Effect of Added Cu(OTf)<sub>2</sub>on the Cu(OTf)<sub>2</sub>(Py)<sub>4</sub>-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates
Effect of Added Cu(OTf)<sub>2</sub>on the Cu(OTf)<sub>2</sub>(Py)<sub>4</sub>-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates作者机构：Department of Radiology University of Tennessee Medical Center Knoxville Tennessee USA Department of Chemistry University of Tennessee Knoxville Tennessee USA
出 版 物：《Natural Science》 (自然科学期刊（英文）)
年 卷 期：2018年第10卷第3期
页 面：125-133页
主 题：Glycinates Boronate Esters Gorlos-Phos Radiofluorination Copper Triflate
摘 要：Cu(OTf)2(Py)4 mediated radiofluorination of the boronate esters of ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper complex following the literature procedure did not provide the fluorinated products. However, the addition of Cu(OTf)2resulted in the radio-fluorination of the boronate esters 11 and 16 to obtain ethyl 4-[18F]fluorobenzoyl glycinate, 17, (48%) and ethyl 3-[18F]phthaloylglycinate (41%) respectively.
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