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摄入贯叶连翘生粉(金丝桃素)会增强患者在大剂量UVA1治疗过程中的红斑反应吗?

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 42-43页

作者： Beattie P.E. dawe r.s. Traynor N.J. 焦婷 Dermatology Department University ofDundee Ninewells Hospital and Medical School Dundee DD1 9SY United Kingdom

Background: st John s wort (sJW) is widely used as a treatment for depr.s.ion. A phototoxic reaction, due to its content of hypericin, can occur in animals and in cell culture, and has been reported in humans. Hypericin displays absorption within the ultraviolet (UV) A1 spectrum and there may therefore be a potential for phototoxicity if taken during high-dose UVA1 therapy. Objectives: To assess the phototoxicity r.s. of sJW ingestion. Methods: Eleven adult volunteers of skin types I and II were exposed to a geometric dose series of UVA1 irradiation from a high-output source (Dermalight Ultra 1; Dr H nle, Martinsreid, Germany; irradiance 70- 77 mW cm- 2) on the photoprotected lower back skin at eight 1.5-cm2 test areas. Irradiation was carried out at baseline and after 10 days of sJW extract 1020 mg (equivalent to 3000 μ g of hypericin) daily. Four, 8, 24 and 48 h after each exposure, the minimal erythema dose (MED) and the pr.s.nce or absence of pigmentation were recorded visually and erythema was assessed objectively with an erythema meter. r.s.lts: The median MED and D0.025, an objective measure of MED, were lower at all time-points after.s.W ingestion. The visual erythemal peak (lowest median MED), which was seen at 8 h postirradiation, was lower after.s.W (median 14 J cm- 2, range 10- 56) than at baseline (median 20 J cm- 2, range 14- 56) (P = 0.047). similarly, the median D0.025 at 8 h postirradiation was lower after.s.W(median 22.0 J cm- 2, range 15.2- 53.9) than at baseline (median 33.7 J cm - 2, range 22.9- 136.0) (P = 0.014). The MED and D0.025 were also significantly different at the 48-h and 4-h time-points, r.s.ectively. significance was not reached at the 24-h time-point. Median intensity of postirradiation erythema increased at all time-points after ingestion of sJW. Despite these differences, the maximum slope of the dose-r.s.onse curve was not increased after.s.W ingestion. Conclusions: These data suggest that sJW extract has the potential to lower

关键词：治疗过程金丝桃素 UVA1 贯叶连翘大剂量红斑反应摄入光毒性反应患者培养的细胞

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UVA1红斑的量效与时程特征

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 25-26页

作者： Beattie P.E. dawe r.s. Ferguson J. Ibbotson s.H. 潘敏 Photobiology Unit Ninewells Hospital and Medical School Ninewells AvenueDundee DD1 9SYUnited Kingdom

Objective: To determine the time course and dose-r.s.onse character.s.ics of UV-A1 erythema in the Tayside region of scotland. Design: Adult volunteers (skin types I and II [n=13]- and III and IV [n=11])were exposed to geometric dose series of UV-A1 irradiation from a high-output source on photoprotected lower back and inner forearm skin. setting: Photobiology unit in a university hospital. MainOutcomeMeasur.s. The minimal erythema dose (MED) was recorded visually and erythema was assessed objectively by erythema meter at 4, 8, 24, and 48 hours after exposure. r.s.lts: Peak erythema (lowest visual MED) was seen at 8 hours on the back and arm in 11 subjects with skin types I and II and on the back at 8 hours in 9 subjects and on the arm at 4 hours in 10 subjects with skin types III and IV. The lowest median (range) MED was 20 J/cm2 (14- 56 J/cm2) on the back and 42 J/cm2 (20 to >80 J/cm2) on the arm at 8 hours for.s.bjects with skin types I and II and 28 J/cm2 (20- 112 J/cm2) at 8 hours on the back and 56 J/cm2 (28- 80 J/cm2) at 4 hours on the arm for.s.bjects with skin types III and IV. The D0.025, an objective measure that corr.s.onds approximately to the visual MED, demonstrated a broad peak from 8 to 24 hours. Conclusions: Our local population is more erythemally sensitive to UV-A1 radiation than repor.s.suggest. Daily dose regimens may r.s. cumulative erythema. Lower.s.arting doses should be used in this population. The wide range of MEDs highlights the need for MED testing.

关键词：最小红斑剂量 UVA1 时程量效 Ⅳ型皮肤大学医院观察指标受试者照射苏格兰

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UVA1光疗法治疗脂质渐进性坏死

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 28-29页

作者： Beattie P.E. dawe r.s. Ibbotson s.H. Ferguson J. 刘艳 Western Infirmary Glasgow G11 6NT United Kingdom Dr.

The primary c ause of collagen degeneration in necrobiosis lipoidica (NL) is proposed to be immunologically mediated vascular disease. Ultraviolet (UV)A1 has been used successfully to treat scleroderma in which both vascular damage and collagen dysregulation also occur. We treated six patients with NL [(five women; mean age of 32 years (range 22-70) and mean disease duration of 2.9 years (range 6 months to 5 years)] with a high-output ultraviolet (UV)A1 2-kW filtered metal halide source (Dr; Dermalight ultrA 1) having an emission spectrum of 340-440 nm. All patients had NL on the shins, which had been unr.s.onsive to potent topical corticosteroid therapy (n = 6) and had r.s.onded minimally or not at all to TL-01UVB (n = 2), topical psoralen plus UVA(PUVA) soaking (n = 2) or oral PUVA(n = 1) therapy. Patients received a variable number of total exposur.s.(15-51), given 3-5 times weekly. NL r.s.lved completely in one patient; this patient had minimal improvement after the first course of 16 exposur.s. but after a further 13 exposur.s. r.s.lution occurred 6 months later. Two subjects obtained moderate improvement in their overall disease severity after 15 and 24 exposur.s. while two had only minimal improvement after 15 and 51 exposur.s. The remaining patient had no improvement after 16 treatments. Patients with the shortest disease duration had the greatest r.s.onse. UVA1 therapy may be of benefit for the treatment of NL as an adjuvant therapy to topical corticosteroids or as a second-line alternative to other phototherapies, and may have a superior outcome in a proportion of patients.

关键词：脂质渐进性坏死 UVA1 光疗法胶原变性硬皮病补骨脂素免疫介导金属卤化物局部激素中度缓

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死海盐光浴疗法与窄波紫外线B单一疗法治疗慢性斑块型银屑病的随机对照研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 50-50页

作者： dawe r.s. Yule s. Cameron H. 王琼 Department of Dermatology University of Dundee Ninewells Hospital and Medical School Dundee DD1 9SY United Kingdom

Background: Dead sea (Ds) salt solution soaks are used in combination with narrowband ultraviolet B (NB- UVB) to treat psoriasis in many centr.s. particularly in continental Europe. No previously published controlled study has assessed Ds salt + NB- UVB balneophototherapy. Objectives: To compareDs salt balneophototherapy with NB- UVB monotherapy for chronic plaque psoriasis. Methods: sixty patients with chronic plaque psoriasis participated in this paired, controlled study, with pretreatment Ds salt soaks randomly allocated to each participant’ s right or left study limb. Psoriasis severity was assessed with a scaling, Erythema and Induration score by a blinded observer. Assessments were weekly during the therapy course, and thereafter 8- weekly until relapse or for up to 1 year after clearance. r.s.lts: The mean area under the psoriasis severity- time curves during treatment was not detectably lower with Ds salt balneophototherapy than with NB- UVB monotherapy (P=0.099). The psoriasis severity score fell slightly more from beginning to end of courses with Ds salt balneophototherapy than with NB- UVB monotherapy (P=0.019). There was no detectable difference in times to relapse. Conclusions: In this population the addition of pretreatment Ds salt soaks to NB- UVB did not r.s.lt in a clinically important improvement in clearance of psoriasis.

关键词：斑块型银屑病浴疗法严重度复发时间盐浸配对设计研究人群盐溶液时间曲线

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对光照射治疗有反应的银屑病史不能预测UVB的疗效

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 18-18页

作者： dawe r.s. Ferguson J. 田中伟 PhotobiologyUnit Department of Dermatology Ninewells Hosp.and Medical SchoolDundee DD1 9SYUnitedKingdom

We pr.s.ectively asked 146 consecutive patients starting narrow-band UVB (NB-UVB) for psoriasis about the effects of sunlight on their ***-eight (60%) patients reported improvementwith sunlight, six(4%) reported worsening, and 52(36%) had not noted any change in their psoriasis with sunlight ***, 101 (69%) were recorded to reach clearance or minimal r.s.dual activity (MrA), 24(16.5%) to achieve moderate improvement, and 21(14.5%)-had other recorded outcomes (mainly ‘did not attend’), with UVB ***-two (72%) of the 58 who did not report improvement with sunlight went on to clearance/MrA with UVB compared to 59/88(67%) of those who did report improvement (95%confidence interval for difference in percentage improving, -10%to 20%.P = 0.49).Patientsreplies to questions about how their psoriasis r.s.onds to sunlight do not appear to predict r.s.onse to UVB phototherapy in our patient population.

关键词：银屑 UVB 照射治疗日光照射微小残留病

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UVA1光疗法治疗生殖器萎缩性硬化苔藓

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 32-32页

作者： Beattie P.E. dawe r.s. Ferguson J. Ibbotson s.H. 潘敏 Western Infirmary Glasgow G11 6NT United Kingdom Dr.

Background. Lichen scler.s.s (Ls) is characterized histologically by an inflammatory T-cell infiltrate, scler.s.s and thickening of the dermis, and epidermal atrophy. Ultraviolet (UV) A1 therapy has been shown to be effective in the management of morphea and scleroderma, diseases that have some histological and clinical similarities with Ls, and more recently in extragenital Ls. Aim. To determine the effectiveness of UVA1 therapy for genital Ls. Methods. seven women with severe genital Ls uncontrolled by ultrapotent topical corticosteroids, with a median age of 62 years (range 48-78) and disease duration of 6-47 years, were treated with UVA1 therapy from a high output source. After completion of UVA1 therapy, a clinician and the patient graded the overall r.s.onse of symptoms and physical signs. r.s.lts. Five patients improved with therapy. Three obtained moderate improvement in overall disease severity and two had minimal improvement. Of these five, one relapsed within 3 months and another after a year. Both had a further course of UVA1 therapy, r.s.lting in minimal improvement in one and moderate improvement in the other. In the remaining three, disease severity had improved to a point where intermittent use of topical corticosteroids r.s.lted in acceptable control. Discussion. UVA1 therapy may be of benefit in the management of vulval Ls, a disease that is often poorly r.s.onsive to standard therapies. The therapy is well tolerated and could provide an acceptable therapeutic option for patients with severe disease.

关键词：生殖器萎缩 UVA1 光疗法严重度硬斑病表皮萎缩硬皮病组织病理学间断应用皮质激素

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Amyloid precursor protein clusters at CNs nodes of ranvier and causes an APPThr668 phosphorylation-dependent increase in Nav1.6 sodium channel currents

Amyloid precursor protein clusters at CNS nodes of Ranvier a...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Melitta sCHACHNEr Gavin s.dawe Department of Physiology Sino-German Neuroscience Institute of Dalian Medical UniversityDalian 116044China Zentrum fur Molekulare Neurobiologie University of HamburgHamburgGermany Department of Pharmacology Yong Loo Lin School of MedicineNational University of Singapore117597Singapore

＜正＞Objective Amyloid precursor protein（APP）,commonly associated with Alzheimer.s.disease（AD）,mar.s.axonal *** its physiological distribution and function along myelinated axons remain *** work was to investigate the physiological distribution of APP and its function in modulating the expr.s.ion of Nav1.6 sodium channel. Understanding the physiological roles of APP in axonal function may offer new insights into the processes by which abnormal processing of APP can contribute to the pathogenesis of *** Immunofluor.s.ences were performed to detect the location of APP along myelinated axons;Western blots were analyzed to investigate the expr.s.ion of APP and sodium channel in the central nervous system（CNs）;Co-immunoprecipitations were done to explore whether APP and sodium channel form a molecular complex;Co-expr.s.ed full length APP or its intracellular domain（AICD,Go proteinbinding domain,Fe65 binding domain,or C31 domain） with Nav 1.6 sodium channels into Xenopus oocytes to study the function of APP in modulation of Nav 1.6 currents using two-electrode voltage clamp technique;Compared conduction velocity and cell surface expr.s.ion between WT and KO of APP and related APPThr668 phosphorylation site mice to elucidate further the mechanism of APP on modulation of Nav 1.6 sodium *** Aaxonal APP for.s.a complex with Nav 1.6 and aggregates only specifically at the nodes of ranvier of the central nervous system（CNs）,but not the peripheral nervous system（PNs）.Notably,coexpr.s.ion of APP or its intracellular domains containing a VTPEEr motif with Nav 1.6 sodium channels in Xenopus oocytes r.s.lted in an increase in peak sodium currents,which was enhanced by APPT668E mutation and blocked by APPT668A mutation and inhibitors of CDK5 and *** cell surface expr.s.ion of Nav 1.6 sodium channels in the white matter of spinal cord is decreased in APP,p35 and JNK3 null ***, APP,p35 and JNK3 deficiency significantly reduce s

关键词： APP sodium channels nodes of ranvier phosphorylation

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Amyloid precursor protein clusters at CNs nodes of ranvier and causes an APPThr668 phosphorylation-dependent increase in Nav1.6 sodium channel currents

Amyloid precursor protein clusters at CNS nodes of Ranvier a...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Toshitaka Futagawa sashi Kesavapany Melitta schachner Gavin s.dawe Department of Clinical r.s.arch Singapore General HospitalSingapore Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Pharmacology and Department of Anatomy Yong Loo Lin School of MedicineNational University of SingaporeSingapore

＜正＞APP,commonly associated with Alzheimer.s.disease,mar.s.axonal *** physiological distribution and function along myelinated axons remain *** report that APP null and APP overexpr.s.ing transgenic（APPtg） mice show minor hypo- and hyper-myelination,*** axoglial interactions, APP aggregates at nodes of ranvier（NOrs） in the ***,coexpr.s.ion of APP or its intracellular domains containing a VTPEEr motif with Navl.6 sodium channels in Xenopus oocytes r.s.lted in an increase in peak sodium currents,which was enhanced by APPT668E mutation and blocked by APPT668A mutation and inhibitors of CDK5 and *** cell surface expr.s.ion of Navl.6 sodium channels in the white matter of spinal cord is decreased in APP,p35 and JNK3 null ***,APP,p35 and JNK3 deficiency significantly reduce spinal conduction ***,APP acts as a novel component at CNs NOrs,modulating Navl.6 sodium channels in an APPThr668 phosphorylation-dependent manner.

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无师自通玩转中音萨克斯管

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2016年

作者：克里斯·施蒂弗－达韦(Chr.s.stieve-dawe)

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电站机组热经济性在线管理系统的开发与应用

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东北农业大学学报 2008年第4期39卷 79-82页

作者：杨大为杨方赵琳东北农业大学工程学院哈尔滨150030 辽宁省水利水电研究所沈阳110001

在电厂现有数据采集系统DAs的基础上,开发基于Web发布的C/s(Client/server)和B/s(Browser.s.rver)混合体系结构的机组能损实时监测系统。结合锦州电厂汽轮发电机组的实际运行情况,对机组的各项热经济性指标进行实时监控、分析计算,提高... 详细信息

在电厂现有数据采集系统DAs的基础上,开发基于Web发布的C/s(Client/server)和B/s(Browser.s.rver)混合体系结构的机组能损实时监测系统。结合锦州电厂汽轮发电机组的实际运行情况,对机组的各项热经济性指标进行实时监控、分析计算,提高机组运营水平及经济效率,在客户端为公司领导、运行人员以及考核人员提供了考核评价的平台。

关键词： DAs系统能损监测运行耗差 C/s和B/s混合结构

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