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英语世界 2024年第10期 127-128页

作者： Julie dawn Fox

Pre-reading task You are going to read an article about the importance of planning and preparation when blogging for business. Before you read, think about your own company. Does it have a blog? Do you know who it is ...

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Electrobiocorrosion by microbes without outer-surface cytochromes

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mLife 2024年第1期3卷 110-118页

作者： dawn E.Holmes Trevor L.Woodard Jessica A.Smith Florin Musat Derek R.Lovley Department of Microbiology University of Massachusetts AmherstAmherstMassachusettsUSA Department of Physical and Biological Science Western New England UniversitySpringfieldMassachusettsUSA Department of Biomolecular Sciences Central Connecticut State UniversityNew BritainConnecticutUSA Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molecular Biology and Biotechnology Facuity of Biology and GeologyBabes-Bolyai UniversityCluj-NapocaRomania

Anaerobic microbial corrosion of iron-containing metals causes extensive economic *** microbes are capable of direct metal-to-microbe electron transfer(electrobiocorrosion),but the prevalence of electrobiocorrosion among diverse methanogens and acetogens is poorly understood because of a lack of tools for their genetic *** studies have suggested that respiration with 316L stainless steel as the electron donor is indicative of electrobiocorrosion,because,unlike pure Fe^(0),316L stainless steel does not abiotically generate H_(2) as an intermediary electron ***,we report that all of the methanogens(Methanosarcina vacuolata,Methanothrix soehngenii,and Methanobacterium strain IM1)and acetogens(Sporomusa ovata and Clostridium ljungdahli)evaluated respired with pure Fe^(0)as the electron donor,but only ***,***,and *** were capable of stainless steel *** electrobiocorrosive methanogens re-quired acetate as an additional energy source in order to produce methane from stainless *** of *** and *** demonstrated how acetogens can provide acetate to methanogens during *** only was Meth-anobacterium strain IM1 not capable of electrobiocorrosion,but it also did not accept electrons from Geobacter metal-lireducens,an effective electron-donating partner for direct interspecies electron transfer to all methanogens that can directly accept electrons from Fe^(0).The finding that ***,***,and *** are capable of electrobiocorrosion,despite a lack of the outer-surface c-type cytochromes previously found to be important in other electrobiocorrosive microbes,demonstrates that there are multiple microbial strategies for making electrical contact with Fe^(0).

关键词： acetogen corrosion Fe^(0) methanogen stainless steel

Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

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四川生理科学杂志 2024年第10期46卷 2326-2326页

作者： Xi dawn Chen Gene Regulation Observatory Broad Institute of MIT and Harvard Cambridge MA 02142 USA. Department of Stem Cell and Regenerative Biology Harvard University Cambridge MA 02138 USA. Systems Synthetic and Quantitative Biology PhD Program Harvard University Cambridge MA 02138 USA. Department of Cancer Biology Dana-Farber Cancer Institute Boston MA 02215 USA. Department of Cell Biology and Pathology Harvard Medical School Boston MA 02115 USA. Department of Chemistry and Chemical Biology Harvard University Cambridge MA 02138 USA. Cancer Program Broad Institute of MIT and Harvard Cambridge MA 02142 USA. Cecil H. and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Dallas TX 75390 USA. The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease Broad Institute of MIT and Harvard Cambridge MA 02142 USA.

Deciphering the context-specific relationship between sequence and function is a major challenge in *** tools for inducing locus-specific hypermutation and evolution in the native genome context are *** we present a programmable platform for long-range,locus-specific hypermutation called helicase-assisted continuous editing(HACE).HACE leverages CRISPR-Cas9 to target a processive helicase-deaminase fusion that incurs mutations across large(>1000-base pair)genomic *** applied HACE to identify mutations in mitogen-activated protein kinase kinase 1(MEK1)that confer kinase inhibitor resistance,to dissect the impact of individual variants in splicing factor 3B subunit 1(SF3B1)-dependent missplicing,and to evaluate noncoding variants in a stimulation-dependent immune enhancer of *** provides a powerful tool for investigating coding and noncoding variants,uncovering combinatorial sequence-to-function relationships,and evolving new biological functions.

关键词： endogenous stimulation continuous

基于中国全科医生的糖尿病医患沟通技能培训设计与开发

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中国全科医学 2024年第7期27卷 816-821页

作者：姚弥林恺樊洁婷纪欣鑫王颖董爱梅韩晓宁齐建光迟春花 Shamil Haroon dawn Jackson KK Cheng Richard Lehman 北京大学第一医院全科医学科北京市100034 北京大学医学部全科医学系北京市100191 汕头大学医学院第一附属医院全科医学中心广东省汕头市515041 火箭军特色医学中心内分泌科北京市100088 汕头大学医学院广东省汕头市515041 北京大学第一医院教育处北京市100034 北京大学第一医院内分泌科北京市100034 北京大学第一医院心血管科北京市100034 北京大学第一医院儿科北京市100034 北京大学第一医院健康管理中心北京市100034 英国伯明翰大学应用健康研究院伯明翰B152TT 英国伯明翰大学医学院伯明翰B152TT

全科医生作为居民健康“守门人”,在基层糖尿病等慢性疾病管理中发挥着重要作用。糖尿病管理可以延缓病情进展、减少糖尿病并发症和改善患者健康结局,这需要患者和医生之间的有效沟通并互相协作。全科医生具备良好的沟通能力有助于与糖... 详细信息

全科医生作为居民健康“守门人”,在基层糖尿病等慢性疾病管理中发挥着重要作用。糖尿病管理可以延缓病情进展、减少糖尿病并发症和改善患者健康结局,这需要患者和医生之间的有效沟通并互相协作。全科医生具备良好的沟通能力有助于与糖尿病患者建立长期的照护关系、帮助患者建立有效的自我管理技能。本文总结了本研究团队在多种理论框架指导下的全科医生糖尿病沟通技能培训的设计和开发:基于系统综述发现的循证依据,通过定性研究进一步探索糖尿病患者与全科医生的沟通体验和想法,以及混合方法研究设计理念获取全科医学对于医患沟通培训内容的优先排序,旨在为高质量的基层糖尿病管理提供新思路,并为基于证据和医学教育框架设计全科医生相关培训项目提供借鉴。

关键词：糖尿病沟通技能在职培训培训设计全科医生

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Femoral neck stress fracture and medial tibial stress syndrome following high intensity interval training: A case report and review of literature

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World Journal of Clinical Cases 2022年第23期10卷 8323-8329页

作者： dawn Suwanie tan Fiona Millicent Cheung Dekai Ng Tin Lung Alan Cheung Department of Orthopaedic Surgery International Orthopaedic ClinicSingapore329563Singapore

BACKGROUND Femoral and tibial stress injuries are commonly found in long distance running *** fractures have rarely been reported in athletes performing high intensity interval training(HIIT)*** objective of this study was to report a case of a patient who presented with medial tibial stress syndrome and femoral neck stress fracture after performing HIIT *** SUMMARY A 26 year old female presented with bilateral medial tibial *** had been performing HIIT exercise for 45 min,five times weekly,for a seven month *** tibial pain was gradual in onset,and was now severe and worse on exercise,despite six weeks of *** resonance imaging(MRI)revealed bilateral medial tibial stress *** she was taking norethisterone for birth control,a dual energy X-ray absorbitometry scan was performed which demonstrated normal bone mineral density of her lumbar spine and femoral *** was managed conservatively with analgesia and physiotherapy,but continued to exercise against medical *** presented again six months later with severe right hip *** of her right hip demonstrated an incomplete stress fracture of her subtrochanteric *** symptoms resolved with strict rest and *** HIIT may cause stress injury of the tibia and femur in young individuals.

关键词： High intensity interval training Medial tibial stress syndrome Femoral neck stress fracture Exercise Fracture Case report

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庆祝制造日：确保下一代技术工人

中国质量 2024年第4期 61-63页

作者：道恩·贝利张睿

在7月17日庆祝“美国制造日”期间，成千上万的美国制造商向学生展示了现代制造业的现实，以此来激励下一代。这一点的重要性不容小觑，因为根据制造业协会和德勤公司的一项劳动力研究，未来十年，美国将需要填补400万个制造业工作岗位...

在7月17日庆祝“美国制造日”期间，成千上万的美国制造商向学生展示了现代制造业的现实，以此来激励下一代。这一点的重要性不容小觑，因为根据制造业协会和德勤公司的一项劳动力研究，未来十年，美国将需要填补400万个制造业工作岗位。该研究报告称，到2028年，技能缺口可能会使超过一半的制造业工作岗位空缺，从而产生2.5万亿美元的未实现经济影响。

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波多里奇卓越绩效计划增强制造业的职业生涯韧性之路

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中国质量 2024年第1期 72-74页

作者：道恩·贝利王夏韵

在最近的美国制造业日庆祝活动中，为了鼓励下一代加入制造业，数千家美国制造商向学生们展示了现代制造业的发展现状。此举的重要性不容低估，因为美国制造业协会（The Manufacturing Institute）和德勤（Deloitte）联合发布的一项劳...

在最近的美国制造业日庆祝活动中，为了鼓励下一代加入制造业，数千家美国制造商向学生们展示了现代制造业的发展现状。此举的重要性不容低估，因为美国制造业协会（The Manufacturing Institute）和德勤（Deloitte）联合发布的一项劳动力研究显示，在未来十年美国将有400万个制造业岗位空缺需要填补。该研究称，到2028年，技能差距可能导致一半以上的制造业岗位出现空缺，从而造成2.5万亿美元的经济影响。

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Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse Mboowa Gerald Kamgang Basile Caminade Cyril Duke dawn C. Githeko Andrew Karanja Ogega Obed M. Elloué Nestor Engone Sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nicaise T. Paupy Christophe Bockarie Moses Otomo Patricks Voua Molecular and Cellular Biology Laboratory (LabMC) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The African Center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa Centers for Disease Control and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia Centre for Research in Infectious Diseases P.O. Box Yaoundé Cameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK Community Health Support Program P.O. Box Kisumu Kenya The African Academy of Sciences Nairobi Kenya Center for Phylosophical Studies and Research (CERP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic Diseases Control Program Ministry of Health Libreville Gabon MIVEGEC Univ. Montpellier CNRS IRD Montpellier France MERIT IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana School of Community Health Sciences Njala University Bo Sierra Leone

We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives

Inflammatory bowel disease in pregnancy

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World Journal of Gastroenterology 2011年第22期17卷 2696-2701页

作者： dawn B Beaulieu Sunanda Kane Division of Gastroenterology Vanderbilt University Nashville TN 37232 United States Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN 55905 United States

Crohn's disease and ulcerative colitis affect women in their child-bearing years. Family planning has come to be a common discussion between the gastroenterologist and the inflammatory bowel disease (IBD) patient. Disease control prior to desired conception and throughout pregnancy is the most important thing to keep in mind when caring for the IBD patient. Continued medical management during pregnancy is crucial in optimizing outcomes. Studies indicate that quiescent disease prior to conception infer the best pregnancy outcomes, similar to those in the general population. Active disease prior to and during pregnancy, can lead to complications such as pre-term labor, low birth weight, and small for gestational age infants. Although there are no definitive long term effects of pregnancy on IBD, there are some limited studies that suggest that it may alter the disease course. Understanding the literature and its limitations is important in the modern era of IBD care. Educating the patient and taking a team approach with the obstetrician will help achieve successful outcomes for mother and baby.

关键词： Inflammatory bowel disease Pregnancy Crohn’s disease Ulcerative colitis Breastfeeding