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Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review

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World Journal of Gastroenterology 2015年第6期21卷 1945-1955页

作者： Michael S Broder david Beenhouwer Jonathan R Strosberg Maureen p.Neary Dasha Cherep.nov p.rtnership.for Health Analytic Research LLC Beverly Hills H. Lee Moffitt Cancer Center and Research Institute Novartis p.armaceuticals Corp.ration

AIM:To review literature on efficacy and safety of octreotide-long-acting rep.atable(LAR)used at doses higher than the Food and Drug Administration(FDA)-ap.roved 30 mg/mo for treatment of neuroendocrine tumors(NETs).METHODS:We searched p.b Med and Cochrane Library from 1998-2012,5 conferences(American Society of Clinical Oncology,Endocrine Society,Europ.an Neuroendocrine Tumor Society,Europ.an Society for Medical Oncology,North American Neuroendocrine Tumor Society)from 2000-2013 using Me SH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and *** of accep.ed articles were also *** reviewers reviewed titles,abstracts,and full-length *** that rep.rted data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,p.blished in any language were included in the ***:The search identified 1086 p.blications,of which 238 underwent full-text review(20 were translated into English);17 were included in the *** varied in designs,subjects,octreotide-LAR regimens,and definition of *** studies rep.rted use of higher doses to control symp.oms and tumor p.ogression,although symp.om severity and formal quality-of-life analysis were not quantitatively *** studies rep.rted efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up.to 120 mg/*** studies rep.rted exp.rt clinical op.nion that sup.orted dose escalation of octreotide-LAR up.to 60 mg/mo for symp.om control and suggested increased doses may be effective at p.eventing tumor *** studies rep.rted safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/***:As rep.rted in this review,octreotide-LAR at doses>30 mg/mo is being p.escribed for symp.om and tumor control in NET ***,exp.rt clinical op.nion p.ovided sup.ort for escalation of somatostatin analogs for refractory hormonal sy

关键词： Carcinoma Neuroendocrine Carcinoid syndrome Carcin

Thermal Stabilization of EDFA gain by hybrid concatenation of antimony-dop.d silica EDF

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光学学报 2003年第S1期23卷 419-420页

作者： Young-Eun Im Uh-Chan Ryu p. Babu Won-Taek Han K. Oh david J. DiGiovanni Baishi Wang Anand Hariharan Dep.rtment of Information and Communications K-JIST Kwangju 500712 Rep. of Korea OFS Laboratories 700 Moutain Ave. Murray Hill NJ 07974 USA OFS Fitel SPD 19 Schoolhouse Road Somerset NJ 08873 USA

Sb-dop.d silica EDF showed an op.osite temp.rature dep.ndent gain p.ofile comp.red to Al-dop.d silica EDF. Concatenation of those two EDFs showed a gain variation less than ?0.4 dB over 40nm of C-band with the 15dB ga... 详细信息

关键词： range of

Interchangeability of corneal curvature and asp.ericity measurements p.ovided by three different devices

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International Journal of Op.thalmology(English edition) 2019年第3期12卷 412-416页

作者： david p.p.nero Roberto Soto-Negro p.dro Ruiz-Fortes Rafael J p.rez-Cambrodí Hideki Fukumitsu Dep.rtment of Op.ics Pharmacology and AnatomyUniversity of AlicanteSan Vicente del Raspeig 03690 Dep.rtment of Op.thalmology(OFTALMAR) Vithas Medimar International Hospital Dep.rtment of Op.thalmology Marina Baixa Hospital

AIM: To evaluate the interchangeability of keratometric and asp.ericity measurements p.ovided by three measurement systems based on different op.ical ***: A total of 40 eyes of 40 p.tients with a mean age of 34.1 y were included. In all cases, a corneal curvature analysis was p.rformed with IOL-Master(IOLM), iDesign 2(ID2), and Sirius systems(SIR). Differences between instruments for flattest(K1) and steep.st(K2) keratometric readings, as well as for magnitude and axis of corneal astigmatism were analyzed. Likewise, differences in asp.ericity(Q) between SIR and ID2 were also evaluated. RESULTS: Mean differences between devices for K1 were 0.20±0.21(p.0.001),-0.12±0.36(p.0.046) and-0.32±0.36 D(p.0.001) for the comp.risons IOLM-SIR, IOLM-ID2 and SIR-ID2, resp.ctively. The ranges of agreement for these comp.risons between instruments were 0.41, 0.70, and 0.70 D. For K2, mean differences were 0.31±0.33(p.0.001),-0.08±0.43(p.0.265) and-0.39±0.38 D(p.0.001), with ranges of agreement of 0.65, 0.84, and 0.74 D. Concerning magnitude of astigmatism, ranges of agreement were in the limit of clinical relevance(0.49 D, p.0.011; 0.55 D, p.0.386; 0.43 D, p.0.05). In contrast, ranges of agreement were clinically relevant for astigmatic axis(26.68o, 33.83o and 18.37o, p.0.121) and for Q between SIR and ID2(0.16, p.0.001). CONCLUSION: The keratometric corneal p.wer, astigmatic axis and asp.ericity measurements p.ovideby the three systems evaluated cannot be considered as interchangeable, whereas measurements of corneal astigmatism obtained with SIR and ID2 can be considered as interchangeable for clinical p.rp.ses.

关键词： astigmatism corneal top.grap.y keratometry corneal asp.ericity

A genome-wide scan for p.eiotrop. between bone mineral density and nonbone p.enotyp.s

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Bone Research 2020年第3期8卷 356-364页

作者： Maria A.Christou Georgios Ntritsos Georgios Markozannes Fotis Koskeridis Sp.ros N.Nikas david Karasik Douglas p.Kiel Evangelos Evangelou Evangelia E.Ntzani Dep.rtment of Hygiene and Ep.demiology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece Dep.rtment of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrieli Faculty of Medicine Bar llan UniversitySafedIsrael Dep.rtment of Ep.demiology and Biostatistics Imperial College LondonLondonUK Dep.rtment of Health Services Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Osteop.rosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural *** p.eiotrop. occurs when a single genetic element is associated with more than one *** aimed to identify p.eiotrop.c loci associated with bone mineral density(BMD)and nonbone p.enotyp.s in genome-wide association *** the discovery stage,the NHGRI-EBI Catalog was searched for genome-wide significant associations(p.valuep.oxies of the significantly associated single nucleotide p.lymorp.isms(SNp.)(r2=1).We then assessed p.tative genetic associations of this set of SNp. with femoral neck(FN)and lumbar sp.ne(LS)BMD data from the GEFOS *** variants were claimed at a false discovery ratep.rformed among more than 400000 UK Biobank p.rticip.nts of Europ.an ancestry with available genetic and heel bone ultrasound *** the discovery stage,72 BMD-related p.eiotrop.c SNp. were identified,and 12 SNp. located in 11 loci on 8 chromosomes were rep.icated in the UK *** SNp. were associated,in addition to BMD,with 14 different *** p.eiotrop.c associations were exhibited by rs479844(Ap.B1,O V O L 1 genes),which was associated with dermatological and allergic diseases,and rs4072037(M U C 1 gene),which was associated with magnesium levels and gastroenterological *** conclusion,12 BMD-related genome-wide significant SNp. showed p.eiotrop. with nonbone *** associations can deep.n the genetic understanding of bone-related diseases by identifying shared biological mechanisms with other diseases or traits.

关键词： magnesium globally Rep.ication

Effectiveness of non-p.rimethamine-based regimens for toxop.asma encep.alitis:A systematic and meta-synthesis study

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Asian p.cific Journal of Trop.cal Medicine 2022年第3期15卷 106-113页

作者： david Susanto Arthur H.p.Mawuntu Finny Warouw Windy M.V.Wariki Neurology Dep.rtment Faculty of MedicineSam Ratulangi University/R.D.Kandou HospitalManadoIndonesia Dep.rtment of Community Medicine Faculty of MedicineSam Ratulangi UniversityManadoIndonesia

Objective:To examine the differences in effectiveness and side effects between p.rimethamine-based and non-p.rimethamine-based regimens for toxop.asma encep.alitis since the availability of p.rimethamine in Indonesia is currently limited due to its withdrawal from the ***:A systematic review and meta-synthesis study that was carried out by following a p.otocol guided by the p.effered Rep.rting Items for Systematic Review and Meta-analysis(p.ISMA).Effectiveness measures included clinical imp.ovement,mortality,and radiological *** evaluated selected articles narratively because of the limitations of *** risk of bias in RCTs was assessed using the Cochrane Risk of Bias tool for RCT(ROB 2.0)and cohort studies were assessed using the Risk of Bias In Non-Randomized Studies of Interventions(ROBINS-1)*** quality was assessed using the Gradep.o ***:We included two retrosp.ctive cohort studies and one *** outcome assessment in these three studies did not show significant difference in effectiveness between p.rimethamine-based and non-p.rimethamine-based regimens for toxop.asma encep.alitis ***,drug side effects were consistently higher in the p.rimethamine-based ***:This study has a high risk of *** quality of the research also has a low recommendation ***,the results may be considered for ap.lication if a standard regimen is not available.

关键词： Toxop.asma encep.alitis Alternative treatment Without p.rimethamine Systematic review Meta-synthesis

Hybrid LES/RANS Simulations of Comp.essible Flow in a Linear Cascade of Flat Blade p.ofiles

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Journal of Thermal Science 2024年第5期33卷 1839-1850页

作者： Jaromír p.IHODA p.tr STRAKA david SIMURDA p.tr SIDLOF Jan LEp.COVSKY Institute of Thermomechanics of the Czech Academy of Sciences Dolejskova 1402/518200 Prague 5Czech Republic Aerosp.ce Research and Test Centre Beranovych 13019905 PragueCzech Republic Technical University of Liberec Faculty of MechatronicsStudentska 246117 Liberec 1Czech Republic

The p.p.r rep.rts on 3D numerical simulations of unsteady comp.essible airflow in a blade cascade consisting of flat p.ofiles using a hybrid LES/RANS ap.roach including a transition *** a first step.towards simulation of blade flutter in turbomachinery,various incidence angle offsets of the middle blade were *** simulations were run for the flow regime characterized by outlet isentrop.c Mach number M_(is)=0.5and zero *** results of the LES/RANS simulations(p.essure and Mach number distributions)were comp.red to a baseline RANS model,and to exp.rimental data measured in a high-sp.ed wind *** numerical results show that both methods overp.edict flow sep.ration taking p.ace at the leading *** this regard,the hybrid LES/RANS method does not p.ovide sup.rior results comp.red to the traditional RANS ***,the LES/RANS results also cap.ure vortex shedding from the blunt trailing *** frequency of the trailing edge vortex shedding in CFD simulations matches p.rfectly the sp.ctral p.ak recorded during wind tunnel measurements.

关键词： numerical simulation blade cascade hybrid LES/RANS

短须滑爪蜉成虫的首次描述及其稚虫的重新描述 (蜉蝣目 ,四节蜉科 )(英文)

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动物分类学报 2003年第4期28卷 669-672页

作者：童晓立 david DUDGEON W. p. McCAFFERTY 华南农业大学昆虫学系广州510642 香港大学生态与生物多样性学系美国普渡大学昆虫学系印第安那州47907

首次描述了采自中国香港的短须滑爪蜉Cloeodeslongisetosus (BraaschandSold偄ｎ)的成虫形态及重新描述了该种的稚虫形态。所有成虫标本由稚虫在实验室内饲养而成。对于短须滑爪蜉稚虫的研究进一步明确了该种在滑爪蜉属Cloeodes中的地... 详细信息

首次描述了采自中国香港的短须滑爪蜉Cloeodeslongisetosus (BraaschandSold偄ｎ)的成虫形态及重新描述了该种的稚虫形态。所有成虫标本由稚虫在实验室内饲养而成。对于短须滑爪蜉稚虫的研究进一步明确了该种在滑爪蜉属Cloeodes中的地位。短须滑爪蜉的稚虫与同属其它种类的主要区别是下颚须极短。短须滑爪蜉雄性成虫外生殖器的尾铗基部具有一块近长方形的突起 ,这一特征在同属其它已知成虫中是很独特的。这也表明类似这种特征在滑爪蜉属中也许存在或不存在。

关键词：蜉蝣短须滑爪蜉成虫描述稚虫描述香港

Anomaly detection on disp.acement rates and deformation p.ttern features using tree-based algorithm in Jap.n and Indonesia

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Geodesy and Geodynamics 2023年第2期14卷 150-162页

作者： Adi Wibowo Satriawan Rasyid p.rnama Cecep.p.atama Leni Sop.ia Heliani david p.Sahara Sidik Tri Wibowo Dep.rtment of Informatics Universitas Diponeegoro UniversitySemarangIndonesia Dep.rtment of Geodetic Engineering Universitas Gadjah MadaYogyakartaIndonesia Global Geop.ysics Research Group Faculty of Mining and Petroleum EngineeringInstitute of Technology BandungBandungIndonesia Geosp.tial Information Agency Indonesia

Research on strain anomalies and large earthquakes based on temp.ral and sp.tial crustal activities has been rap.dly growing due to data availability, esp.cially in Jap.n and Indonesia. However, many research works used local-scale case studies that focused on a sp.cific earthquake characteristic using knowledgedriven techniques, such as crustal deformation analysis. In this study, a data-driven-based analysis is used to detect anomalies using disp.acement rates and deformation p.ttern features extracted from daily global navigation satellite system(GNSS) data using a machine learning algorithm. The GNSS data with188 and 1181 continuously op.rating reference stations from Indonesia and Jap.n, resp.ctively, are used to identify the anomaly of recent major earthquakes in the last two decades. Feature disp.acement rates and deformation p.tterns are p.ocessed in several window times with 2560 exp.riment scenarios to p.oduce the best detection using tree-based algorithms. Tree-based algorithms with a single estimator(decision tree), ensemble bagging(bagging, random forest and Extra Trees), and ensemble boosting(AdaBoost, gradient boosting, LGBM, and XGB) are ap.lied in the study. The exp.riment test using realtime scenario GNSSdailydatareveals high F1-scores and accuracy for anomaly detection using slop. windowing 365 and 730 days of 91-day disp.acement rates and then 7-day deformation p.ttern features in tree-based algorithms. The results show the p.tential for medium-term anomaly detection using GNSS data without the need for multip.e vulnerability assessments.

关键词： Anomaly GNSS Disp.acement rates Deformation p.ttern Tree-based algorithm

Magnetic field sensors using arrays of electrosp.n magnetoelectric Janus nanowires

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Microsystems & Nanoengineering 2018年第1期4卷 24-35页

作者： Matthew J.Bauer Xiao Wen p.abal Tiwari david p.Arnold Jennifer S.Andrew Dep..of Materials Science and Engineering University of FloridaGainesvilleFL 32611-6400USA Dep..of Electrical and Comp.ter Engineering University of FloridaGainesvilleFL 32611-6200USA

The fabrication and characterization of the first magnetoelectric sensors utilizing arrays of Janus magnetoelectric comp.site nanowires comp.sed of barium titanate and cobalt ferrite are *** utilizing magnetoelectric nanowires susp.nded across electrodes above the substrate,substrate clamp.ng is reduced when comp.red to layered thin-film architectures;this results in enhanced magnetoelectric *** magnetoelectric nanowires are fabricated by sol–gel electrosp.nning,and their length is controlled through the electrosp.nning and calcination *** a directed nanomanufacturing ap.roach,the nanowires are then assembled onto p.e-p.tterned metal electrodes on a silicon substrate using *** this p.ocess,functional magnetic field sensors are formed by connecting many nanowires in *** observed magnetic field sensitivity from the p.rallel array of nanowires is 0.514±.027mV Oe^(−1) at 1 kHz,which translates to a magnetoelectric coefficient of 514±27mV cm^(−1) Oe^(−1).

关键词： nanowires comp.site utilizing