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实践中为了获得理想的孵化场卫生进行的审核工作

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国外畜牧学（猪与禽） 2015年第10期35卷 48-51页

作者：高娃 Gerd de lange pas reform孵化技术公司

孵化场是种鸡场与禽蛋和禽肉产品的家禽生产舍之间的重要纽带(图1)。孵化场的目标应该是向养殖场提供高品质的1日龄雏鸡,如果饲养管理到位,这些雏鸡能够充分发挥其遗传潜能。但是,孵化场同时也是细菌(如大肠杆菌属和沙门氏菌属的细菌)... 详细信息

孵化场是种鸡场与禽蛋和禽肉产品的家禽生产舍之间的重要纽带(图1)。孵化场的目标应该是向养殖场提供高品质的1日龄雏鸡,如果饲养管理到位,这些雏鸡能够充分发挥其遗传潜能。但是,孵化场同时也是细菌(如大肠杆菌属和沙门氏菌属的细菌)、支原体(如鸡毒支原体)和真菌(如曲霉菌)等病原微生物传播的中心点或集中地。任其发展将会使家禽生产性能变差,养殖户的抗生素使用量增加,危害禽产品消费者的健康,严重的甚至可能造成贸易壁垒,从而造成重大经济损失。

关键词：鸡毒支原体大肠杆菌属家禽生产禽产品重大经济损失沙门氏菌属出雏禽肉产品病原微生物落盘

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Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics

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Light(Science & Applications) 2021年第4期10卷 648-659页

作者： Daria Kohler Gregor Schindler Lothar Hahn johannes Milvich Andreas Hofmann Kerstin lange Wolfgang Freude Christian Koos Institute of photonics and Quantum Elearo nics(IpQ) Karlsruhe Institute of Technology(KIT)Engesserstrasse 576131 KarlsruheGermany lnstitute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany robert Bosch GmbH Robert-Bosch-Campus 171272 RenningenGermany lnstitute for Autom ation and Applied Informatics(IAI) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health *** this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength ***,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a *** this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic *** Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light *** of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple *** our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light *** expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics.

关键词： passive waveguide pumped

建立市场辅导机制下的“文化保护主义”体系——欧盟影视公共资助模式的思考

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现代传播（中国传媒大学学报） 2007年第2期29卷 108-112页

作者：罗青 Andre lange 中国传媒大学欧洲传媒研究中心欧洲委员会视听传媒观察中心财经市场部

公共资助体系是欧洲国家对以影视为主导的文化创意产业的一系列重要的公共政策,起源于20世纪30年代。世界大战末期的欧洲成为美国电影及美国价值观主导的市场,如何保持欧洲产业的文化多样性和全球竞争力引起了欧洲业界的普遍危机认同。... 详细信息

公共资助体系是欧洲国家对以影视为主导的文化创意产业的一系列重要的公共政策,起源于20世纪30年代。世界大战末期的欧洲成为美国电影及美国价值观主导的市场,如何保持欧洲产业的文化多样性和全球竞争力引起了欧洲业界的普遍危机认同。通过市场和文化的双轨措施实施的公共资助体系,开发出产业之区域整合与互惠模式,创造出一个全新的全球市场竞争力量,保持了欧洲各文化对美国文化强权的抗衡能力的政策模式和产业辅助体系。基于市场竞争和文化多样双重原则下建立起来的视听产业公共资助体系,以“经济和文化”的两手原则为指导,目的是为影视产业的市场化和文化价值服务,其建构的体系原则、资金来源、运营方式均值得尚处于产业化转型,尤其是文化体制改革进程中的中国影视业界借鉴。

关键词：公共资助影视产业文化保护主义欧盟

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骶骨衰竭骨折MrI研究

实用放射学杂志 2005年第11期21卷 1172-1175页

作者：徐文坚徐爱德 S.lange 青岛大学医学院附属医院放射科 department of radiology Knappschafts-Hospital RecklinghausenRuhr-University BochumGermany

目的探讨骶骨衰竭骨折的Mr I表现特征及其诊断价值。方法21例病人,女19例,男2例,平均年龄72.4岁。所有病人均有骨质疏松,其中7例为盆腔肿瘤放疗后发病。Mr I检查使用矢状位、横轴位和冠状位SE T1W I、FSE T2W I和脂肪抑制FSET2W I。其... 详细信息

目的探讨骶骨衰竭骨折的Mr I表现特征及其诊断价值。方法21例病人,女19例,男2例,平均年龄72.4岁。所有病人均有骨质疏松,其中7例为盆腔肿瘤放疗后发病。Mr I检查使用矢状位、横轴位和冠状位SE T1W I、FSE T2W I和脂肪抑制FSET2W I。其中14例同时行SE T1W I增强扫描。所有病人均同时行X线平片、CT平扫检查,其中14例行同位素扫描以证实诊断。结果21例共发生37侧骶骨耳部骨折,其中16例(76.2%)为双侧骨折,5例(23.8%)为单侧骨折。37侧骨折中,32侧(86.5%)显示“蛇形”低信号骨折线。所有病例均显示片状或三角形骨折周围水肿区呈长T1长T2异常信号。14例增强扫描,骨折线均无强化,水肿区呈不均匀强化。3例合并其他部位多发性不全骨折。结论Mr I诊断骶骨衰竭骨折具有特征性,可显示骨折线及骨折周围水肿区。

关键词：骶骨衰竭骨折磁共振成像诊断

development of an internally braced prosthesis for total talus replacement

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World journal of Orthopedics 2017年第3期8卷 221-228页

作者： Markus regauer Mirjam lange Kevin Soldan Steffen peyerl Sebastian Baumbach Wolfgang Bocker Hans polzer Klinik für Allgemeine Unfall und Wiederherstellungschirurgie Klinikum der Ludwig-Maximilians-Universitat München Stryker GmbH

Total loss of talus due to trauma or avascular necrosis,for example,still remains to be a major challenge in foot and ankle surgery with severely limited treatment *** of a custom made total talar prosthesis has shown promising results so *** important factors for long time success are degree of congruence of articular surfaces and ligamentous stability of the ***,our aim was to develop an optimized custom made prosthesis for total talus replacement providing a high level of primary stability.A custom made hemiprosthesis was developed using computed tomography and magnetic resonance imaging data of the affected and contralateral talus considering the principles and technology for the development of the ***(Stryker).Additionally,four eyelets for fixation of artificial ligaments were added at the correspondent footprints of the most important *** modifications can be provided according to the clinical requirements:A tri-articular hemiprosthesis or a bi-articular hemiprosthesis combined with the tibial component of the *** ankle replacement system.A feasibility study was performed using a fresh frozen human *** range of motion of the ankle was measured and ligamentous stability was evaluated by use of standard X-rays after application of varus,valgus or sagittal stress with 150 *** implantation of the prosthesis was technically possible via an anterior approach to the ankle and using standard *** osteotomies were not *** ankle dorsiflexion and plantarflexion were measured as 22-0-28 *** anterior displacement of the talus was 6 mm,maximum varus tilt 3 degrees and maximum valgus tilt 2 *** of an internally braced prosthesis for total talus replacement in humans is technically feasible and might be a reasonable procedure in carefully selected cases with no better alternatives left.

关键词： Ankle Avascular necrosis Total loss of talus prosthesis Hemiprosthesis InternalBrace Talus replacement

Isolation of bacteria from fermented food and grass carp intestine and their efficiencies in improving nutrient value of soybean meal in solid state fermentation

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journal of Animal Science and Biotechnology 2018年第3期9卷 664-673页

作者： Samantha Medeiros jingjing Xie paul W.Dyce Hugh Y.Cai Kees de lange Hongfu Zhang julang Li department of Animal Bio Sciences University of Guelph State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural Sciences Animal Science department Auburn University Animal Health Laboratory University of Guelph College of Life Science and Engineering Foshan University

Background: Soybean meal is an excellent and cost-effective protein source; however, its usage is limited in the piglet due to the presence of anti-nutritional factors and the antigens glycinin and β-conglycinin. The objective of the current study was to screen and select for bacteria that can be efficiently adopted to ferment soybean meal in order to solve this ***: Bacteria were isolated from fermented soy foods and the grass carp intestine, and strains selected for high protease, cellulase and amylase activities. The isolated bacteria were characterized as Bacillus cereus, Bacillus subtilis and Bacilus amyloliquefacien, respectively. Fermentation with food-derived Isolate-2 and fish-derived F-9 increased crude protein content by 5.32% and 8.27%, respectively; improved the amino acid profile by increasing certain essential amino acids, broke down larger soy protein to 35 k Da and under, eliminated antigenicity against glycinin and β-conglycinin, and removed raffinose and stachyose in the soybean meal following a 24-h ***: Our results suggest these two B. amyloliquefaciens bacteria can efficiently solid state ferment soybean meal and ultimately produce a more utilizable food source for growing healthy piglets.

关键词： Allergens Fermentation Food source bacteria Soybean meal

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快速3 T Mr引导经直肠前列腺活检使用室内平板设备进行针导对准的可行性研究

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国际医学放射学杂志 2019年第1期 120-121页

作者： C.G.Overduin j.Heidkamp E.rothgang j.O.Barentsz F.de lange j.j.Fütterer 蒋婷婷 department of radiology and Nuclear Medicine Radboud University Medical Center

摘要目的评估在扫描室内增加平板设备以辅助针导对准在Mr引导下的经直肠前列腺活检的可行性。方法前瞻性纳入20例病人,均在诊断性多参数MrI检查中发现有

关键词：前列腺活检经直肠平板设备

Lifestyle factors in the prevention of coronavirus disease 2019(COVID-19)

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Global Health journal 2020年第4期4卷 146-152页

作者： Klaus W.lange Yukiko Nakamura Institute of psychology University of RegensburgRegensburg 93040Germany

Confinement to the home and psychological distress due to the coronavirus disease 2019(COVID-19)pandemicmay lead to harmful health behaviors,such as overeating,sedentary behavior with reduced physical activity,elevated alcohol and tobacco use and increased screen time causing impaired *** of these behaviors areassociated with non-communicable diseases and can interfere with *** no foods,single nutrientsor dietary supplements are capable of preventing infection with COVID-19,a balanced diet containing sufficientamounts of macronutrients and diverse micronutrients is a prerequisite of an optimally functioning ***-energy“Western”diets and obesity are major risk factors for a more severe course of *** use and tobacco also have detrimental effects on the immune ***,population-wide bodyweight control,reduction of smoking rates and limitation of alcohol consumption are important ***,sufficient restorative sleep is needed for adequate immune *** changes in regard to nutrition,exercise,sleep,smoking and alcohol intake may help shift the populationdistribution of infection risk and aid in preventing severe COVID-19 ***-scale surveys should explorethe effects of lifestyle changes,and the provision of reliable lifestyle information and effective interventions toindividuals and communities during the pandemic is a pressing need.

关键词： COVID-19 prevention Lifestyle Obesity Exercise Sleep

Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells

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World journal of Gastroenterology 2018年第2期24卷 170-178页

作者： peter Wallbaum Sarah rohde Luise Ehlers Falko lange Alexander Hohn Carina Bergner Sarah Marie Schwarzenbock Bernd joachim Krause robert jaster department of MedicineⅡ Division of GastroenterologyRostock University Medical CenterRostock 18057Germany Oscar-langendorff-Institute of physiology Rostock University Medical CenterRostock 18057Germany department of Nuclear Medicine Rostock University Medical CenterRostock 18057Germany

AIM To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells(pSCs).METHODS Quiescent pSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures(early-activated pSCs) and upon re-culturing(fullyactivated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin(α-SMA), a marker of pSC activation, was monitored by immunofluorescence and immunoblot analysis. The rate of DNA synthesis was quantified by 5-bromo-2'-deoxyuridine(Brd U) incorporation assays. real-time pCr was employed to monitor gene expression, and protein levels of interleukin-6(IL-6) were measured by ELISA. Uptake of proline was determined using 18 *** Sustained culture of originally quiescent pSCs inducedcell proliferation, loss of lipid droplets and exhibition of stress fibers, indicating cell activation. When added to pSCs in primary culture, all three D-vitamins diminished expression of α-SMA(to 32%-39% of the level of control cells; p reased the storage of lipids(scores from 1.97-2.15 on a scale from 0-3; controls: 1.49; p re observed when D-vitamins were added to fully-activated cells, while incorporation of Brd U remained unaffected under both experimental conditions. Treatment of re-cultured pSCs with D-vitamins was associated with lower expression of IL-6(-42% to-49%; p rmed at the protein level) and increased expression of the vitamin D receptor gene(209%-321% vs controls; p re was no effect of D-vitamins on the expression of transforming growth factor-β1 and collagen type 1(chain α1). The lowest uptake of proline, a main component of collagen, was observed in calcipotriol-treated *** The three D-vitamins inhibit, with similar efficiencies, activation of pSCs in v

关键词： pancreatic stellate cells Fibrosis Vitamin D2 Vitamin D3 Calcipotriol