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MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus

World Journal of Gastroenterology 2017年第30期23卷 5508-5518页

作者： Loveena Sreedharan George C Mayne david I Watson Timothy Bright Reginald v Lord Alfiya Ansar Tingting Wang Jakob Kist david StJ Astill Damian J Hussey Department of Surgery Flinders Medical Centre Flinders University St vincent’s Centre for Applied Medical Research Department of Anatomical Pathology Flinders Medical Centre

AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's *** High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro *** Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher

关键词： Neosquamous Barretts 食管脱离

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In memoriam Roger v Short(31.7.1930-6.8.2021)

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Asian Journal of Andrology 2022年第6期24卷 681-683页

作者： Trevor G Cooper david J Handelsman Tuen Mun Hong Kong SARChina ANZAC Research Institute Concord HospitalSydneyNSW 2139Australia

FOREWORD FROM TREvOR G COOPER Roger v Short,Fellow of the Royal Society(FRS),born in England in 1930,itally trained as a vet at Bristol University,then completed a Fulbright Scholarship in the states and a PhD at the University of *** research in the University's Department of veterinary Clinical studies until 1972,he became the director of the Medical Research Council Unit of Reproductive Biology in Edinburgh for the next decade,teaming up with Professor david Baird to run a globally renowned research institute where he trained numerous famous *** 2007 to 2014,he was an Editorial Board Member of Asian Journal of Andrology.

关键词： Bristol Edinburgh institute

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Modelling of photovoltaic production and electrochemical storage in an autonomous solar drone

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eScience 2022年第2期2卷 235-241页

作者： Mickael Cosson Benjamin david Ludovic Arzel Philippe Poizot Ahmed Rhallabi Nantes Universite CNRSInstitut des Materiaux de Nantes Jean Rouxel2 rue de la Houssiniere44322NantesFrance XSun 1 Route de la Croix Moriau44350GuerandeFrance

A simple,efficient simulator has been developed to predict the generation of photovoltaic energy and its storage in Li-ion batteries,for an autonomous drone with four wings covered by solar panels based on thin-film gallium arsenide photovoltaic cells(III–v).This simulator allows prediction of the effective photovoltaic power produced by the solar panels as well as the battery pack voltage when the drone is *** parameters such as irra-diance,sun inclination angles,and drone Euler angles are considered as input *** measured photovoltaic power and battery pack voltage are in good agreement with the simulated values,making practical use by the XSun company *** parametric study shows the effects of climatic and geographic conditions on drone *** optimal weather conditions on a sunny day,drone flight can last 12 h.

关键词： Unmanned aerial vehicle Drone flight simulator Simulation Energy storage Photovoltaic energy

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Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions

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International Journal of Oral Science 2013年第3期5卷 130-140页

作者： Carol L Fischer Katherine S Walters david R Drake Deborah v Dawson Derek R Blanchette Kim A Brogden Philip W Wertz Dows Institute for Dental Research College of Dentistry The University of Iowa Central Microscopy Research Facility College of Dentistry The University of Iowa Department of Endodontics College of Dentistry The University of Iowa Department of Pediatric Dentistry College of Dentistry The University of Iowa Department of Periodontics College of Dentistry The University of Iowa Department of Oral Pathology Radiology & Medicine College of Dentistry The University of Iowa

Oral mucosal and salivary lipids exhibit potent antimicrobial activity for a variety of Gram-positive and Gram-negative bacteria;however,little is known about their spectrum of antimicrobial activity or mechanisms of action against oral *** this study,we examine the activity of two fatty acids and three sphingoid bases against Porphyromonas gingivalis,an important colonizer of the oral cavity implicated in *** inhibitory concentrations,minimal bactericidal concentrations,and kill kinetics revealed variable,but potent,activity of oral mucosal and salivary lipids against ***,indicating that lipid structure may be an important determinant in lipid mechanisms of activity against bacteria,although specific components of bacterial membranes are also likely *** micrographs showed ultrastructural damage induced by sapienic acid and phytosphingosine and confirmed disruption of the bacterial plasma *** information,coupled with the association of treatment lipids with *** lipids revealed via thin layer chromatography,suggests that the plasma membrane is a likely target of lipid antibacterial *** a combination of two-dimensional in-gel electrophoresis and Western blot followed by mass spectroscopy and N-terminus degradation sequencing we also show that treatment with sapienic acid induces upregulation of a set of proteins comprising a unique *** stress response,including proteins important in fatty acid biosynthesis,metabolism and energy production,protein processing,cell adhesion and *** or therapeutic lipid treatments may be beneficial for intervention of infection by supplementing the natural immune function of endogenous lipids on mucosal surfaces.

关键词： antimicrobial lipid fatty acid Porphyromonasgingivalis sphingoid base sphingolipid ultrastructure

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Potential of capillary electrophoresis mass spectrometry for the characterization and monitoring of amine-derivatized naphthenic acids from oil sands process-affected water

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Journal of Environmental Sciences 2016年第11期28卷 203-212页

作者： Matthew S.MacLennan Cai Tie Kevin Kovalchik Kerry M.Peru Xinxiang Zhang John v.Headley david D.Y.Chen Department of Chemistry University of British Columbia Vancouver BC V6T 1Z1 Canada. State Key Laboratory of Bioactiue Substance and Function of Natural Medicines Institute of Materia Medica Peking Union Medical College &Chinese Academy of Medical Sciences Beijing 100050 China Water Science and Technology Directorate Science and Technology Branch Environment and Climate Change Canada SaskatoonSK S7N 3H5 Canada College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Capillary electrophoresis coupled to mass spectrometry（CE–MS） was used for the analysis of naphthenic acid fraction compounds（NAFCs） of oil sands process-affected water（OSPW）. A standard mixture of amine-derivatized naphthenic acids is injected directly onto the CE column and analyzed by CE–MS in less than 15 min. Time of flight MS analysis（TOFMS）, optimized for high molecular weight ions, showed NAFCs between 250 and 800 m/z. With a quadrupole mass analyzer, only low-molecular weight NAFCs（between 100 and 450 m/z） are visible under our experimental conditions. Derivatization of NAFCs consisted of two-step amidation reactions mediated by 1-ethyl-3-（3-dimethylaminopropyl）carbodiimide（EDC）, or mediated by a mixture of EDC and N-hydroxysuccinimide, in dimethyl sulfoxide, dichloromethane or ethyl acetate. The optimum background electrolyte composition was determined to be 30%（v/v） methanol in water and 2%（v/v） formic acid. NAFCs extracted from OSPW in the Athabasca oil sands region were used to demonstrate the feasibility of CE–MS for the analysis of NAFCs in environmental samples, showing that the labeled naphthenic acids are in the mass range of 350 to 1500 m/z.

关键词： Capillary electrophoresis Mass spectrometry Electrospray ionization Carbodiimide Oil sands process-affected water Naphthenic acids

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From Prototype to Inference:A Pipeline to Apply Deep Learning in Sorghum Panicle Detection

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Plant Phenomics 2023年第1期5卷 94-109页

作者： Chrisbin James Yanyang Gu Andries Potgieter Etienne david Simon Madec Wei Guo Frédéric Baret Anders Eriksson Scott Chapman School of Agriculture and Food Sciences The University of QueenslandBrisbaneAustralia School of Information Technology and Electrical Engineering The University of QueenslandBrisbaneAustralia Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneAustralia Arvalis Institut du VégétalParisFrance Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Institut National de la Recherche Agronomique ParisFrance

Head(panicle)density is a major component in understanding crop yield,especially in crops that produce variable numbers of tillers such as sorghum and *** of panicle density both in plant breeding and in the agronomy scouting of commercial crops typically relies on manual counts observation,which is an inefficient and tedious *** of the easy availability of red–green–blue images,machine learning approaches have been applied to replacing manual ***,much of this research focuses on detection per se in limited testing conditions and does not provide a general protocol to utilize deep-learning-based *** this paper,we provide a comprehensive pipeline from data collection to model deployment in deep-learning-assisted panicle yield estimation for *** pipeline provides a basis from data collection and model training,to model validation and model deployment in commercial *** model training is the foundation of the ***,in natural environments,the deployment dataset is frequently different from the training data(domain shift)causing the model to fail,so a robust model is essential to build a reliable *** we demonstrate our pipeline in a sorghum field,the pipeline can be generalized to other grain *** pipeline provides a high-resolution head density map that can be utilized for diagnosis of agronomic variability within a field,in a pipeline built without commercial software.

关键词： crops breeding utilize

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Approaches to global stroke care during the COvID-19 pandemic

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Stroke & vascular Neurology 2020年第2期5卷 107-109页

作者： Liping Liu david Wang Michael Brainin Mitchell S v Elkind Enrique Leira Yongjun Wang China National Clinical Research Center for Neurological Diseases BeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstitutePhoenixArizonaUSA Department of Clinical Neurosciences and Preventive Medicine Danube University KremsKremsAustria Department of Neurology Vagelos College of Physicians and SurgeonColumbia UniversityNew YorkNew YorkUSA Department of Epidemiology Mailman School of Public HealthColumbia UniversityNew YorkNew YorkUSA Departments of Neurology and Neurosurgery The University of Iowa Roy J and Lucille A Carver College of MedicineIowa CityIowaUSA Department of Epidemiology The University of Iowa College of Public HealthIowa CityIowaUSA

Since the outbreak of coronavirus disease 2019(COvID-19),the healthcare system of the world has been overwhelmed by this *** most recent statistic showed that there are now over 3 million people infected and over 2590... 详细信息

关键词： infected statistic COv

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Towards standardizing retinal optical coherence tomography angiography:a review

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Light(Science & Applications) 2022年第4期11卷 520-541页

作者： Danuta M.Sampson Adam M.Dubis Fred K.Chen Robert J.Zawadzki david D.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at Moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. Department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. Department of Ophthalmology&vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

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Stable sodium anodes for sodium metal batteries(SMBs) enabled by in-situ formed quasi solid-state polymer electrolyte

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Journal of Energy Chemistry 2023年第2期77卷 290-299,I0008页

作者： Jian Ma Xuyong Feng Yueyue Wu Yueda Wang Pengcheng Liu Ke Shang Hao Jiang Xianglong Hou david Mitlin Hongfa Xiang School of Materials Science and Engineering Anhui Provincial Key Laboratory of Advanced Functional Materials and DevicesHefei University of TechnologyHefei 230009AnhuiChina Materials Science and Engineering Program&Texas Materials Institute(TMI) The University of Texas at AustinAustinTX 78712-1591USA School of Chemistry and Chemical Engineering Anhui Provincial Key Laboratory of Advanced Functional Materials and DevicesHefei University of TechnologyHefei 230009AnhuiChina

A high-performance quasi-solid polymer electrolyte for sodium metal batteries(SMBs)based on in-situ polymerized poly(1,3-dioxolane)(DOL)with 20%volume ratio of fluoroethylene carbonate(FEC),termed"PDFE-20",is proposed in this *** is demonstrated PDFE-20 possesses a room-temperature ionic conductivity of 3.31×10^(-3) S cm^(-1),an ionic diffusion activation energy of 0.10 ev,and an oxidation potential of 4.4 *** based on PDFE-20 and Na_(3)v_(2)(PO_(4))_(3)(NvP)cathodes were evaluated with an active material mass loading of 6.8 mg cm^(-2).The cell displayed an initial discharge specific capacity of 104 mA h g^(-1),and97.1%capacity retention after 100 cycles at 0.5 ***-situ polymerization conformally coats the anode/-cathode interfaces,avoiding geometrical gaps and high charge transfer resistance with ex-situ polymerization of the same *** acts as a plasticizer during polymerization to suppress crystallization and significantly improves ionic *** battery cycling FEC promotes mechanical congruence of electrolyte-electrode interfaces while forming a stable NaF-rich solid electrolyte interphase(SEI)at the *** functional theory(DFT)calculations were also performed to further understand the role FEC in the poly(DOL)-FEC *** work broadens the application of in-situ prepared poly(DOL)electrolytes to sodium storage and demonstrates the crucial role of FEC in improving the electrochemical performance.

关键词： Quasi-solid batteries(QSBs) Quasi-solid electrolytes(QSEs) NaF-rich passivating layer Interfacial stability Sodium metal batteries(SMBs)

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Schoolchildren from disadvantaged backgrounds present a loss of lean tissue mass and significant increase of body fat mass during the COvID-19 lockdown in Germany:results from the MEDdirect study

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World Journal of Pediatrics 2022年第5期18卷 363-367页

作者： david Muhmann Marvin Droste Jorn Schulz Frederike Linge Lea Ladewig Ursula Eisenberg Susanne Roder Rainer Buscher University Hospital Essen PediatricsⅡHufelandstr.5545147 EssenGermany Be Strong for Kids E.v Sundernholz 10845134 EssenGermany Schule Am Steeler Tor Engelbertstr.445127 EssenGermany

Children from socio-economically disadvantaged backgrounds receive unequal opportunities to succeed in school,which will lead to a decreased health literacy as adults[U].This is not only directly associated with an impaired eco-nomic and mental health and wellbeing of young people,but above all with an in creased adult mortality[1-4].While this problem is well known and described,only few and even fewer pediatric studies suggest how to interrupt this downward spiral consistently[5,6].

关键词： disadvantage adult impaired

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