A Detailed View of PLGA-m PEG Microsphere Formation by Double Emulsion Solvent Evaporation Method

作     者：Shui-bin Feng De-hao Fu Lei Nie Peng Zou 索进平 

作者机构：State Key Laboratory of Material Processing and Die and Mould Technology College of Materials Science and Engineering Huazhong University of Science and Technology Department of Orthopedics Union Hospital Tongji Medical College Huazhong University of Science and Technology 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2015年第33卷第7期

页      面：955-963页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：financially supported by the Independent Innovation Foundation of Huazhong University of Science and Technology(No.2013ZHYX008) the National Natural Science Foundation of China(No.81370980) 

主　　题：Microspheres PLGA m PEG Morphology Encapsulation efficiency Release profile 

摘      要：PLGA, m PEG diblock copolymer was synthesized by bulk ring-opening polymerization method. The double emulsion solvent evaporation method was used to prepare bovine serum albumin（BSA）-loaded microspheres. Optical microscopy was used to observe the whole microsphere fabrication process. It is confirmed that the proportion of inner aqueous phase is one of the most critical factors that determines the morphology of microspheres. Double emulsion droplets which have appropriate amount of inner aqueous phase can form closed and dense microspheres, while, too much inner aqueous phase will cause a collapse of the double emulsion droplets, resulting in a loss of drug. The proportion of inner aqueous phase was varied to prepare microspheres of different morphology. The results show that with increasing the amount of inner aqueous phase, a higher percent of broken microspheres and lower encapsulation efficiency appeared, and also, a more severe initial burst release and faster release rate.