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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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儿童肥胖是一种慢性病：控制体重

美国医学会杂志（中文版） 2008年第3期27卷 183-184页

作者： Erinn T. Rhodes, MD, MPH david s. ludwig, MD, PhD 李建国(译) 杨霁云(校) Division of Endocrinology Children's Hospital Bostonand Department of PediatricsHarvard Medical SchoolBostonMassachusetts

儿童面临的医学问题在很多方面与成人不同，因此，对他们的评估、处理和结果的判定必须给予特殊的考虑。几十年前，儿童保健主要集中在急性感染性疾病和缺乏特异性治疗的慢性病，然而在今天，儿童保健则必须重视慢性疾病的生物学和社会... 详细信息

儿童面临的医学问题在很多方面与成人不同，因此，对他们的评估、处理和结果的判定必须给予特殊的考虑。几十年前，儿童保健主要集中在急性感染性疾病和缺乏特异性治疗的慢性病，然而在今天，儿童保健则必须重视慢性疾病的生物学和社会因素。儿童肥胖已经成为这种新型挑战的典型代表，在病人的日常保健中必须充分考虑疾病的生物、心理及社会背景。

关键词：儿童肥胖慢性病控制体重急性感染性疾病儿童保健特异性治疗医学问题社会因素

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儿童使用他汀类药物的隐忧

中国处方药 2008年第10期7卷 9-9页

作者： sarah de Ferranti david s.ludwig Creaty

AAP的新指南既要权衡药物治疗对儿童的未知风险，又要达到预防成年后冠心病发病的目的。

关键词：他汀类药物儿童药物治疗新指南 AAP 冠心病

Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Discovery of new materials using combinatorial synthesis and high-throughput characterization of thin-film materials libraries combined with computational methods

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npj Computational Materials 2019年第1期5卷 547-553页

作者： Alfred ludwig Chair for Materials Discovery and Interfaces Institute for MaterialsFaculty of Mechanical EngineeringRuhr University BochumBochumGermany ZGH Ruhr University BochumBochumGermany

This perspective provides an experimentalist’s view on materials discovery in multinary materials systems—from nanoparticles over thin films to bulk—based on combinatorial thin-film synthesis and high-throughput characterization in connection with highthroughput calculations and materials *** multinary materials systems as well as composition gradients which cover all materials compositions necessary for verification/falsification of hypotheses and predictions are efficiently fabricated by combinatorial synthesis of thin-film materials *** high-quality high-throughput characterization methods enable comprehensive determination of compositional,structural and(multi)functional properties of the materials contained in the *** created multidimensional datasets enable data-driven materials discoveries and support efficient optimization of newly identified materials,using combinatorial ***,these datasets are the basis for multifunctional existence diagrams,comprising correlations between composition,processing,structure and properties,which can be used for the design of future materials.

关键词： synthesis film characterization

securing Data in Multimode Fibers by Exploiting Mode-Dependent Light Propagation Effects

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Research 2023年第3期2023卷 669-682页

作者： stefan Rothe Karl-ludwig Besser david Krause Robert Kuschmierz Nektarios Koukourakis Eduard Jorswieck Jürgen W.Czarske TU Dresden Faculty of Electrical and Computer EngineeringLaboratory of Measurement and Sensor System Technique01062 DresdenGermany TU Braunschweig Faculty of Electrical EngineeringInformation TechnologyPhysicsInstitute for Communications Technology38106 BraunschweigGermany TU Dresden Faculty of Physics01062 DresdenGermany

Multimode fibers hold great promise to advance data rates in optical communications but come with the challenge to compensate for modal crosstalk and mode-dependent losses,resulting in strong *** holographic measurement of the transmission matrix enables not only correcting distortions but also harnessing these effects for creating a confidential data connection between legitimate communication parties,Alice and *** feasibility of this physical-layer-security-based approach is demonstrated experimentally for the first time on a multimode fiber link to which the eavesdropper Eve is physically *** the proper structured light field is launched at Alice’s side,the message can be delivered to Bob,and,simultaneously,the decipherment for an illegitimate wiretapper Eve is *** a real communication scenario,we implement wiretap codes and demonstrate confidentiality by quantifying the level of *** to an uncoded data transmission,the amount of securely exchanged data is enhanced by a factor of *** complex light transportation phenomena that have long been considered limiting and have restricted the widespread use of multimode fiber are exploited for opening new perspectives on information security in spatial multiplexing communication systems.

关键词： distortion destroyed holographic

Current state-of-the-art review of footwear–ground friction

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Friction 2024年第10期12卷 2188-2204页

作者： david REBENDA Tomáš sÁHA Footwear Research Centre University InstituteTomas Bata University in ZlinZlin 76001Czech Republic Faculty of Mechanical Engineering Brno University of TechnologyBron 61600Czech Republic

The most important role of footwear is to ensure safe,functional walking,and foot *** the proper functionality of not only the work shoes,the anti-slip behavior of the shoe under various conditions and environments plays an important role in the prevention of slips,trips,falls,and consequent *** article is intended to review the current understanding of the frictional mechanisms between shoe outsoles and various counterfaces that impact the evaluation of outsole *** research focuses on the mechanisms driving outsole friction on different ground surfaces or the definition and description of parameters that influence outsole ***,the review discusses the effect of various surface contaminants on footwear ***,challenges and outlooks in the field of footwear outsoles are briefly mentioned.

关键词： shoe outsole composite slipperiness coefficient of friction(COF) adhesion safe walk

Combined ab-interno trabeculectomy and cataract surgery induces comparable intraocular pressure reduction in supine and sitting positions

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1192-1198页

作者： Caroline Gietzelt david Kiessling Randolf AWidder ludwig MHeindl Claus Cursiefen Thomas sDietlein Philip Enders Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneKerpener Straße 62Cologne 50924Germany Glaucoma Imaging Center University of Cologne(GICC) Faculty of Medicine and University Hospital CologneKerpener Straße 62Cologne 50924Germany Department of Ophthalmology St Martinus-Krankenhaus DuesseldorfGladbacher Straße 26Düsseldorf 40219Germany

AIM:To analyze the therapeutic effect of combined abinterno trabeculectomy and cataract surgery on intraocular pressure(IOP)levels in supine and sitting postures during a 24-hour IOP ***:Twenty-six eyes of twenty-six patients receiving ab-interno trabeculectomy using electroablation of the trabecular meshwork combined with cataract surgery or stand-alone were included in this retrospective *** change during 24-hour IOP profiles within two years postoperatively were analyzed for eyes receiving surgery(“study eyes”)and compared to fellow eyes,which had not received *** data including mean sitting IOP(siIOP),mean supine IOP(su IOP)and the number of topical antiglaucomatous medications(TAM)were extracted from patients’***:Preoperatively,si IOP was 17.6±5.3 mm Hg in study and 17.1±4.7 mm Hg in fellow eyes(P=0.347).Patients were treated with an average of 2.8±1.0 *** corrected visual acuity(BCVA)was significantly worse in study eyes(Psual field function was marginally not significantly dif ferent(P=0.057).Af ter surger y 9.6±6.8 mo,study eyes had a mean si IOP of 14.5±3.6 mm Hg(IOP reduction:-3.2 mm Hg,P=0.009),a mean su IOP of 18.0±3.5 mm Hg,and an average of 1.3±1.34 TAM(Ps,mean si IOP was 16.2±3.4 mm Hg and mean su IOP was 20.5±5.1 mm ***,the relative IOP increase between sitting and supine postures was approximately 30%in both study and fellow eyes(P=0.99).CONCLUsION:IOP after ab-interno trabeculectomy shows a comparable relative reduction in both supine and sitting *** trabeculectomy is known to lower su IOP overproportionally.

关键词： glaucoma ab-interno trabeculectomy supine intraocular pressure posture-induced intraocular pressure increase intraocular pressure

Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders

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Neural Regeneration Research 2018年第8期13卷 1322-1326页

作者： Mahesh Kandasamy ludwig Aigner Laboratory of stem Cells and Neuroregeneration Department of Animal Science School of Life Sciences Bharathidasan University Faculty Recharge Programme University Grants Commission (UGC-FRP) Institute of Molecular Regenerative Medicine Salzburg Paracelsus Medical University spinal Cord Injury and Tissue Regeneration Center Salzburg Paracelsus Medical University

The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of neuroplasticity in the intact brain and contributes to neural regeneration in response to brain diseases and injury. The occurrence of adult neurogenesis has unequivocally been witnessed in human subjects, experimental and wildlife research including rodents, bats and cetaceans. Adult neurogenesis is a complex cellular process, in which generation of neuroblasts namely, neuroblastosis appears to be an integral process that occur in the limbic system and basal ganglia in addition to the canonical neurogenic niches. Neuroblastosis can be regulated by various factors and contributes to different functions of the brain. The characteristics and fate of neuroblasts have been found to be different among mammals regardless of their cognitive functions. Recently, regulation of neuroblastosis has been proposed for the sensorimotor interface and regenerative neuroplasticity of the adult brain. Hence, the understanding of adult neurogenesis at the functional level of neuroblasts requires a great scientific attention. Therefore, this mini-review provides a glimpse into the conceptual development of neuroplasticity, discusses the possible role of different types of neuroblasts and signifies neuroregenerative failure as a potential cause of dementia.

关键词： neuroplasticity adult neurogenesis neuroblasts reactive neuroblastosis hippocampus ultrasound neuroregenerative disorders neotrophy echolocation