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A metabolic signalling role for arginine in liver cancer

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Life Metabolism 2024年第01期 8-10页

作者： david sokolov Lucas B.Sullivan Human Biology Division Fred Hutchinson Cancer Center

In addition to their canonical roles in biosynthetic pathways, metabolites can be active participants in oncogenic signalling, but our understanding of these signalling mechanisms is incomplete. In a recent article published in Cell, Mossmann et al. find a novel signalling role for accumulated arginine in hepatocellular carcinoma(HCC) mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).It is now appreciated that cancer cells enact specific metabolic changes to accommodate increased proliferation, create permissive tumour microenvironments, and adapt to physiological stressors, among other functions. When considering the roles of different metabolites in cancer, an informative distinction can be made between so-called metabolic roles, in which molecules contribute biomass or energy towards tumour growth, and signalling roles, where molecules modify cellular physiology by interfacing with diverse nutrient-sensing pathways.

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Slc7a5 regulation of neural development

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Neural Regeneration Research 2021年第10期16卷 1994-1995页

作者： Aidan M.sokolov david M.Feliciano Department of Biological Sciences Clemson UniversityClemsonSCUSA

Membrane transport proteins are appreciated for their ability to transport molecules across biological membranes and have received a renewed focus for their role in nervous system *** such group of transporters are members of the solute carrier(SLC)*** transporters shuttle various molecules,including neurotransmitters,fatty acids,amino acids,and inorganic *** such,they play an integral role in supplying cells with essential *** example is that amino acids are transported by SLC family ***7a5 is a SLC family member that transports essential amino acids important for neuronal development,as well as other biological molecules including thyroid hormones T3,T4,and ***7a5 forms a heterodimer with Slc3a2 that facilitates the subcellular distribution of *** acids including leucine,glutamine,and arginine support cell growth by activating the protein kinase,mammalian target of rapamycin complex 1(mTORC1)(Liu et al.,2020).Consistent with this notion is that Slc7a5 transport of amino acids regulates mTORC1 activity in numerous cell types(Nicklin et al.,2009).A recent manuscript expands upon these findings to demonstrate that Slc7a5 plays a previously unrecognized and critical role in the regulation of mTORC1 activity and neuron development(sokolov et al.,2020).

关键词： inorganic solute notion

Towards engineering in memristors for emerging memory and neuromorphic computing: A review

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Journal of Semiconductors 2021年第1期42卷 33-61页

作者： Andrey S.sokolov Haider Abbas Yawar Abbas Changhwan Choi Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Physics Khalifa UniversityAbu Dhabi 127788United Arab Emirates

Resistive random-access memory(RRAM),also known as memristors,having a very simple device structure with two terminals,fulfill almost all of the fundamental requirements of volatile memory,nonvolatile memory,and neuromorphic *** memory and neuromorphic behaviors are currently being explored in relation to a range of materials,such as biological materials,perovskites,2D materials,and transition metal *** this review,we discuss the different electrical behaviors exhibited by RRAM devices based on these materials by briefly explaining their corresponding switching *** then discuss emergent memory technologies using memristors,together with its potential neuromorphic applications,by elucidating the different material engineering techniques used during device fabrication to improve the memory and neuromorphic performance of devices,in areas such as ION/IOFF ratio,endurance,spike time-dependent plasticity(STDP),and paired-pulse facilitation(PPF),among *** emulation of essential biological synaptic functions realized in various switching materials,including inorganic metal oxides and new organic materials,as well as diverse device structures such as single-layer and multilayer hetero-structured devices,and crossbar arrays,is analyzed in ***,we discuss current challenges and future prospects for the development of inorganic and new materials-based memristors.

关键词： RRAM memristor emerging memories neuromorphic computing electronic synapse resistive switching memristor engineering

N-环钯化二茂铁衍生物的合成和应用（英文）

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有机化学 2018年第1期38卷 75-85页

作者： Viacheslav I.sokolov 俄罗斯科学院有机化合物研究所莫斯科119991

近年研究表明二茂铁的环钯化衍生物被广泛地应用于各类偶联反应中,比如Heck反应、Suzuki反应、aza-Claisen重排反应等.主要综述了含氮导向基的二茂铁衍生物的环钯化反应,包括通过不对称诱导或拆分手段合成具有平面手性环钯化合物,基于... 详细信息

近年研究表明二茂铁的环钯化衍生物被广泛地应用于各类偶联反应中,比如Heck反应、Suzuki反应、aza-Claisen重排反应等.主要综述了含氮导向基的二茂铁衍生物的环钯化反应,包括通过不对称诱导或拆分手段合成具有平面手性环钯化合物,基于环金属化反应1,1'-取代二茂铁钯化物的合成,以及其在催化反应的应用.

关键词：环钯化二茂铁基二胺二茂铁基亚胺对映选择性交叉偶联反应 Heck反应 Suzuki反应 aza-Claisen重排

Biological protection of plants in agricultular landscape—state of the art, problems and ways of their decision

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 398-400页

作者： sokolov M S Kolombet L V Research Center for Toxicology and Hygienic Regulation of Biopreparations State Research Center for Applied Microbiology 142279 Obolensk Moscow Region Russia 142253 Serpukhov Moscow reg. Russia

Biological protection of plants: definition and objectives. Technologically, biological protection of plants (hereinafter bioprotection) is a high agricultural technology involving agricultural landscape approach and basee on an ecological imperative, namely “use living beings against living beings”. In a wide sense, present-day bioprotection is a fundamental and applied field of knowledge providing harmless suppression of harmful agents during cultivation and storage of agricultural crops by use natural and (or) artificially constructed organisms (including genetically modified ones having pesticidal properties) and products of their live cycle. The overall objective of bioprotection consists in producing harmless, profitable and high-quality vegetative raw material, food, fodder. At the same time, bioprotection agrotechnologies are important environment forming and environment maintaining factors, steady and positively influencing the health of both rural ethnos, and agrosphere as a whole. Realization of integrated bioprotection approaches should provide minimum destruction of beneficial and non-target organisms, excluding the succession of harmful species and appearance of species resistant to biocontrol agents. 2. Theoretical foundation of bioprotection. The following postulates and imperatives of biosphere science, agrarian and social ecology make the scientific basis of bioprotection: “The Nature knows the how and why of things better”; Steady, balanced development of agrosphere (proceeding from a presumption of life support) is based on biocentrism and biosystem relations, or consortism of its consorbents; Control of the agrosphere by human beings could be effective only in case of primary realization of biocenotic regulation; Biocenotic regulation, dynamics of the number and species diversity of agrosphere is realized through trophically similar cenoconsorcia and tritrophic systems, that provides maintenance and preservation of trophically proved critica

关键词：植物生物保护农业景观农业气候设施园艺

Mechanism and kinetics of iron extraction from high silica boehmite−kaolinite bauxite by hydrochloric acid leaching

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Transactions of Nonferrous Metals Society of China 2021年第10期31卷 3128-3149页

作者： Dmitry VALEEV Denis PANKRATOV Andrei SHOPPERT Artem sokolov Alexandr KASIKOV Alexandra MIKHAILOVA Cristian SALAZAR-CONCHA Ilia RODIONOV Laboratory of Sorption Methods Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences119334 MoscowRussia Department of Chemistry Lomonosov Moscow State University119991 MoscowRussia Department of Non-ferrous Metals Metallurgy Ural Federal University620002 YekaterinburgRussia Tananaev Institute of Chemistry Kola Science Centre of the Russian Academy of Sciences184209 ApatityRussia Laboratory of Crystal Structure Studies A.A.Baikov Institute of Metallurgy and Materials ScienceRussian Academy of Sciences119334 MoscowRussia Universidad Austral de Chile ValdiviaChile Graphite Innovation and Technologies Dartmouth NSCanada

The chemical and mineral compositions of bauxite recovered from the Severoonezhsk Bauxite Mine(Arkhangelsk region,Russia)were studied by XRD,ICP-OES,TG/DSC,SEM,TEM,and Mössbauer *** iron-containing minerals of the bauxites were found to comprise alumogoethite(α-Fe_(1−x)Al_(x)OOH),alumohematite(α-(Fe_(1−x)Al_(x))_(2)O_(3)),alumoakaganeite(β-Fe_(1−x)Al_(x)O(OH,Cl)),and chromite(FeCr_(2)O_(4)).The efficiency of Fe extraction from the bauxite by HCl leaching was 82.5%at 100℃,HCl concentration of 10%,solid/liquid ratio of 1:10,and the process duration of 60 min,with aluminum loss from the bauxites below 4.5%of the total Al contents in the *** of the kinetics of the iron leaching process proved diffusion to be the limiting stage of the process at 90−100℃.Bauxite residue after leaching presented traces of α-Fe_(1−x)Al_(x)OOH and β-Fe_(1−x)Al_(x)O(OH,Cl),and most of the iron content was in the FeCr_(2)O_(4).In bauxite residue after HCl leaching,in addition to iron oxide,the contents of chromium and calcium oxides significantly *** iron chloride liquor after leaching contained the rare earth elements(REE)of 6.8 mg/L Sc,4.1 mg/L Ce and 2.3 mg/L Ga.

关键词： bauxite acid leaching iron extraction kinetics Mössbauer spectroscopy

Enhanced four-wave mixing process near the excitonic resonances of bulk MoS_2

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Photonics Research 2019年第3期7卷 251-259页

作者： BRIAN A.KO ALEXEI V.sokolov MARLAN O.SCULLY ZHENRONG ZHANG HO WAI HOWARD LEE Department of Physics Baylor University The Institute for Quantum Science and Engineering Texas A&M University College Station Princeton University Princeton

Two-dimensional materials are generating great interest due to their unique electrical and optical *** particular, transition metal dichalcogenides such as molybdenum disulfide(MoS_2) are attractive materials due to the existence of a direct band gap in the monolayer limit that can be used to enhance nonlinear optical phenomena, such as Raman spectroscopy. Here, we have investigated four-wave mixing processes in bulk MoS_2 using a multiplex coherent anti-Stokes Raman spectroscopy setup. The observed four-wave mixing signal has a resonance at approximately 680 nm, corresponding to the energy of the A excitonic transition of MoS_2. This resonance can be attributed to the increased third-order nonlinear susceptibility at wavelengths near the excitonic transition. This phenomenon could open the path to using MoS_2 as a substrate for enhancing four-wave mixing processes such as coherent anti-Stokes Raman spectroscopy.

关键词： Two-dimensional materials excitonic resonances MoS2

Electromagnetic shielding effectiveness of amorphous metallic spheroidal-and flake-based magnetodielectric composites

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Journal of Materials Science & Technology 2021年第24期83卷 256-263页

作者： Kun Qian Qifan Li Alexander sokolov Chengju Yu Piotr Kulik Ogheneyunume Fitchorova Yajie Chen Chins Chinnasamy Vincent G.Harris Center for Microwave Magnetic Materials and Integrated Circuits Department of Electrical and Computer EngineeringNortheastern UniversityBostonMA02115USA KRI at Northeastern University LLC141 South Bedford StreetBurlingtonMA01803USA Rogers Innovation Center Rogers Corporation141 South Bedford StreetBurlingtonMA01803USA Carpenter Technology Corporation ReadingPA19601USA

Flexible,lightweight,conductive materials,having both high rf losses and high permeability,are extremely desirable for applications as electromagnetic(EM)*** atomized spherical FeSi-based ferromagnetic metallic particles,having a mean diameter of 14.6μm with a standard deviation of 7.3μm,were measured to have a room temperature saturation magnetic flux density of 1.49 T with a coercivity of 160 A/*** milling of the amorphous particles led to aspect ratios from 1:1(spherical)to>100:1(flake-like).Flake-like particles,suspended in paraffin,were found to not only increase the surface area of fillers enhancing the polarization mechanism but also increase the complex permeability and complex permittivity,and thus provide broadband shielding effectiveness.A loading factor of 40 vol.%of the∼15μm diameter powders provided the largestΔW_(RL=-20 dB)of 9.49 GHz(i.e.,6.55

关键词： Amorphous particle Magnetic alloy powders Microwave absorption Electromagnetic interference shielding

A Mitochondrial Magnesium Transporter Functions in Arabidopsis Pollen Development

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Molecular Plant 2008年第4期1卷 675-685页

作者： Le-Gong Li Lubomir N. sokolov Yong-Hua Yang Dong-Ping Li Julie Ting Girdhar K. Pandy Sheng Luan College of Life Sciences Capital Normal University Beijing 100037 China Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA NJU-NJFU Joint Institute for Plant Molecular Biology College of life Sciences Nanjing University Nanjing 210093 China College of Life Sciences Hunan Normal University Changsha 410006 China

Magnesium is an abundant divalent cation in plant cells and plays a critical role in many physiological processes. We have previously described the identification of a 10-member Arabidopsis gene family encoding putative magnesium transport （MGT） proteins. Here, we report that a member of the MGT family, AtMGTS, functions as a dual-functional Mg-transporter that operates in a concentration-dependent manner, namely it serves as a Mg-importer at micromolar levels and facilitates the efflux in the millimolar range. The AtMGT5 protein is localized in the mitochondria, suggesting that AtMGTS mediates Mg-trafficking between the cytosol and mitochondria. The AtMGT5 gene was exclusively expressed in anthers at early stages of flower development. Examination of two independent T-DNA insertional mutants of AtMGT5 gene demonstrated that AtMGT5 played an essential role for pollen development and male fertility. This study suggests a critical role for Mg^2＋ transport between cytosol and mitochondria in male gametogenesis in plants.

关键词： Mg^2+ -transporter pollen mitochondria Arabidopsis