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Essential oils and functional herbs for healthy aging

Neural Regeneration Research 2019年第3期14卷 441-445页

作者： Snezana Agatonovic-Kustrin Ella Kustrin david w.morton Department of Pharmaceutical and Toxicological Chemistry named after Arzamastsev of the Institute of Pharmacy I.M.Sechenov First Moscow State Medical University(Sechenov University) Sunway College School of Pharmacy and Applied Science La Trobe Institute for Molecular Sciences La Trobe University

As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Recent studies have linked diabetes as a risk factor in developing Alzheimer's disease and other types of dementia. The incidence of patients with type II diabetes and increased levels and activity of α-amylase is higher in patients with dementia. It has been shown that aromatherapy with essential oils from the mint family can improve cognitive performance in Alzheimer's disease patients. Selected monoterpenoids from these essential oils are reported to inhibit acetylcholinesterase, both in vitro and in vivo. Terpenoids are small, fat-soluble organic molecules that can transfer across nasal mucosa if inhaled, or penetrate through the skin after topical application, enter into the blood and cross the blood-brain barrier. Recent evidence supports the idea that the common constituents of essential oils also inhibit α-amylase, a starch digestive enzyme that plays an important role in the control of diabetes. The mint family is a fragrant plant family that contains most of the culinary herbs found in the Mediterranean diet. The Mediterranean diet is considered to be one of the healthiest diets in the world, and is found to be beneficial not only for the heart but also for the brain. Herbs used in this diet are rich in antioxidants that can prevent oxidative damage caused by free radicals. However, our study shows that they also contain biologically active compounds with potent α-amylase and acetylcholinesterase inhibitory activities. Consumption of fresh herbs can help boost memory and reduce sugar levels in the body. The use of herbs as a functional food could lead to significant i

关键词： functional herbs essential oils dementia mediterranean diet diabetes acetylcholinesterase α-amylase mint family

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An Exome-seq Based Tool for Mapping and Selection of Candidate Genes in Maize Deletion Mutants

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Genomics, Proteomics & Bioinformatics 2018年第6期16卷 439-450页

作者： Shangang Jia Kyla morton Chi Zhang david Holding Department of Agronomy and Horticulture Center for Plant Science InnovationBeadle Center for BiotechnologyUniversity of Nebraska School of Biological Sciences Center for Plant Science InnovationBeadle Center for BiotechnologyUniversity of Nebraska

Despite the large number of genomic and transcriptomic resources in maize, there is still much to learn about the function of genes in developmental and biochemical processes. Some maize mutants that were generated by gamma-irradiation showed clear segregation for the kernel phenotypes in B73 ? Mo17 F2 ears. To better understand the functional genomics of kernel development,we developed a mapping and gene identi?cation pipeline, bulked segregant exome sequencing(BSEx-seq), to map mutants with kernel phenotypes including opaque endosperm and reduced kernel size. BSEx-seq generates and compares the sequence of the exon fraction from mutant and normal plant F2 DNA pools. The comparison can derive mapping peaks, identify deletions within the mapping peak, and suggest candidate genes within the deleted regions. we then used the public kernel-speci?c expression data to narrow down the list of candidate genes/mutations and identi?ed deletions ranging from several kb to more than 1 Mb. A full deletion allele of the Opaque-2 gene was identi?ed in mutant 531, which occurs within a $200-kb deletion. Opaque mutant 1486 has a 6248-bp deletion in the mapping interval containing two candidate genes encoding RNA-directed DNA methylation 4(RdDM4) and AMP-binding protein, respectively. This study demonstrates the ef?-ciency and cost-effectiveness of BSEx-seq for causal mutation mapping and candidate gene selection,providing a new option in mapping-by-sequencing for maize functional genomics studies.

关键词： Maize functional genomics Mapping-by-sequencing Exome-seq Opaque mutant Bulked segregation analysis

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Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery

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Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 528-540页

作者： Satu Lakio david A.V.morton Anna P.Ralph Pete Lambert Drug Delivery Disposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVictoria 3052Australia Global and Tropical Health Division Menzies School of Health ResearchDarwinNorthern TerritoryAustralia Department of Medicine Royal Darwin HospitalDarwinNorthern TerritoryAustralia AstraZeneca R&D Pepparedsleden 143183 MölndalSweden

In this study a carrier-free dry powder inhalation(DPI)containing L-arginine(ARG)was *** such,it is proposed that ARG could be used for adjunctive treatment of cystic fibrosis and/or *** processing methods were used to manufacture highdose formulation batches consisting various amounts of ARG and *** formulations were evaluated using several analytical methods to assess suitability for further *** batches had enhanced in vitro aerolization *** future challenges include the highly hygroscopic nature of unformulated ARG powder and identifying the scale of dose of ARG required to achieve the response in lungs.

关键词： Pulmonary delivery L-arginine Spray drying Mechanofusion Dry powder inhaler(DPI) Formulation

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ABSORPTION LINES IN THE SPECTRA OF THE QSO PKS 1448-232

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Chinese Science Bulletin 1983年第8期28卷 1075-1080页

作者：陈建生 DONALD C.morton BRUCE A.PETERSON ALAN E.wRIGHT david L.JAUNCEY Beijing Observatory Academia Sinica Anglo-Australian Obserratory Mt. Stromlo and Siding Spring Observatory Australian National Radio Astronomical Observatory CSIRO Division of Radiophysics. OLD AND NEw OBSERVATIONS Savage Bolton and Wright found that the radio source PKS 1448-232 coincided with a stellar object of a magnitude about 16.4 having an ultraviolet excess. A lowresolution spectrum obtained with the Anglo-Australian 3.~m9 Telescope (AAT) confirmed this object to be a QSO with z_(em)=2.22 and revealed many absorption lines

I. OLD AND NEw OBSERVATIONS Savage, Bolton and wright, found that the radio source PKS 1448-232 coincided with a stellar object of a magnitude about 16.4 having an ultraviolet excess. A lowresolution spectrum obtained with the Anglo-Australian 3.m9 Telescope （AAT） confirmed this object to be a QSO with zem=2.22, and revealed many absorption

关键词： Bolton Australian stellar ultraviolet Anglo Savage magnitude excess morton inverted

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桃园国际机场:一道东亚门户

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空中英语教室（高级版．彭蒙惠英语） 2019年第11期 6-7,38页

作者： david morton VICKY TSUNG 陈信宏(译) 不详

旧称中正国际机场的台湾桃园国际机场,是台湾地区最大的机场。这座机场在1979年正式启用后,至今在Skvtrax颁发的2019年世界最佳机场大奖当中,攀升到第13名。这座原本规模不大的机场如何转变为东亚的国际旅行枢纽?

关键词：国际机场东亚桃园台湾地区

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军用柔性显示器的发展

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现代显示 2008年第3期 27-30,40页

作者： david morton Eric Forsythe 刘文景军用研究实验室东南大学显示技术研究中心

美国军队长期以来一直肯定显示技术在军队系统中所发挥的重要作用,持续支持发展当前的平板显示技术。可折叠显示技术可提供一个比玻璃基显示器更有利的军队应用,因此,美国军队正在支持柔性显示器的研发设计以加速其商品化进程。

关键词：柔性显示器电泳显示胆甾液晶有机发光二极管等离子显示器有源矩阵液晶显示器

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Letter FROM YOUR Editor

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空中英语教室（高级版．彭蒙惠英语） 2019年第4期 1-1页

作者： david morton 不详

Dear readers,The rainy days of April will soon turn our skies gray. But take heart! April showers bring bright May flowers, and soon the air will have the fresh, sweet aroma of spring.

关键词： Letter Editor

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Reimagining large river management using the Resist-Accept-Direct(RAD)framework in the Upper Mississippi River

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Ecological Processes 2023年第1期12卷 645-664页

作者： Nicole K.ward Abigail J.Lynch Erik A.Beever Joshua Booker Kristen L.Bouska Holly Embke Jeffrey N.Houser John F.Kocik Joshua Kocik david J.Lawrence Mary Grace Lemon Doug Limpinsel Madeline R.Magee Bryan M.Maitland Owen McKenna Andrew Meier John M.morton Jeffrey D.Muehlbauer Robert Newman Devon C.Oliver Heidi M.Rantala Greg G.Sass Aaron Shultz Laura M.Thompson Jennifer L.wilkening Minnesota Department of Natural Resources Lake CityMN 55041USA U.S.Geological Survey National Climate Adaptation Science CenterRestonVA 22041USA U.S.Geological Survey Northern Rocky Mountain Science CenterBozemanMT 59715USA Department of Ecology Montana State UniversityBozemanMT 59715USA U.S.Fish and wildlife Service National Wildlife Refuge SystemOak HarborOH 43449USA U.S.Geological Survey Upper Midwest Environmental Sciences CenterLa CrosseWI 54603USA U.S.Geological Survey Midwest Climate Adaptation Science CenterSt.PaulMN 55108USA NOAA NEFSC OronoME 04473USA University of Nebraska-Lincoln LincolnNE 68503USA National Park Service Climate Change Response ProgramFort CollinsCO 80525USA U.S.Fish and wild-life Service National Wildlife Refuge SystemBloomingtonMN 55437USA Habitat Conservation Division NOAAAlaska RegionAnchorageAK 99513USA wisconsin Department of Natural Resources MadisonWI 53703USA Aquatic Sciences Center Center for LimnologyUW-MadisonMadisonWI 53706USA U.S.Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science CenterJamestownND 58401USA U.S.Army Corps of Engineers La CrescentMN 55947USA Alaska wildlife Alliance AnchorageAK 99520USA U.S.Geological Survey Alaska Cooperative Fish and Wildlife Research UnitUniversity of Alaska FairbanksFairbanksAK 99775USA University of North Dakota Grand ForksND 58202USA Minnesota Department of Natural Resources DuluthMN 55804USA wisconsin Department of Natural Resources Boulder JunctionWI 54512USA Great Lakes Indian Fish and wildlife Commission(GLIFwC) OdanahWI 54861USA U.S.Geological Survey National Climate Adaptation Science Centerand School of Natural ResourcesUniversity of TennesseeKnoxvilleTN 37996USA U.S.Fish and wildlife Service National Wildlife Refuge SystemFort CollinsCO 80526USA

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprec-edented social-ecological transformations as climate change and other global stressors *** interconnected,dendritic habitats of rivers,which often demarcate jurisdictional boundaries,generate complex management ***,we explore how the Resist–Accept–Direct(RAD)framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of *** RAD frame-work identifies the full decision space of potential management approaches,wherein managers may resist change to maintain historical conditions,accept change toward different conditions,or direct change to a specified future with novel *** the Upper Mississippi River System,managers are facing social-ecological transformations from more frequent and extreme high-water *** illustrate how RAD-informed basin-,reach-,and site-scale decisions could:(1)provide cross-spatial scale framing;(2)open the entire decision space of potential management approaches;and(3)enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River *** The RAD framework helps identify plausible long-term trajectories in different reaches(or subbasins)of the river and how the associated social-ecological transformations could be managed by altering site-scale *** reach-scale objectives may reprioritize how,where,and when site conditions could be altered to contribute to the basin goal,given the basin’s plausible trajectories of change(e.g.,by coordinating action across sites to alter habitat connectivity,diversity,and redundancy in the river mosaic).Conclusions when faced with long-term systemic transformations(e.g.,>50 years),the RAD framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable,and direct options may open y

关键词： Ecosystem Management Transformation Social-ecological system Anthropocene Climate change Basin planning Cross-scale interactions

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开普敦宣言--推动发展中国家心脏外科手术的开展(中文译文)

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中国循环杂志 2018年第9期33卷 833-834页

作者： Peter Zilla R.morton Bolman Magdi H.Yacoub Friedhelm Beyersdorf Karen Sliwa Liesl Zühlke Robert S.D.Higgins Bongani Mayosgi Alain Carpentier david william 张浩李飞 Christiaan Barnard Department Faculty of Health Sciences University of Cape Town Cape Town South Africa Division of Cardiothoracie Surgery University of Vermont Burlington Vermont America Chain of Hope Chelsea London United Kingdom

目标：敦促国际心脏外科组织机构、工业体系、政府部门等相关领域共同致力于建立一套行之有效的战略措施,通过加强开展＂抢救式＂心脏外科手术的方式,解决发展中国家因风湿性心脏病（RHD）所带来的问题。12年前,来自全球的心脏病学家和... 详细信息

目标：敦促国际心脏外科组织机构、工业体系、政府部门等相关领域共同致力于建立一套行之有效的战略措施,通过加强开展＂抢救式＂心脏外科手术的方式,解决发展中国家因风湿性心脏病（RHD）所带来的问题。12年前,来自全球的心脏病学家和心脏外科医生共同发布了致力于控制非洲地区风湿热和RHD的＂德拉肯斯堡宣言（Drakensberg Declaration）＂.

关键词：心脏外科手术发展中国家宣言译文中文风湿性心脏病心脏病学家组织机构

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47岁男性患者视网膜中央静脉阻塞后的脉络膜新生血管膜

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美国医学会眼科杂志（中文版） 2005年第2期17卷 109-111页

作者： david A. DiLoreto morton F. Goldberg Neil M. Bressler 王建民（译）马景学（校）

1例46岁白人男性患者被转诊于马里兰州巴尔地摩市wilmer眼科研究所，对其患有的黄斑水肿进行诊治。5个月前，转诊眼科医生通过眼底照像和眼底荧光血管造影检查，诊断他的右眼患有无灌注性的视网膜中央静脉阻塞（CVO）（图1）。患者有高... 详细信息

1例46岁白人男性患者被转诊于马里兰州巴尔地摩市wilmer眼科研究所，对其患有的黄斑水肿进行诊治。5个月前，转诊眼科医生通过眼底照像和眼底荧光血管造影检查，诊断他的右眼患有无灌注性的视网膜中央静脉阻塞（CVO）（图1）。患者有高胆固醇血症的病史，服用的药物包括阿司匹林和降脂药物。

关键词：视网膜中央静脉阻塞脉络膜新生血管膜男性患者眼底荧光血管造影检查高胆固醇血症降脂药物眼科研究所黄斑水肿眼底照像眼科医生

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