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Calcite twinning strain variations across the Proterozoic Grenville orogen and Keweenaw-Kapuskasing inverted foreland,USA and Canada

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Geoscience Frontiers 2017年第6期8卷 1357-1384页

作者： john P.Craddock Suzanne D.Craddock Alex Konstantinou Andrew R.C.Kylander-Clark david H.Malone Geology Department Macalester CollegeSt.PaulMN 55105USA School of Earth Sciences and Environmental Sustainability Northern Arizona UniversityFlagstaffAZUSA Cyprus Hydrocarbons Company NicosiaCyprus Department of Earth Science University of CaliforniaSanta BarbaraCA 93106USA Department of Geography-Geology Illinois State UniversityNormalIL 61790-4400USA

We report the calcite twinning strain results of a traverse across the Grenville orogen from Parry Sound,Ontario(NW)to ***,New York(SE),including the younger,adjacent Ordovician Taconic *** four carbonates(marbles,calcite veins,Ordovician limestone)were collected resulting in 68 strain analyses on mechanically twinned calcite(n=2337 grains)across the Central Gneiss Belt(CGB;3 samples),the Central Metasedimentary Belt(CMB;27 samples),the Central Granulite Terrane(CGT;Adirondack's;13 samples)and the Ottawan Orogenic Lid(OOL;11 samples).Twinning strains in the greenschist-grade OOL marbles preserve N-S shortening and U-Pb titanite ages(~1150 Ma;n=4)document these marbles formed during the Shawinigan(1190-1140 Ma)part of the Grenville *** northwest to southeast,the Ottawan(1095-1020 Ma)twinning strain is dominantly a layerparallel shortening fabric oriented N-S(Parry Sound),then becomes parallel to the Grenville thrust direction(NW-SE)across the CMB to the Adirondack Highlands where the sub-horizontal shortening strain becomes margin-parallel(SW-NE).Within the regional sample suite there are two areas studied in detail,the Bancroft shear zone(n=11)and a roadcut on the southeast side of the Adirondack Mountains(***,NY;n=8).Marbles from the Bancroft shear zone contain calcite grains with 2 sets of twin lamellae(e_1 and e_2).The better-developed e_1 sets(n=406)record a horizontal fabric oriented NW-SE whereas the younger e_2 lamellae(n=146)preserve a margin-parallel(SW-NE)horizontal *** the e_1 and e_2 strains record an overprint vertical shortening strain(NEV),perhaps related to extensional orogenic *** also report an Ottawan orogen-aged granoblastic mylonite(1093 Ma,U-Pb zircon;1102 Ma Ar-Ar biotite)in the Keweenaw thrust hanging wall 500 km inboard of the Grenville front and interpret the relations of Grenville-Keweenaw far-field dynamics.

关键词： Orogenic belts Strain Proterozoic

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Deriving the coronal hole electron temperature: electron density dependent ionization / recombination considerations

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Research in Astronomy and Astrophysics 2010年第1期10卷 91-95页

作者： john Gerard Doyle Steven Chapman Paul Bryans david Pérez-Suárez Avninda Singh Hugh Summers Daniel Wolf Savin Armagh Observatory College HillArmagh BT61 9DGN.Ireland Centre for Astrophysics University of Central LancashirePrestonUK Space Science Division Naval Research LaboratoryWashingtonDC 20375USA George Mason University 4400 University DriveFairfaxVA 22020USA Department of Physics & Electronics Deen Dayal Upadhyaya CollegeUniversity of DelhiIndia Department of Physics University of Strathclyde107 RottenrowGlasgowG4 0NGScotland Columbia Astrophysics Laboratory 550 W 120th StNew YorkNY 10027USA

Comparison of appropriate theoretically derived line ratios with observational data can yield estimates of a plasma＇s physical parameters, such as electron density or temperature. The usual practice in the calculation of the line ratio is the assumption of excitation by electrons/protons followed by radiative decay. Furthermore, it is normal to use the so-called coronal approximation, i.e. one only considers ionization and recombination to and from the ground-state. A more accurate treatment is to include ionization/recombination to and from metastable levels. Here, we apply this to two lines from adjacent ionization stages, Mg IX 368A and Mg × 625A, which has been shown to be a very useful temperature diagnostic. At densities typical of coronal hole conditions, the difference between the electron temperature derived assuming the zero density limit compared with the electron density dependent ionization/recombination is small. This, however, is not the case for flares where the electron density is orders of magnitude larger. The derived temperature for the coronal hole at solar maximum is around 1.04MK compared to just below 0.82MK at solar minimum.

关键词： atomic processes - line formation - Sun activity

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Potential of capillary electrophoresis mass spectrometry for the characterization and monitoring of amine-derivatized naphthenic acids from oil sands process-affected water

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Journal of Environmental Sciences 2016年第11期28卷 203-212页

作者： Matthew S.MacLennan Cai Tie Kevin Kovalchik Kerry M.Peru Xinxiang Zhang john V.Headley david D.Y.Chen Department of Chemistry University of British Columbia Vancouver BC V6T 1Z1 Canada. State Key Laboratory of Bioactiue Substance and Function of Natural Medicines Institute of Materia Medica Peking Union Medical College &Chinese Academy of Medical Sciences Beijing 100050 China Water Science and Technology Directorate Science and Technology Branch Environment and Climate Change Canada SaskatoonSK S7N 3H5 Canada College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Capillary electrophoresis coupled to mass spectrometry（CE–MS） was used for the analysis of naphthenic acid fraction compounds（NAFCs） of oil sands process-affected water（OSPW）. A standard mixture of amine-derivatized naphthenic acids is injected directly onto the CE column and analyzed by CE–MS in less than 15 min. Time of flight MS analysis（TOFMS）, optimized for high molecular weight ions, showed NAFCs between 250 and 800 m/z. With a quadrupole mass analyzer, only low-molecular weight NAFCs（between 100 and 450 m/z） are visible under our experimental conditions. Derivatization of NAFCs consisted of two-step amidation reactions mediated by 1-ethyl-3-（3-dimethylaminopropyl）carbodiimide（EDC）, or mediated by a mixture of EDC and N-hydroxysuccinimide, in dimethyl sulfoxide, dichloromethane or ethyl acetate. The optimum background electrolyte composition was determined to be 30%（V/V） methanol in water and 2%（V/V） formic acid. NAFCs extracted from OSPW in the Athabasca oil sands region were used to demonstrate the feasibility of CE–MS for the analysis of NAFCs in environmental samples, showing that the labeled naphthenic acids are in the mass range of 350 to 1500 m/z.

关键词： Capillary electrophoresis Mass spectrometry Electrospray ionization Carbodiimide Oil sands process-affected water Naphthenic acids

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A ten-year experience of inferior vena cava reconstruction for malignancy:The importance of a multidisciplinary approach with hepatobiliary surgery

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 396-398页

作者： Maria R.Baimas-George Ryan C.Pickens Jesse K.Sulzer Dionisios Vrochides john B.Martinie david M.Levi david A.Iannitti Division of Hepatopancreatobiliary Surgery Department of SurgeryCarolinas Medical Center1025 Morehead Medical DriveSuite 600CharlotteNC 28204USA Division of Transplant Surgery Department of SurgeryCarolinas Medical CenterCharlotteNCUSA

To the Editor,Tumor invasion of the inferior vena cava(IVC)through direct erosion is a rare and poor prognostic feature of aggressive hepatic or perihepatic malignancies[1,2].Literature shows poor response to chemotherapy,such that resection often is the only option for improved survival[3].Multidisciplinary collaborations can expand technical options;incorporation of transplant techniques has led to successful R0 resection involving difficult vascular reconstruction and extended resection[4,5].This study describes and analyzes the ten-year collaborative experience of hepatobiliary(HPB)surgeons in management of malignancies involving the perihepatic IVC.

关键词： hepato hepatic invasion

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Evaluation of the Patient with Incidental Left Ventricular Hypertrophy on Echocardiography

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Cardiovascular Innovations and Applications 2019年第B04期4卷 43-51页

作者： Darrell B.Newman,md john P.Bois,md Jeffrey B.Geske,md Department of Cardiovascular Diseases Mayo ClinicRochesterMNUSA

Left ventricular hypertrophy(LVH),or an increase in cardiac mass,usually refl ects pathologic adaptation to chronic pressure or volume *** adaptation in athletes as well as genetic,metabolic,and infi ltrative disorders may also result in increased cardiac *** vast differences in prognosis and therapeutic options associated with different underlying conditions,the evaluation of patients with LVH necessitates a modern,comprehensive evaluation incorporating multimodality *** we present a systematic approach to patients with incidental LVH.

关键词： left ventricular hypertrophy evaluation of patients multimodality imaging

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An ongoing search for potential targets and therapies for lethal sepsis

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Military Medical Research 2015年第3期3卷 145-155页

作者： Guo-Qiang Bao Li He david Lee john D'Angelo Hai-Chao Wang Department of Emergency Medicine North Shore University Hospital The Feinstein Institute for Medical Research 350 Community Drive Department of General Surgery Tangdu Hospital The 4th Military Medical University Department of Ophthalmology University of Alabama at Birmingham

Sepsis, which refers to a systemic inflammatory response syndrome resulting from a microbial infection, represents the leading cause of death in intensive care units. The pathogenesis of sepsis remains poorly understood although it is attributable to dysregulated immune responses orchestrated by innate immune cells that sequentially release early(e.g., tumor necrosis factor(TNF), interleukin-1(IL-1), and interferon-γ(IFN-γ) and late(e.g., high mobility group box 1(HMGB1)) pro-inflammatory mediators. As a ubiquitous nuclear protein, HMGB1 can be passively released from pathologically damaged cells, thereby converging infection and injury on commonly dysregulated inflammatory responses. We review evidence that supports extracellular HMGB1 as a late mediator of inflammatory diseases and discuss the potential of several Chinese herbal components as HMGB1-targeting therapies. We propose that it is important to develop strategies for specifically attenuating injury-elicited inflammatory responses without compromising the infection-mediated innate immunity for the clinical management of sepsis and other inflammatory diseases.

关键词： Innate immune cells Pathogen-associated molecular pattern molecules High mobility group box 1 Herbal components Sepsis Autophagy Endocytosis Double-stranded RNA-activated protein kinase R

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Variation of a floral polymorphism at different spatial scales in the Mediterranean geophyte Narcissus assoanus

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Journal of Plant Ecology 2016年第3期9卷 333-345页

作者： Regina Berjano Perrine Gauthier Chiara Parisi Valentine Vaudey Virginie Pons Alain Renaux david Doblas john D.Thompson UMR 5175 Centre d’Ecologie Fonctionnelle et Evolutive CNRS1919 route de Mende34293 Montpellier cedex 5France Departamento de Biología Vegetal y Ecología University of SevilleApdo 1095.41080 SevilleSpain

Aims Habitat fragmentation impacts the spatial extent and isolation of local populations and *** the biological consequences of these impacts have been well studied at the site level,effects directly related to changes in the spatial configuration of populations in the landscape remain less *** objective of this study is to examine how changes in the spatial-scale configuration of populations are associated with variability in morph rations in the floral polymorphic Mediterranean geophyte Narcissus *** We performed a nested analysis of morph ratio variation at three spatial scales:a 50×50 km regional scale in SE France,in fourteen 1×1 km landscapes located in the same region,and within 12 spatially extensive population *** also quantified variation in the behaviour of pollinators in population patches of contrasting spatial *** FindingsAt a regional scale,morph ratios show a geographic pattern of increasing isoplethy(1:1 morph ratio)away from centres of human population development and in upland *** the landscape scale,isoplethy of local population patches is more correlated with decreased isolation among patches than with patch ***,within local isoplethic populations,small patches can show significantly biased morph *** small isolated patches,pollinators perform shorter flight distances among consecutive flower visits than in spatially extensive *** study of variation in a genetic polymorphism at multiple spatial scales provides new insights into the scale-dependent effects of habitat fragmentation and the potential occurrence of metapopulation dynamics in natural plant populations.

关键词： flower polymorphism habitat fragmentation Mediterranean Narcissus stigma-height polymorphism

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Hepatocellular carcinoma national burden across different geographical regions in the United States between 2001 and 2020

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World Journal of Methodology 2024年第4期14卷 110-120页

作者： Yazan Abboud Raj Malhotra Muhammad Hassaan Arif Maan Anna Mathew Ibrahim Abboud Chun-Wei Pan Saqr Alsakarneh Fouad Jaber Islam Mohamed david Kim Nikolaos T Pyrsopoulos Department of Internal Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States University of California Riverside School of Medicine RiversideCA 92521United States Department of Internal Medicine John H Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine University of Missouri-Kansas CityKansasMO 64108United States Division of Gastroenterology and Hepatology Rutgers New Jersey Medical SchoolNewarkNJ 07101United States

BACKGROUND While prior data showed an increasing incidence of hepatocellular carcinoma(HCC)in the United States,there are limited comprehensive and comparative data on the geographical variations of HCC trends in different demographicspecific *** To evaluate sex and age-specific incidence rates and time trends in different geographical regions in the United *** Age-adjusted HCC incidence rates were collected from the United States Cancer Statistics(USCS)database which covers approximately 98%of the population in the United *** rates were stratified by sex,age,and geographical *** percentage change(APC)and average APC(AAPC)were estimated using Joinpoint Regression.A pairwise comparison was conducted between sex-specific *** There were 467344 patients diagnosed with HCC in the United States in the USCS database between 2001 and *** rates and trends varied by geographical *** looking at the West region(115336 patients),incidence rates of HCC were overall increasing and also increasing in older ***,when evaluating younger adults,HCC incidence rates decreased in men but not in women with a sex-specific absolute AAPC-difference of 2.15(P=0.005).When evaluating the Midwest region(84612 patients),similar results were *** incidence rates were increasing in the overall population and in older adults as well,they were decreasing in younger men but not in women with a sex-specific absolute AAPC-difference of 1.61(P<0.001).For the Northeast region(87259 patients),the analysis showed similar results with decreasing HCC incidence rates in younger men but not counterpart women(Sex-specific AAPC-difference=3.26,P<0.001).Lastly,when evaluating the south(180137 patients),the results were also decreasing in younger men but not in women(Sex-specific AAPC-difference=2.55,P<0.001).CONCLUSION Nationwide analysis covering around 98%of the United States population shows an increasing incidence of HCC across all

关键词： Hepatocellular carcinoma Incidence Epidemiology Health disparity Geography

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Study of Dissolved Chlorofluorocarbons in Lake Washington

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Chinese Journal of Oceanology and Limnology 2003年第2期21卷 171-179页

作者：韩丽君 john L. Bullister david P. Wisegarver Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China National Oceanic and Atmospheric Administration Pacific Marine Environmental Laboratory Seattle WA 98115 USA

Measurements of three chlorofluorocarbons (CFCs): trichlorofluoromethane (CFC-11), dichlorodifluoromethane (CFC-12) and trichlorotrifluoroethane (CFC-113), along with methyl chloroform (CH 3CCl 3) and carbon tetrachloride (CCl 4) were made in water samples from Lake Washington, using Electron Capture-Gas Chromatography (EC-GC). The samples were collected in mid-autumn, a period when the lake’s upper layer undergoes rapid cooling. At the time of sampling, a strong vertical temperature gradient was present in the lake, with surface temperatures of ～14℃, and near bottom (50 meters) temperatures of ～8℃. The concentrations of dissolved CFC-12 and CFC-11 increased with depth, as expected from the higher solubilities of these gases at lower temperatures. Atmospheric measurements made at the sampling site at the time of the cruise, showed that CFC-11 and CFC-12 saturations in the near surface samples were 100 % and 106%, respectively. For the deepest sample (52 meters) CFC-11 and CFC-12 saturations were 102 % and 126 %. Because the surface layer of the lake responds to changes in atmospheric CFCs on a time scale of several weeks, the higher than equilibrium concentrations of CFC-12 observed at the time of sampling may reflect earlier episodes of elevated levels of atmospheric CFC-12 in this urban area. High concentrations of dissolved CFCs in runoff or industrial effluent might also lead to elevated CFC levels in the lake. The cold, deep water of Lake Washington is relatively isolated from the effects of surface gas exchange except during winter, and the supersaturations observed in the deep layer may reflect periods of elevated atmospheric CFC-12 levels from the previous winter season. These results were compared to summertime profiles of CFC-11 and CFC-12 made in 1994.

关键词： chlorofluorocarbons(CFCs) solubilities saturations Electron Capture-Gas Chromatography (EC-GC)

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A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2406-2416页

作者： Pedro Martín-Acosta Qianli Meng john Klimek Ashok P.Reddy Larry david Stefanie Kaech Petrie Bingbing X.Li Xiangshu Xiao Program in Chemical Biology Department of Chemical Physiology and BiochemistryOregon Health&Science UniversityPortlandOR 97239USA Proteomics Shared Resource Oregon Health&Science UniversityPortlandOR 97239USA Knight Cancer Institute Oregon Health&Science UniversityPortlandOR 97239USA Department of Neurology Oregon Health&Science UniversityPortlandOR 97239USA

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge,unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for target identification. One major limitation of this approach is the efficient synthesis of appropriately substituted clickable photoaffinity probes. Herein, we describe an efficient and consistent method to prepare such probes. We further employed this method to prepare a highly stereo-congested probe based on naturally occurring triterpenoid betulinic acid. With this photoaffinity probe, we identified tropomyosin as a novel target for betulinic acid that can account for the unique biological phenotype on cellular cytoskeleton induced by betulinic acid.

关键词： Betulinic acid Cancer Diazirine Natural product Photoaffinity probe Tropomyosin

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