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Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening

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World Journal of Gastrointestinal Endoscopy 2010年第3期2卷 81-89页

作者： Felix W Leung Abdulrahman m Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi mizukami melvin Schapiro Konstantinos Triantafyllou Research and medical Services Sepulveda Ambulatory Care CenterVeterans Affairs Greater Los Angeles Healthcare SystemNorth Hills david Geffen School of medicine University of CaliforniaLos Angeles King Khalid University Hospital Department of Internal medicine and Gastro-enterology University of Bologna Department of medicine University of Chicago School of MedicineChicago Department of Internal medicine National Taiwan University Hospital Endoscopy Center Yokohama Municipal Citizen's Hospital Hepatogastroenterology Unit 2nd Dep artment of Internal Medicine-PropaedeuticAttikon Univer-sity General HospitalMedical SchoolAthens University

Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer *** data from 1966 to 2009 were searched to identify relevant articles on the *** were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and *** colonoscopy was initially dev eloped as an unsedated ***-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice *** increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated *** use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer *** to assess its applicability in diverse practice settings deserve to be conducted and supported.

关键词： Unsedated colonoscopy Sedation-risk-free colonoscopy Colon cancer screening

间隔1周的CT复查对肺气肿容积和密度测量的可重复性

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国际医学放射学杂志 2012年第2期 197-197页

作者： D.Chong m.S.Brown H.J.Kim E.m.van Rikxoort L.Guzman m.F.mcNitt-Gray 肖立志 Center for Computer Vision and Imaging Biomarkers David Geffen School of MedicineUCLA924 Westwood BLVD.Ste.615Los AngelesCAUSA

目的肺气肿病人CT肺容积和密度测量1周后重复评估。评估屏气对重复性的影响。方法 44例病人间隔7d在吸气状态行HRCT检查,计算CT肺容积、密度在-950HU(RA950-raw)以下相关区,第15百分位数密度(PD15-raw)。通

关键词：慢性阻塞性肺疾病肺气肿 CT 密度测量法重复性

新近诊断的乳腺癌:对比增强能谱乳腺X线摄影与乳腺mRI评价病变范围的比较

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国际医学放射学杂志 2018年第1期 90-90页

作者： S.A.Lee-Felker L.Tekchandani m.Thomas E.Gupta D.AndrewsTang A.Roth 张俊峰 Department of Radiological Sciences David Geffen School of Medicine at UCLA

摘要目的以病理和影像随访作为参考标准,比较对比增强能谱乳腺摄影与乳腺mRI对新近诊断乳腺癌病人额外病灶检出的诊断价值。材料与方法本研究经机构伦理委员

关键词：对比增强 mRI 病变范围乳腺癌

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浩瀚宇宙的秘密上海天文馆

室内设计与装修 2021年第9期 92-98页

作者：无 V.Guy maxwell(设计) 陈昕昉(设计) 邝薇薇(设计) Charles Wolf(设计) Anthony Guaraldo(设计) Jorge Arias(设计) margarita Calero(设计) michael Caton(设计) Christina Ciardullo(设计) Eugene Colberg(设计) Regina Jiang(设计) Jörg Kiesow(设计) Aidan Kim(设计) Stefan Knust(设计) 李欣亚(设计) Francelle Lim(设计) Xiaoyun mao(设计) david monnar(设计) Nikita Payusov(设计) James Rhee(设计) Yong Kyun Roh(设计) 阮玲丽(设计) Na Sun(设计) 徐震(设计) Stephanie Tung(设计) 黄泽修(设计) 于乐川(设计) Fred Zhang(设计) Ennead建筑设计事务所不详

上海天文馆由Ennead建筑设计事务所设计合伙人Thomas ***设计。其方案致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动这一基本关系的认知。作为上海科... 详细信息

上海天文馆由Ennead建筑设计事务所设计合伙人Thomas ***设计。其方案致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动这一基本关系的认知。作为上海科技馆分馆,全新的上海天文馆占地38000 m^(2),为全球规模最大的天文学主题博物馆。

关键词：建筑设计事务所天文现象主题博物馆上海科技馆沉浸式体验地球轨道全球规模天文学

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血管性因素对认知损害和痴呆的促成作用美国心脏协会／美国卒中协会对医疗卫生专业人员的声明

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国际脑血管病杂志 2012年第2期20卷 85-124页

作者：无无无无无曹雯炜（译）糜建华（译）宋叶平（译）余寿芬（译）王飞（译）李焰生（译）美国心脏协会卒中委员会流行病学与预防委员会心血管护理委员会心血管放射学和介入委员会心血管外科和麻醉学委员会上海交通大学医学院附属仁济医院神经科上海200127

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveimpairment）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveimpairment，VCI）的定义、神经病理... 详细信息

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveimpairment）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveimpairment，VCI）的定义、神经病理学、基础科学和病理生理学研究、神经影像学的作用、血管性和其他相关危险因素的作用以及潜在的防治方法进行了回顾，旨在为临床医生提供一份总体指导，以进一步加深对VCI和痴呆及其防治的理解。方法写作组成员由写作组联合主席基于先前在相关领域的研究成果提名，并经美国心脏协会（AmericanHeartAssociation，AHA）卒中委员会科学声明监督委员会、流行病学和预防委员会以及文稿监督委员会批准。写作组采用系统文献回顾（主要涵盖1990年至2010年5月期间的文献）、以往公布的指南、个人资料以及专家观点总结现有证据，提出当前知识的不足，并对适当的问题根据AHA标准制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并认可了最终版本。经AHA的同行评议以及卒中委员会领导阶层、流行病学和预防委员会以及科学声明监督委员会审阅后，最终获得AHA科学咨询和协调委员会批准。结果VCI概念的提出涵盖了与所有类型脑血管性脑损害（而不仅仅是卒中）相关的整个认知障碍（cognitivedisorder）谱，其范围从轻度认知损害到完全痴呆。神经血管单元和脑血流调节机制障碍可能是VCI的潜在病理生理学过程的重要组成部分。脑淀粉样血管病已成为阿尔茨海默病（Alzheimerdisease，AD）、微梗死、微出血、脑出血以及VCI风险的一个重要标志。老年认知损害的神经病理学改变常常是AD与微血管性脑损害的混合状态，二者可叠加和协同增高认知损害风险。就此而言，mRI和其他神经影像学技术在VCI的确定和识别中起着重要作用，并提供证据说明以白质高信号和小的深部梗死为特征的皮质下型VCI很常见。在许多情况下，VCI的风险标志同样也是卒中的传统危险因素。这些危险因素包括但不仅限于心房颤动、高血压、糖尿病和高胆固醇血症。而且，这些血管危险因素也可能是AD的风险标志。颈动脉内膜一中膜厚度和动脉僵硬度是动脉老化的标记物，也可能成为VCI的风险标志。目前，美国食品药物管理局尚未批准任何VCI的特异性治疗方法。不过，对卒中和心血管病传统危险因素的评价和控制，可能对包括老年人群在内的VCI的预防具有作用。结论血管性因素在认知损害和痴呆中的促成作用很重要。近年来，在临床前、神经病理学、神经影像学、生理学和流行病学研究基础上，对VCI的认识得到了不断提高。推荐使用跨学科的、转化的以及交互的方法进一步加深对此领域的了解，并更好地掌握其神经心理学特征。需要开展前瞻性定量临床一病理学一神经影像学研究，以提高对神经影像学改变的病理学基础，以及血管病变和AD病变在VCI和AD临床演变中的复杂的丰互作用的认识。可能需要在中年期尽早肝始对血管危险标志进行长期干预，以预防或延迟VCI或AD发病的研究。住高危人群I}1强化控制血管危险因素则是另一个重要的研究方向。

关键词： AHA科学声明血管性痴呆阿尔茨海默病危险因素预防治疗

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin david Hyde marcelo Sandoval-Denis matthew E.Smith merje Toome-Heller Nalin N.Wijayawardene Nelson menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene mayra Soares Ahto Agan Alexandre Reis machado Andrés Argüelles-moyao Andrew Detheridge Angelina de meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner m.Catherine Aime maarjaÖpik maría Isabel mujica martin metsoja martin Ryberg martti Vasar masao murata matthew PNelsen michelle Cleary milan C.Samarakoon mingkwan Doilom mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom may Torda Varga Wei Li Victor Rafael matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.mikryukov Yongzhong Lu Yosuke matsuda Yumiko miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

SPIRIT 2013声明：定义临床研究方案的标准条目

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中国循证医学杂志 2013年第12期13卷 1501-1507页

作者： An-Wen Chan Jennifer m.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.m.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie david moher 钟丽丹郑颂华吴泰相李幼平商洪才张伯礼唐旭东吕爱平卞兆祥 SPIRIT中文工作組

临床研究方案是临床研究设计、实行、报告和评价的基础。然而，临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》（Standard Protocol Items：Recommendations for Interventional Tri... 详细信息

临床研究方案是临床研究设计、实行、报告和评价的基础。然而，临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》（Standard Protocol Items：Recommendations for Interventional Trials 2013 ）,简称SPIRIT2013声明，一个临床研究方案必须报告的条目指引的系统建立和范围。

关键词：临床研究条目标准

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饥饿可能是2型糖尿病复发的驱动因素

英国医学杂志中文版 2018年第9期21卷 539-539页

作者：聂小敏(译) 包玉倩(校) 上海交通大学附属第六人民医院内分泌代谢科

在去年的一期BmJ杂志上，我看到meCombie和同事们在文章中讨论2型糖尿病（T2Dm）的缓解。5年前，当我被诊断为T2Dm时，我决定通过节食来减肥。我体重减轻了13k，现在体重维持在71～72kg。我的体质指数（BmI）是24．3kg／m2。我的血压只... 详细信息

在去年的一期BmJ杂志上，我看到meCombie和同事们在文章中讨论2型糖尿病（T2Dm）的缓解。5年前，当我被诊断为T2Dm时，我决定通过节食来减肥。我体重减轻了13k，现在体重维持在71～72kg。我的体质指数（BmI）是24．3kg／m2。我的血压只有一次曾达到130／70mmHg，通常都在120／80mmHg以下。不过说来也怪，我的胆固醇超标已经有至少40年了，我接受过冠状动脉旁路移植术，安装了心脏起搏器，也接受了经导管主动脉瓣置人术。我目前88岁，每天步行2英里。

关键词：驱动力糖尿病类型饥饿恶化

*** the link between reduced reading ability and cognitive decline in older adults with acquired vision impairment:a feasibility study

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Annals of Eye Science 2019年第1期 204-204页

作者： Swaathi Balaji Karine Elalouf Andrea Urqueta-Alfaro Julie-Andrée marinier Aaron Johnson Natalie Phillips Eva Kehayia m.Kathy Pichora-Fuller Walter Wittich École d'Optométrie Universitéde MontréalMontréalQCCanada Centre de recherche interdisciplinaire en réadaptation du montréal métropolitain MontrealQCCanada Department of Psychology Concordia UniversityMontréalQCCanada School of Physical and Occupational Therapy McGill UniveristyMontréalQCCanada Department of Psychology University of Toronto at MississaugaMississaugaOntarioCanada

Background:Reading enables us to obtain information,to engage in leisure,educational,business and other activities,and fosters cognitive *** vision loss can have a negative effect on an individual’s ability to read,and,by extension,reduce overall quality of *** addition,a growing body of research on the association between reading and cognition has linked a decrease in reading ability with negative changes in cognitive ***,the purpose of the current study is to test the feasibility of a research protocol that will be used to study the association between reduced reading ability and cognitive impairment,specifically in older adults with acquired vision ***:Seven participants(age range,27-60 years,mage=44,4 males)completed a series of questionnaires and assessments that measured their cognitive,hearing,and reading *** participants had normal hearing,vision and cognition,with the exception of one(two pre-existing hearing conditions).Cognition was tested using the Rey Auditory Verbal Learning Test(RAVLT),the RAVLT 50-word Recognition test,the Verbal Fluency Test,an auditory Trail-making task,and an auditory 1-N-back memory *** was used to assess ear health,and hearing was measured with self-administered computerized audiometry(Home Hearing Test)and a speech-in-noise test(Canadian Digit Triplet Test).Questionnaires included the Hearing Handicap Inventory for the Elderly,and a multiple-choice questionnaire on subjective reading ability and reading ***,reading acuity,speed and comprehension were assessed using the International Reading Speed Texts and the ***:In testing the feasibility of this protocol,the uninterrupted length of testing time,including obtaining consent,was determined to be between 60-90 *** of the assessments and tests(RAVLT,mNRead,audiogram)were reported to be mentally ***,all pilot participants were able to complete all *** the exception of s

关键词： Cognition vision impairment reading rehabilitation