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Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

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Use of respiratory "head out" plethysmographs for evaluation of pulmonary function in rats

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： WU Rui QU Lin-hai Sue McPHERSON Steve mason Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

OBJECTIVE To demonstrate that the DSI/Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home pens. METHODS Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI/Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Waters correction) interval was observed for animals dosed at 100 mg·kg from4-23 h *** QTcV effects(19%increase with 100 mg-kg"1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT changes. DSI allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI/ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI/ponemah JET system(v5.00) pro

关键词： ECG dog

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Use of respiratory "head out" plethysmographs for evaluation...

Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

作者： WU Rui QU Lin-hai Sue MCPHERSON Steve mason Safety Pharmacology WuXi AppTec(Suzhou)Co.Ltd

To evaluate the use of respiratory "head out" plethysmographys for use as a respiratory function assessment tool in rats as part of the respiratory system assessment required under the ICH S7A ***(20 mg·kg~(-1) iv) and Theophylline(10 mg·kg~(-1)iv) were selected for use as reference compounds in this *** Sprague- Dawley rats,approximately 7 -8 weeks of age and in the weight range 246 -303 g were selected as the test *** approximate one week acclimation period preceded the study,during which animals were pre-selected for the suitability by assessment of their ability to stay in the restraint chambers("head-out" plethysmographys) for a target of about 2.5 h-Any rat demonstrating excessive excitability or abnormal breathing patterns were removed from the *** the day of dosing, animals were placed in "head out" plethysmographs and allowed to acclimate to the chambers for at least 5 min prior to each data collection *** following the acclimation period,ventilatory parameters(tidal volume,respiratory rate,and derived respiratory minute volume(RMV) were measured for an approximate 15 min period predose,continuously for the following approximate 2.5 h,then for approximate 15 min at approximately 4 and 24 h *** obtained were consistent with the literature and based on the results of this study,this assay,using respiratory "head out" plethysmographys to assess respiratory function,is considered acceptable for use in Pulmonary assessments under the ICH guideline.

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Use of the DSI/Ponemah jacketed external telemetry system fo...

FPGA将会在汽车和消费电子市场中获得广泛应用

作者： WU Rui QU Lin-hai Sue McPHERSON Steve mason Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd

OBJECTIVE To demonstrate that the DSI/Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home pens. METHODS Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI/Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Water s correction) interval was observed for animals dosed at 100 mg·kg~(-1) from 4-23 h *** QTcV effects(19%increase with 100 mg·kg~(-1) Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT changes. DSI allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI/ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI/ponemah JET system(

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今日电子 2006年第4期 60-61页

作者： Martin mason Actel公司

市场分析家预测2002～2008年整个可编程逻辑市场的规模将翻三番.尽管可编程逻辑市场的成长一直都是由通信和网络行业对高价值和大容量元件的需求所推动,但下一轮扩张动力将来源自不同的领域,即以价值为基础(value-based)的汽车和消费电... 详细信息

市场分析家预测2002～2008年整个可编程逻辑市场的规模将翻三番.尽管可编程逻辑市场的成长一直都是由通信和网络行业对高价值和大容量元件的需求所推动,但下一轮扩张动力将来源自不同的领域,即以价值为基础(value-based)的汽车和消费电子市场.

关键词：电子市场 FPGA 消费汽车可编程逻辑应用市场分析高价值大容量元件

存储市场的宁静革命──SAS、SATA与光纤信道技术的弹性

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电子与电脑 2006年第8期6卷 93-95页

作者： Harry mason LSI Logic存储元件事业群

在化繁为简的趋势下,存储市场目前正进行着一项重要变革:两种不同的技术--并行SCSI与并行ATA--正逐渐被序列式的后起之秀取代.虽然如此,业者也不需贸然进行汰换及升级,因为技术上的兼容性与其它市场因素,将确保各种技术在转换过程中,维... 详细信息

在化繁为简的趋势下,存储市场目前正进行着一项重要变革:两种不同的技术--并行SCSI与并行ATA--正逐渐被序列式的后起之秀取代.虽然如此,业者也不需贸然进行汰换及升级,因为技术上的兼容性与其它市场因素,将确保各种技术在转换过程中,维持一段和平共存的日子.

关键词：存储市场技术光纤信道 SATA SAS 并行ATA 宁静弹性 SCSI 转换过程

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宇宙射线对汽车电子系统的损伤分析

电子产品世界 2007年第C期14卷 117-118页

作者： Matin mason Actel公司硅芯片产品市场总监

设想一下：如果你驾驶最新款的汽车，以每小时75英里的速度在高速公路上疾驰，并一边欣赏着流行的乐曲。突然间，引擎管理系统或稳定控制系统失效。面对这个情势，您不仅可能会遭遇严重（甚至致命）的车祸，而车厂的声誉也可能遭到损害... 详细信息

设想一下：如果你驾驶最新款的汽车，以每小时75英里的速度在高速公路上疾驰，并一边欣赏着流行的乐曲。突然间，引擎管理系统或稳定控制系统失效。面对这个情势，您不仅可能会遭遇严重（甚至致命）的车祸，而车厂的声誉也可能遭到损害，如果类似情况不止出现在你身上的话。

关键词：汽车电子系统损伤分析线对宇宙高速公路系统失效稳定控制管理系统

中国家具与西方藏家：鉴赏趣味不断转变的历史

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收藏．拍卖 2008年第3期 53-55页

作者： Lark mason

拉克·梅森（Lark mason）是原纽约苏富比拍卖行高级副总裁，他梳理了中国家具如何被西方收藏家认识、发现的脉络。实际上，西方收藏者与中国藏家对“中国家具”的认识有着极大的偏颇——西方人认识中国家具的途径最初是作为出口的贸易... 详细信息

拉克·梅森（Lark mason）是原纽约苏富比拍卖行高级副总裁，他梳理了中国家具如何被西方收藏家认识、发现的脉络。实际上，西方收藏者与中国藏家对“中国家具”的认识有着极大的偏颇——西方人认识中国家具的途径最初是作为出口的贸易产品，在1876年费城举行的百年博览会、1892年芝加哥举行的世界哥伦布博览会上都能看到中国家具的身影；在20世纪20年代以前，西方收藏者一直认为最美最好的中国家具是漆器家具。随着日后资讯、交通的逐渐发达以及中西方学者如王世襄等人学术专著的发表，西方收藏家对中国家具的认识才开始日趋完整、丰富。

关键词：中国家具西方人 20世纪20年代历史趣味鉴赏苏富比拍卖行高级副总裁

6Gb/s SAS部署推进存储技术飞速发展

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微电脑世界 2011年第9期 99-100页

作者： Harry mason

6Gb/s SAS市场正处于全面发展的鼎盛时期。服务器主板纷纷采用6Gb/s SAS器件或RAID控制器。支持SATA和SAS驱动器连接增量扩展的SAS扩展器在系统和驱动器存储设备领域获得大量部署。SAS可保护原有中间件投资,正快速改变主流服务器市场,... 详细信息

6Gb/s SAS市场正处于全面发展的鼎盛时期。服务器主板纷纷采用6Gb/s SAS器件或RAID控制器。支持SATA和SAS驱动器连接增量扩展的SAS扩展器在系统和驱动器存储设备领域获得大量部署。SAS可保护原有中间件投资,正快速改变主流服务器市场,并上升为领先的企业存储互联技术。从3Gb/s SAS到6Gb/s SAS的演进还在不断发展,并新增了标准化分区和扩展器发现等增强型企业级功能。新添加的改进功能将有助于开辟全新的市场和应用领域,从而推动SAS进一步向高可用性存储解决方案方向发展。

关键词： SAS 存储技术部署服务器市场 RAID控制器存储解决方案服务器主板存储设备

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来自班尼·兰达的最新消息

数码印刷 2013年第3期 57-58页

作者： Dennis mason OutputLinks传媒集团GreensheetBiz公司

最近,我们有幸采访到Indigo印刷机的发明者班尼·兰达先生,并向其了解了纳米印刷技术的最新进展。基于采用的超细颗粒新型油墨技术,纳米印刷旨在进一步降低油墨用量并拓宽数字印刷的应用领域。在drupa 2012上,兰达推出全系列的单张纸和... 详细信息

最近,我们有幸采访到Indigo印刷机的发明者班尼·兰达先生,并向其了解了纳米印刷技术的最新进展。基于采用的超细颗粒新型油墨技术,纳米印刷旨在进一步降低油墨用量并拓宽数字印刷的应用领域。在drupa 2012上,兰达推出全系列的单张纸和卷筒纸纳米印刷机,并现场接受新设备的预定。在drupa 2012之后,整个印刷行业都翘首期盼兰达纳米数字印刷技术的最新发展情况。具体的采访内容总结如下。

关键词：数字印刷技术 drupa 消息 Indigo 油墨技术印刷机超细颗粒印刷行业