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Open Journal of Ophthalmology 2013年第3期3卷 70-72页

作者： david Woo Kenneth Ooi Jennifer Sandbach Fredrick Joshua Department of Ophthalmology Prince of Wales Hospital Sydney Australia. Department of Ophthalmology The Canberra Hospital Canberra Australia

Purpose: To report an unusual case of retinal microvasculopathy secondary to mixed connective tissue disease (MCTD) on a background history of fragile-X syndrome (FXS). Methods: Case report and literature review. Results: A cotton wool spot was discovered in a 29-year-old female who presented with an ischaemic digit secondary to Raynaud’s phenomenon. She also has a background history of MCTD and FXS. Fundus examination and automated perimetry findings were normal. Magnet resonance imaging and computed tomography aortogram did not demonstrate any evidence of vasculitis in the head and neck. She was tested positively for U1-ribonuclear peptide. Interestingly, the re-distribution of Fragile-X related gene 1 has been suggested to trigger autoimmune responses in experiments. This finding makes the case peculiar as it suggests an alternate explanation for this patient’s clinical findings. Conclusion: Retinal vasculopathy is a rare complication of MCTD. The background history of FXS potentially highlights an alternate autoimmune pathogenetic mechanism.

关键词： Retinal Microvasculopathy Mixed Connective Tissue Disease Fragile-X-Syndrome

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大沙鼠洞道利用机制及地面行为时间分配特征

生态学杂志 2012年第6期31卷 1492-1498页

作者：夏参军刘伟乔洪海杨维康徐峰 david Blank 中国科学院新疆生态与地理研究所中国科学院干旱区生物地理与生物资源重点实验室乌鲁木齐830011 中国科学院研究生院北京100049 四川大学生命科学学院成都610064

2010年5—11月,在古尔班通古特沙漠南部采用焦点动物取样法研究了大沙鼠(Rhombomys opimus)的昼间洞道利用机制(地面活动强度、进洞频率)以及地面行为时间分配。结果表明:大沙鼠在春夏秋三季地面活动时间占总观察时间的77.62%、66.13%和... 详细信息

2010年5—11月,在古尔班通古特沙漠南部采用焦点动物取样法研究了大沙鼠(Rhombomys opimus)的昼间洞道利用机制(地面活动强度、进洞频率)以及地面行为时间分配。结果表明:大沙鼠在春夏秋三季地面活动时间占总观察时间的77.62%、66.13%和80.93%,进洞频率分别为0.50、0.31和0.19次.min-1,地面活动强度和进洞频率均具有明显的季节性变化;在其地面行为中,摄食是大沙鼠任一季节最主要的行为,不同季节摄食比例均超过50%;储食是大沙鼠春季两秋两季次重要的行为,其时间比例分别达到了17.19%和25.46%;夏季大沙鼠修饰行为比例明显升高(27.78%),而储食行为比例明显下降(7.1%)。本研究结果说明,食物因子是促使大沙鼠进行地面活动的重要因素之一;另外,温度、生理周期、捕食风险可影响大沙鼠地面活动强度、进洞频率以及地面行为时间分配。

关键词：大沙鼠地面活动强度进洞频率时间分配

A Life Cycle Comparison of Remote, Deployed Expeditionary Waste Management Scenarios

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Journal of Environmental Protection 2021年第2期12卷 141-159页

作者： david Chester Chandrani Mukherjee Jeremy Slagley Eric Mbonimpa Thomas Hornstein Department of Systems Engineering and Management Air Force Institute of Technology Wpafb OH USA

The current barrier to acquisition and utilization of viable waste-to-energy (WTE) technologies at remote or deployed expeditionary sites requires high capital and operation & maintenance costs. The impacts to environment and human health of differing expeditionary waste management strategies were compared using the Life Cycle Assessment software SimaPro 8.0. Emissions of individual waste management scenarios were compiled from peer-reviewed literature, converted to values compatible with SimaPro’s waste scenario inputs, and the calculated impacts compared using SimaPro’s pre-loaded methodologies. These calculated impacts and the economic impacts confirm that open-air burning of waste is not only dangerous to humans and the environment, but is also not cost-effective. Considering the economic effects and the mitigated human and environmental health impacts, WTE technologies may be a viable waste management strategy for the future.

关键词： Life Cycle Assessment (LCA) Municipal Solid Waste (MSW) Incineration Sanitary Landfill Open Burn Pits

A Non-Blinded, Case Controlled Pilot Study to Evaluate a Novel Mask Ventilation Technique in Patients with Established Risk Factors for Difficult Mask Ventilation

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Open Journal of Anesthesiology 2016年第10期6卷 165-174页

作者： Dennis Grech david Kam Gregory Bryan Harry Israel Alex Bekker Department of Anesthesia and Perioperative Care Rutgers New Jersey Medical School Newark NJ USA Department of Anesthesiology Albert Einstein College of Medicine Montefiore Medical Center Bronx NY USA

Traditionally, there are two main methods of mask placement during face mask ventilation: one handed (CE) grip and two handed grip (THT). One handed grip is limited by air leaks between mask and patients face on the side opposite to stabilizing hand. Two handed grips provide protection against air leak but require second provider to deliver tidal volumes when using a self inflating bag or anesthesia circuit on manual ventilation. This study introduces modified CE grip which creates a firm seal at patient’s face on both sides of mask, enabling adequate tidal volume delivery with provider’s second hand. Using left hand, provider places the fifth digit along inferior border of body of left mandible. The fourth digit is placed along inferior border of body right mandible. Standing 6 inches to the left and immediately behind a supine patient on an OR table, provider rotates clockwise 45 degrees at hip, keeping elbow against their body, and lifts patient’s chin to 45 degrees. Rotational force at hip augments hand strength while tilting chin. The thumb applies pressure along left border of facemask, and the second and third digits apply pressure to right border of facemask. Methods: Patients with known predictors of difficult mask ventilation (Edentulous, bearded, Obstructive sleep apnea (OSA), mallampati 3 or 4) were in experimental group. Normal patients assigned as Controls. After induction of general anesthesia, provider ventilated patient using adult sized facemask. The anesthesia ventilator delivered standardized tidal volumes. TV, airway pressures, HR and O2 saturation were recorded after each breath. Results: All groups, except OSA, showed improvement, in tidal volumes with the novel technique compared to the traditional CE grip. Conclusion: The novel submandibular technique, an important skill, increases tidal volumes during mask ventilation for certain high risk patients.

关键词： Mask Ventilation CE Grip Tidal Volume Airway Skills

Application of Regularized Logistic Regression and Artificial Neural Network Model for Ozone Classification across El Paso County, Texas, United States

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Journal of Data Analysis and Information Processing 2023年第3期11卷 217-239页

作者： Callistus Obunadike Adekunle Adefabi Somtobe Olisah david Abimbola Kunle Oloyede Department of Computer Science Austin Peay State University Clarksville USA

This paper focuses on ozone prediction in the atmosphere using a machine learning approach. We utilize air pollutant and meteorological variable datasets from the El Paso area to classify ozone levels as high or low. The LR and ANN algorithms are employed to train the datasets. The models demonstrate a remarkably high classification accuracy of 89.3% in predicting ozone levels on a given day. Evaluation metrics reveal that both the ANN and LR models exhibit accuracies of 89.3% and 88.4%, respectively. Additionally, the AUC values for both models are comparable, with the ANN achieving 95.4% and the LR obtaining 95.2%. The lower the cross-entropy loss (log loss), the higher the model’s accuracy or performance. Our ANN model yields a log loss of 3.74, while the LR model shows a log loss of 6.03. The prediction time for the ANN model is approximately 0.00 seconds, whereas the LR model takes 0.02 seconds. Our odds ratio analysis indicates that features such as “Solar radiation”, “Std. Dev. Wind Direction”, “outdoor temperature”, “dew point temperature”, and “PM10” contribute to high ozone levels in El Paso, Texas. Based on metrics such as accuracy, error rate, log loss, and prediction time, the ANN model proves to be faster and more suitable for ozone classification in the El Paso, Texas area.

关键词： Machine Learning Ozone Prediction Pollutants Forecasting Atmospheric Monitoring Air Quality Logistic Regression Artificial Neural Network

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Spermotrend Improves Semen Quality and Infertility in Men with Varicocele —Spermotrend and Male Infertility

作者： (美)托马斯(Thomas david)

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Advances in Reproductive Sciences 2024年第2期12卷 83-97页

作者： Melida Aguilar Chamorro Sergio Antonio Vargas Collado david Marquez Soriano Clinica Seniors Managua Nicaragua Scientific Department Catalysis S.L. Madrid Spain

Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ***, with the code: NCT05222841 on 15/06/2021.

关键词： Antioxidants Dietary Supplementation Male Infertility Spermatogenesis Varicocele Pygeum africanum

3 - 100 Novel Role for Fanconi Anemia Pathway in Clustered DNA Damage Repair

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IMP & HIRFL Annual Report 2012年第1期 193-194页

作者： Zhu Jiayun Asaithamby Aroumougame Chen david Hu Burong

COVID-19 Vaccine, Asymptomatic Cases, Risk Communication and Community Engagement in Sub-Saharan Africa

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Open Journal of Preventive Medicine 2021年第3期11卷 71-79页

作者： david Houéto Ferdinand Daga Alexandre Timé Romulus Honhonou Maurice Agonnoudé School of Public Health (ENATSE) University of Parakou Parakou Benin Institute of nursing and obstetrics Education (IFSIO) University of Parakou Parakou Benin School of Medicine (FM) University of Parakou Parakou Benin

African region will probably be the last region in COVID-19 vaccine uptake. But that shouldn’t be a problematic issue if the emphasis is maintained on the role Risk Communication and Community Engagement (RCCE) can play in controlling the COVID-19 pandemic through the adoption of preventive measures. We used the issue of asymptomatic cases to illustrate the importance that should still be given to preventive measures such as hand washing, mask wearing, physical and social distancing, knowing that vaccines have never been 100% effective. Also with the issue of variants in COVID-19, the vaccine couldn’t be considered as a panacea. Lessons from the Nordic countries are strong arguments to put emphasis on preventive measures in the region.

关键词： COVID-19 Vaccine Asymptomatic Preventive Measures Risk Communication and Community Engagement

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灵宝扩建工程6英寸换流阀的设计和试验

电网技术 2010年第12期34卷 136-141页

作者：查鲲鹏温家良王高勇杨晓楠周军川高冲 david A Jackson 中国电力科学研究院北京市海淀区100192 AREVA输配电集团

对灵宝扩建工程6英寸换流阀的设计、绝缘和运行试验进行了介绍,并给出了试验电路拓扑。灵宝扩建工程是世界上首次基于6英寸晶闸管换流阀将额定直流电流提升至4 500 A的工程实践。直流换流阀的设计是直流输电工程的关键技术之一,直接影... 详细信息

对灵宝扩建工程6英寸换流阀的设计、绝缘和运行试验进行了介绍,并给出了试验电路拓扑。灵宝扩建工程是世界上首次基于6英寸晶闸管换流阀将额定直流电流提升至4 500 A的工程实践。直流换流阀的设计是直流输电工程的关键技术之一,直接影响工程的安全可靠运行。

关键词：灵宝扩建工程 6英寸换流阀绝缘试验运行试验