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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Animal models for studying hepatitis C and alcohol effects on liver

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World Journal of Gastroenterology 2011年第20期17卷 2515-2519页

作者： david f Mercer Department of Surgery Liver/Small Bowel Transplant Program University of Nebraska Medical Center 983285 Nebraska Medical Center

Chronic consumption of ethanol has a dramatic effect on the clinical outcome of patients with hepatitis C virus (HCV) infection, but the mechanism linking these two pathologies is unknown. Presently, in vitro systems are limited in their ability to study the interaction between a productive wild-type HCV infection and chronic ethanol exposure. Mouse models are potentially very useful in dissecting elements of the HCV-ethanol relationship. Experiments in mice that transgenically express HCV proteins are outlined, as are experiments for the generation of mice with chimeric human livers. The latter models appear to have the most promise for accurately modeling the effects of chronic ethanol intake in HCV-infected human livers.

关键词： Mouse models Hepatitis C Ethanol Transgenic mice

Predictions of decreased surface roughness after shot peening using controlled media dimensions

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Journal of Materials Science & Technology 2020年第23期58卷 120-129页

作者： Siavash Ghanbari david f.Bahr School of Materials Engineering Purdue UniversityWest LafayetteIN47907USA

Shot peening induces residual compressive stresses on metallic substrates, often used to decrease fatigue crack growth. The relationship between surface roughness and the magnitude of the stress can be affected by peening media size or the extent of peening. Generally, an ideal condition from shot peening would be a high compressive residual stress and a low surface roughness, but these tend to be inversely *** study proposes a method for decreasing roughness and increasing residual stress concurrently using a distribution of shot sizes in a single shot peening passage based on finite element modeling that has been calibrated using by experimental results. Numerical models predict mixed shot sizes will create a smoother surface than using monodispersed shot at 100 % coverage. The residual stress profile for mixed shot sizes showed a broad range of compressive residual stresses in comparison with the largest impact ball size. This newly proposed method can improve the surface quality and the extent of the compressive residual stresses in a single-shot peening passage.

关键词： Numerical analysis Shot peening Roughness

The embryology of persistent cloaca and urogenital sinus malformations

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Asian Journal of Andrology 2020年第2期22卷 124-128页

作者： david f M Thomas University of Leeds LeedsWest Yorkshire LS29JTUK

Cloacal malformations are characterized by the confluence of the lower urinary tract,the female reproductive tract,and the rectum to create a common channel with a single opening on the *** presence of a cloaca is a normal phase of early human embryological *** the 4^th and 7^th weeks of gestation,the cloaca undergoes subdivision to form the hindgut and urogenital *** of this process results in the congenital anomaly termed persistent cloaca(PC).The term urorectal septum malformation sequence(URSMS)is also used to describe this *** classic description of this process which is still cited in many standard textbooks dates from the 19th ***,this has been increasingly called into question by the findings of studies using modern scientific *** sinus anomalies are defined by the confluence of the urethra and vagina to form a common channel of varying length with a single perineal *** this condition,the anorectal canal opens separately on the *** presence of a urogenital sinus represents a transient phase of the normal development of the lower genital tract in the female ***,the form of urogenital sinus most commonly encountered in the developed world is a feature of disordered sexual differentiation and does not arise simply from the persistence of the anatomical structure which is a feature of normal fetal development.

关键词： cloaca embryology urogenital sinus

Taxonomic and phylogenetic composition show biotic resistance to exotic invasion in acid seep springs

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Ecological Processes 2021年第1期10卷 77-88页

作者： david f.Barfknecht david J.Gibson School of Biological Sciences Southern Illinois University–CarbondaleCarbondaleIL 62901-6509USA

Background:few studies have incorporated the evolutionary insights provided by analysis of phylogenetic structure along with community composition to assess the effects of exotic invasion on freshwater ***,we assess the taxonomic and phylogenetic relationships among acid seep springs to investigate the potential homogenization or resistance of communities due to invasion of an exotic ***:Multivariate community analyses indicated differences in community and phylogenetic composition and dispersion among acid seep springs,associated with gradients in soil moisture,canopy cover,and phylogenetic *** contrast,univariate analyses showed differences in taxonomic diversity but not phylogenetic diversity among acid seep ***:Despite exotic invasion,individual acid seep springs remained taxonomically and phylogenetically distinct from each *** and phylogenetic diversity metrics revealed different aspects of composition,reinforcing the importance of including both in analyses of plant communities for understanding community assembly following exotic invasion and for management *** acid seep springs,taxonomic and phylogenetic composition appear to be driven more through environmental filtering by light and moisture than by the competitive effects following invasion of an exotic grass in support of Elton’s biotic resistance hypothesis.

关键词： Acid seep springs Diversity Community Phylogenetics Exotic invasion Environmental filtering NMDS Unifrac Vector analysis

Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza

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Science China(Life Sciences) 2010年第2期53卷 273-285页

作者： SPENCER david f Department of Biochemistry and Molecular Biology Dalhousie University

Salvia miltiorrhiza *** a well-known traditional Chinese *** roots have been formulated and used clinically for the treatment of various ***,little genetic information has so far been available and this fact has become a major obstacle for molecular *** address this lack of genetic information,an Expressed Sequence Tag (EST) library from whole plantlets of *** was *** the 12959 cDNA clones that were randomly selected and subjected to single-pass sequencing from their 5′ ends,10288 ESTs (with sizes≥100 bp) were selected and assembled into 1288 contigs,leaving 2937 singletons,for a total of 4225 *** were analyzed using BLASTX (against protein databases),RPS-BLAST (against a conserved domain database) as well as the web-based KEGG Automatic Annotation Server for metabolic enzyme *** on the metabolic enzyme assignment,expression patterns of 14 secondary metabolic enzyme genes in different organs and under different treatments were verified using real-time PCR ***,a total of 122 microsatellites were identified from the ESTs,with 89 having sufficient flanking sequences for primer *** set of ESTs represents a significant proportion of the *** transcriptome,and gives preliminary insights into the gene complement of *** will prove useful for uncovering secondary metabolic pathways,analyzing cDNA-array based gene expression,genetic manipulation to improve yield of desirable secondary products,and molecular marker identification.

关键词： expressed sequence tags Salvia miltiorrhiza Bge. gene identification microsatellite

Early history of inflatable penile prosthesis surgery： a view from someone who was there

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Asian Journal of Andrology 2015年第2期17卷 225-229页

作者： david f Mobley Institute for Academic Medicine Houston Texas18300 Katy Fwy Ste 325 Houston TX 77094 USA.

The publication of the use of an inflatable penile prosthesis （IPP） in 1973 by Dr. fB Scott. changed the world of treatment options for erectile dysfunction （ED）. Much has been written since then about techniques, improvements, management of difficult cases, complications and their management, and mechanical and device changes over time. few reports, if any, are available in the medical literature regarding the early development, surgical techniques, and controversies surrounding its introduction to the world＇s urological community. This article is, for the most part, the observations of one who was ＂there＂ in the early and mid 1970＇s and was a witness to the history of this remarkable marvel of creativity, engineering, design, and to the personalities involved.

关键词： @@

Efficient Convex Optimization Approaches to Variational Image fusion

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Numerical Mathematics(Theory,Methods and Applications) 2014年第2期7卷 234-250页

作者： Jing Yuan Brandon Miles Greg garvin Xue-Cheng Tai Aaron fenster Medical Imaging Lab Robarts Research InstituteUniversity of Western OntarioLondon ONCanada N6A 5B7 Department of Medical Imaging St Jospeh’s HealthCareLondon ONCanada Department of Mathematics University of BergenBergenNorway

Image fusion is an imaging technique to visualize information from multiple imaging sources in one single image,which is widely used in remote sensing,medical imaging *** this work,we study two variational approaches to image fusion which are closely related to the standard TV-L_(2) and TV-L_(1) image approximation *** investigate their convex optimization formulations,under the perspective of primal and dual,and propose their associated new image decomposition *** addition,we consider the TV-L_(1) based image fusion approach and study the specified problem of fusing two discrete-constrained images f_(1)(x)∈L_(1) and f_(2)(x)∈L_(2),where L_(1) and L_(2) are the sets of linearly-ordered discrete *** prove that the TV-L_(1) based image fusion actually gives rise to the exact convex relaxation to the corresponding nonconvex image fusion constrained by the discretevalued set u(x)∈L_(1)∪L_(2).This extends the results for the global optimization of the discrete-constrained TV-L_(1) image approximation[8,36]to the case of image *** a big numerical advantage of the two proposed dual models,we show both of them directly lead to new fast and reliable algorithms,based on modern convex optimization *** with medical images,remote sensing images and multi-focus images visibly show the qualitative differences between the two studied variational models of image *** also apply the new variational approaches to fusing 3D medical images.

关键词： Convex optimization primal-dual programming combinatorial optimization totalvariation regularization image fusion

Biocompatibility pathways and mechanisms for bioactive materials:The bioactivity zone

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Bioactive Materials 2022年第4期7卷 306-322页

作者： david f.Williams Wake forest Institute of Regenerative Medicine 391 Technology Way.Winston-SalemNorth Carolina27101USA

This essay analyzes the scientific evidence that forms the basis of bioactive materials,covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of *** is a detailed assessment of performance in areas such as bone-induction,cell adhesion,immunomodulation,thrombogenicity and antimicrobial *** is the modulation of biological activity by characteristics of the interfacial region that incorporates the material surface and the immediate local host *** the term‘bioactive material’is widely used and has a well understood general meaning,it would be useful now to concentrate on this interfacial region,considered as‘the bioactivity zone’.Bioactivity phenomena are either due to topographical/micromechanical characteristics,or to biologically active species that are presented in the bioactivity *** of topographical/micromechanical effects are the modulation of the osteoblast-osteoclast balance,nanotopographical regulation of cell adhesion,and bactericidal *** of bioactivity by biologically active species include their influence,especially of metal ions,on signaling pathways in bone formation,the role of cell adhesion molecules and bioactive peptides in cell attachment,macrophage polarization by immunoregulatory molecules and antimicrobial *** much experimental data exists to demonstrate the potential of such phenomena,there are considerable barriers to their effective clinical *** essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials,especially when the material is modified in a manner designed to specifically induce that activity.

关键词： Bioactivity Host response Biomaterial Medical technology Cell signaling