检索结果-南通市图书馆

Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2018年第2期8卷 51-63页

作者： Georgia M Parkin Madhara Udawela Andrew Gibbons Brian dean Molecular Psychiatry Laboratory the Florey Institute of Neuroscience and Mental Health CRC for Mental Health Research Centre for Mental Health the Faculty of Health Arts and Design Swinburne University

Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders.

关键词： Glia Excitatory amino acid transporter Psychiatry Affective disorders Glutamate transporter Glutamate Schizophrenia

Hurricane disturbances, tree diversity, and succession in North Carolina Piedmont forests, USA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2019年第1期30卷 219-231页

作者： Weimin Xi Robert K.Peet Michael T.Lee dean L.Urban Department of Biology University of North Carolina at Chapel Hill Department of Biological and Health Sciences Texas A & M University-Kingsville The Nicholas School of the Environment Duke University

Windthrow plays a critical role in maintaining species diversity in temperate forests. Do large-scale strong wind events(i.e., tropical cyclones, including hurricanes,typhoons and severe cyclonic storms) increase tree diversity in severely damaged forest areas? Do hurricanes(tropical cyclones that occurs in the Atlantic Ocean and northeastern Pacific Ocean) lead to altered relative abundance of shade-tolerant and shade-intolerant species? Did historic hurricanes alter the succession trajectory of the damaged forests? We used nearly 70-year tree demographic data to assess the effects of two major hurricanes on woody species diversity in Piedmont forests, North Carolina, USA. Species richness(S) and Shannon–Wiener's diversity index(H') were used to evaluate the changes in tree diversity. The changes in composition were assessed with Nonmetric Multidimensional Scaling. The pre-hurricane successional phase can strongly influence both the damage severity and subsequent responses. Although there is often an immediate drop in diversity following a hurricane, understory tree diversity quickly increases to levels that exceed those prior to the disturbance. This leads to an increase in diversity in stands that were substantially damaged. Hurricanes significantly decrease the dominance of shade-intolerant canopy species while increasing preestablished, more shade-tolerant species. We conclude that large, and infrequent hurricanes help to maintain local tree diversity, but also accelerate the increase in dominance of understory species such as red maple and beech.

关键词： Wind disturbance Tree species diversity Plant succession Disturbance-diversity relationship Piedmont forests

The calculus of violence

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The calculus of violence

Utility of Doppler ultrasonography for predicting improvement of platelet count after transjugular intrahepatic portosystemic shunt

作者： Aaron Sheehan-dean.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Gastroenterology Report 2017年第4期5卷 305-308,I0003页

作者： Kianoush Ansari-Gilani Babak Seddigh Tonekaboni dean A Nakamoto Jamak Modaresi Esfeh Department of Diagnostic Radiology University Hospitals Case Medical CenterClevelandOHUSA Department of Gastroenterology and Hepatology Shahid Beheshti UniversityTehranIran Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOHUSA

*** pressure gradient(PPG)after transjugular intrahepatic portosystemic shunt(TIPS)12mmHg(P=0.098 and P=0.075).Platelets increased significantly when FVG≤100 cm/s(n=95)vs FVG>100 cm/s(n=26)one week(37.0×10^(3) vs 11.0×10^(3);P=0.005 vs 0.07)and one month after TIPS placement(17.0×10^(3) vs 5.2×10^(3);P=0.01 vs 0.21).***>100 cm/s is not associated with increase in post-TIPS platelet *** the other hand,findings suggestive of proper TIPS function(FVG≤100 cm/s and PPG≤12mmHg)predict a significant increase in post-TIPS platelet count.

关键词： liver cirrhosis transjugular intrahepatic portosystemic shunt platelet count Doppler ultrasound

Thylakoid Transit Peptide Is Related to the Expression and Localization of NdhB Subunits in Soybean

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2021年第1期90卷 99-110页

作者： Siyi Fu Tao Yun Dexuan Ma Bingsong Zheng dean Jiang Yi He State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou311300China China Science and Technology Exchange Center Beijing100045China State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou310058China

The chloroplast NAD(P)H dehydrogenase(NDH)complex,as one of the most important photosynthesis protein complexes in thylakoid membrane,is involved in photosystem I(PSI)cyclic electron transport(CEF).Under abiotic environmental stress,the photosynthetic apparatus is susceptible to the damage caused by the strong light ***,the enhancement of NDHdependent CEF could facilitate the alleviation of the damage to the photosynthetic *** NdhB subunit encoded by chloroplast genome is one of most important subunits of NDH complex and consists of 510 amino ***,according to cloning ndhB from Melrose(cultivated soybean),ACC547(wild salt-tolerant soybean),S113-6 and S111-9(hybrid descendant),based on the comparison and analysis of the sequences of NdhB subunits,we found that there is a novel thylakoid transit peptide of NdhB subunit in *** addition,crosslink immunoprecipitation,immunogold labeling and co-expression of GFP fusion protein indicated that the novel thylakoid transit peptide is favorable to the expression and localization of NdhB subunit in ***,we suggest that this novel thylakoid transit peptide plays the same role as chaperonin and contributes to facilitating the expression and localization of NdhB subunit.

关键词： NDH complex NdhB subunit thylakoid transit peptide

An Ultrasonic Backscatter Instrument for Cancellous Bone Evaluation in Neonates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2015年第3期1卷 336-343页

作者： Chengcheng Liu Rong Zhang Ying Li Feng Xu dean Ta Weiqi Wang Department of Electronic Engineering Fudan University Department of Neonatology Children’s Hospital of Fudan University Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention (MICCAI) of Shanghai

Ultrasonic backscatter technique has shown promise as a noninvasive cancellous bone assessment tool. A novel ultrasonic backscatter bone diagnostic （UBBD） instrument and an in vivo application for neonatal bone evaluation are introduced in this study. The UBBD provides several advantages, including noninvasiveness, non- ionizing radiation, portability, and simplicity. In this study, the backscatter signal could be measured within 5 s using the UBBD. Ultrasonic backscatter measurements were performed on 467 neonates （268 males and 199 females） at the left calcaneus. The backscatter signal was measured at a central frequency of 3.5 MHz. The delay （-/-1） and duration （7-2） of the backscatter signal of interest （SOl） were varied, and the apparent integrated backscatter （AIB）, frequency slope of apparent backscatter （FSAB）, zero frequency intercept of apparent backscatter （FIAB）, and spectral centroid shift （SCS） were calculated. The results showed that the SOl selection had a direct influence on cancellous bone evaluation. The AIB and FIAB were positively correlated with the gestational age （｜R｜ up to 0.45, P 〈 0.001） when -/-1 was short （〈 8 μS）, while negative correlations （｜R｜ up to 0.56, P 〈 0.001） were commonly observed for T1 〉 10 IJS. Moderate positive correlations （IRI up to 0.45, P 〈 0.001） were observed for FSAB and SCS with gestational age when 71 was long （〉 10 μs）. The 7-2 mainly introduced fluctuations in the observed correlation coefficients. The moderate correlations observed with UBBD demonstrate the feasibility of using the backscatter signal to evaluate neonatal bone status. This study also proposes an explicit standard for in vivo SOl selection and neonatal cancellous bone assessment.

关键词： ultrasonic backscatter cancellous bone evaluation signal of interest (SOI) backscatter instrument neonatal bone status

Virtual Fluorescence Translation for Biological Tissue by Conditional Generative Adversarial Network

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenomics 2023年第4期3卷 408-420页

作者： Xin Liu Boyi Li Chengcheng Liu dean Ta Academy for Engineering and Technology Fudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 200433China Center for Biomedical Engineering Fudan UniversityShanghai 200433China

Fluorescence labeling and imaging provide an opportunity to observe the structure of biological tissues,playing a crucial role in the field of ***,when labeling and imaging biological tissues,there are still some challenges,e.g.,time-consuming tissue preparation steps,expensive reagents,and signal bias due to *** overcome these limitations,we present a deep-learning-based method for fluorescence translation of tissue sections,which is achieved by conditional generative adversarial network(cGAN).Experimental results from mouse kidney tissues demonstrate that the proposed method can predict the other types of fluorescence images from one raw fluorescence image,and implement the virtual multi-label fluorescent staining by merging the generated different fluorescence images as ***,this proposed method can also effectively reduce the time-consuming and laborious preparation in imaging processes,and further saves the cost and time.

关键词： Virtual fluorescence labeling Image translation Tissues section Generative adversarial network

Changes in forest structure, species diversity and spatial pattern following hurricane disturbance in a Piedmont North Carolina forest, USA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2008年第1期1卷 43-57页

作者： Weimin Xi Robert K.Peet dean L.Urban Department of Biology University of North Carolina at Chapel HillChapel HillNC 29599-3280USA The Nicholas School of the Environment and Earth Sciences Duke UniversityDurhamNC 27708USA

Aims Large hurricanes have profound impacts on temperate forests,but owing to their infrequent nature these effects have rarely been examined in *** 1996,Hurricane Fran significantly damaged many long-term tree census plots in the Duke Forest on the North Carolina Piedmont,thereby providing an exceptional opportunity to examine pre-and post-hurricane forest compositional *** goal was to examine immediate,short-term(0–4 years)and longer term(;5 year)hurricane-induced structural,spatial and compositional changes in the tree population(stem d.b.h>1 cm)in the context of our detailed,long-term knowledge of the dynamics of these *** We surveyed stem damage and tree mortality in 34 long-term permanent plots(ca.70-year record;404–1012 m^(2))and 7 large mapped tree stands(ca.20-year record;5250–65000 m^(2))representing both transition-phase,even-aged pine stands and uneven-aged upland hardwood *** employed three types of damage measures to quantify stand-level damage severity:percentage of stems damaged,percentage of basal area lost and a‘stand-level damage index’.Second-order spatial analysis(Ripley’s K-function)was used to investigate patterns in tree *** findings Our study found hurricane effects on the structural attributes of Piedmont forests to be variable and *** in tree species composition,however,were *** was the major damage type for the overstory trees[diameter at breast height(d.b.h.)>10 cm]apparently due to the exposure of the crowns to high wind combined with heavy rainfall prior to and during the ***,juvenile trees and small trees(1–10 cm d.b.h.)of the understory and midstory were mainly damaged by being pinned or bent by their damaged large ***-induced tree mortality varied weakly among species,was positively correlated with pre-hurricane tree size and remained up to 2-fold higher than pre-hurricane background mortality 5 years after the ***

关键词： delayed tree mortality disturbance ecology hurricane damage d Hurricane Fran spatial point pattern analysis stand dynamics structural heterogeneity

Regioselective oxidation of tetracycline by permanganate through alternating susceptible moiety and increasing electron donating ability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第1期32卷 281-288页

作者： Xiaohua Jiang William AJefferson dean Song Hanyang Cheng Fengmin Li Zhimin Qiang Aiqian Zhang Huijuan Liu Jiuhui Qu College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China The State Agriculture Ministry Laboratory of Quality&Safety Risk Assessment for Tobacco Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Enuironmental SciencesChinese Academy of SciencesBeijing 100085China

Permanganate has attracted much attention in wide range of chemistry and particularly in degradation of environmental ***,few studies have discussed the feature of regioselective reactivity of permanganate with specific moiety of the target ***,we studied the reaction between permanganate and tetracycline that is an emerging micropollutant with different species containing several electron-rich *** second-order rate constants increased from 6.0 to 9.0 and could be quantitatively modeled by considering the speciation of both reactants,yielding kTC0=11.7(mol/L)^-1 sec^-1,kTC-=35.7(mol/L)^-1 sec^-1,kTC2-=43.1(mol/L)^-1 sec^-1 for individual reaction *** products were then identified as the hydroxylated and demethylated *** result suggested a rate-limiting step of simple hydroxylation at the phenolic and/or alkene moieties,while the demethylation should be caused by the unavoidably formed manganese oxide via single electron *** is supported by the DFT calculation,indicating the primary oxidation of phenolic group of TC0 with activation barrier of 44.5 kcal/mol and of alkene group of TC-and TC2-with activation barriers of 44.0 and 43.4 kcal/mol,*** is in agreement with the experimental results,implying the alternation of regioselectivity associated with the deprotonation *** result was further supported by performing the Fukui function and electrostatic potential analysis,reflecting the more probable site and better electron donating tendency beneficial to the permanganate oxidation.

关键词： Permanganate oxidation of tetracycline Regioselective reactivity Rate-limiting hydroxylation step Altered susceptible moiety Increased electronegativity