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Commentary on “Disposable circumcision suture device： clinical effect and patient satisfaction”

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Asian Journal of Andrology 2015年第3期17卷 516-516页

作者： de-hong cao Qiang Dong Qiang Wei department of Urology West China Hospital Sichuan University Chengdu China

dear Editor, We read with great interest this excellent article by Lv et al. who described their study of the new disposable circumcision suture device （DCSD） for male circumcision. The study assessed the clinical effect and satisfaction of 942 patients in the conventional, Shang ring, and DCSD circumcision groups. The findings indicated that DCSD circumcision was associated with a significant decrease in intraoperative and postoperative pain compared with the other two methods.

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The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia:a retrospective,single-center study

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Asian Journal of Andrology 2024年第1期26卷 112-118页

作者： Jin Li Xian-Yan-Ling Yi Ze-Yu Chen Bo Chen Yin Huang Da-Zhou Liao Pu-Ze Wang de-hong cao Jian-Zhong Ai Liang-Ren Liu West China School of Medicine Sichuan UniversityChengdu 610041China department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia(BPH)on the efficacy of transurethral ***,imaging,and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University(Chengdu,China)from July 2019 to december 2021 were ***-up data included the quality of life(QoL),International Prostate Symptom Score(IPSS),and IPSS storage and voiding(IPSS-s and IPSS-v).Moreover,urinary creatinine(Cr),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),and prostaglandin estradiol(PGE2)were measured in 30 patients with BPH and 30 healthy *** indicators were determined by subgroup analyses and receiver operating characteristic(ROC)curve *** the 313 patients with BPH included,patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate ***,good bladder sensation,compliance,and detrusor contractility(Dc)were predictors of low postoperative IPSS and *** urinary concentrations of BDNF/Cr,NGF/Cr,and PGE2/Cr in patients were significantly higher than those in healthy participants(all Pder function had poor *** combined levels of urinary BDNF/Cr,NGF/Cr,and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladderfunction and postoperative recovery.

关键词： BPH function of bladder IPSS:urodynamics

Commentary on -＂Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction＂

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Asian Journal of Andrology 2015年第5期17卷 854-854页

作者： de-hong cao Liang-Ren Liu Qiang Wei department of Urology West China Hospital Sichuan University ChengduSichuan Province China

dear Editor, We read with interest of the article written by Park et al. They performed a randomized controlled trial to compare efficacy and safety between 50 mg once-daily and 200 mg on-demand dosing use of udenafil for the treatment of type 2 diabetic patients with erectile dysfunction （ED）. Their findings indicated that the most common drug-related adverse events （AEs） were flushing （8,9% vs 2,5%） and headache （3.8% vs 1.3%） between the on-demand group and the daily-dosed group. Although the authors believed that the udenafil was well-tolerated in both groups, unfortunately, they failed report the total incidence of AEs to assess the safety of the two groups.

关键词： daily-dosed compare well-tolerated

ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

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Military Medical Research 2024年第5期11卷 643-662页

作者： Hang Xu Yi-Fan Li Xian-Yan-Ling Yi Xiao-Nan Zheng Yang Yang Yan Wang Da-Zhou Liao Jia-Peng Zhang Ping Tan Xing-Yu Xiong Xi Jin Li-Na Gong Shi Qiu de-hong cao hong Li Qiang Wei Lu Yang Jian-Zhong Ai department of Urology West China HospitalSichuan UniversityChengdu610041China Institute of Urology West China HospitalSichuan UniversityChengdu610041China Animal Experimental Center West China HospitalSichuan UniversityChengdu610041China Research Core Facility West China HospitalSichuan UniversityChengdu610041China

Background Cell metabolism plays a pivotal role in tumor progression,and targeting cancer metabolism might effectively kill cancer *** aimed to investigate the role of hexokinases in prostate cancer(PCa)and identify a crucial target for PCa *** The Cancer Genome Atlas(TCGA)database,online tools and clinical samples were used to assess the expression and prognostic role of ADP-dependent glucokinase(ADPGK)in *** effect of ADPGK expression on PCa cell malignant phenotypes was validated in vitro and in *** proteomics,metabolomics,and extracellular acidification rate(ECAR)and oxygen consumption rate(OCR)tests were performed to evaluate the impact of ADPGK on PCa *** underlying mechanisms were explored through ADPGK overexpression and knockdown,co-immunoprecipitation(Co-IP),ECAR analysis and cell counting kit-8(CCK-8)*** ADPGK was the only glucokinase that was both upregulated and predicted worse overall survival(OS)in prostate adenocarcinoma(PRAD).Clinical sample analysis demonstrated that ADPGK was markedly upregulated in PCa tissues ***-PCa *** ADPGK expression indicates worse survival outcomes,and ADPGK serves as an independent factor of biochemical *** vitro and in vivo experiments showed that ADPGK overexpression promoted PCa cell proliferation and migration,and ADPGK inhibition suppressed malignant ***,proteomics,and ECAR and OCR tests revealed that ADPGK significantly accelerated glycolysis in ***,ADPGK binds aldolase C(ALDOC)to promote glycolysis via AMP-activated protein kinase(AMPK)*** was positively correlated with ADPGK,and high ALDOC expression was associated with worse survival outcomes in *** In summary,ADPGK is a driving factor in PCa progression,and its high expression contributes to a poor prognosis in PCa *** accelerates PCa glycolysis and progression by activating ALDOC-AMPK signaling,suggesting

关键词： Prostate cancer(PCa) ADP-dependent glucokinase(ADPGK) Aldolase C(ALDOC) AMPK Glycolysis

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智能客户端在医学影像管理中的应用

中国数字医学 2007年第8期2卷 32-34页

作者：曹厚德上海市静安区中心医院上海西康路259号200040

智能客户端(Smart Client)是新一代由***架构支持的应用程序,它将Windows平台跟Internet应用结合起来,兼具传统的胖客户端和瘦客户端之长,提供用户丰富的操作体验和高级功能,同时又易于管理,可以集中部署和升级。由于智能客户端模式自... 详细信息

智能客户端(Smart Client)是新一代由***架构支持的应用程序,它将Windows平台跟Internet应用结合起来,兼具传统的胖客户端和瘦客户端之长,提供用户丰富的操作体验和高级功能,同时又易于管理,可以集中部署和升级。由于智能客户端模式自身具有诸多的优势,基于智能客户端模式的影像存储和通讯系统(Picture Archiving and Communication System,PACS)亦具有许多卓越的特性。随着该技术逐渐得到医院用户的了解和掌握,智能客户端模式必将会在包括PACS在内的医学信息系统领域得到越来越广泛的应用。

关键词：智能客户端胖客户端瘦客户端 PACS 医学影像信息管理

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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R290及其冷冻油混合物互溶特性研究

上海海事大学学报 2004年第3期25卷 66-70页

作者：熊爱凌韩厚德曹红奋上海海事大学商船学院上海200135

天然绿色制冷剂丙烷(R290)与冷冻油的互溶特性研究已成为替代CFCs和HCFCs的焦点。本文分析了丙烷与制冷空调中常用制冷剂的热力学特性,阐述了丙烷替代R22的途径,并着重通过丙烷与所选润滑油的互溶性对比实验,得出了丙烷制冷空调系统中... 详细信息

天然绿色制冷剂丙烷(R290)与冷冻油的互溶特性研究已成为替代CFCs和HCFCs的焦点。本文分析了丙烷与制冷空调中常用制冷剂的热力学特性,阐述了丙烷替代R22的途径,并着重通过丙烷与所选润滑油的互溶性对比实验,得出了丙烷制冷空调系统中可采用的最佳冷冻油及其配比。

关键词：丙烷特性制冷剂替代冷冻油互溶性制冷性能

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan cao Zhiqun He Chunjun Liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury