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与现有的其他重建算法相比，基于深度学习的重建算法可以改善大脑平扫CT影像

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国际医学放射学杂志 2021年第5期 612-613页

作者： L.j.Oostveen F.j.A.Meijer F.de lange E.j.Smit S.A.pegge S.C.A.Steens 余子意

摘要目的在大脑平扫CT(NCCT)中,对比商用的深度学习重建算法(DLr)、混合迭代重建(Hybrid-Ir)算法和基于模型的迭代重建(MBIr)算法的影像质量和重建时间。方法

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Liver-specific gene expression in mesenchymal stem cells is induced by liver cells

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World journal of Gastroenterology 2005年第29期11卷 4497-4504页

作者： Claudia lange philipp Bassler Michael V. Lioznov Helge Bruns Dietrich Kluth Axel r. Zander Henning C. Fiegel Center of Bone Marrow Transplantation University Hospital Hamburg-Eppendorf Martinistrasse 52 D-20246 Hamburg Germany department of pediatric Surgery University Hospital Hamburg-Eppendorf Martinistrasse 52 D-20246 Hamburg Germany

AIM： The origin of putative liver cells from distinct bone marrow stem cells, e.g. hematopoietic stem cells or multipotent adult progenitor cells was found in recent in vitro studies. Cell culture experiments revealed a key role of growth factors for the induction of liver-specific genes in stern cell cultures. We investigated the potential of rat mesenchymal stem cells （MSC） from bone marrow to differentiate into hepatocytic cells in vitro. Furthermore, we assessed the influence of cocultured liver cells on induction of liver-specific gene expression. METHODS： Mesenchymal stem cells were marked with green fluorescent protein （GFp） by retroviral gene transduction. Clonal marked MSC were either cultured under liver stimulating conditions using fibronectin-coated culture dishes and medium supplemented with SCF, HGF, EGF, and FGF-4 alone, or in presence of freshly isolated rat liver cells. Cells in cocultures were harvested and GFp＋ or GFp- cells were separated using fluorescence activated cell sorting. rT-pCr analysis for the stem cell marker Thyl and the hepatocytic markers CK-18, albumin, CK-19, and AFp was performed in the different cell populations. rESULTS： Under the specified culture conditions, rat MSC cocultured with liver cells expressed albumin-, CK-18, CK-19, and AFp-rNA over 3 weeks, whereas MSC cultured alone did not show liver specific gene expression, CONCLUSION： The results indicate that （1） rat MSC from bone marrow can differentiate towards hepatocytic lineage in vitro, and （2） that the microenvironment plays a decisive role for the induction of hepatic differentiation of rMSC.

关键词： Mesenchymal stem cells Liver-specific differentiation Coculture

The Influence of pain: Quality of Life after <i>pectus excavatum</i>Correction

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Open journal of pediatrics 2014年第3期4卷 216-221页

作者： Wietse p. Zuidema Alida F. W. van der Steeg jan W. A. Oosterhuis Christien Sleeboom Stefan M. van der Heide Elly S. M. de lange-de Klerk Hugo A. Heij department of Cardio-Thoracic Surgery Radboud University Medical Center Nijmegen The Netherlands department of Epidemiology and Biostatistics VU University Medical Center Amsterdam The Netherlands department of Surgery VU University Medical Center Amsterdam The Netherlands pediatric Surgical Center of Amsterdam Emma Children’s Hospital AMC and VU University Medical Center Amsterdam The Netherlands

Introduction: The main indication for surgery of thoracic wall deformities (TWD) is psychological due to cosmetic complaints. The assumption is that appearances have a negative effect on?self-esteem and quality of life?(QoL). Correction should result in improvement. Methods: prospective trial. QoL was assessed using the?CHQ and the WHOQOL-bref. Measurements were taken before surgery (T1) and 6 weeks thereafter (T2). results: Forty-two patients were included.?WHOQOL-bref showed differences between pre-operative and?six weeks past surgery on facet body image (p = 0.003).?Self-esteem (CHQ) did not show a significant improvement at T2.?Concerning the scores on the single step questionnaire (SSQ),?33 patients were “very” to “extremely satisfied” with appearance and increased self-esteem (p rning the domain “pain and physical complaints”, CHQ did show a significant change (p re complaints at T2. Conclusion: Six weeks after surgical correction of a TWD satisfaction with the “new” chest is good;pain seems to be a problem with possible negative influence on self-esteem.

关键词： pain Quality of Life (Qol) pectus Chest Wall deformity

Transmission dynamics model and the coronavirus disease 2019 epidemic:applications and challenges

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Medical review 2022年第1期2卷 89-109页

作者： jinxing Guan Yang Zhao Yongyue Wei Sipeng Shen Dongfang You ruyang Zhang Theis lange Feng Chen departments of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina China International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjing 211166JiangsuChina Center of Biomedical BigData Nanjing Medical UniversityNanjing 211166JiangsuChina department of public Health University of CopenhagenCopenhagenDenmark

Since late 2019,the beginning of coronavirus disease 2019(COVID-19)pandemic,transmission dynamics models have achieved great development and were widely used in predicting and ***,we provided an introduction to the history of disease transmission,summarized transmission dynamics models into three main types:compartment extension,parameter extension and population-stratified extension models,highlight the key contribution of transmission dynamics models in COVID-19 pandemic:estimating epidemiological parameters,predicting the future trend,evaluating the effectiveness of control measures and exploring different possibilities/***,we pointed out the limitations and challenges lie ahead of transmission dynamics models.

关键词： compartment model coronavirus disease 2019 novel coronavirus pneumonia SEIr SIr transmission dynamics model.

Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach

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World journal of Gastroenterology 2012年第43期18卷 6226-6234页

作者： Falko lange Katja rateitschak Christina Kossow Olaf Wolkenhauer robert jaster department of Systems Biology and Bioinformatics University of Rostock 18057 Rostock Germany department of Medicine Ⅱ Division of Gastroenterology University Medicine Rostock 18057 Rostock Germany Stellenbosch Institute for Advanced Study Wallenberg Research Centre at Stellenbosch University Stellenbosch 7600 South Africa

AIM:To gain insights into the molecular action of erlotinib in pancreatic cancer (pC) cells. METHODS:Two pC cell lines, BxpC-3 and Capan-1, were treated with various concentrations of erlotinib, the specific mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and protein kinase B (AKT) inhibitor XIV. DNA synthesis was measured by 5-bromo-2'-deoxyuridine (BrdU) assays. Expression and phosphorylation of the epidermal growth factor receptor (EGFr) and downstream signaling molecules were quantified by Western blot analysis. The data were processed to calibrate a mathematical model, based on ordinary differential equations, describing the EGFrmediated signal transduction. rESULTS:Erlotinib significantly inhibited BrdU incorporation in BxpC-3 cells at a concentration of 1 mol/L, whereas Capan-1 cells were much more resistant. In both cell lines, MEK inhibitor U0126 and erlotinib attenuated DNA synthesis in a cumulative manner, whereas the AKT pathway-specific inhibitor did not enhance the effects of erlotinib. While basal phosphorylation of EGFr and extracellular signal-regulated kinase (ErK) did not differ much between the two cell lines, BxpC-3 cells displayed a more than five-times higher basal phospho-AKT level than Capan-1 cells. Epidermal growth factor (EGF) at 10 ng/mL induced the phosphorylation of EGFr, AKT and ErK in both cell lines with similar kinetics. In BxpC-3 cells, higher levels of phospho-AKT and phospho-ErK (normalized to the total protein levels) were observed. Independent of the cell line, erlotinib efficiently inhibited phosphorylation of EGFr, AKT and ErK. The mathematical model successfully simulated the experimental findings and provided predictions regarding phosphoprotein levels that could be verified experimentally. CONCLUSION:Our data suggest basal AKT phosphorylation and the degree of EGF-induced activation of AKT and ErK as molecular determinants of erlotinib efficiency in pC cells.

关键词： Erlotinib pancreatic cancer Epidermal growth factor receptor Signal transduction Mathematical modeling

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洋葱状炭纳米粒子的无催化剂合成(英文)

新型炭材料 2010年第1期25卷 1-8页

作者： M. Bystrzejewski M.H. rummeli T. Gemming H. lange A. Huczko dept of Chemistry Warsaw University Pasteur 1 str. 02-093 Warsaw Poland IFW Dresden Helmholtzstr. 20 01069 Dresden Germany

描述了基于NaN3-C6Cl6混合物热解一步合成洋葱状碳纳米粒子的方法。应用EMS,XrD,ramans研究了缓冲气体(Ar或空气)对炭产物的得率、形貌和结构的影响。产物包含洋葱炭、非晶碳和NaCl,通过简单的纯化处理即可完全除去副产物。洋葱状炭纳... 详细信息

描述了基于NaN3-C6Cl6混合物热解一步合成洋葱状碳纳米粒子的方法。应用EMS,XrD,ramans研究了缓冲气体(Ar或空气)对炭产物的得率、形貌和结构的影响。产物包含洋葱炭、非晶碳和NaCl,通过简单的纯化处理即可完全除去副产物。洋葱状炭纳米粒子的形成由热解过程中压力迅速增加产生的震动波诱导苯基活性分子合并所制。

关键词：碳纳米洋葱热解气相反应 XrD raman光谱

Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis

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World journal of Gastroenterology 2019年第9期25卷 1116-1131页

作者： peter deibert Adhara Lazaro denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas lange Faculty of Medicine Department of MedicineInstitute of Exercise and Occupational MedicineMedical CenterUniversity of Freiburg department of Nutrition Institute for Sports and Sports ScienceUniversity of Freiburg Faculty of Medicine Department of MedicineDivision of GastroenterologyHepatologyEndocrinology and Infectious DiseasesMedical CenterUniversity of Freiburg University Hospital of Freiburg Occupational Medicine Faculty of Medicine Department of Radiology-Medical PhysicsMedical CenterUniversity of Freiburg

BACKGrOUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat *** To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy *** Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(Mr-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod pod? device. pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SpSS software, results were expressed as median(interquartile range).rESULTS Twenty-two subjects(Mr-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(Mr-G:-6.4(3.6) kg, p p ropped in both groups(Mr-G:-2.3(1.5)kg/m^2, p = 0.003; LC-G:-3.0(3.4) kg/m^2, p = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ***, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid *** Comprehensive lifestyle intervention and meal replacement regimen have compar

关键词： Non-alcoholic steatohepatitis Meal replacement therapy Soy protein Lifestyle change Weight reduction Obesity

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生长猪氨基酸利用的数量观点:理论与实践

动物营养学报 2004年第3期16卷 6-12页

作者： C.F.M.de lange 印遇龙 department of Animal and poultry Science University of Guelph GuelphONCanada

本文综述了影响生长猪氨基酸利用的主要因素,探讨了养猪生产中有关氨基酸营养问题。结果表明:通过测定体沉积蛋白质(pD)中氨基酸的沉积、生理氨基酸损失(主要是皮肤和毛发、肠道内源氨基酸损失)与不可避免的氨基酸的分解代谢来估测氨基... 详细信息

本文综述了影响生长猪氨基酸利用的主要因素,探讨了养猪生产中有关氨基酸营养问题。结果表明:通过测定体沉积蛋白质(pD)中氨基酸的沉积、生理氨基酸损失(主要是皮肤和毛发、肠道内源氨基酸损失)与不可避免的氨基酸的分解代谢来估测氨基酸的需要量,估测氨基酸需要量的数据必须建立在蛋白质沉积、活体量、饲喂水平、饲料原料组成和饲料原料的可利用氨基酸含量上。既然pD是氨基酸需要量的决定因素,在建立日粮最佳氨基酸水平时,必须认真考虑活体重或动物间的差异对pD的影响。因此,饲料组成与机体蛋白质中氨基酸组成的变化对用于蛋白质沉积需要的可利用氨基酸利用的影响必须进行更精确的定量。

关键词：生长猪氨基酸分解代谢需要量

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嵌入虚拟机监视器的高性能虚拟网络

仪器仪表学报 2012年第5期33卷 1195-1200页

作者：唐源夏磊崔峥 john lange peter Dinda patrick Bridges 李建平电子科技大学计算机科学与工程学院西北大学电子工程与计算机学院新墨西哥大学计算机学院

由虚拟机和虚拟覆盖网相结合而构成的虚拟计算环境,在云计算和绿色计算中发挥非常重要的作用,然而,现有的虚拟计算环境在性能上难以满足高性能分布式计算的要求。设计和实现了一种高性能虚拟网络:VNET/p。基于网络第2层建立虚拟机互连模... 详细信息

由虚拟机和虚拟覆盖网相结合而构成的虚拟计算环境,在云计算和绿色计算中发挥非常重要的作用,然而,现有的虚拟计算环境在性能上难以满足高性能分布式计算的要求。设计和实现了一种高性能虚拟网络:VNET/p。基于网络第2层建立虚拟机互连模型,对一组虚拟机进行抽象,使其位于同一局域网中。与早期的用户层虚拟网络系统不同,VNET/p嵌入于可扩展、高性能的palacios虚拟机监视器中。试验结果表明,VNET/p具有高带宽的特点,其性能接近于实际硬件的性能。

关键词：虚拟化虚拟机监视器覆盖网络高性能计算