检索结果-南通市图书馆

Rare Metals 2022年第3期41卷 822-829页

作者： A-Lin Li Guo-Hua Li Shi-Gang Lu Zhi-Min Ren Jian-Tao Wang Hao-xiang zhuo Wei Quan Gang-Ning Zhang Fu-Juan Han Yi-Mian Xia Jing Wang Yi Zhang National Power Battery Innovation Center Grinm Group Company LtdBeijing 100088China China Automotive Battery Research Institute Company Ltd Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China Materials Genome Institute Shanghai UniversityShanghai 200444China

Non-aqueous electrolyte solvents play a pivotal role in improving the cycling performance of high-voltage Li-rich Mn-based layered cathode materials. In this study, a fluoroether (1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, TFEPE) was added to 1.2 mol·L^(-1)LiPF_(6)EC/EMC/deC at different concentrations to synthesize a series of electrolytes for enhancing the cycling performance of highvoltage Li_(1.18)Mn_(0.50)Ni_(0.26)Co_(0.06)O_(2)(LMNC).

关键词： materials. cycling 1,2

Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury

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Neural Regeneration Research 2017年第12期12卷 2059-2066页

作者： Yu Pan Wei-bei Dou Yue-heng Wang Hui-wen Luo Yun-xiang Ge Shu-yu Yan Quan Xu Yuan-yuan Tu Yan-qing Xiao Qiong Wu zhuo-zhao Zheng Hong-liang Zhao department of Rehabilitation Beijing Tsinghua Changgung Hospital Beijing China School of Clinical Medicine Tsinghua University Beijing China department of Electronic Engineering Tsinghua University Beijing China department of Radiology Beijing Tsinghua Changgung Hospital Beijing China

Brain plasticity, including anatomical changes and functional reorganization, is the physiological basis of functional recovery after spinal cord injury（SCI）. The correlation between brain anatomical changes and functional reorganization after SCI is unclear. This study aimed to explore whether alterations of cortical structure and network function are concomitant in sensorimotor areas after incomplete SCI. Eighteen patients with incomplete SCI（mean age 40.94 ± 14.10 years old; male：female, 7：11） and 18 healthy subjects（37.33 ± 11.79 years old; male：female, 7：11） were studied by resting state functional magnetic resonance imaging. Gray matter volume（GMV） and functional connectivity were used to evaluate cortical structure and network function, respectively. There was no significant alteration of GMV in sensorimotor areas in patients with incomplete SCI compared with healthy subjects. Intra-hemispheric functional connectivity between left primary somatosensory cortex（BA1） and left primary motor cortex（BA4）, and left BA1 and left somatosensory association cortex（BA5） was decreased, as well as inter-hemispheric functional connectivity between left BA1 and right BA4, left BA1 and right BA5, and left BA4 and right BA5 in patients with SCI. Functional connectivity between both BA4 areas was also decreased. The decreased functional connectivity between the left BA1 and the right BA4 positively correlated with American Spinal Injury Association sensory score in SCI patients. The results indicate that alterations of cortical anatomical structure and network functional connectivity in sensorimotor areas were non-concomitant in patients with incomplete SCI, indicating the network functional changes in sensorimotor areas may not be dependent on anatomic structure. The strength of functional connectivity within sensorimotor areas could serve as a potential imaging biomarker for assessment and prediction of sensory function in patients with incomplete SCI. This trial was register

关键词： nerve regeneration incomplete spinal cord injury gray matter volume functional connectivity sensorimotor areas functionalmagnetic resonance imaging brain plasticity non-concomitant anatomical structure network imaging biomarker neural regeneration

文化景观对建构地方集体记忆的影响——以徽州呈坎古村为例

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地理科学 2017年第1期37卷 110-117页

作者：孔翔卓方勇华东师范大学中国现代城市研究中心/创新战略研究中心上海200241

以对黄山市徽州区呈坎古村居民和游客的问卷调查和半结构式访谈为基础,综合运用独立样本t检验和Arc GIS空间分析等方法,分析了文化景观在地方集体记忆建构中的作用。结果显示,无论居民或游客,都对呈坎古村的宗族文化和风水文化形成了集... 详细信息

以对黄山市徽州区呈坎古村居民和游客的问卷调查和半结构式访谈为基础,综合运用独立样本t检验和Arc GIS空间分析等方法,分析了文化景观在地方集体记忆建构中的作用。结果显示,无论居民或游客,都对呈坎古村的宗族文化和风水文化形成了集体记忆,而罗东舒祠和水口园林等文化景观则在建构地方集体记忆中发挥了重要作用。但由于与景观接触的方式不同,居民比游客更重视景观的真实性,相对排斥重建和新建的景观,也较少受到导游词的影响;而游客则对景观的真实性不敏感,文化景观和导游解说都可能影响游客的地方记忆。因此,为更好引导对古村落的集体记忆的建构,不仅要重视保护传统文化景观,更要在景观重建或新建过程中尊重居民的建议,争取在居民的传统意识和游客的旅游想象中实现平衡。

关键词：地方集体记忆文化景观徽州文化呈坎

“全校性”创业教育：现状、成效与趋势——访美国知名高校创业研究者卡尔·施拉姆等人

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中国电化教育 2019年第12期 87-94页

作者：卓泽林向敏华南师范大学国际与比较教育研究所/粤港澳大湾区教育发展高等研究院广东广州510631 温州医科大学创新创业教育学院浙江温州325035

国务院副总理孙春兰于2019年10月14日出席中国"互联网+"大学生创新创业大赛相关活动时强调要将创新创业融入人才培养全过程。"全校性"创业教育以广泛性为着眼点,在教学理念上超越以往只针对少数人的精英式教育,其内涵在于覆盖性地培养... 详细信息

国务院副总理孙春兰于2019年10月14日出席中国"互联网+"大学生创新创业大赛相关活动时强调要将创新创业融入人才培养全过程。"全校性"创业教育以广泛性为着眼点,在教学理念上超越以往只针对少数人的精英式教育,其内涵在于覆盖性地培养学生创业精神和创业思维,这与我国面向全体学生开展创业教育在逻辑和内涵上具有一致性。该文深入访谈了卡尔·施拉姆、杰尔姆·卡茨和布鲁斯·金玛三位学者,他们从各自的教育背景和岗位上对美国高校"全校性"创业教育兴起的原因做出了回答,并针对考夫曼基金会主导下美国高校"全校性"创业教育项目的开展取得了何种成效以及需突破何种困境等现实问题进行了探讨,同时还对学界认为高校推动"全校性"创业教育有悖于大学使命和学院传统的观点,以及在全校范围内开展创业教育是否存在合理性等富有争议的问题提出了不同见解。卡尔·施拉姆(Carl Schramm)是国际上公认的创新创业及经济增长研究领域的重要领袖,他在考夫曼基金会(Kaufman Foundation)担任了10年主席,随后执教于雪城大学(Syracuse University)的信息研究学院。在担任考夫曼基金会主席期间,在卡尔的领导下,考夫曼基金会发展成为一个全球性机构,成为经济增长和创新创业最大私人资助机构。卡尔在创业研究领域也颇有建树,他的著作主要有《真正创新的内部》《医疗保健及其成本》《创业力》《好的资本主义,坏的资本主义》。杰尔姆·卡茨(Jerome A. Katz)先后在罗德学院、哈佛大学和密歇根大学学习,现就职于圣路易斯大学(Saint Louis University)管理部门,他致力于创业教育和中小企业研究,曾经两次被《INC》商业杂志评为世界顶级的小企业研究人员之一。他的主要著作有:《创业、企业的出现与增长》《中小企业创业管理》《创业型小型企业》等,并在《商业投资》《创业:理论与实践》等国际顶级学术期刊上发表多篇论文。布鲁斯·金玛(Bruce Kingma)是信息经济学、经济发展、图书馆学和非营利组织管理领域的教授。他在雪城大学信息研究学院和惠特曼管理学院担任联合讲席教授。金玛教授在雪城大学担任主管创业教育副教务长期间(2007-2013年)转变了该校的创业教育发展模式,将重点放在帮助学生、退伍军人、教师和社区成员创业上。他与整个校园的教师合作,在创业教育中创建了以实践为基础、以学科为重点的项目。这种体验式创业教育模式使该校的创业教育年入学率每年增加至7500多名学生;每年产生超过100个新的学生创业项目;并在《福布斯》《美国新闻》《普林斯顿评论》《创业家》杂志、《彭博社》和《商业周刊》上获得了全国前10的创业教育排名。2012年,时任总统奥巴马邀请金玛教授在白宫举行的美国全国创业教育峰会上发言。

关键词：美国高校 “全校性”创业教育现状合理性访谈

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学术资本主义视域下的大学创新创业转型

高教探索 2020年第3期 66-73页

作者：卓泽林向敏华南师范大学国际与比较教育研究所广东省决策咨询研究基地港澳青少年教育研究中心华南师范大学粤港澳大湾区教育发展高等研究院温州医科大学创新创业教育学院广州510631

自20世纪70年代末以来,美国公立大学试图挣脱公共使命枷锁的束缚,转向推动全校性的创新创业教育。基于马里兰大学的质性研究指出,该校创新创业遵循从局部性向全校性拓展的轨道,并在实践上采取构建创新创业基础设施、增加创新创业课程与... 详细信息

自20世纪70年代末以来,美国公立大学试图挣脱公共使命枷锁的束缚,转向推动全校性的创新创业教育。基于马里兰大学的质性研究指出,该校创新创业遵循从局部性向全校性拓展的轨道,并在实践上采取构建创新创业基础设施、增加创新创业课程与项目、修订终身教职晋升政策和寻求校友外部资金等举措。但由于整个实施过程中学校领导层的权力过于集中,缺乏寻求各方主体积极投入和参与,因此,在取得一定成效的基础上也引起了张力。我国高校在推行全校性的创新创业教育的过程中应当汲取马里兰大学的有益经验,避免实施过程中过于强调自上而下,导致缺乏多方互动和各类主体共同参与的倾向。

关键词：美国马里兰大学学术资本主义创新创业

Effects of total flavonoids of Rhododendra simsii on ameliorating brain injury via G protein-coupled SOCE pathway mediated by STIM and Orai in subacute phase of ischemia/reperfusion

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中国药理学与毒理学杂志 2021年第10期35卷 768-769页

作者： LU Jia-jun JIANG Chen-chen HE Yu-xiang SHI Lei YIN Xiu-yun CHEN zhuo CAO Di HAN Jun department of Pharmacology Drug Research and Development CenterSchool of pharmacyWannan Medical CollegeWuhu 241002China Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui Wuhu 241002China Anhui Provincial Engineering Research Center for Polysaccharide Drugs Wuhu 241002China

OBJECTIVE To explore the effect of total flavonoids of Rhododendra simsii(TFR)on improving cerebral ischemia/reperfusion injury(CIRI)and its relationship with STIM/Orai-regulated operational Ca^(2+)influx(SOCE)*** Oxygen-glucose deprivation/reoxygenation(OGD/R)PC12 cells were used to simulate CIRI in vitro,and the intracellular Ca^(2+)concentration and apoptosis rate of PC12 cells were detected by laser confocal microscope and flow cytometry,*** regulation of STIM/Orai on SOCE was analyzed by STIM/Orai gene silencing and STIM/O rai gene *** CIRI model was established by MCAO in SD *** activities of inflammatory cytokines IL^(-1),IL-6 and TNF-αin serum were detected by *** pathological changes of ischemic brain tissue and the infarction of rat brain tissue were detected by HE staining and TTC *** protein and mRNA expression levels of STIM1,STIM2,Orai1,caspase-3 and PKB in brain tissue were detected by Western blotting and RT-qPCR,*** The results of in vitro experiment showed that the fluorescence intensity of Ca^(2+)and apoptosis rate in PC12 cells treated with TFR were significantly lower than those in OGD/R group,and this trend was enhanced by SOCE antagonist ***1/STIM2/Orai1 gene silencing significantly reduced apoptosis and Ca^(2+)overload in OGD/R model,while TFR combined with overexpression of STIM1/STIM2/Orai1 aggravated apoptosis and Ca2+*** the in vivo experiment,TFR significantly reduced the brain histopathological damage,infarction of brain tissue,the contents of IL^(-1),IL-6 and TNF-αin the serum in MCAO rats and down-regulated the expression of STIM1,STIM2,Orai1 and caspase-3 protein and mRNA in the brain tissue,and up-regulated the expression of *** above effects were enhanced by the addition of *** The above results indicate that TFR may reduce the contents of inflammatory factors and apoptosis,decrease Ca2+overload and ameliorate brain injury b

关键词： total flavonoids of Rhododendra simsii cerebral ischemia/reperfusion injury STIM/Orai store-operated calcium entry 2-APB

Electronic structure of single-crystalline graphene grown on Cu/Ni(111) alloy film

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Chinese Physics B 2019年第8期28卷 250-253页

作者： Xue-Fu Zhang Zhong-Hao Liu Wan-Ling Liu xiang-Le Lu zhuo-Jun Li Qing-Kai Yu Da-Wei Shen Xiao-Ming Xie State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT)Chinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology Shanghai Tech UniversityShanghai 200031China CAS Center for Excellence in Superconducting Electronics (CENSE) Shanghai 200050China

Graphene with a Dirac cone-like electronic structure has been extensively studied because of its novel transport properties and potential application for future electronic *** epitaxially grown graphene,the process conditions and the microstructures are strongly dependent on various substrate materials with different lattice constants and interface *** angle-resolved photoemission spectroscopy,here we report an investigation of the electronic structure of single-crystalline graphene grown on Cu/Ni(111)alloy film by chemical vapor *** a relatively low growth temperature,graphene on Cu/Ni(111)exhibits a Dirac cone-like dispersion comparable to that of graphene grown on Cu(111).The linear dispersions forming Dirac cone are as wide as 2 e V,with the Fermi velocity of approximately 1.1×10^6 m/*** cone opens a gap of approximately 152 meV at the binding energy of approximately 304 *** findings would promote the study of engineering of graphene on different substrate materials.

关键词： single-crystal graphene electronic structure Cu/Ni(111)

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铝及其合金中溶气的物理化学

轻金属 2006年第1期 53-57页

作者：尹卓湘贵州工业大学材料科学与冶金工程学院贵州贵阳550003

应用化学热力学及动力学的基本原理,在阐明铝合金中气体反应行为基础上,根据铝合金的吸氢及析氢机理,从理论上分析了铝合金中针孔成因,进而得出了针孔严重程度的定量判据式(即计算模型)。

关键词：铝合金气体反应热力学机理针孔判据式

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面向视觉手势交互的映射关系自适应调整

华南理工大学学报（自然科学版） 2014年第8期42卷 52-57页

作者：梁卓锐徐向民华南理工大学电子与信息学院广东广州510640

在基于机器视觉手势交互中经常需要大幅度手部移动,合适的映射关系对于用户在较舒适的操作范围内完成交互任务是十分必要的.文中结合用户的交互心理测试,提出一种基于用户操作特点的映射关系自适应调整方法:基于Borg's CR-10尺度心理感... 详细信息

在基于机器视觉手势交互中经常需要大幅度手部移动,合适的映射关系对于用户在较舒适的操作范围内完成交互任务是十分必要的.文中结合用户的交互心理测试,提出一种基于用户操作特点的映射关系自适应调整方法:基于Borg's CR-10尺度心理感知实验测试用户的手部移动的感知,根据人体工程学建立一种基于速度调整的映射方程;根据交互过程中的用户手部移动情况,在每次连续交互操作结束后对映射方程进行调整.此外利用Kinect搭建用户测试系统测试该调整方法性能.实验结果表明,文中提出的映射关系调整方法能有效降低用户大幅度手部移动的几率,同时保持了用户的操作表现.

关键词：映射关系自适应调整操作空间视觉手势交互

Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3643-3660页

作者： Jie Wang Zilong Zhang Yan zhuo Zhuan Zhang Rongrong Chen Li Liang Xiaohe Jiang Di Nie Chang Liu Zhiwen Zou xiang Li Jiaxin Li Bingqi Wang Rui Wang Yong Gan Miaorong Yu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Jiangxi Medical College Nanchang UniversityNanchang 330006China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum(ER)presents an opportunity to amplify the synergistic effects of chemotherapy and *** this study,we initially validated celastrol(CEL)as an inducer of immunogenic cell death(ICD)by promoting ER stress and autophagy in colorectal cancer(CRC)***,an ER-targeted strategy was posited,involving the codelivery of CEL with PD-L1 small interfering RNAs(siRNA)using KdeL peptide-modified exosomes derived from milk(KME),to enhance chemoimmunotherapy *** findings demonstrate the efficient transportation of KME to the ER via the Golgi-to-ER *** to their non-targeting counterparts,KME exhibited a significant augmentation of the CEL-induced ICD ***,it facilitated the release of danger signaling molecules(DAMPs),thereby stimulating the antigen-presenting function of dendritic cells and promoting the infiltration of T cells into the ***,the ER-targeted delivery of PD-L1 siRNA resulted in the downregulation of both intracellular and membrane PD-L1 protein expression,consequently fostering the proliferation and activity of CD8^(+)T ***,the ER-targeted formulation exhibited enhanced anti-tumor efficacy and provoked anti-tumor immune responses against orthotopic colorectal tumors in ***,a robust ER-targeted delivery strategy provides an encouraging approach for achieving potent cancer chemoimmunotherapy.

关键词： Chemoimmunotherapy Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death siRNA Chemoimmunotherapy Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death siRNA