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Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 842-859页

作者： Bo-Tao Duan Xue-Kai Zhao Yang-Yang Cui de-zheng liu Lin Wang Lei Zhou Xing-Yuan Zhang department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina department of Ophthalmology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely *** study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC *** To establish a GILncSig that can predict the prognosis of HCC *** Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation *** GI-LncRNAs were then analyzed for functional *** GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA *** addition,we explored the effects of the GILncSig and TP53 on *** A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and *** GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA *** Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic *** operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published ***,the GILncSig may have a better predictive performance than TP53 mutation status *** We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.

关键词： Genomic instability Long noncoding RNA Hepatocellular carcinoma Prognosis Diagnosis

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Fatigue-resistant sliding ferroelectricity

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Science China Materials 2024年第10期67卷 3417-3418页

作者： zheng liu School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

The direction of spontaneous polarization in ferroelectricity can be reoriented by an external electric *** special feature of ferroelectricity is important candidates for fabricating advanced nonvolatile random-access memory[1].However,repeatedly switching polarization induces the ferroelectric device performance degenerates due to a reduction of polarization.

关键词： polarization ferroelectric field.

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Effect of Pre-strain on Microstructure and Stamping Performance of High-strength Low-alloy Steel

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 774-780页

作者：刘坡 WEN Zhicheng liu zheng 许峰 School of Mechanical Engineering Guilin University of Aerospace TechnologyGuilin 541004China School of Automotive Engineer-ing Changshu Institute of TechnologyChangshu 215500China

In this study,pre-strain ranging from 0 to 0.12 was applied through uniaxial tension on high-strength low-alloy(HSLA)specimens with four kinds of grain *** of pre-strain and grain size on me-chanical property was investigated through tensile *** of the pre-strained and tensile tested samples were analyzed,*** 30.8°v-bending and following flattening,as well as Erichson cupping tests,were performed on the pre-strained *** show the elongation ratio of grain and dislocation density increases with *** platform is removed when pre-strain is larger than 0.06 while yielding plateau period decreases with pre-strain less than 0.06 due to reduction of pinning *** 30.8°v-bending and the following flattening tests are successfully accomplished on all the pre-strained samples with different grain *** in grain size,along with increase in pre-strain,causes increase in strength and decrease in elongation rate as well as cupping ***-strain causes very slight effect on bending ability,much less than that on mechanical property and cupping test *** impact of the pre-strain and grain size on HSLA steel deformability is inconspicuous.

关键词： strain hardening dislocation texture bending erichson cupping test

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Polynomial-Time Key-Recovery Attacks Against NTRURe Encrypt from ASIACCS'15

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Journal of Systems Science & Complexity 2024年第3期37卷 1308-1325页

作者： liu Zhen PAN Yanbin zheng Jinwei School of Cyber Science and Technology Hubei Key Laboratory of Applied MathematicsHubei UniversityWuhan 430062China Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

In ASIACCS 2015, Nu nez, et al. proposed a proxy re-encryption scheme, named NTRURe Encrypt, based on NTRU, which allows a proxy to translate ciphertext under the delegator’s public key into a re-encrypted ciphertext that can be decrypted correctly by delegatee’s private key. Because of the potential resistance to quantum algorithm, high efficiency and various applications in real life,NTRURe Encrypt has drawn lots of attention and its security has been widely discussed and *** PQCrypto2019, liu, et al. proposed two key recovery attacks against it. However, their first attack heavily relies on a weaken decryption oracle, and the second attack needs to collect about 260ciphertexts from the same message by theoretical analysis, which makes both of the attacks unrealistic. In this paper, inspired by the broadcast attack against NTRU, the authors find out that for NTRURe Encrypt the delegator and the delegatee can efficiently recover each other’s private key in polynomial time without any unrealistic assumptions. In addition, the authors also show how to fix NTRURe Encrypt to resist the proposed attacks. As a by-product, the authors also show how to commit broadcast attacks against NTRU 2001 with even dg, which was thought infeasible before.

关键词： Broadcast attack key recovery NTRU NTRUReEncrypt

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Improving the spaceborne GNSS-R altimetric precision based on the novel multilayer feedforward neural network weighted joint prediction model

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defence Technology（防务技术） 2024年第2期32卷 271-284页

作者： Yiwen Zhang Wei zheng Zongqiang liu Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China China Academy of Aerospace Science and Innovation Beijing 100176China State Key Laboratory of Space-Ground Integrated Information Technology Beijing Institute of Satellite Information EngineeringBeijing 100194China

Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater *** present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically ***,GNSS-R satellite constellations that meet the global altimetry needs to be ***,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric ***,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is ***,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is ***,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry.

关键词： GNSS-R satellite constellations Sea surface altimetric precision Underwater navigation Multilayer feedforward neural network

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Foundation models meet visualizations: Challenges and opportunities

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Computational Visual Media 2024年第3期10卷 399-424页

作者： Weikai Yang Mengchen liu zheng Wang Shixia liu School of Software Tsinghua UniversityBeijing 100084China Microsoft Redmond 98052USA

Recent studies have indicated that foundation models, such as BERT and GPT, excel atadapting to various downstream tasks. This adaptability has made them a dominant force in buildingartificial intelligence (AI) systems. Moreover, a newresearch paradigm has emerged as visualizationtechniques are incorporated into these models. Thisstudy divides these intersections into two researchareas: visualization for foundation model (VIS4FM)and foundation model for visualization (FM4VIS).In terms of VIS4FM, we explore the primary roleof visualizations in understanding, refining, and evaluating these intricate foundation models. VIS4FMaddresses the pressing need for transparency, explainability, fairness, and robustness. Conversely, in termsof FM4VIS, we highlight how foundation models canbe used to advance the visualization field itself. Theintersection of foundation models with visualizations ispromising but also introduces a set of challenges. Byhighlighting these challenges and promising opportunities, this study aims to provide a starting point forthe continued exploration of this research avenue.

关键词： visualization artificial intelligence(AI) machine learning foundation models visualization for foundation model(VIS4FM) foundation model for visualization(FM4VIS)

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An Integrated External Archive Local Disturbance Mechanism for Multi-Objective Snake Optimizer

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Chinese Journal of Electronics 2024年第4期33卷 989-996页

作者： Leifu GAO zheng liu Institute for Optimization and decision Analytics Liaoning Technical University

It is an interesting research direction to develop new multi-objective optimization algorithms based on meta-heuristics. Both the convergence accuracy and population diversity of existing methods are not *** paper proposes an integrated external archive local disturbance mechanism for multi-objective snake optimizer(IMOSO) to overcome the above shortcomings. There are two improved strategies. The adaptive mating between subpopulations strategy introduces the special mating behavior of snakes with multiple husbands and wives into the original snake optimizer. Some positions are updated according to the dominated relationships between the newly created individuals and the original individuals. The external archive local disturbance mechanism is used to re-search partial non-inferior solutions with poor diversities. The perturbed solutions are non-dominated sorting with the generated solutions by the next iteration to update the next external archive. The main purpose of this mechanism is to make full use of the non-inferior solution information to better guide the population evolution. The comparison results of the IMOSO and 7 state-of-the-art algorithms on WFG benchmark functions show that IMOSO has better convergence and population diversity.

关键词： Accuracy Sociology Metaheuristics Diversity methods Benchmark testing Statistics Convergence

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Understanding the global cancer statistics 2022:growing cancer burden

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Science China(Life Sciences) 2024年第10期67卷 2274-2276页

作者： Yuxi liu Zhibo zheng School of Basic Medicine Shanghai Medical College Fudan UniversityShanghai 200032China department of Thoracic Surgery Department of International MedicalServicesPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

The International Agency for Research on Cancer(IARC)established in 1965 as the cancer agency of the World Health Organization,focuses on cancer research and dedicates to developing strategies for cancer control *** F... 详细信息

关键词： cancer Cancer globally

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Joint alignment and steering to manage interference

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Digital Communications and Networks 2024年第2期10卷 429-438页

作者： Zhao Li Xiujuan Liang Yinghou liu Jia liu zheng Yan School of Cyber Engineering Xidian UniversityXi'an710126China Technol.on Commun.Net.Lab. The 54th Research Inst.of China Elec.Technol.Group Corp.Shijiazhuang050081China School of Computer Science and Technology Xidian UniversityXi'an710126China The department of Communications and Networking(Comnet) Aalto University02150EspooFinland

In wireless communication networks,mobile users in overlapping areas may experience severe interference,therefore,designing effective Interference Management(IM)methods is crucial to improving network ***,when managing multiple disturbances from the same source,it may not be feasible to use existing IM methods such as Interference Alignment(IA)and Interference Steering(IS)*** is because with IA,the aligned interference becomes indistinguishable at its desired Receiver(Rx)under the cost constraint of degrees-of-Freedom(DoF),while with IS,more transmit power will be consumed in the direct and repeated application of IS to each *** remedy these deficiencies,Interference Alignment Steering(IAS)is proposed by incorporating IA and IS and exploiting their advantages in *** IAS,the interfering Transmitter(Tx)first aligns one interference incurred by the transmission of one data stream to a one-dimensional subspace orthogonal to the desired transmission at the interfered Rx,and then the remaining interferences are treated as a whole and steered to the same subspace as the aligned ***,two improved versions of IAS,i.e.,IAS with Full Adjustment at the Interfering Tx(IAS-FAIT)and Interference Steering and Alignment(ISA),are *** former considers the influence of IA on the interfering user-pair's *** orthogonality between the desired signals at the interfered Rx can be maintained by adjusting the spatial characteristics of all interferences and the aligned interference components,thus ensuring the Spectral Efficiency(SE)of the interfering communication *** ISA,the power cost for IS at the interfered Tx is minimized,hence improving SE performance of the interfered *** the proposed methods are realized at the interfering and interfered Txs cooperatively,the expenses of IM are shared by both *** in-depth simulation results show that joint use of IA and

关键词： Interference Interference management Interference alignment Interference steering Spectral efficiency

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Data-driven evacuation and rescue traffic optimization with rescue contraflow control

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Journal of Safety Science and Resilience 2024年第1期5卷 1-12页

作者： zheng liu Jialin liu Xuecheng Shang Xingang Li School of Management Engineering Zhengzhou University of AeronauticsZhengzhou 450046China Collaborative Innovation Center for Aviation Economy development of Henan Province Zhengzhou University of AeronauticsZhengzhou 450046China School of Systems science Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Transport Industry of Big Data Application Technologies for Comprehensive Transport Beijing Jiaotong UniversityBeijing 100044China School of Transportation Engineering Shandong Jianzhu UniversityJinan 250101China

In response to local sudden disasters,e.g.,high-rise office or residential building fire disasters,road occupation can cause conflicts,and traffic directions may be opposite between evacuation vehicles and rescue vehicles;moreover,lane contraflow can be adopted to meet these surge traffic ***,lane contraflow that provides more roads for rescue vehicles reduces the traffic supply in the evacuation *** is unclear how to control the number of contraflow roads used by rescue vehicles to coordinate evacuation and rescue traffic ***,we adjust the critical rescue traffic volume of reversing the normal road traffic direction to control rescue ***,we propose a multiobjective mixed integer linear programming formulation for evacuation and rescue traffic ***,considering that the upper limit of the critical rescue traffic volume is unknown and that the proposed formulation includes multiple objectives and multi-priority vehicle classes,a three-stage solving algorithm is ***,a large-scale evacuation and rescue traffic optimization result dataset is obtained for the Nguyen–Dupuis road network,and the impact of different rescue contraflow control plans on evacuation and rescue traffic is studied based on data-driven sta-tistical *** results show that by adjusting the optimal rescue traffic route,the critical rescue traffic volume for reversing the normal road traffic direction can reduce the interference of rescue traffic to evacuation traffic operation performance without reducing rescue traffic operation performance,and can be used to coor-dinate evacuation and rescue traffic operation under rescue contraflow.

关键词： Evacuation and rescue traffic optimization Rescue contraflow control Multiobjective mixed integer linear programming Three-stage solving algorithm Data-driven statistical analysis

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