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深圳水围柠盟人才公寓

世界建筑导报 2019年第1期34卷 42-57页

作者： Chris Lai Jasmine M.Y.Tsoi Kwan Yee Wong Cindy Yan david wen Demi Han Zachary Bao Jack Ou Nita Lin Red Liu Ann Hu Morning Dong Ananda de Vos Helene Pohl Arnound Stavenuiter Bert Oostdijk 王晓勇 DOFFICE创始点咨询(深圳)有限公司 IVY Photography & Production

在深圳,城中村一直都是一个热门的话题,多种观点相互碰撞。在过去的一二十年里,城中村的改造就意味着大规模的拆迁,彻底推倒重建,拆迁改善了生活环境,创造了财富,但导致了城市空间匀质化,同时,造成了一些社会问题,更割断了城市的历史。... 详细信息

在深圳,城中村一直都是一个热门的话题,多种观点相互碰撞。在过去的一二十年里,城中村的改造就意味着大规模的拆迁,彻底推倒重建,拆迁改善了生活环境,创造了财富,但导致了城市空间匀质化,同时,造成了一些社会问题,更割断了城市的历史。目前深圳市新出台的政策是通过综合整治,让城中村全面进入柔性改造的通道,鼓励在原来的用地上开展城中村的综合整治。然而新政策出台不久之后,却又发生了原住民反对综合整治,要求城市更新的情况。说明政策的转变对城中村的居民和开发企业都产生了很大的影响,“综合整治”和“拆除重建”的投入产出模型完全不同,两种模式的转变,意味着居民的诉求和企业的战略都应当做出相应的调整,在新形势下共同努力,继续探索。为此,我们选登了通过综合整治获得比较成功的水围村项目,该项目保留了城市的肌理、文脉和集体记忆,同时,也提升了消防、市政配套,及改善了生活设施。并增加空中连廊、电梯,创造出了一个符合现代标准的宜居空间立体的社区。该项目改造后,由政府返租补贴,并以低于市场的价格出租,以确保改造后的房源租金在可负担的范围内。水围村项目为城中村的改造提供了一种可能,并引发了社会各界对城中村改造的再思考,这也反映出有关城中村的争论还在继续,城中村的改造还需要不断的探索……

关键词：深圳市水围城中村改造柔性改造综合整治公寓人才城市空间

Ferroelectric artificial synapse for neuromorphic computing and flexible applications

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Fundamental Research 2023年第6期3卷 960-966页

作者： Qing-Xuan Li Yi-Lun Liu Yuan-Yuan Cao Tian-Yu Wang Hao Zhu Li Ji wen-Jun Liu Qing-Qing Sun david Wei Zhang Lin Chen State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China National Integrated Circuit Innovation Center No.825 Zhangheng RoadShanghai 201203China

Research of artificial synapses is increasing in popularity with the development of bioelectronics and the appearance of wearable *** the high-temperature treatment process of inorganic materials is not compatible with flexible substrates,organic ferroelectric materials that are easier to process have emerged as *** organic synaptic device based on P(VDF-TrFE)was prepared in this *** device showed reliable P/E endurance over 104 cycles and a data storage retention capability at 80℃ over 104 ***,it possessed excellent synaptic functions,including short-term/long-term synaptic plasticity and spike-timing-dependent *** addition,the ferroelectric performance of the device remained stable even under bending(7 mm bending radius)or after 500 bending *** work shows that low-temperature processed organic ferroelectric materials can provide new ideas for the future development of wearable electronics and flexible artificial synapses.

关键词： Organic artificial synapse Neuromorphic computing Synaptic devices Wearable electronics Ferroelectric

2-Hexyl-4-Pentylenic Acid(HPTA) Stimulates the Radiotherapy-induced Abscopal Effect on Distal Tumor through Polarization of Tumor-associated Macrophages

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Biomedical and Environmental Sciences 2021年第9期34卷 693-704页

作者： DUAN wen Hua JIN Li Ya CAI Zu Chao LIM david FENG Zhi Hui Department of Occupational Health and Occupational Medicine School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina School of Health Sciences Western Sydney UniversityCampbelltown 2560Australia

Objective The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid(HPTA)in combination with radiotherapy(RT)on distant unirradiated breast *** Using a rat model of chemical carcinogen(7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer,tumor volume was monitored and treatment response was evaluated by performing HE staining,immunohistochemistry,immunofluorescence,q RT-PCR,and western blot *** The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant,unirradiated breast *** mechanism of action included tumor-associated macrophage(TAM)infiltration into distant tumor tissues,M1 polarization,and inhibition of tumor angiogenesis by IFN-γ.Conclusion The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors via M1-polarized TAMs,and HPTA may be considered as a new therapeutic for amplifying the efficacy of local RT for non-targeted breast tumors.

关键词： Breast cancer Abscopal effect 2-hexyl-4-pentylenic acid(HPTA) Radiotherapy(RT) Tumor-associated macrophages(TAMs) Polarization Angiogenesis

Deep potentials for materials science

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Materials Futures 2022年第2期1卷 89-115页

作者： Tongqi wen Linfeng Zhang Han Wang Weinan E david J Srolovitz Department of Mechanical Engineering The University of Hong KongHong KongHong Kong Special Administrative Region of China DP Technology BeijingPeople’s Republic of China AI for Science Institute BeijingPeople’s Republic of China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijingPeople’s Republic of China HEDPS CAPTCollege of EngineeringPeking UniversityBeijingPeople’s Republic of China School of Mathematical Sciences Peking UniversityBeijingPeople’s Republic of China Department of Mathematics and Program in Applied and Computational Mathematics Princeton UniversityPrincetonNJUnited States of America International Digital Economy Academy(IDEA) ShenzhenPeople’s Republic of China

To fill the gap between accurate(and expensive)ab initio calculations and efficient atomistic simulations based on empirical interatomic potentials,a new class of descriptions of atomic interactions has emerged and been widely applied;*** learning potentials(MLPs).One recently developed type of MLP is the deep potential(DP)*** this review,we provide an introduction to DP methods in computational materials *** theory underlying the DP method is presented along with a step-by-step introduction to their development and *** also review materials applications of DPs in a wide range of materials *** DP Library provides a platform for the development of DPs and a database of extant *** discuss the accuracy and efficiency of DPs compared with ab initio methods and empirical potentials.

关键词： deep potential atomistic simulation machine learning potential neural network

Geology, geochronology, and exploration of the Jiama giant porphyry copper deposit (11 Mt), Tibet, China: A review

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China Geology 2023年第2期6卷 338-357,I0042-I0045页

作者： Bin Lin Ju-xing Tang Pan Tang wen-bao Zheng Yang Song Fa-qiao Li Qiu-feng Leng Zhi-chao Wang Jing Qi Miao Sun Juan david Bello Rodríguez MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Department of Geology and Geological Engineering University LavalQC G1V 0A6Canada The Key Laboratory of the Ministry of Education on Solid Waste Treatment and Recycling School of Environment and ResourceSouthwest University of Science and TechnologyMianyang 621010China Chengdu Center China Geological SurveyChengdu 610081China School of Earth Science and Resources China University of Geosciences(Beijing)Beijing 100083China

Jiama,with more than 11 Mt of copper metal,is the largest porphyry-skarn copper system in the Gangdese metallogenic belt,Tibet,China,creating ideal conditions for deciphering the origin of porphyry ores in a collision *** massive studies of the geology,chronology,petrogenesis,and ore-related fluids and their sources in Jiama,there is a lack of systematic summaries and reviews of this *** contrast to traditional porphyry copper systems in a subduction setting,recent studies and exploration suggest that the Jiama deposit includes porphyry-type Mo-Cu,skarn-type Cu polymetallic,vein-type Au and manto *** paper reviews the latest studies on the geology,chronology,petrogenesis,fluid inclusions,and isotopic geochemistry(hydrogen,oxygen,sulfur,and lead)of the Jiama ***,a multi-center complex mineralization model was constructed,indicating that multi-phase intrusions from the same magma reservoir can form multiple hydrothermal *** centers are mutually independent and form various orebodies or are superimposed on each other and form thick,high-grade ***,a new comprehensive exploration model was established for the Jiama porphyry copper *** models established in this study help to refine the theories on continental-collision metallogeny and porphyry copper systems.

关键词： Copper deposit Porphyry copper system O-S-Pb isotope Multicenter complex mineralization Comprehensive exploration model Mineral exploration engineering Gangdese metallogenic belt Jiama Tibet

Specialising neural network potentials for accurate properties and application to the mechanical response of titanium

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npj Computational Materials 2021年第1期7卷 1908-1918页

作者： Tongqi wen Rui Wang Lingyu Zhu Linfeng Zhang Han Wang david J.Srolovitz Zhaoxuan Wu Department of Materials Science and Engineering City University of Hong KongKowloonHong KongSARChina Hong Kong Institute for Advanced Study City University of Hong KongKowloonHong KongSARChina Beijing Institute of Big Data Research BeijingChina Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijingChina Department of Mechanical Engineering The University of Hong KongHong KongSARChina International Digital Economy Academy(IDEA) ShenzhenChina

Large scale atomistic simulations provide direct access to important materials phenomena not easily accessible to experiments or quantum mechanics-based calculation *** and efficient interatomic potentials are the key enabler,but their development remains a challenge for complex materials and/or complex *** learning potentials,such as the Deep Potential(DP)approach,provide robust means to produce general purpose interatomic ***,we provide a methodology for specialising machine learning potentials for high fidelity simulations of complex phenomena,where general potentials do not *** an example,we specialise a general purpose DP method to describe the mechanical response of two allotropes of titanium(in addition to other defect,thermodynamic and structural properties).The resulting DP correctly captures the structures,energies,elastic constants andγ-lines of Ti in both the HCP and BCC structures,as well as properties such as dislocation core structures,vacancy formation energies,phase transition temperatures,and thermal *** DP thus enables direct atomistic modelling of plastic and fracture behaviour of *** approach to specialising DP interatomic potential,DPspecX,for accurate reproduction of properties of interest“X”,is general and extensible to other systems and properties.

关键词： titanium enable neural

基于网络药理学探究滇黄精抗疲劳作用及其机制

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云南农业大学学报（自然科学版） 2024年第1期39卷 101-110页

作者：张楠杨帆马仲帅马舒韵李曦明温燕龙李凌飞云南农业大学食品科学技术学院云南昆明650201

【目的】基于网络药理学探究滇黄精(Polygonatum kingianum)潜在的抗疲劳机制。【方法】使用中药系统药理学数据库与分析平台(TCMSP)、CNKI和DrugBank数据库搜寻滇黄精的主要活性成分,并利用SwissTargetPrediction数据库预测各活性成分... 详细信息

【目的】基于网络药理学探究滇黄精(Polygonatum kingianum)潜在的抗疲劳机制。【方法】使用中药系统药理学数据库与分析平台(TCMSP)、CNKI和DrugBank数据库搜寻滇黄精的主要活性成分,并利用SwissTargetPrediction数据库预测各活性成分的作用靶点;通过Disgenet数据库获取与疲劳有关的靶点;借助Venny 2.1.0和Cytoscape v3.9.0构建滇黄精—活性成分—抗疲劳靶点网络,根据其节点度值筛选滇黄精的主要活性成分。通过String数据库构建蛋白质互作(protein-protein interaction,PPI)网络,通过节点度值筛选滇黄精抗疲劳的关键靶点。使用david数据库对筛选的关键靶点进行基因本体论(gene ontology,GO)分析及京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。使用AutoDock Vina软件对滇黄精的主要活性成分与抗疲劳关键靶点进行分子对接。【结果】获得滇黄精活性成分38种;预测得到滇黄精抗疲劳靶点30个;筛选出滇黄精抗疲劳的主要活性成分3个,分别是3′-甲氧基大豆苷元、黄芩素和β-谷甾醇。PPI网络分析结果表明:EGFR、STAT3、PTPN11、ERBB2、ESR1和JAK2为滇黄精抗疲劳的关键靶点。GO分析和KEGG通路分析表明:滇黄精抗疲劳作用主要涉及68个条目和39个通路。分子对接结果显示:滇黄精的主要活性成分与抗疲劳关键靶点结合稳定。【结论】本研究通过网络药理学构建了滇黄精—活性成分—抗疲劳拓扑网络,挖掘出滇黄精抗疲劳的主要活性成分及抗疲劳关键靶点,并对主要活性成分与关键靶点进行分子对接。研究结果为滇黄精的抗疲劳功效提供了理论依据。

关键词：滇黄精抗疲劳网络药理学分子对接

Vacuolar Sorting Receptor （VSR） Proteins Reach the Plasma Membrane in Germinating Pollen Tubes

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Molecular Plant 2011年第5期4卷 845-853页

作者： Hao Wang Xiao-Hong Zhuang Stefan Hillmer david G. Robinson Li-wen Jiang School of Life Sciences Centre for Cell and Developmental Biology The Chinese University of Hong Kong Shatin New Territories Hong Kong China State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong Shatin New Territories Hong Kong China Department of Cell Biology Heidelberg Institute for Plant Science University of Heidelberg Germany

Vacuolar sorting receptors （VSRs） are type I integral membrane proteins that mediate the vacuolar transport of soluble cargo proteins via prevacuolar compartments （PVCs） in plants. Confocal immunofluorescent and immunogold Electron Microscope （EM） studies have localized VSRs to PVCs or multivesicular bodies （MVBs） and trans-Golgi network （TGN） in various plant cell types, including suspension culture cells, root cells, developing and germinating seeds. Here, we provide evidence that VSRs reach plasma membrane （PM） in growing pollen tubes. Both immunofluorescent and immunogold EM studies with specific VSR antibodies show that, in addition to the previously demonstrated PVC/MVB localization, VSRs also localize to PM in lily and tobacco pollen tubes prepared from chemical fixation or high-pressure freezing/frozen substitution. Such a PM localization suggests an additional role of VSR proteins in mediating protein transport to PM and endocytosis in growing pollen tubes. Using a high-speed Spinning Disc Confocal Microscope, the possible fusion between VSR-positive PVC organelles and the PM was also observed in living tobacco pollen tubes transiently expressing the PVC reporter GFP-VSR. In contrast, the lack of a prominent PM localization of GFP-VSR in living pollen tubes may be due to the highly dynamic situation of vesicular transport in this fast-growing cell type.

关键词： Plasma membrane pollen tube vacuolar sorting receptor.

基于网络药理学及分子对接探讨恒古骨伤愈合剂抑制2型糖尿病成骨细胞铁死亡的潜在机制

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现代医药卫生 2024年第7期40卷 1081-1087页

作者：何文李宁许智杰杨茂伟姚啸生辽宁中医药大学辽宁沈阳110847 中国医科大学附属第一医院辽宁沈阳110002 辽宁中医药大学附属医院辽宁沈阳110032

目的从网络药理学及分子对接角度探讨恒古骨伤愈合剂抑制成骨细胞铁死亡治疗2型糖尿病骨质疏松症的潜在作用机制。方法通过TCMSP数据库和BATMAN-TCM数据库检索获得中药成分及作用靶点,通过GeneCards与OMIM数据库查询获得2型糖尿病骨质... 详细信息

目的从网络药理学及分子对接角度探讨恒古骨伤愈合剂抑制成骨细胞铁死亡治疗2型糖尿病骨质疏松症的潜在作用机制。方法通过TCMSP数据库和BATMAN-TCM数据库检索获得中药成分及作用靶点,通过GeneCards与OMIM数据库查询获得2型糖尿病骨质疏松症的疾病靶点。借助STRING11.0数据库构建蛋白质相互作用网络(PPI)图,进行拓扑分析,筛选网络中重要靶点。将潜在治疗靶点导入david在线数据库,进行基因本体(GO)富集分析、京都基因与基因组百科全书(KEGG)通路富集分析,最后进行分子对接模拟以验证网络药理学结果。结果通过网络药理学筛选共获得223个潜在治疗靶点。恒古骨伤愈合剂治疗2型糖尿病骨质疏松的关键活性物质为木犀草素、20(R)-人参皂苷Rh2、山柰酚、黄芩素、β-谷甾醇等,关键靶点为白细胞介素-6(IL-6)、蛋白激酶B1(Akt1)、肿瘤坏死因子(TNF)、丝裂原活化蛋白激酶3(MAPK3)、缺氧诱导因子-1A(HIF-1A)等。GO和KEGG富集分析结果表明,恒古骨伤愈合剂治疗2型糖尿病骨质疏松主要包括脂多糖的反应、对缺氧的反应、炎症反应等生物学过程,调控HIF-1A、TNF、IL-17、磷脂酰肌醇-3-激酶/蛋白激酶B(PI3K/Akt)等信号通路。分子对接结果表明7-O-甲基异微凸剑叶莎醇、黄芩素、山柰酚、槲皮素与HIF-1A均有较好的结合活性。结论通过网络药理学和分子对接技术发现恒古骨伤愈合剂可能通过多靶点治疗2型糖尿病骨质疏松,可能通过HIF-1A信号通路减少氧化应激,抑制成骨细胞铁死亡,达到治疗2型糖尿病骨质疏松症的目的。

关键词：恒古骨伤愈合剂 2型糖尿病骨质疏松网络药理学铁死亡氧化应激