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Self-assembled bright luminescent hierarchical materials from a tripodal benzoate antenna and heptadentate Eu(III) and Tb(III) cyclen complexes

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frontiers of Chemical Science and Engineering 2019年第1期13卷 171-184页

作者： Aramballi J.Savyasachi david f.caffrey Kevin Byrne Gerard Tobin Bruno D'Agostino Wolfgang Schmitt Thorfinnur Gunnlaugsson School of Chemistry and Trinity Biomedical Sciences Institute (TBSI) University of Dublin Trinity College Dublin Dublin 2 Ireland School of Chemistry and Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) University of Dublin Trinity College Dublin Dublin 2 Ireland

The europium heptadentate coordinatively unsaturated (Eu(III)) and the terbium (Tb(III)) 1,4,7,10-tetraazacyclododecane (cyclen) complexes 1 and 2 were used in conjunction with ligand 3 (1,3,5-benzene-trisethynylbenzoate) to form the supramolecular self-assembly structures 4 and 5;this being investigated in both the solid and the solution state. The resulting self-assemblies gave rise to metal centered emission (both in the solid and solution) upon excitation of 3, confirming its role as a sensitizing antenna. Drop-cased examples of ligand 3, and the solid forms of 4 and 5, formed from both organic and mixture of organic-aqueous solutions, were analyzed using Scanning Electron Microscopy, which showed significant changes in morphology;the ligand giving rise to one dimensional structures, while both 4 and 5 formed amorphous materials that were highly dense solid networks containing nanoporous features. The surface area (216 and 119 m2·g^-1 for 4 and 5 respectively) and the ability of these porous materials to capture and store gases such as N2 investigated at 77 K. The self-assembly formation was also investigated in diluted solution by monitoring the various photophysical properties of 3–5. This demonstrated that the most stable structures were that consisting of a single antennae 3 and three complexes of 1 or 2 (e.g., 4 and 5) in solution. By monitoring the excited state lifetimes of the Eu(III) and Tb(III) ions in H2O and D2O respectively, we showed that their hydration states (the q-value) changed from -2 to 0, upon formation of the assemblies, indicating that the three benzoates of 3 coordinated directly to the each of the three lanthanide centers. finally we demonstrate that this hierarchically porous materials can be used for the sensing of organic solvents as the emission is highly depended on the solvent environment;the lanthanide emission being quenched in the presence of acetonitrile and THf, but greatly enhanced in the presence of methanol.

关键词： self-assembly supramolecular chemistry lanthanides Eu(III) and Tb(III) complexes luminescence metallostars

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Predictions of decreased surface roughness after shot peening using controlled media dimensions

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Journal of Materials Science & Technology 2020年第23期58卷 120-129页

作者： Siavash Ghanbari david f.Bahr School of Materials Engineering Purdue UniversityWest LafayetteIN47907USA

Shot peening induces residual compressive stresses on metallic substrates, often used to decrease fatigue crack growth. The relationship between surface roughness and the magnitude of the stress can be affected by peening media size or the extent of peening. Generally, an ideal condition from shot peening would be a high compressive residual stress and a low surface roughness, but these tend to be inversely *** study proposes a method for decreasing roughness and increasing residual stress concurrently using a distribution of shot sizes in a single shot peening passage based on finite element modeling that has been calibrated using by experimental results. Numerical models predict mixed shot sizes will create a smoother surface than using monodispersed shot at 100 % coverage. The residual stress profile for mixed shot sizes showed a broad range of compressive residual stresses in comparison with the largest impact ball size. This newly proposed method can improve the surface quality and the extent of the compressive residual stresses in a single-shot peening passage.

关键词： Numerical analysis Shot peening Roughness

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The embryology of persistent cloaca and urogenital sinus malformations

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Asian Journal of Andrology 2020年第2期22卷 124-128页

作者： david f M Thomas University of Leeds LeedsWest Yorkshire LS29JTUK

Cloacal malformations are characterized by the confluence of the lower urinary tract,the female reproductive tract,and the rectum to create a common channel with a single opening on the *** presence of a cloaca is a normal phase of early human embryological *** the 4^th and 7^th weeks of gestation,the cloaca undergoes subdivision to form the hindgut and urogenital *** of this process results in the congenital anomaly termed persistent cloaca(PC).The term urorectal septum malformation sequence(URSMS)is also used to describe this *** classic description of this process which is still cited in many standard textbooks dates from the 19th ***,this has been increasingly called into question by the findings of studies using modern scientific *** sinus anomalies are defined by the confluence of the urethra and vagina to form a common channel of varying length with a single perineal *** this condition,the anorectal canal opens separately on the *** presence of a urogenital sinus represents a transient phase of the normal development of the lower genital tract in the female ***,the form of urogenital sinus most commonly encountered in the developed world is a feature of disordered sexual differentiation and does not arise simply from the persistence of the anatomical structure which is a feature of normal fetal development.

关键词： cloaca embryology urogenital sinus

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Taxonomic and phylogenetic composition show biotic resistance to exotic invasion in acid seep springs

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Ecological Processes 2021年第1期10卷 77-88页

作者： david f.Barfknecht david J.Gibson School of Biological Sciences Southern Illinois University–CarbondaleCarbondaleIL 62901-6509USA

Background:few studies have incorporated the evolutionary insights provided by analysis of phylogenetic structure along with community composition to assess the effects of exotic invasion on freshwater ***,we assess the taxonomic and phylogenetic relationships among acid seep springs to investigate the potential homogenization or resistance of communities due to invasion of an exotic ***:Multivariate community analyses indicated differences in community and phylogenetic composition and dispersion among acid seep springs,associated with gradients in soil moisture,canopy cover,and phylogenetic *** contrast,univariate analyses showed differences in taxonomic diversity but not phylogenetic diversity among acid seep ***:Despite exotic invasion,individual acid seep springs remained taxonomically and phylogenetically distinct from each *** and phylogenetic diversity metrics revealed different aspects of composition,reinforcing the importance of including both in analyses of plant communities for understanding community assembly following exotic invasion and for management *** acid seep springs,taxonomic and phylogenetic composition appear to be driven more through environmental filtering by light and moisture than by the competitive effects following invasion of an exotic grass in support of Elton’s biotic resistance hypothesis.

关键词： Acid seep springs Diversity Community Phylogenetics Exotic invasion Environmental filtering NMDS Unifrac Vector analysis

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Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza

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Science China(Life Sciences) 2010年第2期53卷 273-285页

作者： SPENCER david f Department of Biochemistry and Molecular Biology Dalhousie University

Salvia miltiorrhiza *** a well-known traditional Chinese *** roots have been formulated and used clinically for the treatment of various ***,little genetic information has so far been available and this fact has become a major obstacle for molecular *** address this lack of genetic information,an Expressed Sequence Tag (EST) library from whole plantlets of *** was *** the 12959 cDNA clones that were randomly selected and subjected to single-pass sequencing from their 5′ ends,10288 ESTs (with sizes≥100 bp) were selected and assembled into 1288 contigs,leaving 2937 singletons,for a total of 4225 *** were analyzed using BLASTX (against protein databases),RPS-BLAST (against a conserved domain database) as well as the web-based KEGG Automatic Annotation Server for metabolic enzyme *** on the metabolic enzyme assignment,expression patterns of 14 secondary metabolic enzyme genes in different organs and under different treatments were verified using real-time PCR ***,a total of 122 microsatellites were identified from the ESTs,with 89 having sufficient flanking sequences for primer *** set of ESTs represents a significant proportion of the *** transcriptome,and gives preliminary insights into the gene complement of *** will prove useful for uncovering secondary metabolic pathways,analyzing cDNA-array based gene expression,genetic manipulation to improve yield of desirable secondary products,and molecular marker identification.

关键词： expressed sequence tags Salvia miltiorrhiza Bge. gene identification microsatellite

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Early history of inflatable penile prosthesis surgery： a view from someone who was there

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Asian Journal of Andrology 2015年第2期17卷 225-229页

作者： david f Mobley Institute for Academic Medicine Houston Texas18300 Katy Fwy Ste 325 Houston TX 77094 USA.

The publication of the use of an inflatable penile prosthesis （IPP） in 1973 by Dr. fB Scott. changed the world of treatment options for erectile dysfunction （ED）. Much has been written since then about techniques, improvements, management of difficult cases, complications and their management, and mechanical and device changes over time. few reports, if any, are available in the medical literature regarding the early development, surgical techniques, and controversies surrounding its introduction to the world＇s urological community. This article is, for the most part, the observations of one who was ＂there＂ in the early and mid 1970＇s and was a witness to the history of this remarkable marvel of creativity, engineering, design, and to the personalities involved.

关键词： @@

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Biocompatibility pathways and mechanisms for bioactive materials:The bioactivity zone

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Bioactive Materials 2022年第4期7卷 306-322页

作者： david f.Williams Wake forest Institute of Regenerative Medicine 391 Technology Way.Winston-SalemNorth Carolina27101USA

This essay analyzes the scientific evidence that forms the basis of bioactive materials,covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of *** is a detailed assessment of performance in areas such as bone-induction,cell adhesion,immunomodulation,thrombogenicity and antimicrobial *** is the modulation of biological activity by characteristics of the interfacial region that incorporates the material surface and the immediate local host *** the term‘bioactive material’is widely used and has a well understood general meaning,it would be useful now to concentrate on this interfacial region,considered as‘the bioactivity zone’.Bioactivity phenomena are either due to topographical/micromechanical characteristics,or to biologically active species that are presented in the bioactivity *** of topographical/micromechanical effects are the modulation of the osteoblast-osteoclast balance,nanotopographical regulation of cell adhesion,and bactericidal *** of bioactivity by biologically active species include their influence,especially of metal ions,on signaling pathways in bone formation,the role of cell adhesion molecules and bioactive peptides in cell attachment,macrophage polarization by immunoregulatory molecules and antimicrobial *** much experimental data exists to demonstrate the potential of such phenomena,there are considerable barriers to their effective clinical *** essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials,especially when the material is modified in a manner designed to specifically induce that activity.

关键词： Bioactivity Host response Biomaterial Medical technology Cell signaling

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Male infertility： lifestyle factors and holistic, complementary, and alternative therapies

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Asian Journal of Andrology 2016年第3期18卷 410-418,I0008,I0009页

作者： david f Yao Jesse N Mills Department of Urology UCLA 1260 15^th St #1200 Santa Monica CA 90404 USA.

While we may be comfortable with an allopathic approach to male infertility, we are also responsible for knowledge about lifestyle modifications and holistic, complementary, and alternative therapies that are used by many of our patients. This paper provides an evidence-based review separating fact from fiction for several of these therapies. There is sufficient literature to support weight reduction by diet and exercise, smoking cessation, and alcohol moderation. Supplements that have demonstrated positive effects on male fertility on small randomized controlled trial （RCT） include aescin, coenzyme Qlo, glutathione, Korean red ginseng, L-carnitine, nigella sativa, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant. There is no support for the use of Vitamin C, Vitamin E, or saffron. The data for Chinese herbal medications, acupuncture, mind-body practice, scrotal cooling, and faith-based healing are sparse or inconclusive.

关键词： alcohol antioxidants caffeine faith-based healing male infertility obesity scrotal cooling sperm tobacco traditional Chinese medicine

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CD8:Adhesion Molecule,Co-Receptor and Immuno-Modulator

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Cellular & Molecular Immunology 2004年第2期1卷 81-88页

作者： david K Cole George f Gao Nuffield Department of Clinical Medicine John Radcliffe HospitalUniversity of OxfordHeadington Oxford OX3 9DUUnited Kingdom.

CD8 is a cell surface glycoprotein found in cytotoxic T lymphocytes,which are important components in cellular immunity,*** the immune response to cancer and chronic *** are two forms of CD8, either as an αα homodimer or αβ *** acts as an“assistant”or co-receptor in the function of cytotoxic T cells where specific immunity is mediated by interaction of specific T cell receptor(αβTCR)and its ligand peptide major histocompatibility complex(pMHC).CD8 also binds to pMHC but away from the interface of pMHC and TCR contact,thereof no influence on the specificity of this *** the TCR and CD8 bind to the same pMHC at the same time,CD8 is defined as a co-receptor,functioning through its signalling via its cytoplasmic tyrosine phosphorylation pathway;if CD8 binds to pMHC independently of the TCR,it is defined as an adhesion *** present,the co-receptor function theory is dominated in the field. Recent study has also shown that murine CD8αα binds to TL antigen,an MHC homologue,therefore acts as an *** this review,we discuss these current understandings of the three aspects of the CD8 functions and their structural *** & Molecular Immunology.2004;1(2):81-88.

关键词： CD8 T cell adhesion co-receptor immuno-modulator

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