检索结果-南通市图书馆

Strategies for Precise Engineering and Conjugation of Antibody Targeted-nanoparticles for Cancer Therapy

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2020年第3期40卷 463-473页

作者： Yuan-yuan GUO Lu HUANG Zhi-ping ZHANG de-hao fu department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430077China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Improvements in the diagnosis and treatment of cancer are urgently needed for use in ***(NPs)can reduce the side effects of traditional chemotherapy by sustained release of loaded drugs and increase therapeutic *** can also enhance endothelial permeation retention by size effect and its accumulation in tumor cells through passive ***,it is critical to treat cancer with a controlled targeted drug which can be specifically delivered into tumor cells and released there,resulting in a targeted therapy to eradicate tumor cells while sparing normal *** this end,antibody-mediated targeting therapy has been developed,but imperfections in antibodies(Abs)limit this ***,the combination of NPs and Abs has been highly valued in recent years,because conjugating special Abs on the surface of NPs can increase targeting efficiency,enabling selective delivery of anti-cancer drugs to tumor *** this mini-review,we would like to enumerate the strategies for the conjugation of Abs to the surface of the NPs as well as the precise engineering of targeted *** application of targeting antibody fragments in this drug delivery system will also be discussed.

关键词： cancer drug delivery nanoparticle antibody conjugation

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture design for Flexible and Stretchable Supercapacitors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan Zhang Cheng hao Tongtong fu Dian Yu Jane Howe Kaiwen Chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

Preoperative evaluation of pancreatic ductal adenocarcinoma with synchronous liver metastasis: Diagnosis and assessment of unresectability

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第45期22卷 10024-10037页

作者： hao-Jun Shi Chen Jin de-Liang fu department of Pancreatic Surgery Pancreatic Disease Institute Huashan Hospital Fudan University

AIM To identify predictors for synchronous liver metastasis from resectable pancreatic ductal adenocarcinoma(PDAC) and assess unresectability of synchronous liver *** Retrospective records of PDAC patients with synchronous liver metastasis who underwent simultaneous resections of primary PDAC and synchronous liver metastasis, or palliative surgical bypass, were collected from 2007 to 2015. A series of pre-operative clinical parameters, including tumor markers and inflammation-based indices, were analyzed by logistic regression to figure out predictive factors and assess unresectability of synchronous liver metastasis. Cox regression was used to identify prognostic factors in liver-metastasized PDAC patients after surgery, with intention to validate their conformance to the indications of simultaneous resections and palliative surgical bypass. Survival of patients from different groups were analyzed by the Kaplan-Meier method. Intra- and post-operative courses were compared, including complications. PDAC patients with no distant metastases who underwent curative resection served as the control *** CA125 > 38 U/mL(OR = 12.397, 95%CI: 5.468-28.105, P dependently predicted synchronous liver metastasis from resectable PDAC. CA125 > 62 U/mL(OR = 5.181, 95%CI: 1.612-16.665, P = 0.006) and age > 62 years(OR = 3.921, 95%CI: 1.217-12.632, P = 0.022) correlated with unresectability of synchronous liver metastasis, both of which also indicated a worse long-term outcome of liver-metastasized PDAC patients after surgery. After the simultaneous resections, patients with postoperatively elevated serum CA125 levels had shorter survival than those with post-operatively reduced serum CA125 levels(7.7 mo vs 16.3 mo, P = 0.013). The survival of liver-metastasized PDAC patients who underwent the simultaneous resections was similar to that of non-metastasized PDAC patients who underwent cu

关键词： CA125 Pancreatic ductal adenocarcinoma Liver metastasis Unresectability Prognosis

Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第2期23卷 265-274页

作者： hao-Jun Shi Chen Jin de-Liang fu department of Pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalFudan UniversityShanghai 200040China

AIM To evaluate the impact of glycemic control and nutritional status after total pancreatectomy(TP) on complications, tumor recurrence and overall *** Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected before and after surgery, and during the follow-up were evaluated. The associations of glycemic control and nutritional status with complications, tumor recurrence and long-term survival were determined. Risk factors for postoperative glycemic control and nutritional status were *** High early postoperative fasting blood glucose(FBG) levels(OR = 4.074, 95%CI: 1.188-13.965, P = 0.025) and low early postoperative prealbumin levels(OR = 3.816, 95%CI: 1.110-13.122, P = 0.034) were significantly associated with complications after TP. Postoperative Hb A1 c levels over 7%(HR = 2.655, 95%CI: 1.299-5.425, P = 0.007) were identified as one of the independent risk factors for tumor recurrence. Patients with postoperative Hb A1 c levels over 7% had much poorer overall survival than those with Hb A1 c levels less than 7%(9.3 mo vs 27.6 mo, HR = 3.212, 95%CI: 1.147-8.999, P = 0.026). Patients with long-term diabetes mellitus(HR = 15.019, 95%CI: 1.278-176.211, P= 0.031) and alcohol history(B = 1.985, SE = 0.860, P = 0.025) tended to have poor glycemic control and lower body mass index levels after TP, *** At least 3 mo are required after TP to adapt to diabetes and recover nutritional status. Glycemic control appears to have more influence over nutritional status on longterm outcomes after TP. Improvement in glycemic control and nutritional status after TP is important to prevent early complications and tumor recurrence, and improve survival.

关键词： Total pancreatectomy Glycemic control Nutritional status Complication Tumor recurrence Prognosis

敦煌三危山出产多色颜料的矿物学及谱学特征研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光谱学与光谱分析 2025年第1期45卷 152-159页

作者：李林筱谭宇辰先怡衡铁付德孙满利艾昊梁云孙凤西北大学文化遗产学院陕西西安710127 中国国家博物馆北京100006

敦煌三危山火焰沟发现一处古代多色颜料开采遗址,该遗址的发现对研究我国西北地区古代矿物颜料的来源有着一定的学术意义。为判断三危山出产颜料的矿物种属及其谱学特征,本文应用偏光显微镜、X射线衍射、激光拉曼光谱、X射线荧光光谱多... 详细信息

敦煌三危山火焰沟发现一处古代多色颜料开采遗址,该遗址的发现对研究我国西北地区古代矿物颜料的来源有着一定的学术意义。为判断三危山出产颜料的矿物种属及其谱学特征,本文应用偏光显微镜、X射线衍射、激光拉曼光谱、X射线荧光光谱多种光谱分析手段对所出产多色颜料矿物开展科学分析。结果表明,三危山古矿出产矿物颜料属天然矿物,主要化学成分为Fe_(2)O_(3)(平均含量66%)和SiO_(2)等,部分样品呈现富硅铝的特征,且均存在不同程度的烧失;主要物相以赤铁矿、针铁矿为主,少许铁矾类,脉石矿物包括石英、高岭石及少许黏土矿物。同时进一步通过拉曼光谱对矿物颜料的显色物相进行分析,2号亮黄色矿物显色物相和前述主要物相一致,均为铁矾类(黄钾铁矾和黄钠铁矾)。除4号样品外,所有呈红棕色的样品主要显色物相均为α-Fe_(2)O_(3)即赤铁矿,而4号样品显色物相为针铁矿,呈色本应为黄色,但致其呈色变为红棕色是由于和赤铁矿伴生存在,且赤铁矿显色能力远强于针铁矿,故改变了4号样品的呈色。综上,该古矿遗址所出产的红色矿物颜料主要为赤铁矿,黄色矿物颜料为黄钾铁矾和黄钠铁矾。黄钾铁矾作为优良的颜料,在岩画及壁画也多有使用,但在莫高窟目前已研究的壁画上暂未发现使用,三危山古矿实证了铁矾类颜料矿物的存在,该发现在一定程度上拓宽了对西北地区黄色矿物颜料的维度。同时也为后续研究该矿冶遗址出产颜料的流向,提供了基础性的数据支撑。

关键词：敦煌采矿遗址矿物颜料呈色拉曼光谱

Pattern control for large-scale spacecraft swarms in elliptic orbits via density fields

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2022年第3期35卷 367-379页

作者： Chihang YANG hao ZHANG Weida fu Key Laboratory of Space Utilization Technology and Engineer Center for Space UtilizationChinese Academy of SciencesBeijing 100094China University of Chinese Academy of Sciences Beijing 100049China DFH Satellite Co. LtdBeijing 100094China

Space swarms,enabled by the miniaturization of spacecraft,have the potential capability to lower costs,increase efficiencies,and broaden the horizons of space *** formation control problem of large-scale spacecraft swarms flying around an elliptic orbit is *** objective is to drive the entire formation to produce a specified spatial *** relative motion between agents becomes complicated as the number of agents ***,a density-based method is adopted,which concerns the density evolution of the entire swarm instead of the trajectories of *** density-based method manipulates the density evolution with Partial Differential Equations(Pdes).This density-based control in this work has two aspects,global pattern control of the whole swarm and local collision-avoidance between nearby *** global behavior of the swarm is driven via designing velocity *** each spacecraft,the Q-guidance steering law is adopted to track the desired velocity with accelerations in a distributed ***,the final stable velocity field is required to be zero in the classical density-based approach,which appears as an obstacle from the viewpoint of astrodynamics since the periodic relative motion is always *** solve this issue,a novel transformation is constructed based on the periodic solutions of Tschauner-Hempel(TH)*** relative motion in Cartesian coordinates is then transformed into a new coordinate system,which permits zero-velocity in a stable *** local behavior of the swarm,such as achieving collision avoidance,is achieved via a carefully-designed local density estimation *** simulations are provided to demonstrate the performance of this approach.

关键词： Collision avoidance density-based feedback control Distributed control Formation flight Large-scale swarms Pattern generation Pde-based control TH equation

Symmetry theories of Hamiltonian systems with fractional derivatives

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1847-1853页

作者： ZHOU Sha fu hao fu JingLi Institute of Mathematical Physics Zhejiang Sci-Tech University Hangzhou 310018 China China Jingye Engineering Corporation Limited Shenzhen Branch Shenzhen 518054 China

The Noether and Lie symmetries as well as the conserved quantities of Hamiltonian system with fractional derivatives are es-tablished. The definitions and criteria for the fractional symmetrical transformations and quasi-symmetrical transformations inthe Noether sense of Hamiltonian system are first discussed. Then, using the invariance of Hamiltonian action under the infini-tesimal transformations with respect to time, generalized coordinates and generalized momentums, the fractional Noethertheorem of the system is obtained. further, the Lie symmetry and conserved quantity of the system are acquired. Two exam-ples are presented to illustrate the application of the results.

关键词： symmetry conserved quantity Hamiltonian system fractional derivative

Influence of sub boundary layer vortex generator height and attack angle on cross-flows in the hub region of compressors

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2022年第8期35卷 30-44页

作者： hao fu Ling ZHOU Lucheng JI School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute for Aero Engine Tsinghua UniversityBeijing 100084China

It has been recently shown that Sub Boundary layer Vortex Generator(SBVG,abbreviated as VG hereafter)can suppress the Cross-Flow(CF),and therefore,can eliminate corner separation and increase aerodynamic loading when installed on the end wall inside middle-load compressor ***,when VGs are applied in high-load compressors,it is difficult to achieve ideal *** is because the definition of the VG attack angle in the presence of CF in existing research is confusing,and the stronger CF in high-load compressors worsens the problem and results in an improper design and optimization range of VG attack ***,this paper clarifies the definition of the VG attack angle in the presence of CF and reveals the CF controlling mechanism of VG on a flat *** differences in the flow phenomena around a VG both with and without CF are also *** numerical results show that a larger height or attack angle of the VG generates a greater CF suppression ***,the cross velocity increases when surmounting the primary vortex induced by the VG,except that this enhanced CF is less conspicuous for larger VG *** to the cases without CF,the VG suffers an additional loss because of the stronger separation and primary vortex loss caused by the CF.

关键词： Compressors Corner separation Cross-flow Flat plate Vortex generator

Structures and Properties of Polyimide with Different Pre-imidization degrees

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第8期38卷 840-846,I0006页

作者： fu-Yao hao Jian-Hua Wang Sheng-Li Qi Guo-Feng Tian de-Zhen Wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

A series of polyimide(PI)films derived from pyromellitic dianhydride(PMDA)and 4,4'-oxydianiline(ODA)were prepared with the employment of chemical pre-imidization,and the pre-imidization degree(pre-ID)was found influential on structures and properties of the films ***,a certain degree of chemical imidization could promote the in-plane orientation of molecular chains inside the film,which then enhanced the mechanical strength and reduced the coefficient of thermal expansion(CTE)of the ***,such pre-imidization process could expand the internal space gap inside the films,thereby lowering their dielectric constant and glass transition *** study provides a new approach for preparing high-performance PI films through chemical imidization.

关键词： Polyimide Pre-imidization Stacking model In-plane orientation