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Neural Regeneration Research 2015年第4期10卷 537-539页

作者： Jung Mi Park david c.hess Departments of Neurology Georgia Regent’s University

The only two treatments effective for acute ischemic stroke are reperfusion therapies. Despite testing of hundreds of neuroprotective agents and treatments, tissue plasminogen activator （tPA）, approved by the Food and Drug Administration （FDA） in 1996, remains the only FDA-approved drug for the treatment of ischemic stroke. Recently,

关键词： Breaking out from the neuroprotective logjam RIc

Lab-to-clinic application of stem cell therapy for stroke

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chinese Neurosurgical Journal 2016年第4期2卷 219-222页

作者： Mia c.Borlongan Sonya Kong david c.hess center of Excellence for Aging and Brain Repair Morsani College of Medicine University of South Florida 12901 Bruce B.Downs Blvd. Tampa FL 33612 USAResearch Service at James Haley VA Hospital Tampa FL 33612USA Department of Neurology Medical College of Georgia Augusta University 1120 15th Street Augusta GA 30912 USA

Stem cell therapy or 'cell therapy' has been demonstrated to be a potent treatment intervention in animal models of acute ischemic stroke,and recently has been introduced as an experimental therapy in early phase clinical *** the many stem cells,the bone marrow adherent cell type known as mesenchymal stem ceils have emerged in laboratory studies as a safe and effective therapy for ischemic stroke and other brain *** particular,a unique population of adherent bone marrow-derived cells,called MultiStem cells,display immunomodulatory effects and are a promising allogeneic cell therapy in acute ischemic ***,we describe the preclinical evidence supporting the use of MultiStem in the acute setting of ischemic stroke and the translation into an early phase clinical trial in ischemic stroke.

关键词： Multistem cerebral ischemia Preclinical clinical Translational

In Situ Studies of Model catalysts with Polarization Modulation Infrared Reflection Absorption Spectroscopy (PM-IRAS)

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In Situ Studies of Model Catalysts with Polarization Modulat...

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

第三十五届国际光谱会议

作者： E.Ozensoy c.hess D.W.Goodman Department of chemistry Texas A&M University P.O.Box 30012 College StationTX 77842-3012USA

The catalytic reaction between cO and O or NO has been studied on model catalysts using polarization-modulation infrared reflection absorption spectroscopy(PM-IRAS) within a wide pressure regime(10～1 bar).On an atomically flat single crystal Pd surface,formation of an isocyanate(-NcO)species was followed under high pressure conditions of cO and *** relationship between the-NcO formation and the total

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来源： cnki会议评论

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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作者： hess david J.

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熔融纺丝:一种生产弹性纤维的新方法

国外纺织技术（纺织针织服装化纤染整） 2001年第6期 14-15页

作者： c.hess 贾慧萍

自20世纪50年代聚氨酯弹性纤维实现商业化以来,许多事物发生了巨大的变化.如今,如果没有适量的弹性纤维,人们似乎很难制造具有弹性的诸如内衣、游泳衣、运动服和演出服、睡衣、休闲服和户外服装等.

关键词：弹性纤维熔融纺丝 ELFIS方法合成纤维聚氨酯纤维

Portal vein embolization for induction of selective hepatic hypertrophy prior to major hepatectomy: rationale,techniques, outcomes and future directions

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cancer Biology & Medicine 2016年第4期13卷 426-442页

作者： david Li david c.Madoff Department of Radiology Division of Interventional Radiology New York-Presbyterian Hospital Weill Cornell Medical Center

The ability to modulate the future liver remnant(FLR) is a key component of modern oncologic hepatobiliary surgery practice and has extended surgical candidacy for patients who may have been previously thought unable to survive liver resection. Multiple techniques have been developed to augment the FLR including portal vein embolization(PVE), associating liver partition and portal vein ligation(ALPPS), and the recently reported transhepatic liver venous deprivation(LVD). PVE is a well-established means to improve the safety of liver resection by redirecting blood flow to the FLR in an effort to selectively hypertrophy and ultimately improve functional reserve of the FLR. This article discusses the current practice of PVE with focus on summarizing the large number of published reports from which outcomes based practices have been developed. Both technical aspects of PVE including volumetry, approaches, and embolization agents; and clinical aspects of PVE including data supporting indications, and its role in conjunction with chemotherapy and transarterial embolization will be highlighted. PVE remains an important aspect of oncologic care; in large part due to the substantial foundation of information available demonstrating its clear clinical benefit for hepatic resection candidates with small anticipated FLRs.

关键词： Portal vein embolization future liver remnant hypertrophy liver regeneration liver cancer hepatocellular carcinoma liver metastases

Understanding bark thickness variations for Araucaria angustifolia in southern Brazil

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Journal of Forestry Research 2021年第3期32卷 1077-1087页

作者： Emanuel Arnoni costa Veraldo Liesenberg césar Augusto Guimaraes Finger AndréFelipe hess cristine Tagliapietra Schons Graduate Program in Forest Engineering Santa Catarina State University(UDESC)LagesSC 88520-000Brazil Department of Forest Engineering Federal University of Uberlandia(UFU)Monte CarmeloMG 38500-000Brazil Graduate Program in Forest Engineering Federal University of Santa Maria(UFSM)Santa MariaRS 97105-900Brazil Graduate Program in Agroecosystems Federal Technological University of Parana(UFTPR)Dois VizinhosPR 85660-000Brazil

This study aimed to understand bark thickness variations of Araucaria angustifolia(Bertol.)Kuntze trees growing in natural forest remnants in southern Brazil,and their relationship with quantitative and qualitative *** thickness must be accurately estimated in order to determine timber volume *** is an important variable for the sustainable management and conservation of araucaria *** spite of its importance and visibility,bark thickness variations have not been evaluated for this key species in southern Brazil.A total of 104 trees were selected,and their qualitative and quantitative attributes such as diameter at breast height(D_(BH)),height(H),crown base height(c_(BH)),crown length(c_(L)),social position(S_(P)),stoniness(S_(T)),position on the relief(P_(R)),vitality(V_T)and branch arrangement(B_(A))were *** trees were categorized into two groups:red bark or gray *** analysis and artificial neural networks(ANN)were used for modelling bark *** results indicate that:(1)bark thickness showed good correlation to D_(BH),with 0.76 as coefficient of determination(RS_P),0.540 as Mean Absolute Error(M_(AE))and 22.4 root-meansquare error in percentage(R_(MSE%));(2)the trend changed according to bark colour,with significant differences for the intersection(_0–Pr>F:p=0.0124)and slope(β_(1)–Pr>F:p=0.0126)of bark thickness curves between groups;(3)the highest correlation of bark thickness was found with:D_(BH)(ρ=0.88),H(ρ=0.58),c_(BH)(ρ=0.46),S_(P)(ρ=-0.52),and B_(A)(ρ=-0.32);(4)modelling with ANN confirmed high adjustment(R^(2)=0.99)and accuracy(R_(MSE%)=3.0)of the *** is an efficient and robust technique for the modelling of various qualitative and quantitative attributes commonly used in forest *** effective use of ANN to estimate araucaria bark in natural forests reinforces its potential,besides the possibility of application for other forest species.

关键词： Dendrometry attributes crown characteristics Prediction models Bark factor Parana-pine

coronavirus disease-2019: A tocsin to our aging, unfit, corpulent, and immunodeficient society

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Journal of Sport and Health Science 2020年第4期9卷 293-301页

作者： david c.Nieman Department of Biology College of Arts and SciencesAppalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

Acute and chronic respiratory illnesses cause widespread morbidity and mortality,and this class of illness now includes the novel coronavirus severe acute respiratory syndrome that is causing coronavirus disease-2019(cOVID-19).The world is experiencing a major demographic shift toward an older,obese,and physically inactive *** factor assessments based on pandemic data indicate that those at higher risk for severe illness from cOVID-19 include older males,and people of all ages with obesity and related comorbidities such as hypertension and type 2 *** in and of itself leads to negative changes in innate and adaptive immunity,a process termed *** causes systemic inflammation and adversely impacts immune function and host defense in a way that patterns *** primary prevention strategies to reduce the risk for cOVID-19 at both the community and individual levels include mitigation activities and the adoption of lifestyle practices consistent with good immune *** and human studies support the idea that,in contrast to high exercise workloads,regular moderate-intensity physical activity improves immunosurveillance against pathogens and reduces morbidity and mortality from viral infection and respiratory illnesses including the common cold,pneumonia,and *** odds are high that infectious disease pandemics spawned by novel pathogens will continue to inflict morbidity and mortality as the world’s population becomes older and more ***-19 is indeed a wake-up call,a tocsin,to the world that primary prevention countermeasures focused on health behaviors and hygiene demand our full attention and support.

关键词： cOVID-19 Exercise Immunology Infection Obesity

ANALYSIS OF LIQUID SLUG MOTION IN A VOIDED LINE

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Journal of Hydrodynamics 1993年第3期5卷 75-88页

作者： Yang, Jiandong Wigget, david c Wuhan Univ of Hydraulic and Electric Engineering Wuhan China

A quasi two-dimensional two-phase flow cylinder model of slug motion in a voided line developed in this paper can predict reasonably the change of flow pattern of the slug, air entrainment, holdup and the distribution of axial velocity. However, if using the theory of transfer momentum to estimate the pressure-time history of slug at the elbow, the result of calculation is not good in agreement with that of experiment. Analysis of the experiment results and the estimations of using the theory of transient two-phase flow indicate that an evident water hammer response occurs in the slug, when the high-speed slug impacts on the elbow, and the peaks and waveform of pressure-time history are dependent mainly on the propagation of transient two-phase flow in the slug.

关键词： Pipe flow Water hammer