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Effect of Added Cu(OTf)2on the Cu(OTf)2(Py)4-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates

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Natural Science 2018年第3期10卷 125-133页

作者： david w. Blevins George w. Kabalka Dustin R. osborne Murthy R. Akula Department of Radiology University of Tennessee Medical Center Knoxville Tennessee USA Department of Chemistry University of Tennessee Knoxville Tennessee USA

Cu(OTf)2(Py)4 mediated radiofluorination of the boronate esters of ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper complex follow.ng the literature procedure did not provide the fluorinated products. How.ver, the addition of Cu(OTf)2resulted in the radio-fluorination of the boronate esters 11 and 16 to obtain ethyl 4-[18F]fluorobenzoyl glycinate, 17, (48%) and ethyl 3-[18F]phthaloylglycinate (41%) respectively.

关键词： Glycinates Boronate Esters Gorlos-Phos Radiofluorination Copper Triflate

Sequential Preparation of [18F]FLT and [18F]FMISO Employing Advion NanoTek®Microfluidic Synthesis System

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Advances in Molecular Imaging 2019年第4期9卷 53-59页

作者： Murthy R. Akula Thomas L. Collier david w. Blevins George w. Kabalka Dustin osborne

One of the commercially available capillary-based microfluidic synthesizers is Advion NanoTek Microfluidic Synthesis System and is currently being used across the globe. The goal of this study is to demonstrate the system capability to perform the synthesis of tw. compounds sequentially w.thout cleaning the equipment betw.en the syntheses. w. have chosen to prepare tw. key radiotracers [F-18]FLT and [F-18]FMISO. The basic microfluidic flow.chemistry module w.s reconfigured to allow.the hydrolysis of the second tracer in a vial using reactor 1 as a heat source and the system w.s integrated to semi-preparative high-performance liquid chromatography w.th a column selector and solvent selector. The decay corrected radio chemical yields of [18F]FLT and [18F]FMISO w.re found to be 28.5% and 38.6% respectively. The specific activity w.s determined to be >2 Ci/μmol.

关键词： Sequential Microfluidic [18F]FLT [18F]FMISO

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爱的信笺

新东方英语（中英文版） 2010年第12期 52-54页

作者： david osborne 蒋明思

你问过我，当我出航时，你可以寄什么给我——在千里之外的航船上，那些我想要却无法得到的东西。我想这份清单不难列出，只恐不易兑现。

关键词：英语翻译方法译文阅读材料

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节能的现代热风炉

节能的现代热风炉

中国金属学会2003中国钢铁年会

作者： david osborne 奥钢联工业(英国)有限公司

本篇论文讨论了新建和改造热风炉的现代设计,包括改善热风炉温度、炉容、炉役等,并且还论述了现代内部和外部燃烧室热风炉的典型生产参数。也考虑了热风炉和高炉在单位能源消耗上降低的可能性。考虑了不同大小的高炉,其热风炉的选择有... 详细信息

本篇论文讨论了新建和改造热风炉的现代设计,包括改善热风炉温度、炉容、炉役等,并且还论述了现代内部和外部燃烧室热风炉的典型生产参数。也考虑了热风炉和高炉在单位能源消耗上降低的可能性。考虑了不同大小的高炉,其热风炉的选择有所不同,并且还讨论了提高废热的回收效果。

关键词：现代热风炉热风温度耐材设计陶瓷喷嘴降低的能源消耗废热回收

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太空商业的前景

世界科学 1987年第2期 10-13页

作者： david osborne 陈正权

今天,太空业的本质就是开拓新的经济领域。自从人类首次进入太空迄今仅仅四分之一世纪,就已有数百家公司直接参与了太空商业活动。今后二十五年里,太空商业活动的规模将可与今天的电子计算机工业相媲美。未来学家们指出,此后的二十五年... 详细信息

今天,太空业的本质就是开拓新的经济领域。自从人类首次进入太空迄今仅仅四分之一世纪,就已有数百家公司直接参与了太空商业活动。今后二十五年里,太空商业活动的规模将可与今天的电子计算机工业相媲美。未来学家们指出,此后的二十五年将会取得更伟大的成绩:在太空设置的太阳能板组可通过微波把电能传送到地球上;在月球和其他星球上开采矿物;也许,人类还会在火星上定居。位于马萨诸塞州坎

关键词：地球同步轨道宇航局国家航空卫星轨道太空站航天飞机

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把爱寄绐我

疯狂英语（阅读版） 2006年第9期 45-47页

作者： david E.osborne 朱俊

这是一位即将退役的海军写给新婚妻子的书信。读罢,不禁想起了林觉民的《与妻书》,“窗外疏梅筛月影,依稀掩映,吾与汝并肩携手,低低切切,何事不语,何情不诉!……”两封“与妻书”,一中一外,一古一今,同中有异。新婚燕尔,分隔两地,借信... 详细信息

这是一位即将退役的海军写给新婚妻子的书信。读罢,不禁想起了林觉民的《与妻书》,“窗外疏梅筛月影,依稀掩映,吾与汝并肩携手,低低切切,何事不语,何情不诉!……”两封“与妻书”,一中一外,一古一今,同中有异。新婚燕尔,分隔两地,借信笺传情,字里行间无不流露出浓情蜜意,这是两者的共同点。但由于所处时代以及环境等种种不同,两者又各有特色:海军的“与妻书”通过一系列的排比句细说深情和思念,将爱情的甜蜜和生活的幸福烘托得恰到好处;而林觉民的《与妻书》,确切说是“与妻诀别书”,却是一字一血泪,一语一悲恸!有心的读者不妨把两者对比来读,相信会有所感悟。

关键词：圣诞树南瓜装饰雪人气味冰柱满月伪装海盗海军

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政府的优势和局限性——如何提供有效的公共服务

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杭州 2007年第1期 75-77页

作者： david osborne Ted Gaebler 朱云夫

本文译自美国政治研究专家奥斯本和盖伯勒合著的《重塑政府》一书的附录,略有增删。文中就如何采用最有效的服务种类,对三类社会组织(即公共部门,一般指政府;私营部门;非赢利机构等第三部门**)的擅长和局限性进行了比较,给出了判断标准... 详细信息

本文译自美国政治研究专家奥斯本和盖伯勒合著的《重塑政府》一书的附录,略有增删。文中就如何采用最有效的服务种类,对三类社会组织(即公共部门,一般指政府;私营部门;非赢利机构等第三部门**)的擅长和局限性进行了比较,给出了判断标准,希望对我们构建和谐社会有所启发。

关键词：第三部门私营部门公共部门重塑政府非赢利局限性公共服务判断标准政府服务优势

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脊髓性肌萎缩症的分子及病理机制

脊髓性肌萎缩症的分子及病理机制

Observatory science w.th eXTP

中华医学会第十八次全国神经病学学术会议

作者：孔玲玲 david Valdivia Noah Pyles Melissa Crow.er Rhiannon Desideri Crystal Davis Melissa osborne Yimin Hua Adrian Krainer Frank Rigo Frank Bennett Cathleen Lutz Kathryn J.Sw.doba Tom Craw.ord Charlotte J.Sumner Department of Neurology Johns Hopkins University School of Medicine The Jackson Laboratory Cold Spring Harbor Laboratory Isis Pharmaceuticals Neuroscience Johns Hopkins University School of Medicine

Background Promising treatments that increase SMN expression and markedly improve disease outcomes in SMA mice are currently advancing to clinical trials in SMA patients.Although preclinical therapeutic studies highlight the requirement for early intervention,there is little human data to guide w.en SMN induction may be required in human patients.In order to advance our understanding of human SMA,w. are characterizing

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Row.inson Gloria Sala Giulia Stratta Thomas M.Tauris Joern w.lms XueFeng w. Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio david R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edw.rd F.Brow. Niccolo Bucciantini Luciano Burderi Edw.rd M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew.Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Gallow.y Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iw.saw. Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kaw.i Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-w.i Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Bisw.jit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-w.instein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternw.rte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New.York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this w.ite Paper w. present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting w.ite dw.rfs, low.and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP w.ll be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar w.nds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational w.ves

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