Effectiveness of non-pyrimethamine-based regimens for toxoplasma encephalitis:A systematic and meta-synthesis study
作者机构：Neurology DepartmentFaculty of MedicineSam Ratulangi University/R.D.Kandou HospitalManadoIndonesia Department of Community MedicineFaculty of MedicineSam Ratulangi UniversityManadoIndonesia
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2022年第15卷第3期
页 面：106-113页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100204[医学-神经病学] 10[医学]
主 题：Toxoplasma encephalitis Alternative treatment Without pyrimethamine Systematic review Meta-synthesis
摘 要：Objective:To examine the differences in effectiveness and side effects between pyrimethamine-based and non-pyrimethamine-based regimens for toxoplasma encephalitis since the availability of pyrimethamine in Indonesia is currently limited due to its withdrawal from the ***:A systematic review and meta-synthesis study that was carried out by following a protocol guided by the Preffered Reporting Items for Systematic Review and Meta-analysis(PRISMA).Effectiveness measures included clinical improvement,mortality,and radiological *** evaluated selected articles narratively because of the limitations of *** risk of bias in RCTs was assessed using the Cochrane Risk of Bias tool for RCT(ROB 2.0)and cohort studies were assessed using the Risk of Bias In Non-Randomized Studies of Interventions(ROBINS-1)*** quality was assessed using the GradePro ***:We included two retrospective cohort studies and one *** outcome assessment in these three studies did not show significant difference in effectiveness between pyrimethamine-based and non-pyrimethamine-based regimens for toxoplasma encephalitis ***,drug side effects were consistently higher in the pyrimethamine-based ***:This study has a high risk of *** quality of the research also has a low recommendation ***,the results may be considered for application if a standard regimen is not available.
维普期刊数据库