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On CAP Representations for Even Orthogonal Groups I:A Correspondence of Unramified Representations

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Chinese Annals of Mathematics,Series B 2015年第4期36卷 485-522页

作者： david GINZBURG Dihua JIANG david SOUDRY School of Mathematical Sciences Sackler Faculty of Exact Sciences Tel-Aviv University School of Mathematics University of Minnesota

The authors prove the local unramified correspondence for a new type of construction of CAP representations of even orthogonal groups by a generalized automorphic descent method. This method is expected to work.for al... 详细信息

关键词： Automorphic representations Fourier coefficients Satak. parametertransfer

A methodological framework.for improving air quality monitoring network.*** to environment management

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Journal of Environmental Sciences 2021年第4期33卷 138-147页

作者： david Galán-Madruga Department of Atmospheric Pollution National Center for Environment HealthHealth Institute Carlos IIICtra.Majadahonda a Pozuelo km 2228220 MadridSpain

This work.aims to provide a methodology framework.which allows to improve the performance and efficiency of an air quality monitoring network.AQMN).It requires to be constituted by a minimum and reliable number of measurement ***,the AQMN efficiency should be assessed over time,as a consequence of the possible emergence of new emission sources of air pollutants,which could lead to variations on their spatial distribution within the target ***_(10)particles data monitored by the Community of Madrid's(Spain)AQMN between 2008 and 2017 were used to develop a methodology to optimize the AQMN *** annual spatial distribution of average PM_(10)levels over the studied period monitored by all current stations vs those more representative was provided by a geographic information system(GIS),and the percentage of similarity between both postulates was quantified using simple linear regression(>95%).As one innovative tool of this study,the practical application of the proposed methodology was validated using PM_(10)particles data measured by AQMN during 2007 and 2018,reaching a similitude degree higher than 95%.The influence of temporal variation on the proposed methodological framework.was around 20%.The proposed methodology sets criteria for identifying non-redundant stations within AQMN,it is also able to appropriately assess the representativeness of fixed monitoring sites within an AQMN and it complements the guidelines set by European legislation on air pollutants monitoring at fixed stations,which could help to tack.e efforts to improve the air quality management.

关键词： Air quality Ambient air monitoring network PM_(10)particles Redundant stations Optimization Environment management

Numerical analysis for the prediction of bump prone conditions:A southern Appalachian pillar coal bump case study

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International Journal of Mining Science and Technology 2021年第1期31卷 75-81页

作者： Christopher Newman david Newman Appalachian Mining&Engineering Inc.LexingtonKY 40503USA

Two miners were fatally injured when a pillar bump occurred during retreat mining in a southern West Virginia coal *** mine was operating in the Eagle seam with overmining in the No.2 Gas and Powellton seams.A coal bump is defined as a sudden and violent failure of coal caused by the release of stored strain energy in the *** significant strides have been made by academia,industry,and regulatory agencies to better understand bump conditions and mitigation techniques,coal bumps represent a long standing,highly site-specific engineering problem in which the exact failure mechanism is not clearly *** this case history,a cut-by-cut analysis of retreat mining operations was conducted on the 4 East Main leading up to the pillar bump *** input parameters were derived from site-specific geologic information and mine geometry for the analysis of pillar stress conditions and energy release using *** overview of stress conditions in the panel was presented including a precursor event that occurred two crosscuts inby the bump *** methodology presented in the paper for the evaluation of the fatal bump event can be used for the identification of bump prone conditions prior to development and retreat of a mining area.

关键词： Bump Burst Coal Energy release rate LaModel Numerical modeling

Participation of CD45,Nk.-P1A and ANk.1 antigen in rat hepatic Nk.cell(pit cell)-mediated target cell cytotoxicity

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World Journal of Gastroenterology 2000年第4期6卷 546-552页

作者： david Vermiilen Bülent Ahishali Vasilis Triantis k.rin Vanderk.rk.n Peter J. k.k.ppen Eddie Wisse Laboratory for Cell Biology and Histology. Department of Hematology and immunology Free University of Brussels(VUB)Brussels-JetteBelgium k.Vanderk.rk.n is a postdoctoral researcher of the Fund for Scientific Research Flanders. Department of Surgery and Pathology Leiden University Medical CenterLeidenThe Netherlands

AIM Several triggering receptors have beendescribed to be involved in natural k.ller（Nk.cell-mediated target *** these studies,Nk.ells derived from blood or spleen were *** are liver-specific Nk.cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood Nk.*** aim of this study was to characterize the roleof the Nk.triggering molecules Nk.-P1A,ANk.1antigen,and CD45 in pit cell-mediated k.lling oftarget *** 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,*** Flow cytometric analysis showed thatpit cells expressed CD45,Nk.-P1A,and *** of pit cells with monoclonalantibody（mAb）to CD45（ANk.4）not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit *** mAbs to Nk.-P1A（3.2.3）and ANk.1 antigen（ANk.1）had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive（FcγR+）P815 cytolysis *** enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof *** These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and ***-P1A andANk.1 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway.

关键词： hepatic Nk cells pit cells cytolysis apoptosis perforin/granzyme pathway

The Two Hyperplane Conjecture

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Acta Mathematica Sinica,English Series 2019年第6期35卷 728-748页

作者： david JERISON Department of Mathematics Massachusetts Institute of Technology

We introduce a conjecture that we call the Two Hyperplane Conjecture, saying that an isoperimetric surface that divides a convex body in half by volume is trapped between parallel hyperplanes. The conjecture is motivated by an approach we propose to the Hots Spots Conjecture of J. Rauch using deformation and Lipschitz bounds for level sets of eigenfunctions. We will relate this approach to quantitative connectivity properties of level sets of solutions to elliptic variational problems, including isoperimetric inequalities, Poincar′e inequalities, Harnack.inequalities, and NTA(non-tangentially accessibility). This paper mostly ask. questions rather than answering them, while recasting k.own results in a new light. Its main theme is that the level sets of least energy solutions to scalar variational problems should be as simple as possible.

关键词： Minimal surfaces isoperimetric elliptic variational problems hot spots conjecture

Meta-analysis reveals that reproductive strategies are associated with sexual differences in oxidative balance across vertebrates

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Current Zoology 2018年第1期64卷 1-11页

作者： david COSTANTINI UMR 7221 Museum National d'Histoire Naturelle 7 rue Cuvier 75231 Paris Cedex 05 France Department of Evolutionary Ecology Leibniz Institute for Zoo and Wildlife Research Alfred-Kowalke-Str. 17 Berlin 10315 Germany Behavioural Ecology & Ecophysiology Group Department of Biology University of Antwerp Universiteitsplein 1 Wilrijk 2610 Belgium

Oxidative stress is a k.y physiological mechanism underlying life-history tradeoffs. Here, I use meta-analytic techniques to test whether sexual differences in oxidative balance are common in vertebrates and to identify which factors are associated with such differences. The dataset included 732 effect size estimates from 100 articles （82 species）. Larger unsigned effect size （meaning larger sexual differences in a given mark.r） occurred in： reptiles and fish; those species that do not pro- vide parental care; and oviparous species. Estimates of signed effect size （positive values meaning higher oxidative stress in males） indicated that females were less resistant to oxidative stress than males in： reptiles while males and females were similar in fish, birds, and mammals; those species that do not provide parental care; and oviparous species. There was no evidence for a significant sexual differentiation in oxidative balance in fish, birds, and mammals. Effect size was not associ- ated with： the number of offspring; whether the experimental animals were reproducing or not; biomark.r （oxidative damage, non-enzymatic, or enzymatic antioxidant）, the species body mass; the strain （wild vs. domestic）; or the study environment （wild vs. captivity）. Oxidative stress tended to be higher in females than males across most of the tissues analyzed. Levels of residual heterogeneity were high in all models tested. The findings of this meta-analysis indicate that diversification of reproductive strategies might be associated with sexual differences in oxidative balance. This explorative meta-analysis offers a starting platform for future research to investigate the rela-tionship between sex and oxidative balance further.

关键词： antioxidants oviparity oxidative damage parental care vertebrates viviparity.

Phage lytic enzymes: a history

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Virologica Sinica 2015年第1期30卷 26-32页

作者： david Trudil New Horizons Diagnostic Corporation Baltimore MD 21227 USA

There are many recent studies regarding the efficacy of bacteriophage-related lytic enzymes: the enzymes of ‘bacteria-eaters' or viruses that infect bacteria. By degrading the cell wall of the targeted bacteria, these lytic enzymes have been shown to efficiently lyse Gram-positive bacteria without affecting normal flora and non-related bacteria. Recent studies have suggested approaches for lysing Gram-negative bacteria as well(Briersa Y, et al., 2014). These enzymes include: phage-lysozyme, endolysin, lysozyme, lysin, phage lysin, phage lytic enzymes, phageassociated enzymes, enzybiotics, muralysin, muramidase, virolysin and designations such as Ply, PAE and others. Bacteriophages are viruses that k.ll bacteria, do not contribute to antimicrobial resistance, are easy to develop, inexpensive to manufacture and safe for humans, animals and the environment. The current focus on lytic enzymes has been on their use as anti-infectives in humans and more recently in agricultural research models. The initial translational application of lytic enzymes, however, was not associated with treating or preventing a specifi c disease but rather as an extraction method to be incorporated in a rapid bacterial detection assay(Bernstein D, 1997).The current review traces the translational history of phage lytic enzymes–from their initial discovery in 1986 for the rapid detection of group A streptococcus in clinical specimens to evolving applications in the detection and prevention of disease in humans and in agriculture.

关键词： bacteriophage phage lytic enzymes translational application lysin

The genetic architecture of autism spectrum disorders(ASDs) and the potential importance of common regulatory genetic variants

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Science China(Life Sciences) 2015年第10期58卷 968-975页

作者： david SAFFEN Institutes of Brain Science Fudan University

Currently, there is great interest in identifying genetic variants that contribute to the risk.of developing autism spectrum disor- ders （ASDs）, due in part to recent increases in the frequency of diagnosis of these disorders worldwide. While there is nearly universal agreement that ASDs are complex diseases, with multiple genetic and environmental contributing factors, there is less agreement concerning the relative importance of common vs rare genetic variants in ASD liability. Recent observations that rare mutations and copy number variants （CNVs） are frequently associated with ASDs, combined with reduced fecundity of individuals with these disorders, has led to the hypothesis that ASDs are caused primarily by de novo or rare genetic muta- tions. Based on this model, large-scale whole-genome DNA sequencing has been proposed as the most appropriate method for discovering ASD liability genes. While this approach will undoubtedly identity many novel candidate genes and produce important new insights concerning the genetic causes of these disorders, a full accounting of the genetics of ASDs will be incomplete absent an understanding of the contributions of common regulatory variants, which are lik.ly to influence ASD liability by modifying the effects of rare variants or, by assuming unfavorable combinations, directly produce these disorders. Because it is not yet possible to identify regulatory genetic variants by examination of DNA sequences alone, their identitication will require experimentation. In this essay, I discuss these issues and describe the advantages of measurements of allelic expression imbalance （AEI） of mRNA expression for identifying cis-acting regulatory variants that contribute to ASDs.

关键词： common-disease-common-variant model common-disease-rare-variant model copy number variant (CNV) aUelic expression imbalance (AEI)

Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses

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Open Journal of Gastroenterology 2015年第4期5卷 21-27页

作者： John k. Chia Andrew Y. Chia david Wang Rabiha El-Habbal EV Med Research LLC Lomita USA

After decades of research, functional dyspepsia (FD) remains one of the most elusive gastrointestinal disorders. Endoscopic appearance of mild inflammation of the gastric mucosa without ulceration and microscopic evidence of mild chronic inflammation are often considered as normal findings since no etiology could be found other than H. Pylori. Enteroviruses infect the gastrointestinal tract and have been shown to persist in the stomach of symptomatic patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we evaluated FD patients with and without the diagnosis of ME/CFS, and were able to support the viral protein staining with finding of double-stranded RNA in 63% of the same stomach biopsies by immunoperoxidase staining. Furthermore, we clarified the possible cross-reaction with creatine k.nase brain subtype (Ck.), present in parietal cells, using antibody competition experiments and western blot analysis of stomach proteins. Viral protein+ and dsRNA+ biopsies were infectious in SCID mice. More research is needed to elucidate the mechanism of enterovirus infection of the stomach associated with FD and chronic gastritis.

关键词： Functional Dyspepsia Chronic Gastritis Enterovirus Double Stranded RNA