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THE INTERACTION OF Co（II）， Ni（II）， Cu（II） AND Zn（II） wITH 6－AMINOPENICILLANIC ACID IN AQUEOUS SOLUTION

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Chinese Chemical Letters 1995年第6期6卷 531-532页

作者： Zhang, XD Guan, w Liu, QT Yang, P Liaoning Univ Dept Chem Shenyang 110036 Peoples R China Shanxi Univ Dept Chem Taiyuan 030006 Peoples R China

The complex formation equilibria of M2+ ions(M=Co,Ni,Cu,Zn) with 6-aminopenicillanic acid(6-APA)have been studied through potentiometric titrations. The results show that all of metal ions form 1:1 complexes(M(APA)+,N(APA)(OH)) with 6-APA in solution. Formation constants of the complexes were determined at 4O℃in aqueous solution having a fixed ionic Strength(0.1M NaClO4) and cormlated with the second-order rate constants for metal-ion Catalysed hydrolysis of peicillin.

关键词： II Co THE AQUEOUS INTERACTION OF SOLUTION AMINOPENICILLANIC AND ACID Zn Cu Ni

watching cartoons activates the medial prefrontal cortex in children

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Chinese Science Bulletin 2007年第24期52卷 3371-3375页

作者： HAN ShiHui JIANG Yi Glyn w. HUMPHREYS department of Psychology Peking University Beijing 100871 China Functional Imaging Center Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China Behavioral Brain Sciences School of Psychology University of Birmingham Birmingham UK

The medial prefrontal cortex (MPFC) of human adults is involved in attributing mental states to real human agents but not to virtual artificial characters. This study examined whether such differential MPFC activity can be observed in children who are more fascinated by cartoons than adults. we measured brain activity using functional magnetic resonance imaging (fMRI) while 10-year-old children watched movie and cartoon clips, simulating real and virtual visual worlds, respectively. we showed neuroimaging evidence that, in contrast to adults, the MPFC of children was activated when perceiving both human agents and artificial characters in coherent visual events. Our findings suggest that, around the age of 10 years, the MPFC activity in children is different from that in adults in that it can be spontaneously activated by non-human agents in a virtual visual world.

关键词： fMRI MPFC 漫画刺激中间脑前额皮层小孩

Allogenic banking of dental pulp stem cells for innovative therapeutics

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world Journal of Stem Cells 2015年第7期7卷 1010-1021页

作者： Pierre-Yves Collart-Dutilleul Franck Chaubron John de Vos Frederic J Cuisinier Bio Nano Laboratory EA 4203 Montpellier 1 University Institut Clinident Bio Pharma Biopole Clermont-Limagne INSERM U1040 Genetic Instability of Human Pluripotent Stem Cells CHRU Montpellier Hospital Saint-EloiInstitut de Recherche en Biothérapie

Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. we also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat.

关键词： Adult stem cells Multipotent stem cells Cell-based therapy Cell tissue bank

Enhancing Electrochemical Reduction of CO_(2) to Formate by Regulating the Support Morphology

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Chinese Journal of Structural Chemistry 2021年第3期40卷 376-382,274页

作者： ZHAO Xiu-Hui ZHUO de-Huang CHEN Qing-Song GUO Guo-Cong College of Chemistry Fuzhou UniversityFuzhou 350116China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Electroreduction of CO_(2) to formic acid has attracted extensive attention,because it is a promising strategy to re-utilize CO_(2) and reduce greenhouse gas emissions that may favor the mitigation of energy and environment *** great efforts have been made to tune the structure and composition of catalysts aiming to improve CO_(2) conversion efficiency,seldom studies have been focused on the support *** this work,ordered,porous TiO_(2) nanotube arrays have been used as model support to study the impact of pore structure for CO_(2) electrochemical *** has been revealed that Pd supported on TiO_(2) nanotube arrays substrate exhibits enhanced performance towards CO_(2) reduction,showing a higher formate Faradaic efficiency of 20%over than Pd supported on TiO_(2) film *** study will shed new light on the design and synthesis of efficient catalysts by tuning the morphology of support for CO_(2) conversion.

关键词： CO_(2)ER morphology electrochemistry formate

London 2012:Young Chinese Athletes Begin to Prepare for Gold

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China Today 2008年第10期57卷 22-27页

作者： de YONGJIAN

CHINESE athletes achieved remarkable success at the XXIX Olympic Games,earning a record number of gold medals in disciplines long dominated by China,such as weightlifting,diving and gymnastics. But they also scored impressively in other events,such as swimming,fencing and archery,establishing a presence that is certain to reap victories in London in 2012.

关键词： 2010年伦敦筹备工作活动策划金牌运动会

Psychiatric hospitalization during the two SARS-CoV-2 pandemic waves:New warnings for acute psychotic episodes and suicidal behaviors

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world Journal of Psychiatry 2021年第11期11卷 1095-1105页

作者： Fabio Panariello Sara Longobardi Lorenzo Cellini Diana de Ronchi Anna Rita Atti department of Biomedical and NeuroMotor Sciences Institute of PsychiatryUniversity of BolognaBologna 40126Italy

BACKGROUND The subsequent waves of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic have represented a dramatic health emergency characterized by significant consequences on mental *** variations in the incidence rates of acute relapse of psychiatric disorders may represent significant"sentinel events"for assessing the mental health response to an unprecedented stressful *** To investigate the variation in psychiatric hospitalization rates and differences in sociodemographic and clinical-psychopathological peculiarities at Bologna"Maggiore"General Hospital Psychiatric ward(GHPw)between the first two waves SARS-CoV-2 pandemic and the same periods of the previous 3 *** secondary purpose of the study was to suggest a diachronic response pathway to stress by reporting additional literature data on coping *** This observational and retrospective study collected information on admission to the GHPw at the"Maggiore"Hospital in Bologna in the index periods defined as follows:the first period between February 24,2020 and April 30,2020(first epidemic wave)and the second period between October 8,2020,and January 7,2021(second pandemic wave).Absolute numbers and proportion of admitted patients,their sociodemographic and clinical-psychopathological characteristics were compared with the same parameters recorded in the two same periods of the previous 3 *** strict inclusion or exclusion criteria were provided in the data collection to collect information on all patients requiring acute psychiatric *** During the first wave,there was a significant reduction in hospitalization rates,although there was a simultaneous increase in compulsory hospitalizations and the acute relapse of schizophrenia spectrum and other psychotic *** the second wave,hospitalization rates reached those recorded during the same period of the previous 3 years,mainly due to the rise of bipolar and related diso

关键词： SARS-CoV-2 Schizophrenia spectrum and other psychotic disorders Bipolar and related disorders depressive disorders Anxiety disorders,trauma-and stressorrelated disorders Suicide behavior Coping strategies

Review of primary sclerosing cholangitis with increased IgG4 levels

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world Journal of Gastroenterology 2020年第23期26卷 3126-3144页

作者： Charis D Manganis Roger w Chapman Emma L Culver Translational Gastroenterology Unit and Oxford NIHR Biomedical Research Centre John Radcliffe HospitalOxford OX39DUUnited Kingdom

Primary sclerosing cholangitis(PSC) is a chronic progressive liver disease. Subtypes of PSC have been described, most recently PSC with elevated serum and/or tissue IgG4 subclass. we aim to summarise the clinical phenotype,disease associations, differential diagnosis, response to therapy and pathogenic mechanisms underlying PSC-high IgG4 subtype. we reviewed Pub Med,MEDLINE and Embase with the search terms "primary sclerosing cholangitis","IgG4", and "IgG4-related sclerosing cholangitis(IgG4-SC)". Elevated serum IgG4 are found in up-to one-quarter, and abundant IgG4-plasma cell infiltrates in the liver and bile ducts are found in up-to one-fifth of PSC patients. This group have a distinct clinical phenotype, with some studies reporting a more aggressive course of liver and associated inflammatory bowel disease, compared to PSCnormal IgG4 and the disease mimic IgG4-SC. Distinguishing PSC-high IgG4 from IgG4-SC remains challenging, requiring careful assessment of clinical features,organ involvement and tissue morphology. Calculation of serum IgG4:IgG1 ratios and use of a novel IgG4:IgG RNA ratio have been reported to have excellent specificity to distinguish IgG4-SC and PSC-high IgG4 but require validation in larger cohorts. A role for corticosteroid therapy in PSC-high IgG4 remains unanswered, with concerns of increased toxicity and lack of outcome data. The immunological drivers underlying prominent IgG4 antibodies in PSC are incompletely defined. An association with PSC-high IgG4 and HLA class-II haplotypes(B*07, DRB1*15), T-helper2 and T-regulatory cytokines(IL4, IL10,IL13) and chemokines(CCL1, CCR8) have been described. PSC-high IgG4 have a distinct clinical phenotype and need careful discrimination from IgG4-SC,although response to immunosuppressive treatments and long-term outcome remains unresolved. The presence of IgG4 likely represents chronic activation to persistent antigenic exposure in genetically predisposed individuals.

关键词： Primary sclerosing cholangitis IgG4 IgG4-related disease IgG4-related sclerosing cholangitis

Neurochemical plasticity of Müller cells after retinal injury: overexpression of GAT-3 may potentiate excitotoxicity

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Neural Regeneration Research 2015年第9期10卷 1376-1378页

作者： Clarissa S.Schitine Fernando G.de Mello Ricardo A.M.Reis Laboratório de Neuroquímica Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Laboratório de Neuroanatomia Celular Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro

The retina is a multilayered tissue that develops following a central-to-peripheral gradient. Its structure derives from multipotent precursors, as shown through clonal analysis of retinal cell lineage. These progenitors generate diverse cell types, controlled by complex influences of intrinsic and extrinsic factors （Hatakevama and Kagevama, 2004）.

关键词： GAT Neurochemical plasticity of M ller cells after retinal injury overexpression of GAT-3 may potentiate excitotoxicity RGCs

Baryon resonance analysis from SAID

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Chinese Physics C 2009年第12期33卷 1063-1068页

作者： R. A. Arndt w. J. Briscoe M. w. Paris I. I. Strakovsky R. L. workman Center for Nuclear Studies Department of Physics The George Washington University Washington D.C. 20052 USA

we discuss the analysis of data from πN elastic scattering and single pion photo- and electroproduction. The main focus is a study of low-lying non-strange baryon resonances. Here we concentrate on some difficulties ... 详细信息

关键词： non-strange baryons N(1440) pion-nucleon elastic scattering pion photo- and electro-production