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Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease

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World Journal of Gastroenterology 2021年第42期27卷 7350-7361页

作者： david Bernstein Nitzan Roth Angela Kim Marica Epstein david Hirschwerk Charlotte l Kvasnovsky Sanjaya K Satapathy Department of Medicine/Hepatology Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious Diseases Department of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical Center Zucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States

BACKGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.

关键词： COVID-19 liver enzymes Outcomes Predictors

Stochastic Earned Duration Analysis for Project Schedule Management

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Engineering 2022年第2期8卷 148-161页

作者： Fernando Acebes david Poza JoséManuel González-Varona Adolfo lópez-Paredes GIR INSISOC-Department of Business Organization and CIM School of Industrial EngineeringUniversity of ValladolidValladolid 47011Spain

Earned duration management(EDM)is a methodology for project schedule management(PSM)that can be considered an alternative to earned value management(EVM).EDM provides an estimation of devia-tions in schedule and a final project duration *** is a key difference between EDM and EVM:In EDM,the value of activities is expressed as work periods;whereas in EVM,value is expressed in terms of *** this paper,we present how EDM can be applied to monitor and control stochastic *** explain the methodology,we use a real case study with a project that presents a high level of uncertainty and activities with random *** analyze the usability of this approach according to the activities network topology and compare the EVM and earned schedule methodology(ESM)for PSM.

关键词： Earned duration management Earned value management Stochastic project control Duration forecasting Uncertainty

p-Cresol mineralization and bacterial population dynamics in a nitrifying sequential batch reactor

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Journal of Environmental Sciences 2014年第9期26卷 1885-1893页

作者： Carlos david Silva lizeth Beristain-Montiel Flor de Maria Cuervo-lópez Anne-Claire Texier Department of Biotechnology-CBS Universidad Autónoma Metropolitana-IztapalapaMexico City 09340Mexico Department of Process and Technology-CNI Universidad Autónoma Metropolitana-CuajimalpaMexico City 05300Mexico

The ability of a nitrifying sludge to oxidize p-cresol was evaluated in a sequential batch reactor （SBR）. p-Cresol was first transformed to p-hydroxybenzaldehyde and p-hydroxybenzoate, which were later mineralized. The specific rates of p-cresol consumption increased throughout the cycles. The bacterial population dynamics were monitored by using denaturing gradient gel electrophoresis 0DGGE） and sequencing of DGGE fragments. The ability of the sludge to consume p-cresol and intermediates might be related to the presence of species such as Variouorax paradoxus and Thauera mechernichensis, p-Cresol （25 to 200 mg C/l） did not affect the nitrifying SBR performance （ammonium consumption efficiency and nitrate production yield were close to 100% and 1, respectively）. This may be related to the high stability observed in the nitrifying communities. It was shown that a nitrifying SBR may be a good alternative to eliminate simultaneously ammonium and p-cresol, maintaining stable the respiratory process as the bacterial community.

关键词： Nitrificationp-Cresol oxidationSequential batch reactorPopulation dynamicsEcological indices

Welfare and Market Impacts of Food Safety Measures in China: Results from Urban Consumers' Valuation of Product Attributes

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Journal of Integrative Agriculture 2014年第6期13卷 1404-1411页

作者： david l. Ortega H. Holly Wang Nicole J. Olynk Widmar Department of Agricultural Foodand Resource EconomicsMichigan State University Department of Agricultural Economics Purdue University

This study provides an economics assessment of various food safety measures in China. A choice experiment approach is used to elicit Chinese consumer preferences for various food safety attributes using data from a 2008 urban consumer survey. An alternative welfare calculation is used to model aggregate market impacts of select food safety measures. Our results show that the largest welfare gains are found in the current government-run certiifcation program. The implementation of a third-party certiifcation system, a traceability network and a product label would generate signiifcant value and would help reduce current system inefifciencies in China. This study builds on previous research and provides an alternative approach for calculating consumer valuation of safety and quality attributes that can be used to estimate aggregate economic and welfare impacts.

关键词： food safety consumer welfare food policy China

Hierarchical charge distribution controls self-assembly process of silk in vitro

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Frontiers of Materials Science 2015年第4期9卷 382-391页

作者： YiZHANG Cencen ZHANG lijie lIU david l. KAPlAN Hesun ZHU Qiang lU National Engineering laboratory for Modern Silk & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China College of Textile and Clothing Engineering Soochow University Suzhou 215123 China Department of Biomedical Engineering Tufts University Medford MA 02155 USA Textile College Henan Institute of Engineering Zhengzhou 450007 China Research Center of Materials Science Beijing Institute of Technology Beijing 100081 China

Silk materials with different nanostructures have been developed without the understanding of the inherent transformation mechanism. Here we attempt to reveal the conversion road of the various nanostructures and determine the critical regulating factors. The regulating conversion processes influenced by a hierarchical charge distribution were investigated, showing different transformations between molecules, nanoparticles and nanofibers. Various repulsion and compressive forces existed among silk fibroin molecules and aggregates due to the exterior and interior distribution of charge, which further controlled their aggregating and deaggregating behaviors and finally formed nanofibers with different sizes. Synergistic action derived from molecular mobility and concentrations could also tune the assembly process and final nanostructures, it is suggested that the complicated silk fibroin assembly processes comply a same rule based on charge distribution, offering a promising way to develop silk-based materials with designed nanostructures.

关键词： silk self-assembly charge nanostructure nanofiber

Immunopathology of inflammatory bowel disease

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World Journal of Gastroenterology 2014年第1期20卷 6-21页

作者： Kori l Wallace li-Bo Zheng Yoshitake Kanazawa david Q Shih F Widjaja Foundation Inflammatory Bowel and Immunobiology Research InstituteCedars-Sinai Medical CenterLos Angeles CA 90048United States Department of Gastroenterology The Second Hospital of Hebei Medical University

Inflammatory bowel disease (IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system. The host microbiome, as well as viruses and fungi, play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system. New technologies have allowed researchers to be able to quantify the various components of the microbiome, which will allow for future developments in the etiology of IBD. Various components of the mucosal immune system are implicated in the pathogenesis of IBD and include intestinal epithelial cells, innate lymphoid cells, cells of the innate (macrophages/monocytes, neutrophils, and dendritic cells) and adaptive (T-cells and B-cells) immune system, and their secreted mediators (cytokines and chemokines). Either a mucosal susceptibility or defect in sampling of gut luminal antigen, possibly through the process of autophagy, leads to activation of innate immune response that may be mediated by enhanced toll-like receptor activity. The antigen presenting cells then mediate the differentiation of naïve T-cells into effector T helper (Th) cells, including Th1, Th2, and Th17, which alter gut homeostasis and lead to IBD. In this review, the effects of these components in the immunopathogenesis of IBD will be discussed.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Microbiome, Autophagy, T helper 17, Innate immune system, Adaptive immune system, Innate lymphoid cells, Tl1A

Profile of retinal diseases in adult patients attending two major eye clinics in Kinshasa,the Democratic Republic of Congo

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1652-1659页

作者： Nelly N.Kabedi david l.Kayembe Jean-Claude Mwanza Departmemt of Ophthalmology School of MedicineUniversity of KinshasaKinshasa XIDemocratic Republic of Congo Department of Ophthalmology School of MedicineUniversity of North Carolina at Chapel HillNC 27599USA

AIM:To determine the frequency and types of retinal diseases and the extend of the related visual loss in adult patients attending two public eye clinics of Kinshasa,Democratic Republic of ***:Review of medical records of patients with retinal diseases seen in the major eye clinics in Kinshasa,the University Hospital of Kinshasa(UHK)and Saint Joseph Hospital(SJH),from January 2012 to December *** and diagnoses were retrieved and *** measures were frequency and prevalence of retinal diseases,blindness and low ***:A total of 40965 patients aged 40 y or older were examined during this period in both *** these,1208 had retinal disease,giving a 3-year and an annual prevalence of 3%and 1%,*** age was 61.7±10.7 y,and 55.8%of the patients were *** hypertension(68.1%)and diabetes(43.3%)were the most common systemic *** retinopathy(41.8%),diabetic retinopathy(37.9%),age-related macular degeneration(AMD;14.6%),and chorioretinitis and retinal vein occlusion(7.3%each)were the most common retinal diseases,with 3-year prevalence rates of 1.3%,1.0%,0.43%,and 0.21%*** low vision and blindness were present in 26.8%and 8.4%of the patients at *** causes of low vision and blindness were diabetic retinopathy(14.8%),AMD(4.9%),retinal detachment(2.8%),and retinal vein occlusion(2.5%).The prevalence was significantly higher among males than females,and at the UHK than ***:Retinal diseases are common among Congolese adult patients attending eye clinics in *** cause a significant proportion of low vision and blindness.

关键词： retinal disorders Kinshasa,Democratic Republic of Congo sub-Saharan Africa pattern

A facile and sensitive method of quantifying glutaminase binding to its ninhibitor CB-839 in tissues

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Journal of Genetics and Genomics 2020年第7期47卷 389-395页

作者： Yicheng Chen Yiqing Zhao david l.Bajor Zhenghe Wang J.Eva Selfridge Department of Genetics and Genome Sciences Case Western Reserve University10900 Euclid AvenueClevelandOH44106USA Department of Medicine Case Western Reserve University10900 Euclid AvenueClevelandOH.44106USA Case Comprehensive Cancer Center Case Western Reserve University10900 Euclid AvenueClevelandOH44106USA Seidman Cancer Center University Hospitals Cleveland Medical CenterWOO Euclid AvenueClevelandOH44106USA

Many cancer types reprogram their metabolism to become addicted to *** of the critical enzymes in the utilization of glutamine in these cells is ***-839(telaglenastat)is a drug that targets glutaminase that is currently being evaluated in many clinical trials for efficacy in various cancer types that are known to be driven by glutamine *** its use,there are limited assays available for testing the pharmacodynamic on-target effects of CB-839 on the limited,small-volume patient samples that are obtained in early-phase clinical ***,we developed an assay based on the cellular thermal shift assay technique using AlphalllSA technology to show that CB-839 specifically engages glutaminase in colon cancer cell lines in vitro and in minute quantities of mouse xenograft ***,we show that this assay detects CB-839 binding to glutaminase in platelets of patients collected while receiving CB-839 on a clinical *** assay may be used to study the pharmacodynamic profile of CB-839 in very small tissue samples obtained from patients on a clinical trial and may be useful infuture studies designed to screen other in hibitors of glutaminase.

关键词： Glutaminase Method Cancer

The evolution of lower extremity reconstruction

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Plastic and Aesthetic Research 2022年第1期9卷 182-195页

作者： Brogan G.A.Evans david l.Colen Division of Plastic and Reconstructive Surgery Department of SurgeryYale School of MedicineNew HavenCT 06510USA

Reconstruction of the lower extremity is a complex task that has evolved greatly in both technique and indication over the past *** advances in treating traumatic lower extremity injuries focused on primary amputation to avoid the high mortality of *** introduction of antibiotics improved surgical debridement and local reconstructive options,enhancing the viability of lower extremities with simple and proximal *** the advent of microvascular surgery,free tissue transfer techniques provided a means to reconstruct more distal and complex *** these surgical techniques have continued to evolve,so too have indications for reconstruction,patient management and post-operative care-now with a greater emphasis on patient quality of life and limb *** purpose of this article is to outline the evolution of lower extremity reconstruction,and how the standard of practice has changed over time.

关键词： lower extremity lower extremity reconstruction limb salvage free flap perforator flap vascularized bone flap orthoplastic surgery