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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 179-186页

作者： Wenpan Li Shasha Jing Xiu Xin Xirui Zhang Kang chen dawei chen Haiyang Hu Department of Pharmaceutics School of Pharmacy Shenyang Pharmaceutical University

In this study, the CaP/pDNA nanoparticles were prepared using Triton X-100/Butanol/Cyclohexane/Water reverse microemulsion system. Optimization of preparation conditions was based on evaluation of particle size by Box–Behnken design method. The particle sizes of the optimized CaP/pDNA nanoparticles were found to be 60.23 ± 4.72 nm, polydispersity index was 0.252 and pDNA encapsulate efficiency was more than 90%. The optimized CaP/pDNA nanoparticles have pH sensitivity and biocompatibility. Further, optimized CaP/pDNA nanoparticles showed higher transfection efficiency.

关键词： CaP nanoparticles pDNA Reverse microemulsion method Box–Behnken design Transfection and expression

Integrated sensing and communication based outdoor multi-target detection,tracking,and localization in practical 5G Networks

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Intelligent and Converged Networks 2023年第3期4卷 261-272页

作者： Ruiqi Liu Mengnan Jian dawei chen Xu Lin Yichao cheng Wei cheng Shijun chen the Wireless Research Institute ZTE CorporationBeijing 100029China the State Key Laboratory of Mobile Network and Mobile Multimedia Technology Shenzhen 518055China

The 6th generation(6G)wireless networks will likely to support a variety of capabilities beyond communication,such as sensing and localization,through the use of communication networks empowered by advanced *** sensing and communication(ISAC)has been recognized as a critical technology as well as a usage scenario for 6G,as widely agreed by leading global standardization *** utilizes communication infrastructure and devices to provide the capability of sensing the environment with high resolution,as well as tracking and localizing moving objects *** both the requirements for communication and sensing simultaneously,ISAC-based approaches celebrate the advantages of higher spectral and energy efficiency compared to two separate systems to serve two purposes,and potentially lower costs and easy deployment.A key step towards the standardization and commercialization of ISAC is to carry out comprehensive field trials in practical networks,such as the 5th generation(5G)networks,to demonstrate its true capacities in practical *** this paper,an ISAC-based outdoor multi-target detection,tracking and localization approach is proposed and validated in 5G *** proposed system comprises of 5G base stations(BSs)which serve nearby mobile users normally,while accomplishing the task of detecting,tracking,and localizing drones,vehicles,and pedestrians *** trial results demonstrate the relatively high accuracy of the proposed method in practical outdoor environment when tracking and localizing single targets and multiple targets.

关键词： integrated sensing and communication prototype 5G track detection localization trial

Magnetic field induced synthesis of(Ni, Zn)Fe2O4 spinel nanorod for enhanced alkaline hydrogen evolution reaction

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Progress in Natural Science:Materials International 2023年第2期33卷 172-177页

作者： Mingkun Xia Yan zhang Jiangyue Xiao Peng Zhao Zhongjun Hou Fanglin Du dawei chen Shuo Dou College of Material Science and Engineering Qingdao University of Science and Technology Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education Northeast Forestry University

Recently, the introduction of external fields(light, thermal, magnetism, etc.) during electrocatalysis reactions gradually becomes a new strategy to modulate the catalytic activities. In this work, an external magnetic field was innovatively employed for the synthesis progress of(Ni, Zn)Fe2O4spinel oxide(M-(Ni, Zn)Fe2O4). Results indicated the magnetic field(≤250 m T) would affect the morphology of catalyst due to the existing Fe ions, inducing the M-(Ni, Zn)Fe2O4nanosphere particles to be uniform and coral-like nanorods. In addition, the electronic structure of the catalyst was regulated by the valence state of Fe, changing the bonding of metal to oxygen atoms in different spinel sites. The results manifested that the M-(Ni, Zn)Fe2O4requires a lower overpotential of only 67m V to deliver 10 m A cm-2for hydrogen evolution reaction(HER) in alkaline electrolyte. Moreover, M-(Ni, Zn)Fe2O4respectively as the anode and cathode electrode for the overall water splitting, the catalysis system requires a cell voltage of only 1.76 V to gain a current density of 50 m A cm-2, combining with an excellent discharging stability after 10 h. This work provides a facile synthesis strategy toward the design of efficient non-noble metal catalysts for alkaline HER and overall water splitting.

关键词： Hydrogen evolution reaction Magnetic field Water splitting Spinel oxide Electron modulation

全基因组测序分析生畜肉中沙门氏菌血清型、耐药性与毒力因子

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肉类研究 2024年第4期38卷 23-29页

作者：刘靓李兵兵李洁李双姝孙敏杨鹏飞邢亚东陈大伟淮安市疾病预防控制中心江苏省食品安全风险监测重点实验室(致病菌)江苏淮安223003

了解市售生畜肉中沙门氏菌(Salmonella)血清型、序列型(sequence typing,ST)分布、耐药性和毒力因子特征,探讨ST与耐药性和毒力的关系。收集2020—2023年从生畜肉中分离的68株沙门氏菌,用血清凝集法鉴定其血清型,微量肉汤稀释法进行药... 详细信息

了解市售生畜肉中沙门氏菌(Salmonella)血清型、序列型(sequence typing,ST)分布、耐药性和毒力因子特征,探讨ST与耐药性和毒力的关系。收集2020—2023年从生畜肉中分离的68株沙门氏菌,用血清凝集法鉴定其血清型,微量肉汤稀释法进行药物敏感检测;全基因组测序分析多位点序列分型、耐药基因与毒力因子,并结合系统发育树分析其相关性。结果表明:68株沙门氏菌可分为14种血清型,以鼠伤寒沙门氏菌和肠炎沙门氏菌为主,ST以ST19、ST34和ST11为主;多重耐药菌株占比69.12%(47/68),对氨苄西林(76.47%)、四环素(55.88%)和萘啶酸(52.94%)耐药率较高;68株沙门氏菌均携带菌毛吸附相关因子、镁离子转运相关因子、非菌毛类吸附相关因子、调控相关因子和分泌系统相关因子;生畜肉中污染的沙门氏菌血清型种类多样,耐药性严重且携带多种毒力因子,需要加强畜类养殖和生产销售的管理。

关键词：沙门氏菌全基因组测序序列型耐药性毒力因子

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大学物理课程思政体系建设探究

物理通报 2024年第10期 61-64页

作者：斯小琴陈大伟黄英华岳生伟安徽建筑大学城市建设学院安徽合肥238076

为实现高等学校教育的“三全育人”人才培养要求,此文从思想政治教育概念的厘定出发,明确了大学物理课程思政建设的重点内容,阐述了在当前社会生活形态下高等学校大学物理课程思政建设的必要性.概要介绍了课题组挖掘物理学史课程思政元... 详细信息

为实现高等学校教育的“三全育人”人才培养要求,此文从思想政治教育概念的厘定出发,明确了大学物理课程思政建设的重点内容,阐述了在当前社会生活形态下高等学校大学物理课程思政建设的必要性.概要介绍了课题组挖掘物理学史课程思政元素,融入物理教学并进行思政体系建设的基本策略.最后指出大学物理课程思政建设的关键在课程思政教师队伍建设.

关键词：课程思政大学物理体系建设

低聚糖对植物乳杆菌AUH2103抑菌作用的影响

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食品与发酵工业 2024年第6期50卷 116-121页

作者：严浩东张臣臣徐晶晶陈大卫康文丽潘丽娜唐溶雪李威顾瑞霞扬州大学食品科学与工程学院江苏扬州225000 扬州大学江苏省乳品生物技术与安全控制重点实验室江苏扬州225000 澳优乳业(中国)有限公司湖南长沙410127 人体微生态制品湖南省工程研究中心湖南长沙410127

对致病菌的抑制能力是评价益生菌功能特性的重要指标。该文使用单层平板扩散法和细胞黏附法测试了植物乳杆菌AUH2103的抑菌能力。结果显示,将碳源替换为低聚半乳糖(galactooligosaccharides,GOS)与低聚果糖(fructooligosaccharides,FOS)... 详细信息

对致病菌的抑制能力是评价益生菌功能特性的重要指标。该文使用单层平板扩散法和细胞黏附法测试了植物乳杆菌AUH2103的抑菌能力。结果显示,将碳源替换为低聚半乳糖(galactooligosaccharides,GOS)与低聚果糖(fructooligosaccharides,FOS)后,植物乳杆菌AUH2103的抑菌能力与在MRS中的结果无显著差异;而将碳源替换为2′-岩藻糖基乳糖(2′-focusllactose,2′-FL)后,由于生长能力变弱导致抑菌效果不明显。在低聚糖存在的情况下,植物乳杆菌AUH2103对于Caco-2细胞的黏附能力变强;在植物乳杆菌AUH2103与低聚糖存在的情况下,致病菌与Caco-2细胞的黏附能力出现明显下降。该研究表明,在低聚糖存在的情况下,植物乳杆菌AUH2103可以通过抑制致病菌对于Caco-2细胞的黏附产生抑菌效果。

关键词：低聚糖益生菌抑菌细胞黏附

Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 655-661页

作者： Chun Chu Ping Xu Haoyue Zhao Qing chen dawei chen Haiyang Hu Xiuli Zhao Mingxi Qiao Shenyang Pharmaceutical University

Various biotin-modified liposomes incorporated with docetaxel(DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome(PDL), 0.5%(mol) biotin modified liposome(0.5 BDL), 1%(mol) biotin modified liposome(1 BDL) and 2%(mol) biotin modified liposome(2 BDL) were prepared using thin film dispersion method. The prepared liposomes were characterized by measuring encapsulation efficiency(EE), particle size, Zeta-potential, physical stability and drug release profiles in vitro. MTT assay was performed to elevate the cytotoxicity of liposomes on MCF-7 cells. In vivo evaluation was further performed to investigate the effect of biotin surface density on the pharmacokinetic profiles. All the prepared liposomes exhibited high encapsulation efficiency, small particle size, narrow particle distribution and sustained release profiles in vitro. In MTT assay, 0.5 BDL showed largest tumor cell toxicity, compared with DTX solution. All liposomes containing DTX showed prolonged blood circulation in vivo, and 0.5 BDL showed the longest circulation time among the biotin modified liposome. Surface modification of liposome had a negative impact on the circulation of liposomes in the blood, which needs to be considered when designing the ligand mediated targeting delivery systems. A proper amount of biotin liposome with 0.5% molar ratio is expected to produce the best anti-tumor effect.

关键词： Docetaxel Liposomes Biotin Ligand density Tumor targeting

Exposure to Fipronil Insecticide in the Sixth Total Diet Study-China,2016-2019

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China CDC weekly 2022年第9期4卷 185-189,I0009-I0011页

作者： Zhibin Liu dawei chen Bing Lyu Jingguang Li Yunfeng Zhao Yongning Wu NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina Nanchang Key Laboratory of Detection and Control of Food Safety Nanchang Inspection and Testing CenterNanchangJiangxi ProvinceChina

Summary What is already known about this topic?Fipronil is classified as a“possible human carcinogen”by the United States Environmental Protection ***-term exposure to fipronil may cause damage to liver,thyroid,and ***,fipronil and its metabolites are ubiquitous in the environment and *** is added by this report?The dietary intake of fipronil in China was within acceptable levels with low health *** were the main dietary intake contributor of fipronil for Chinese adult populations(55.3%),followed by vegetables(30.7%),meats(5.90%),cereals(5.30%),and other food categories contributed less than 2%.What are the implications for public health practice?The study results will help health managers understand the health risk of fipronil,and help to better formulate monitoring plans in *** is still necessary to strengthen the monitoring of fipronil in foods,especially animal-derived foods.

关键词： cereal intake nil

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膳食营养与长寿老年人骨骼肌质量的关系

上海预防医学 2024年第6期36卷 589-595页

作者：梁肖肖蔡诗媛阮慧娟黄娇艳黄悠杨施汉平陈大伟李雪上海交通大学医学院公共卫生学院上海200025 上海健康医学院附属崇明医院临床营养科上海202150 上海交通大学医学院附属新华医院临床营养科上海200092

【目的】通过分析我国长寿老年人的营养素摄入、膳食结构等特点,探索可能影响长寿人群骨骼肌质量的特定膳食成分。【方法】于我国上海市崇明地区招募206名≥90岁的长寿老年人。应用3天24小时膳食回顾调查法,由专业营养师面对面访谈采集... 详细信息

【目的】通过分析我国长寿老年人的营养素摄入、膳食结构等特点,探索可能影响长寿人群骨骼肌质量的特定膳食成分。【方法】于我国上海市崇明地区招募206名≥90岁的长寿老年人。应用3天24小时膳食回顾调查法,由专业营养师面对面访谈采集膳食信息与一般人口学资料。采用生物阻抗分析(BIA)法测量骨骼肌指数(SMI),并根据2019年亚洲肌少症工作组标准诊断低骨骼肌质量。采用t检验、卡方检验及logistic回归等方法分析膳食营养素摄入量及其与骨骼肌质量之间的关系。【结果】在食物摄入种类方面,与骨骼肌正常的长寿老年人相比,低骨骼肌质量的长寿老年人谷类(含杂豆)、蔬菜的摄入量均偏低(P<0.05)。在营养素摄入量方面,低骨骼肌质量的长寿老年人总能量、碳水化合物、膳食纤维、维生素D、叶酸、磷、钾、镁、铁、锰的摄入量均偏低(P<0.05)。校正多种重要混杂因素后,多因素logistic回归结果显示,叶酸、膳食纤维仍是影响骨骼肌质量的重要因素。叶酸及膳食纤维摄入水平较低,长寿老年人患低骨骼肌质量的风险较高[OR_(叶酸T1、膳食纤维T1)(95%CI):2.90(1.11~7.61);4.09(1.53~10.91)]。【结论】在长寿老年人群中,低骨骼肌质量者谷类(含杂豆)、蔬菜的摄入量低于骨骼肌正常者。此外,低叶酸、膳食纤维摄入水平与低骨骼肌质量的患病风险增加有关。

关键词：长寿老年人骨骼肌质量营养素叶酸膳食纤维

Combined treatment of non-small cell lung cancer using radiotherapy and immunotherapy: challenges and updates

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Cancer Communications 2021年第11期41卷 1086-1099页

作者： Shijie Shang Jie Liu Vivek Verma Meng Wu James Welsh Jinming Yu dawei chen Department of Radiation Oncology Shandong Cancer Hospital Affiliated to Shandong UniversityJinanShandong 250117P.R.China Department of Radiation Oncology Laboratory of Radio-ImmunologyCancer Research CenterShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Department of Radiation Oncology The University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTexas 77030the United States of America

The efficacy of immunotherapy for advanced non-small cell lung cancer(NSCLC)remains unsatisfactory,as the majority of patients either do not experience an objective response or acquire secondary *** a result,several methods to enhance the systemic efficacy of immunotherapy have been investigated,including a large area of active research by combining immunotherapy with radiation therapy(RT).Given the rapidly burgeoning concept of combining immunotherapy and RT for increasing therapeutic benefit,we review the progress in this field thus far and explore further avenues for enhancing this *** review commences with a discussion of the only two existing randomized trials(and a pooled analysis)showing that the addition of RT to immunotherapy improves the abscopal response rate,progression-free survival,and overall survival in metastatic NSCLC *** then discussed factors and biomarkers that may be associated with a proportionally greater benefit to additional RT,such as low programmed cell death protein ligand 1(PD-L1)status,tumor mutational burden(TMB),and patient’s immune ***,the implementation of RT to overcome immunotherapy resistance is discussed,including a mechanistic discussion and methods with which these mechanisms could be ***,the emerging role of low-dose RT is discussed,which may help to overcome inhibitory signals in the tumor stroma that limit T-cell *** together,given the current state of this rapidly expanding realm,these futuristic strategies may be reflected upon to further enhance the efficacy of immunotherapy for a wider group of patients.

关键词： immune checkpoint inhibitors immunotherapy immunotherapy combined with radiotherapy low-dose radiotherapy non-small cell lung cancer radiotherapy