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Modifi cation of sleep architecture in an animal model of experimental cirrhosis

World Journal of Gastroenterology 2009年第41期15卷 5176-5180页

作者： Anabel Jiménez-Anguiano Vanessa Díaz-Medina Blanca Eugenia Farfán-Labonne Gloria Giono-Chiang david Kersenobich Mario García-Lorenzana Maria Concepción Gutiérrez-ruiz Javier Velázquez-Moctezuma Area of Neuroscience Department of Biology of Reproduction Universidad Autónoma Metropolitana-Iztapalapa CP 09340 Mexico City Mexico Cell Physiology Laboratory Department of Health Sciences Universidad Autónoma Metro-politana-Iztapalapa CP 09340 Mexico City Mexico Unit of Liver Pancreas and Motility Faculty of Medicine Universidad Nacional Autónoma de México Mexico City D.F CP 09340 Mexico

AIM： To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCh administration. METHODS： Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were im- planted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological confirmation of cirrhosis was performed after 11 wk. RESULTS： The results showed a progressive decrease in total wake time that reached statistical significance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep （SWS）Ⅱ and rapid eye movement sleep （REM sleep） in most of the 11 wk. SWS I showed no significant variations. During the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. CONCLUSION： These data suggest that hepatic failure produced by CCh administration is capable of modifying the sleep pattern even after only a few doses.

关键词： Experimental cirrhosis Sleep Rapid eye movement sleep CCI4 Wakefulness

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Clinical and anatomic predictors of need for repeat atrial fibrillation ablation

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World Journal of Cardiology 2017年第9期9卷 742-748页

作者： Yaanik Desai Mathew R Levy Shahriar Iravanian Edward C Clermont Heval M Kelli Robert L Eisner Mikhael F El-Chami angel R Leon david B Delurgio Faisal M Merchant Emory University School of Medicine Cardiology Division Department of MedicineEmory University School of Medicine Division of Cardiology Department of MedicineUniversity of Pennsylvania Department of Radiology Emory University School of Medicine

AIM To identify predictors of need for repeat procedures after initial atrial fibrillation(AF) ablation. METHODS We identified a cohort undergoing first time AF ablation at our institution from January 2004 to February 2014 who had cardiac magnetic resonance(CMR) imaging performed prior to ablation. Clinical variables and anatomic characteristics(determined from CMR) were assessed as predictors of need for repeat ablation. The decision regarding need for and timing of repeat ablation was at the discretion of the treating physician. RESULTS From a cohort of 331 patients, 142 patients(43%) underwent repeat ablation at a mean of 13.6 ± 18.4 mo afterthe index procedure. Both male gender(81% vs 71%, P = 0.05) and lower ejection fraction(57.4% ± 10.3% vs 59.8% ± 9.4%, P = 0.04) were associated with need for repeat ablation. On pre-ablation CMR, mean pulmonary vein(PV) diameters were significantly larger in all four PVs among patients requiring repeat procedures. In multivariate analysis, increased right superior PV diameter significantly predicted need for repeat ablation(odds ratio 1.08 per millimeter increase in diameter, 95%CI: 1.00-1.16, P = 0.05). There were also trends toward significance for increased left and right inferior PV sizes among those requiring repeat *** Increased PV size predicts the need for repeat AF ablation, with each millimeter increase in PV diameter associated with an approximately 5%-10% increased risk of requiring repeat procedures.

关键词： Atrial fibrillation ablation Repeat ablation Cardiac magnetic resonance imaging Pulmonary veins Imaging

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An inter-laboratory study of DNA-based identity,parentage and species testing in animal forensic genetics

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Forensic Sciences Research 2022年第4期7卷 708-713页

作者： Sreetharan Kanthaswamy Torsten Brendel Luis Cancela Denise A.Andrade de Oliveira Bertram Brenig Carmen Cons Julian A.Crespi Markéta Dajbychová Andreas Feldl Tomohito Itoh Vincenzo Landi Amparo Martinez Malgorzata Natonek-Wisniewska Robert F.Oldt Anna Radko Oscar Ramírez Clementina Rodellar Manuel ruiz-Girón david Schikorski María Elena Turba Guillermo Giovambatista School of Mathematics and Natural Sciences Arizona State University(ASU)at the West CampusGlendaleAZUSA California National Primate Research Center University of CaliforniaDavisCAUSA Evolutionary Biology Graduate Program School of Life SciencesArizona State UniversityTempeAZUSA Eurofins Genomics Europe Applied Genomics GmbH EbersbergGermany IDENTITAS MontevideoUruguay Laboratório de Genética Escola de Veterinária da UFMGBelo HorizonteBrazil Institute of Veterinary Medicine University of GoettingenGoettingenGermany Facultad de Veterinaria Laboratorio de Genética Bioquímica(LAGENBIO)Instituto Agroalimentario de Aragón-IA2(Universidad de Zaragoza-CITA)ZaragozaSpain Facultad de Ciencias Veterinarias UNLP IGEVET-Instituto de Genética Veterinaria(UNLP-CONICET LAPLATA)La PlataArgentina Genomia s.r.o. PlzeňCzech Republic Maebashi Institute of Animal Science Livestock Improvement Association of Japan(LIAJ)MaebashiJapan Department of Veterinary Medicine Animal Breeding and GeneticsUniversity of Bari“Aldo Moro”ValenzanoItaly Department of Genetics Faculty of Veterinary SciencesUniversity of CórdobaCórdobaSpain Department of Animal Molecular Biology National Research Institute of Animal ProductionBalicePoland Vetgenomics SL BarcelonaSpain Laboratorio de Biología Molecular y Genómica Hispalis Biolab S.L.U.SevilleSpain Laboratoire LABOFARM-GENINDEXE LOUDEACCedexFrance Genefast SRL ForlìItaly

The probative value of animal forensic genetic evidence relies on laboratory accuracy and ***-laboratory comparisons allow laboratories to evaluate their performance on specific tests and analyses and to continue to monitor their *** International Society for Animal Genetics(ISAG)administered animal forensic comparison tests(AFCTs)in 2016 and 2018 to assess the limitations and capabilities of laboratories offering forensic identification,parentage and species determination *** AFCTs revealed that analyses of low DNA template concentrations(≤300 pg/μL)constitute a significant challenge that has prevented many laboratories from reporting correct identification and parentage ***,a lack of familiarity with species testing protocols,interpretation guidelines and representative databases prevented over a quarter of the participating laboratories from submitting correct species determination *** laboratories showed improvement in their genotyping accuracy over ***,the use of forensically validated standards,such as a standard forensic short tandem repeat(STR)kit,preferably with an allelic ladder,and stricter guidelines for STR typing,may have prevented some common issues from occurring,such as genotyping inaccuracies,missing data,elevated stutter products and loading *** AFCTs underscore the importance of conducting routine forensic comparison tests to allow laboratories to compare results from each *** should keep improving their scientific and technical capabilities and continuously evaluate their personnel’s proficiency in critical techniques such as low copy number(LCN)analysis and species *** this is the first time that the ISAG has conducted comparison tests for forensic testing,findings from these AFCTs may serve as the foundation for continuous improvements of the overall quality of animal forensic genetic testing.

关键词： Forensic sciences forensic genetics comparison test forensic DNA analysis individual identification parentage test species test

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单线态磷宾的合成及反应活性

单线态磷宾的合成及反应活性

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中国化学会第30届学术年会

作者：刘柳 david A.ruiz Guy Bertrand 赵玉芬加利福尼亚大学圣地亚哥分校化学与生物化学系厦门大学化学系

磷宾(phosphinidene)是卡宾和氮宾的含磷类似物。磷宾具有一个单配位的磷原子,该磷原子外层具有16个电子和一个未占据的空轨道(Fig.1)。我们基于现代量子化学的计算方法,成功设计并且合成了第一例单线态的膦基磷宾。我们利用紫外光照射... 详细信息

磷宾(phosphinidene)是卡宾和氮宾的含磷类似物。磷宾具有一个单配位的磷原子,该磷原子外层具有16个电子和一个未占据的空轨道(Fig.1)。我们基于现代量子化学的计算方法,成功设计并且合成了第一例单线态的膦基磷宾。我们利用紫外光照射相应的膦基磷烯铜前体,首次在室温下分离表征了该化合物。该膦基磷宾可以在氩气下室温保存数周,并且和卡宾的化学活性相似,可以与缺电子的烯烃以及异氰反应生成相应的[2+1]环加成产物以及[1+1]偶联产物。另外,大位阻的取代基对热力学稳定磷宾起到关键作用。在没有位阻效应的影响下,单线态的磷宾会二聚生成二磷烯(R-P=P-R)。

关键词：磷宾单线态单配位磷环加成偶联

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Trends in Global and Mexico Research in Wildfires: A Bibliometric Perspective

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Open Journal of Forestry 2023年第2期13卷 182-199页

作者： Daniel Alejandro Cadena Zamudio Betsabé ruiz Guerra José Luis Arispe Vázquez José German Flores Garnica Leslie Carnero Avilés Rocío Toledo Aguilar david Heriberto Noriega Cantú Adriana Antonio Bautista Juan Mayo Hernandez david Castillo Quiroz Norma Tolama Nava Roger Guevara Hernández Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Iguala de la Independencia Guerrero México Instituto de Ecología A.C Xalapa Veracruz México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Tepatitlán Guadalajara México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Delicias Chihuahua México Universidad Autónoma Agraria Antonio Narro Saltillo Coahuila México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Saltillo Coahuila México

In the last two decades, unprecedented changes have taken place in the frequency and severity of wildfires;in different regions of the world, some fires were even classified as megafires. Although there are studies about the diverse effects of fire, which have made significant theoretical contributions, a comprehensive review of the changes in fire research is required to understand worldwide patterns, particularly in those countries where fire activity is on the rise, such is the case of Mexico. The objective of this study was to analyze the trends in the research on wildfires published in Mexico and worldwide over a 40-year timescale. For this purpose, the Web of Science database, bibliometric tools, and the keywords TI = Forest fire* OR TI = Wildfire* were used to extract as many articles as possible related to fires from 1980 to 2020, without being restricted to those studies whose title included any of the variants of the keywords. There were 8458 publications about fires in the vegetation cover, with a notable increase in the frequency of studies in the previous decade;52% of the studies were concentrated in five countries and 20% of the articles focused on the study of different aspects of the soil. Mexico ranks thirteenth in volume of scientific production and studies in the country have focused mainly on the description of the quantitative relationship between the size of the affected area and the number of occurrences in the landscape, meanwhile, studies on fires and the consequences on the biotic interactions have been little explored.

关键词： Global Warming Fire Regime Forest Ecosystems Biotic Interactions Anthropogenic Activities

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Effect of Nicotine on Dopamine and Glutathione Levels in Presence of Oligoelements in Brain Regions of Young Rats——Effect of Nicotine on Brain Regions of Rat

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Neuroscience & Medicine 2012年第3期3卷 281-286页

作者： david Calderón Guzmán Ernestina Hernández García Francisca Trujillo Jiménez Gerardo Barragán Mejía Hugo Juárez Olguín José A. Saldivar González Daniel Santamaria del angel Norma Osnaya Brizuela Departamento de Farmacología Facultad de Medicina Universidad Nacional Autónoma de México Laboratorio de Farmacología INP México City México Laboratorio de Neuroquímica Instituto Nacional de Pediatría (INP) México City México Laboratorio de Patología Experimental México City México

Aim: The purpose of this study was to understand the mechanism of nicotine mediated addiction and the role of oligoelements in reducing its effect. Methods: Male Wistar rats (weight 80 g) were treated with single and repeated doses of nicotine and/or oligoelements as follows: group 1 (control) NaCl 0.9%;group 2, nicotine (1 mg/kg);group 3, oligoelements (50 μl/rat);and group 4, nicotine (1 mg/kg) + oligoelements (50 μl/rat). All drugs were intraperitoneally administered for 4 days. Blood for the measurement of glucose was obtained from all the animals. Samples of the brain regions (cortex, hemispheres and cerebellum + medulla oblongata) of each rat were obtained and used to measure the concentrations of dopamine, GSH levels, and lipid peroxidation (TBARS) using fluorescence and spectrophotometric methods. Results: Glucose level increased in rats treated with nicotine and oligoelements (p < 0.05), while GSH level decreased in cerebellum/medulla oblongata and hemispheres (p < 0.05) of the same animals. TBARS levels increased in cerebellum/medulla oblongata and hemispheres of animals treated with nicotine and oligoelements, but decreased in the same regions (p < 0.05) in rats treated only with oligoelements. The levels of dopamine decreased in cortex and hemispheres, but increased in cerebellum/medulla and oblongata regions of rats treated with both compounds (p < 0.05). Conclusions: Nicotine and oligoelements are associated with increase in the level of glucose, an effect that was more pronounced in the group treated with both drugs. Reduction of oxidative stress and dopamine metabolism may be involved in this effect.

关键词： Glutathione Lipid Peroxidation Oxidative Stress

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局部晚期乳腺癌患者双时相18F-FDGPET/CT显像的纹理特征及基于标准摄取值的相关参数

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中华核医学与分子影像杂志 2018年第6期38卷 454-455页

作者：唐军 Ana María Garcia-Vicente david Molina Julián Pérez-Beteta Mariano AmoSalas Alicia Martínez-González Gloria Bueno María Jesús Tello-Galán angel Soriano-Castrejón 上海交通大学医学院附属苏州九龙医院核医学科 Nuclear Medicine Department University General Hospital Ciudad RealSpain

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显... 详细信息

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显像(注药后3 h显像,PET-2)。图像经软件分割后计算得到基于SUV的相关参数[最大SUV(SUVmax)、平均SUV(SUVmean)和SUV峰值(SUVpeak)]、代谢肿瘤体积(MTV)和病灶糖酵解总量(TLG)。同时计算18项三维纹理特征分析参数,其中包括行程长度矩阵(RLM)特征、共生矩阵(CM)特征和能量特征(空间能量和总能量)。研究PET-1和PET-2上述参数的差别。结果 PET-1、PET-2间基于SUV的相关参数和MTV的差异有统计学意义,与PET-1相比,PET-2的SUV相关参数更高,但MTV更低。PET-1、PET-2间有明显差异的纹理特征分析参数为短行程增强(RSE)、低灰度行程增强(LGLRE)、短行程高灰度增强(SRHGLE)、行程百分比(RP)、长行程增强(LRE)、灰度非均匀性(GLNU)、同质性(HOM)和差异性(DIS)。纹理特征分析参数与MTV和TLG相关。结论双时相18F-FDG PET/CT显像图像的纹理特征分析参数间有明显差异。因此,18F-FDG PET/CT显像时应考虑到代谢特征的动态变化,即延迟显像时肿瘤组织表现出的异质性更强,且瘤体越大异质性越强。

关键词：双时相18F-FDG PET/CT 乳腺肿瘤肿瘤异质性纹理特征

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Persistent Xerophthalmia in a Patient with Rheumatological Disease and Priiviary Sjogren’s Syndrome: Case Report from Northern Brazil

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Open Journal of Ophthalmology 2023年第2期13卷 263-266页

作者： Camile Smith de Oliveira Brito Horlando Junior Santos Lages Alcantara Joao de Joao Oliveira Leitao Limeira Julie Souza da Silvat Sebastiao Barreto Falcao Neto Joao Vlctor Oliveira de Melot Youssef Sabba Tayah david Tayah Milton ruiz Alves Federal University of Amazonas Manaus Brazil

This case study aims to contribute to the literature in order to highlight the importance of this collaboration between medical specialties. A female patient R.N.N. F, age 66, from the city of Manaus, with a previous diagnosis of Sjogren’s syndrome in regular follow-up by the Rheumatology team at the Araujo Lima outpatient clinic and referred to the Ophthalmology sector for complementary evaluation related to visual discomfort. The fundoscopy performed in the patient was within normal limits, but the symptoms experienced by her proved to be an important clinical finding, which has ratified the need for regular and multidisciplinary follow-up. This report unequivocally demonstrates that even in the face of tests considered within the expected limits for a given population, the clinical presentation can be specific and particular for each analyzed individual. Early screening exams should contemplate the patient in a holistic and individualized way whenever possible.

关键词： Sjogren’s Syndrome Ophthalmology Rheumatology Screening Disease

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外包:CFO借力用力之道

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商学院 2009年第5期 77-78页

作者： Richard J.ruiz IBM全球信息科技服务部

david是无锡一家小型软件公司的CFO。虽然金融危机也让这位年轻的CFO感受到一丝寒意,但在春意盎然的此时坐在办公室里,看着自己的财务报表,脸上依然露出了久违的笑意。通过利用与IBM的新合同,企业自身的资金能量得到释放,而巨大压力交给... 详细信息

david是无锡一家小型软件公司的CFO。虽然金融危机也让这位年轻的CFO感受到一丝寒意,但在春意盎然的此时坐在办公室里,看着自己的财务报表,脸上依然露出了久违的笑意。通过利用与IBM的新合同,企业自身的资金能量得到释放,而巨大压力交给了IBM。新合同将公司投资最大的计算机设备外包给IBM在无锡的一个云计算中心。公司现在可以借助IBM的计算能力开发他们自己的软件,而不需要自己建设相应的基础设施。随着业务的增长,还可以利用IBM获得更多的能力。

关键词： CFO 用力外包软件公司金融危机财务报表 CF0 办公室

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美国国家级干旱监测业务产品介绍

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干旱气象 2006年第1期24卷 90-94页

作者： Mark Svoboda Doug LeComte Mike Hayes Richard Heim Karin Gleason Jim angel Brad Rippey Rich Tinker Mike Palecki david Stooksbury david Miskus Scott Stephens 王涓力（译）不详中国气象局兰州干旱气象研究所甘肃兰州730020

美国需要改进干旱监测与评估方法。干旱是代价昂贵的自然灾害(联邦应急管理局(FEMA),1995;W ilhite,2000),但经常被评估和预报产品的开发者忽略。相比于其他灾害,干旱表现得更模糊并且不适合用传统的评估或预报方法,它相对缓慢的发生以... 详细信息

美国需要改进干旱监测与评估方法。干旱是代价昂贵的自然灾害(联邦应急管理局(FEMA),1995;W ilhite,2000),但经常被评估和预报产品的开发者忽略。相比于其他灾害,干旱表现得更模糊并且不适合用传统的评估或预报方法,它相对缓慢的发生以及其影响的复杂性,需要有一套新的方法来对它进行评估。干旱监测和预报技术的提高会使我们为应对干旱灾害做更好的准备工作,进行更好的应对实践,从而减少社会对干旱及其影响的脆弱性。为追踪和展示全美国干旱的程度、空间范围以及其影响,开发了新的干旱监测工具,研发了每周发布的国家级干旱监测业务产品(the DroughtMoni-tor)。该产品将干旱程度分为4个级

关键词：干旱监测产品介绍美国国家级评估方法业务自然灾害预报产品预报方法干旱灾害

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