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Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus

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Neuroprotection 2024年第2期2卷 167-178页

作者： Aravind Parthasarathy Ramesha Hanumanthappa Sarojini R.Bulbule Kiran P.c. Hemalatha Nanjaiah Gopinath G. Siddaiah B.M. david Muniswamy Devaraju Kuramkote Shivanna Neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoology Karnatak UniversityDharwadIndia

Backgrounds:Oxidative stress impairs the function of calcium-binding proteins and deregulates calcium signaling in living *** have previously explored the overexpression of calcium-binding protein genes in a reactive oxygen and nitrogen species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze gene expression of major calcium-binding proteins(calcineurin,calmodulin,calsyntenin,synaptotagmin,and calreticulin)and N-methyl-D-aspartic acid(NMDA)receptor subunits(glutamate receptor ionotropic[GluN]GluN1,GluN2A,and GluN2B)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assigned to two stress induction groups and a control group without stress(n=6).Stress was induced by using H_(2)O_(2)(3%in water)or by immobilization(using a sticky mat)over a period of 30 *** of calcium-binding protein genes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of genes encoding calcium-binding proteins calcineurin,calsyntenin,synaptotagmin and NMDA receptor subunit GluN1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,pced rats,neurons in the cA2 region of the hippocampus were fewer and appeared disorganized compared with control ***,stressinduced rats showed decreased mobility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxygen and nitrogen species(RONS)can also lead to stress in rats by affecting their calcium signaling,buffering capacity in the neurons leading to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization NMDA receptors

From non-alcoholic fatty liver disease to metabolic-associated steatotic liver disease:Rationale and implications for the new terminology

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World Journal of Hepatology 2024年第6期16卷 863-866页

作者： Stephen david Howard Malnick Doron Zamir Department of Internal Medicine c Kaplan Medical CenterRehovot 76100Israel Department of Internal Medicine D Barzilai Medical CenterAshkelon 7830604Israel

Non-alcoholic fatty liver disease(NAFLD)was the term first used to describe hepatic steatosis in patients with the metabolic syndrome who did not consume excess amounts of *** liver disease(ALD)has many similarities to NAFLD in both pathogenesis and *** entity is now the most prevalent chronic liver disease worldwide as a consequence of the epidemic of *** to incorporate the importance of the metabolic syndrome in the development of steatosis resulted in the renaming of NAFLD as metabolic-associated fatty liver *** new term,however,has the disadvantage of the use of terms that may be perceived as *** terms fatty and non-alcoholic have negative connotations in many *** addition,non-alcoholic is not usually a term applicable to pediatric cases of hepatic ***,an international collaborative effort,with participants from 56 countries,after a global consultation process,recommended to change the nomenclature to steatotic liver disease-including metabolic dysfunction-associated steatotic liver disease,metabolic-associated steatohepatitis and metabolic dysfunction-associated *** new terminology is consistent with most of the previously published epidemiological studies and will have a major impact on research into diagnosis,prognosis and treatment.

关键词： Non-alcoholic fatty liver disease Steatosis metabolic-associated steatotic liver disease Nomenclature

Electrifying Ba_(0.5)Sr_(0.5)co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

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Journal of Energy chemistry 2024年第4期91卷 99-110页

作者： Marwan Laqdiem Julio García-Fayos Laura Almar Alfonso J.carrillo Álvaro Represa JoséM.López Nieto Sonia Escolástico david catalán-Martinez Jose M.Serra Instituto de Tecnología Química(Universitat Politècnica de València–consejo Superior de Investigaciones científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(OTMs)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTMs could provide oxygen from different sources(air,water,cO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,OTMs can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTM material(Ba_(0.5)Sr_(0.5)co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the OTM is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.The O_(2)permeation flux reached for the electrified membranes was~3.7 NmL min^(-1)cm^(-2),corresponding to the flux obtained with an OTM non-electrified at 900℃.The influence of depositing a porous ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(cMR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect Mixed ionic-electronic conductors catalytic membrane reactors

Atomic Dispersed Hetero‑Pairs for Enhanced Electrocatalytic cO_(2)Reduction

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Nano-Micro Letters 2024年第1期16卷 55-67页

作者： Zhaoyong Jin Meiqi Yang Yilong Dong Xingcheng Ma Ying Wang Jiandong Wu Jinchang Fan Dewen Wang Rongshen Xi Xiao Zhao Tianyi Xu Jingxiang Zhao Lei Zhang david J.Singh Weitao Zheng Xiaoqiang cui State Key Laboratory of Automotive Simulation and control School of Materials Science and EngineeringKey Laboratory of Automobile Materials of MOEElectron Microscopy CenterJilin UniversityChangchun 130012People’s Republic of China Key Laboratory of Photonic and Electronic Bandgap Materials Ministry of Educationand College of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbin 150025People’s Republic of China college of chemistry Jilin UniversityChangchun 130012People’s Republic of China Department of Physics and Astronomy and Department of chemistry University of MissouriColumbiaMO 65211USA

Electrochemical carbon dioxide reduction reaction(cO_(2)RR)involves a variety of intermediates with highly correlated reaction and ad-desorption energies,hindering optimization of the catalytic *** example,increasing the binding of the*cOOH to the active site will generally increase the*cO desorption *** this relationship may be expected to dramatically improve the intrinsic activity of cO_(2)RR,but remains an unsolved ***,we addressed this conundrum by constructing a unique atomic dispersed hetero-pair consisting of Mo-Fe di-atoms anchored on N-doped carbon *** system shows an unprecedented cO_(2)RR intrinsic activity with TOF of 3336 h−1,high selectivity toward cO production,Faradaic efficiency of 95.96%at−0.60 V and excellent *** calculations show that the Mo-Fe diatomic sites increased the*cOOH intermediate adsorption energy by bridging adsorption of*cOOH *** the same time,d-d orbital coupling in the Mo-Fe di-atom results in electron delocalization and facilitates desorption of*cO ***,the undesirable correlation between these steps is *** work provides a promising approach,specifically the use of di-atoms,for breaking unfavorable relationships based on understanding of the catalytic mechanisms at the atomic scale.

关键词： cO_(2)reduction reaction Atomic dispersed catalyst Hetero-diatomic pair Ad-desorption energy Linear scaling relation

The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua david Wong Louise McEwan James Walters Rachel Esler Matthew J.Roberts Geoff coughlina John W.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(Pca)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/cT)ordered at Department of Urology,The Wesley Hospital,Brisbane,QLD,Australia for non-Pca related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/cT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/cT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/cT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).Pca was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/cT was concordant with the 18F-FDG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/cT had Pca on *** was no statistically significant difference in the 18F-FDG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/cT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk

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General Psychiatry 2024年第3期37卷 352-363页

作者： Pianpian Zhao Zhimin Ying chengda Yuan Haisheng Zhang Ao Dong Jianguo Tao Xiangjiao Yi Mengyuan Yang Wen Jin Weiliang Tian david Karasik Geng Tian Houfeng Zheng The Affiliated Hangzhou First People’s Hospital School of MedicineWestlake UniversityHangzhouZhejiangChina Westlake Laboratory of Life Sciences and Biomedicine HangzhouZhejiangChina Diseases&Population(DaP)Geninfo Lab School of Life SciencesWestlake UniversityHangzhouZhejiangChina Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhouZhejiangChina Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Dermatology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiangChina Department of Global Statistics Eli Lilly and CompanyBranchburgNew JerseyUSA Azrieli Faculty of Medicine Bar-Ilan UniversitySafedIsrael Binzhou Medical University YantaiShandongChina

Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms,while more studies demonstrate that depression negatively affects bone density and increases fracture *** To explore the relationship between major depressive disorder(MDD)and fracture *** We conducted a nested case-control analysis(32670 patients with fracture and 397017 individuals without fracture)and a matched cohort analysis(16496 patients with MDD and 435492 individuals without MDD)in the same prospective UK Biobank data ***,we investigated the shared genetic architecture between MDD and fracture with linkage disequilibrium score regression and the MiXeR statistical *** used the conditional/conjunctional false discovery rate approach to identify the specific shared *** calculated the weighted genetic risk score for individuals in the UK Biobank and logistic regression was used to confirm the association observed in the prospective *** We found that MDD was associated with a 14%increase in fracture risk(hazard ratio(HR)1.14,95%cI 1.14 to 1.15,pcase-control analysis,while fracture was associated with a 72%increase in MDD risk(HR 1.72,95%cI 1.64 to 1.79,pched cohort analysis,suggesting a longitudinal and bidirectional ***,genetic summary data suggested a genetic overlap between MDD and ***,we identified four shared genomic loci,with the top signal(rs7554101)near *** protein encoded by SGIP1 is involved in cannabinoid receptor type 1 *** found that genetically predicted MDD was associated with a higher risk of fracture and vice *** addition,we found that the higher expression level of SGIP1 in the spinal cord and muscle was associated with an increased risk of fracture and *** The genetic pleiotropy between MDD and fracture highlights the bidirectional association observed in the epidemiological *** shared ge

关键词： fracture matched osteoporosis

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： JONATHAN PELTIER WEIWEI ZHANG LEOPOLD VIROT cHRISTIAN LAFFORGUE LUcAS DENIEL DELPHINE MARRIS-MORINI GUY AUBIN FARAH AMAR DENH TRAN XINGZHAO YAN cALLUM G.LITTLEJOHNS cARLOS ALONSO-RAMOS KE LI david J.THOMSON GRAHAM REED LAURENT VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the Dc Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large Dc electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the Dc Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external Dc electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora Valeria García-Zárate Ana Varela-constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna c Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R colunga-Pedraza Olga G cantú-Rodríguez césar H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López david Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BAcKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHScT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter

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Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo Kim Hyunju K.connor Jaewoong Jung Brian M.Walsh david Sibeck Kip D.Kuntz Frederick S.Porter catriana K.Paw U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael collier Space Research Institute Austrian Academy of Sciences8042 GrazAustria Geophysical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Administration(NASA)Goddard Space Flight center GreenbeltMaryland 20771USA Astronomy Department University of Maryland College ParkCollege ParkMaryland 20742USA center for Space Physics Boston UniversityBostonMassachusetts 02215USA Department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA Howard University WashingtonDC 20059USA

The Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind *** suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray *** this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is *** assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause *** create synthetic soft X-ray images by using the Open Geospace General circulation Model(OpenGGcM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson *** then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea *** the filte red images,we calculate RS and its accuracy for different LEXI locations,look directions,and solar wind densities by using the OpenGGcM subsolar magnetopause location as ground *** method estimates RS with an accuracy ofceeds>10 *** accuracy improves for greater solar wind densities and during southward interplanetary magnetic *** method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field ***,the technique will enable quantitative analysis of the magnetopause motion and help reveal the daysi

关键词： soft X-ray magnetopause reconnection low-pass filter LEXI SMILE