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The Allelopathic Phenomenon. It's possible modulate the dynamic of these interactions?

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The Allelopathic Phenomenon. It's possible modulate the dyna...

Making bridges between preclinical and clinical insights into age-related cognitive decline

中国第二届植物化感作用学术研讨会暨中国植物保护学会植物化感作用专业委员会成立大会

作者： Francisco A.Macías Alberto Oliveros-Bastidas david marín José M.G.Molinillo Grupo de Alelopatía Departamento de Química OrgánicaFacultad de CienciasUniversidad de CádizC/ República Saharaui s/n11510-Puerto Real (Cádiz) Spain

Allelopathic phenomenon has been defined as that produced mediated by secondary metabolites released by one species to influence to the development of other species. These natural products exhibit a diversity of biological activities. But, they can suffer physical, chemical as well as microbial degradation. This microbial degradation can be produced by a wide variety of fungi and other microorganisms. Sometimes the degradation products are as active or even more than the original released compounds.

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Women in visual neural regeneration research

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neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the new York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** national Eye Institute(nEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the national Science Foundation(nSF),the nEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

The assembly of plant-patch networks in Mediterranean alpine grasslands

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Journal of Plant Ecology 2020年第3期13卷 273-280页

作者： david S.Pescador José maría Iriondo Gianalberto Losapio Adrián Escudero Departamento de Biología y Geología Física y Química InorgánicaEscuela Superior de Ciencias Experimentales y TecnologíaUniversidad Rey Juan CarlosMóstolesSpain Department of Environmental Systems Science ETH ZurichZurichSwitzerland Department of Biology Stanford UniversityStanfordCAUSA

Aims Harsh environmental conditions in alpine ecosystems shape vegetation structure into patches,where many different plant species cluster and grow ***,which factors are important for the structure and dynamics of such plant–patch networks remains poorly *** aim to assess which and how environmental and biotic factors predict the assembly of plant–patch networks along a mountain *** We examined the distribution of plant species in more than 5500 vegetation patches in 37 Mediterranean alpine grasslands distributed along a 500 m altitudinal gradient(national Park of Sierra Guadarrama,Spain).We established a plant–patch network for each grassland community and analyzed how nestedness and modularity vary with environmental(altitude,insolation and soil conditions)and biotic factors(number of species per plot,mean patch area and total pasture area).Important Findings Plant–patch networks showed consistent,non-random patterns characterized by a nested,but not modular,structure,which suggests that positive associations among co-occurring specialists promote their growth within patches as subsets of a pool with more generalist *** nestedness and modularity of plant–patch networks varied among ***,nestedness decreased with increasing species per plot and increased with mean patch area,while it was independent of environmental variables;modularity increased with increasing pasture area and species per *** negative relationship between species per plot and nested patterns may be linked to the restricted number of species that can coexist within the same patch at a given ***,the positive relationship between patch size and nestedness indicates that the growth of rare plant species within vegetation patches occupied by more abundant species is facilitated in bigger rather than smaller ***,these results indicate that the nested assembly of vegetation patches may be independent of abiotic cond

关键词： alpine ecosystems community assembly ecological networks metacommunity modularity nestedness patch dynamics

Determination of Soil Aggregate Porosity Using the Modified Water Saturation Method

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Pedosphere 2019年第6期29卷 794-800页

作者： david MORET-FERnánDEZ maría Victoria LóPEZ Departamento de Suelo y Agua Estación Experimental de Aula Dei Consejo Superior de Investigaciones Científicas (EEAD-CSIC)

The need to find a simple method for measuring soil aggregate porosity (φ) is justified by the growing interest of researchers in this important parameter of soil physical status. The aim of this study was to present a simple method (AM) for estimating the total 0 of a single soil aggregate. In this case, soil aggregate 0 was calculated as the quotient between the pore volume, estimated from the weight of the aggregate saturated with ethanol, and the total volume (V T ) of aggregate, calculated from the particle density and dry aggregate weight. The V T estimated with AM was compared with the corresponding volume measured with the photogrammetry (PHM) technique using soil aggregates of 8–16 mm in diameter and collected from three different tillage systems: conventional tillage (CT), reduced tillage (RT), and no tillage (nT). next, the AM was used to study the effects of the tillage system on soil aggregate φ. Although a strong relationship ( R 2 = 0.99, P n aggregate V T measured with PHM and that estimated with AM was obtained, AM tended to underestimate aggregate V T with an average deviation of 2.85%. This difference may be due to ethanol evaporation during the first 10 s before the ethanol-saturated aggregate was weighed. The use of AM to determine the effects of different tillage systems on aggregate φ showed that this method was sensitive to detect significant differences among the tillage treatments. The results showed that AM could be an accurate, simple, and inexpensive alternative to estimate φ of a single soil aggregate.

关键词： Aggregate stability Bulk density Particle density Photogrammetry technique Tillage system

A methodological framework for improving air quality monitoring network *** to environment management

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Journal of Environmental Sciences 2021年第4期33卷 138-147页

作者： david Galán-Madruga Department of Atmospheric Pollution National Center for Environment HealthHealth Institute Carlos IIICtra.Majadahonda a Pozuelo km 2228220 MadridSpain

This work aims to provide a methodology framework which allows to improve the performance and efficiency of an air quality monitoring network(AQMn).It requires to be constituted by a minimum and reliable number of measurement ***,the AQMn efficiency should be assessed over time,as a consequence of the possible emergence of new emission sources of air pollutants,which could lead to variations on their spatial distribution within the target ***_(10)particles data monitored by the Community of Madrid's(Spain)AQMn between 2008 and 2017 were used to develop a methodology to optimize the AQMn *** annual spatial distribution of average PM_(10)levels over the studied period monitored by all current stations vs those more representative was provided by a geographic information system(GIS),and the percentage of similarity between both postulates was quantified using simple linear regression(>95%).As one innovative tool of this study,the practical application of the proposed methodology was validated using PM_(10)particles data measured by AQMn during 2007 and 2018,reaching a similitude degree higher than 95%.The influence of temporal variation on the proposed methodological framework was around 20%.The proposed methodology sets criteria for identifying non-redundant stations within AQMn,it is also able to appropriately assess the representativeness of fixed monitoring sites within an AQMn and it complements the guidelines set by European legislation on air pollutants monitoring at fixed stations,which could help to tackle efforts to improve the air quality management.

关键词： Air quality Ambient air monitoring network PM_(10)particles Redundant stations Optimization Environment management

Proteomic analysis of F_(1)hybrids and intermediate variants in a Littorina saxatilis hybrid zone

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Current Zoology 2022年第3期68卷 351-359页

作者： Angel P.DIZ Mónica R.ROMERO Juan GALInDO maría SAURA david O.F.SKIBInSKI Emilio ROLÁn-ALVAREZ Centro de Investigación mariña(CIM-UVIGO) Universidade de VigoVigo 36310Spain Departamento de Mejora Genética Animal INIAMadrid 28040Spain Institute of Life Science Swansea University Medical SchoolSwansea SA28PPUK

Proteomic analysis was carried out on the Crab(upper-shore)and Wave(lower-shore)ecotypes of Littorina saxatilis from a hybrid zone at Silleiro Cape,*** profiles of individual snails were *** expression in F_(1)hybrid snails bred in the laboratory and snails with intermediate shell phenotypes collected from the mid-shore were compared with Crab and Wave ecotypes using analytical approaches used to study *** analysis over many protein spots showed that the F_(1)snails are distinct from both ecotypes but closer to the Wave *** intermediate snails are highly variable,some closer to the Crab and others to the Wave *** on a protein by protein basis,some proteins are significantly closer in expression to the Crab and others to the Wave ecotype for both F_(1)and intermediate ***,a significant majority of proteins were closer in expression to the Wave ecotype for the F_(1),consistent with the multivariate *** such significant majority toward either the Crab or Wave ecotype was observed for the intermediate *** closer similarity of F_(1)and Wave ecotype expression patterns could be the result of similar selective pressures in the similar mid-shore and low-shore *** a significantly larger number of proteins,intermediate snails were closer in expression to the ecotype having the lower expression,for both Crab and Wave *** is somewhat unexpected as lower expression might be expected to be an indication of impairment of function and lower *** analysis could be important for the identification of candidate proteins useful for gaining improved understanding of adaptation and barriers to gene flow in hybrid zones.

关键词： F_(1)hybrids gene expression marine invertebrates molecular phenotype reproductive isolation speciation

Visual perception alterations in COVID-19:a preliminary study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： maría Begoña Coco-martín Luis Leal-Vega Irene Alcoceba-Herrero Ainhoa Molina-martín Dolores de-Fez maría JoséLuque Carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara david PPiñero Group of Applied Clinical neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision