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Construction and validation of somatic mutation-derived long noncoding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 842-859页

作者： Bo-Tao Duan Xue-Kai Zhao Yang-Yang Cui de-zheng Liu Lin Wang Lei Zhou Xing-Yuan Zhang department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina department of Ophthalmology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina

BACKGROUND Long non-coding RNAs(LncRNAs)have been found to be a potential prognostic factor for cancers,including hepatocellular carcinoma(HCC).Some LncRNAs have been confirmed as potential indicators to quantify genomic instability(GI).Nevertheless,GI-LncRNAs remain largely *** study established a GI-derived LncRNA signature(GILncSig)that can predict the prognosis of HCC *** To establish a GILncSig that can predict the prognosis of HCC *** Identification of GI-LncRNAs was conducted by combining LncRNA expression and somatic mutation *** GI-LncRNAs were then analyzed for functional *** GILncSig was established in the training set by Cox regression analysis,and its predictive ability was verified in the testing set and TCGA *** addition,we explored the effects of the GILncSig and TP53 on *** A total of 88 GI-LncRNAs were found,and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and *** GILncSig was constructed by 5 LncRNAs(miR210HG,AC016735.1,AC116351.1,AC010643.1,LUCAT1).In the training set,the prognosis of high-risk patients was significantly worse than that of low-risk patients,and similar results were verified in the testing set and TCGA *** Cox regression analysis and stratified analysis confirmed that the GILncSig could be used as an independent prognostic *** operating characteristic curve analysis of the GILncSig showed that the area under the curve(0.773)was higher than the two LncRNA signatures published ***,the GILncSig may have a better predictive performance than TP53 mutation status *** We established a GILncSig that can predict the prognosis of HCC patients,which will help to guide prognostic evaluation and treatment decisions.

关键词： Genomic instability Long noncoding RNA Hepatocellular carcinoma Prognosis Diagnosis

从ChatGPT审视负责任创新:阻碍因素与转型方向

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新疆师范大学学报（哲学社会科学版） 2024年第1期45卷 139-150,F0002页

作者：胡泳朱政德北京大学新闻与传播学院北京100871

ChatGPT的勃兴再次激化了技术创新加速和社会适应水平滞后两者间的尖锐矛盾,使人类被迫面临前所未有的经济、政治、文化和环境风险,进而使有关负责任创新的呼声愈演愈烈。但作为技术伦理准则的负责任创新沿袭了熊彼特范式下基于竞争逻... 详细信息

ChatGPT的勃兴再次激化了技术创新加速和社会适应水平滞后两者间的尖锐矛盾,使人类被迫面临前所未有的经济、政治、文化和环境风险,进而使有关负责任创新的呼声愈演愈烈。但作为技术伦理准则的负责任创新沿袭了熊彼特范式下基于竞争逻辑的创新,其设计的ARDR模型一方面从未在根本上调控创新较之于负责任的支配性优势,另一方面把负责任简化为线性流程,导致负责任看似获得与创新并列的地位,实则在创新蕴含的人际竞争、公司竞争、国际竞争面前屡屡沦为点缀。唯有在后熊彼特范式下依托基于共生逻辑的创新保卫负责任,才能建构起真正具备约束力的伦理准则,削弱不负责任创新赖以扩散的社会基础,使通过负责任停滞促成制度跟进变为可能。实现上述目标不仅要求各国完善内部治理,而且需要负责任的大国制定跨国人工智能治理框架,使人工智能的发展对全人类有益。

关键词： ChatGPT 负责任创新技术伦理建设竞争逻辑共生逻辑

Pd/WO_(3)催化剂的合成及其催化糠醛选择性加氢性能研究

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现代化工 2024年第6期44卷 156-160页

作者：常德政高岩河南省冶金研究所有限责任公司河南郑州450053 河南省冶金余热固废资源利用工程技术研究中心河南郑州450053

糠醛是木制纤维素的水解产物,由于其分子结构中含有多个官能团且官能团的结构异常敏感,糠醛选择性催化加氢可制得2-甲基呋喃、糠醇、四氢糠醇、呋喃、四氢呋喃等一系列高附加值化学品。因此,制备了一种高活性、高选择性(四氢糠醇)、稳... 详细信息

糠醛是木制纤维素的水解产物,由于其分子结构中含有多个官能团且官能团的结构异常敏感,糠醛选择性催化加氢可制得2-甲基呋喃、糠醇、四氢糠醇、呋喃、四氢呋喃等一系列高附加值化学品。因此,制备了一种高活性、高选择性(四氢糠醇)、稳定性好及贵金属负载量低的负载型催化剂。采用硼氢化钠液相化学还原法合成了具有不同Pd负载量的Pd/WO_(3)催化剂(0.34%、2.0%和4.5%),考察了Pd的负载量及反应温度对Pd/WO_(3)催化糠醛选择性加氢的影响,结果表明,最佳反应条件为:2.0%Pd、反应时间为2 h、反应温度为150℃,此时糠醛转化率为99.0%,四氢糠醇选择性达92.2%。低温反应(100℃)时升高Pd负载量有利于提高催化剂性能,高温反应(150℃)时Pd最佳负载量为2.0%。

关键词：糠醛选择性加氢 Pd/WO_(3) 高分散

Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang zheng-de Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Respiratory Shenzhen Children's HospitalShenzhen 518038China department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua zheng-de Xie Han-Min Liu Hai-Lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong Lin Hong-Mei Xu de-Yu Zhao Mei Zeng Zhi-Min Chen Li-Su Huang department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina department of Clinical Epidemiology Aarhus UniversityAarhusDenmark department of Respirology Children's Hospital of Soochow UniversitySuzhouChina department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

使用遗传算法增强GH4169高温合金BP-ANN本构模型的预测稳定性

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Journal of Central South University 2024年第3期31卷 693-708页

作者：郑德宇夏玉峰滕海灏余盈燕 Chongqing Key Laboratory of Advanced Mold Intelligent Manufacturing School of Materials Science and EngineeringChongqing UniversityChongqing 400044China

为了更好地描述GH4169高温合金的塑性流动行为,利用Gleeble 1500热模拟试验机进行了不同变形温度和应变速率下的GH4169高温合金等温热压缩试验。基于真实应力-应变数据建立了GH4169高温合金反向传播人工神经网络(BP-ANN)本构模型,并进... 详细信息

为了更好地描述GH4169高温合金的塑性流动行为,利用Gleeble 1500热模拟试验机进行了不同变形温度和应变速率下的GH4169高温合金等温热压缩试验。基于真实应力-应变数据建立了GH4169高温合金反向传播人工神经网络(BP-ANN)本构模型,并进一步考察了本构模型的预测稳定性与模型参数之间的关系。预测结果发现,GH4169高温合金BP-ANN本构模型的输出对模型参数具有很强的依赖性。针对这一问题,本研究采用遗传算法(GA)优化BP-ANN本构模型的方法,建立GA-BP-ANN集成本构模型。优化后的结果表明,GH4169高温合金的GA-BP-ANN集成本构模型大幅增强了BP-ANN本构模型的预测稳定性,提升了BP-ANN本构模型的泛化能力。

关键词： GH4169高温合金应力-应变反向传播人工神经网络遗传算法

铁锰改性生物炭对水稻镉吸收和土壤微生物群落的影响

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中国环境科学 2024年第4期44卷 2297-2308页

作者：王德正谭文韬曾鹏马兰心周航辜娇峰廖柏寒中南林业科技大学环境科学与工程学院湖南长沙410004

通过盆栽试验,研究铁锰改性生物炭(BC_(FM))对水稻Cd吸收和土壤微生物群落结构的影响.结果表明,BC_(FM)可有效降低水稻对Cd的吸收,改变土壤微生物群落结构.与对照相比,添加0.5~2g/kg BC_(FM)后土壤有机质、土壤阳离子交换量、土壤总Fe和... 详细信息

通过盆栽试验,研究铁锰改性生物炭(BC_(FM))对水稻Cd吸收和土壤微生物群落结构的影响.结果表明,BC_(FM)可有效降低水稻对Cd的吸收,改变土壤微生物群落结构.与对照相比,添加0.5~2g/kg BC_(FM)后土壤有机质、土壤阳离子交换量、土壤总Fe和总Mn无显著变化;而添加4g/kg BC_(FM)后,土壤有机质、土壤阳离子交换量、土壤总Fe和Mn含量分别显著(Pdesulfobacterota和Nitrospirae等门水平物种的相对丰度降低.热图分析结果表明,BC_(FM)可提高水稻根际土壤中Bacillus、Citrifermentans、Geobacter、desulfovibrio等参与铁锰氧化还原和硫酸盐还原细菌的相对丰度.RDA和网络分析表明,BC_(FM)可通过影响土壤总Fe、有机质含量和Cd的生物有效性来改变土壤微生物群落结构,促进土壤细菌间的正交互作用.因此,BC_(FM)可作为一种有效的、生态安全的钝化剂用于Cd污染农田土壤修复.

关键词：铁锰改性生物炭水稻 Cd吸收微生物群落结构铁锰氧化还原菌

褐土全氮含量Vis/NIRS组合预测模型的构建

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光谱学与光谱分析 2024年第8期44卷 2310-2317页

作者：张秀全马世兴李志伟郑德聪宋海燕山西农业大学农业工程学院山西太谷030801 山西农业大学信息科学与工程学院山西太谷030801

准确掌握农田土壤全氮含量对于评估土壤肥力,合理施用氮肥具有重要意义。为综合利用各个单预测模型的优势,提升整体预测性能、降低模型方差,提高鲁棒性,以农田褐土土壤为研究对象,基于近红外-可见光高光谱数据,提出了一种基于标准差的... 详细信息

准确掌握农田土壤全氮含量对于评估土壤肥力,合理施用氮肥具有重要意义。为综合利用各个单预测模型的优势,提升整体预测性能、降低模型方差,提高鲁棒性,以农田褐土土壤为研究对象,基于近红外-可见光高光谱数据,提出了一种基于标准差的预测有效度组合预测模型(CPM),用于预测土壤全氮含量。对原高光谱数据采用Savitzky-Golay平滑和一阶微分变换,采用树模型进行特征波段提取,利用决策树回归(DTR)(模型1)、高斯核回归(GKR)(模型2)、随机森林回归(RF)(模型3)、LASSO回归(模型4)、多层感知器回归(MLP)(模型5)5个单预测模型,通过单预测模型的线性组合建立组合预测模型。结果表明:(1)通过广义简约梯度优化算法求得组合预测模型中5个单预测模型的权重分别为ω_(1)*=0.407,ω_(2)*=0.378,ω_(30*=0.215,ω_(4)*=0,ω_(5)*=0;(2)对于所有数据,基于5种单预测模型和组合预测模型对土壤全氮含量预测的预测有效度分别为M_(1)=0.855,M_(2)=0.856,M_(3)=0.847,M_(4)=0.785,M_(5)=0.796,M_(CPM)=0.880;与单模型预测有效度最大值相比,组合预测模型预测有效度提高了2.924%;(3)对于所有数据,基于5种单预测模型和组合预测模型对土壤全氮含量预测的预测精度和标准差分别为E(A_(1))=0.924,σ(A_(1))=0.075,E(A_(2))=0.928,σ(A_(2))=0.077,E(A_(3))=0.923,σ(A_(3))=0.082,E(A_(4))=0.882,σ(A_(4))=0.109,E(A_(5))=0.889,σ(A_(5))=0.104,E(A_(CPM))=0.937,σ(A_(CPM))=0.066,与单模型预测精度最大值相比,组合预测模型预测精度提高了0.970%,模型稳定性提高了12.000%,且为优性组合预测。组合预测模型可用于可见光-近红外光谱数据的农田褐土土壤全氮含量的有效估测,可为农田土壤全氮含量的快速监测提供依据和参考。

关键词：可见光-近红外高光谱预测全氮含量组合预测模型

基于协同钝化策略制备高性能柔性钙钛矿太阳能电池

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物理学报 2024年第7期73卷 316-324页

作者：王辉郑德旭姜箫曹越先杜敏永王开刘生忠张春福西安电子科技大学微电子学院西安710071 中国科学院大连化学物理研究所大连116023 中国核能电力股份有限公司市场开发部北京100045

柔性钙钛矿太阳能电池由于可弯曲、重量轻、高功质比等特点,受到广泛关注.提升柔性钙钛矿太阳能电池转换效率最有效的策略是钝化钙钛矿薄膜内部的晶界缺陷以及钝化钙钛矿薄膜与电荷传输层的界面缺陷.本文设计制备了以柔性聚对苯二甲酸... 详细信息

柔性钙钛矿太阳能电池由于可弯曲、重量轻、高功质比等特点,受到广泛关注.提升柔性钙钛矿太阳能电池转换效率最有效的策略是钝化钙钛矿薄膜内部的晶界缺陷以及钝化钙钛矿薄膜与电荷传输层的界面缺陷.本文设计制备了以柔性聚对苯二甲酸乙二醇酯(polyethylene glycol terephthalate,PET)为基材的柔性反式钙钛矿太阳能电池,采用了辛基氯化胺(octadecylamine hydrochloride,OACl)添加剂及表面钝化的协同钝化策略,提高了钙钛矿薄膜的结晶质量,改善了钙钛矿薄膜内部及界面处的缺陷,并最终得到了光电转换效率为20.80%的柔性反式钙钛矿太阳能电池.本文为制备高效柔性钙钛矿太阳能电池提供了一种有效策略.

关键词：柔性钙钛矿太阳能电池反式缺陷钝化