navigate the challenges for sustainable data management on a global *** from the current state of practice,how do we move forward to a practice in which we make use of global data to have an impact on world hunger?In particular,how do we find,collect and manage the data?How can this be effectively deployed to improve practice in the field?And how can we make sure that these practices are leading to the global goals of improving production,distribution and sustainability of the global food supply?These questions cannot be answered yet,but they are the focus of ongoing and future research to be published in this journal and elsewhere.

关键词： Agriculture Data science Data sharing Sustainability Vocabulary management

REDUCING THE COST OF GREEN

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Journal of Green Building 2006年第1期1卷 46-54页

作者： dean Sherwin Construction Cost Management United States

INTRODUCTION There is a general perception that building green will cost ***,we want to examine to what extent this is true,what are the factors influencing increased costs,and,perhaps most important,look for ways of controlling these costs.A few studies have tracked the cost of leeD Certified buildings in the last few years,and the general finding as well as the consensus is that a leeD Certified building does not involve significantly more cost,whereas leeD Silver,Gold,and Platinum designations do—the higher the certification achieved,the greater the extra *** average additional costs seem to be in the range of 2–5%for Silver,5–10%for Gold,and 10%or more for Platinum.

关键词： leeD Silver cost Platinum