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Hydrogen spillover in nonreducible oxides:Mechanism and catalytic utilization

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Nano Research 2022年第12期15卷 10357-10365页

作者： Songhyun lee Hyungjun Kim Ryong Ryoo Jeong Young Park Minkee Choi charles D.davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana47907USA Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and TechnologyDaejeon34141Republic of Korea Department of Chemistry Korea Advanced Institute of Science and TechnologyDaejeon34141Republic of Korea KENTECH Laboratory for Chemical Environmental and Climate TechnologyKorea Institute of Energy Technology(KENTECH)200 Hyeoksin-roNaju58330Republic of Korea Center for Nanomaterials and Chemical Reactions Institute for Basic Science(IBS)Daejeon34141Republic of Korea

Hydrogen(H)spillover in nonreducible oxides such as zeolites and Al2O3 has been a highly controversial phenomenon in heterogeneous *** industrial catalysts are predominantly prepared using these materials as supports,it is important to understand the mechanism and catalytic functions of H spillover on their *** the past decade,fundamental studies on zeolite-encapsulated metal catalysts have revealed that H spillover and reverse spillover can be utilized in the design of hydrogenation and dehydrogenation catalysts with improved *** experimental and theoretical studies have indicated that H spillover can occur in nonreducible oxides when they possess substantial acid sites that aid the surface migration of active *** the present review,we will discuss the possible mechanisms of H spillover in nonreducible oxides and the unique opportunities of using this phenomenon for the design of advanced hydroprocessing catalysts.

关键词： hydrogen spillover nonreducible oxides zeolites hydroprocessing catalysts

Effects of laponite and silica nanoparticles on the cleaning performance of amylase towards starch soils

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Particuology 2009年第6期7卷 459-465页

作者： Wai Peng lee Alberto Martinez Dan Xu Anju Brooker david W. York Yulong Ding Institute of Particle Science Engineering University of Leeds Leeds LS2 9IT UK Procter Gamble Newcastle Technical Centre Newcastle upon Tyne NE12 9TS UK

This work aims to understand the effect of nanoparticle-enzyme interactions and how such interactions affect starch based soil removal. Silica and laponite are used as the model nanoparticles, and s-amylase is employed as the model enzyme. The results show that, if the nanoparticles and enzyme are added simultaneously, laponite enhances the enzyme performance toward starch soil removal, whereas silica imposes a small effect on the enzymatic activity towards the same soil substrates. However, when nanoparticles are added first, the enzyme activity is not affected much by laponite but is hindered significantly by silica nanoparticles. Furthermore, sequential addition of the enzyme followed by silica nanoparticles improves soil removal. Electron microscopic analyses, measurements of the enzyme activity in suspen- sions of nanoparticles, and particle size characterisation suggest that dense coverage of soil surface by the silica nanoparticles be likely a mechanism for the experimentally observed hindrance of soil removal when silica nanoparticles are added before enzyme.

关键词： Enzyme Nanoparticles Laponite Silica Interaction Starch

Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma

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World Journal of Gastroenterology 2017年第32期23卷 5936-5944页

作者： Kwangil Yim Daeyoun david Won In Kyu lee Seong-Taek Oh Eun Sun Jung Sung Hak lee Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Surgery Uijeongbu St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM To evaluate a novel grading system to predict lymph node metastasis(LNM) in patients with submucosal invasive colorectal carcinoma(SICRC).METHODS We analyzed the associations between LNM and various clinicopathological features in 252 patients with SICRC who had undergone radical surgery at the Seoul Saint Mary's hospital between 2000 and *** LNM was observed in 31 patients(12.3%). The depth and width of the submucosal invasion, lymphatic invasion, tumor budding, and the presence of poorly differentiated clusters(PDCs) were significantly associated with the incidence of LNM. Using multivariate analysis, the receiver operating characteristic curvewas calculated and the area under curve(AUC) was used to compare the ability of the different parameters to identify the risk of LNM. The most powerful clinicopathological parameter for predicting LNM was lymphatic invasion(difference AUC = 0.204), followed by the presence or absence of tumor budding(difference AUC = 0.190), presence of PDCs(difference AUC = 0.172) and tumor budding graded by the Ueno method(difference AUC = 0.128). CONCLUSION Our results indicate that the tumor budding and the depth multiplied by the width measurements of submucosal invasion can provide important information for patients with SICRC.

关键词： Colorectal 癌症瘤侵略淋巴节点转移

Trends and outcomes of liver transplantation among older recipients in the United States

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World Journal of Transplantation 2022年第8期12卷 259-267页

作者： Kenji Okumura Joon Sub lee Abhay Dhand Hiroshi Sogawa Gregory Veillette Devon John Ryosuke Misawa Roxana Bodin david C Wolf Thomas Diflo Seigo Nishida Department of Surgery Westchester Medical Center/New York Medical CollegeValhallaNY 10595United States

BACKGROUND The average age of recipients and donors of liver transplantation(LT)is *** there has been a change in the indications for LT over the years,data regarding the trends and outcomes of LT in the older population is *** To assess the clinical characteristics,age-related trends,and outcomes of LT among the older population in the United *** We analyzed data from the United Network for Organ Sharing database between *** sample was split into younger group(18-64 years old)and older group(≥65 years old).RESULTS Between 1987-2019,155758 LT were performed in the United *** this period there was a rise in median age of the recipients and percentage of LT recipients who were older than 65 years increased(P<0.05)with the highest incidence of LT among older population seen in 2019(1920,23%).Common primary etiologies of liver disease leading to LT in older patients when compared to the younger group,were non-alcoholic steatohepatitis(16.4%vs 5.9%),hepatocellular carcinoma(14.9%vs 6.9%),acute liver failure(2.5%vs 5.2%),hepatitis C cirrhosis(HCV)(19.2%vs 25.6%)and acute alcoholic hepatitis(0.13%vs 0.35%).In older recipient group female sex and Asian race were higher,while model for end-stage liver disease(MELD)score and rates of preoperative mechanical ventilation were lower(P<0.01).Median age of donor,female sex,body mass index(BMI),donor HCV positive status,and donor risk index(DRI)were significantly higher in older group(P<0.01).In univariable analysis,there was no difference in post-transplant length of hospitalization,one-year,three-year and five-year graft survivals between the two *** multivariable Cox-Hazard regression analysis,older group had an increased risk of graft failure during the five-year post-transplant period(hazard ratio:1.27,P<0.001).Other risk factors for graft failure among recipients were male sex,African American race,re-transplantation,presence of diabetes,mechanical ventilation at th

关键词： Liver transplant Elderly Outcomes Hepatocellular carcinoma Nonalcohol steatohepatitis

Expression of multiple glutamate transporter splice variants in the rodent testis

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Asian Journal of Andrology 2011年第2期13卷 254-265页

作者： Aven lee Ashley R Anderson Amanda C Barnett Anthony Chan david V Pow Centre for Clinical Research Royal Brisbane and Women＇s Hospital The University of Queensland Brisbane QId 4029 Australia

Glutamate is a regulated molecule in the mammalian testis. Extracellular regulation of glutamate in the body is determined largely by the expression of plasmalemmal glutamate transporters. We have examined by PCR, western blotting and immunocytochemistry the expression of a panel of sodium-dependent plasmalemmal glutamate transporters in the rat testis. Proteins examined included： glutamate aspartate transporter （GLAST）, glutamate transporter 1 （GLT1）, excitatory amino acid carrier 1 （EAAC1）, excitatory amino acid transporter 4 （EAAT4） and EAAT5. We demonstrate that many of the glutamate transporters in the testis are alternately spliced. GLAST is present as exon-3- and exon-9-skipping forms. GLT1 was similarly present as the alternately spliced forms GLT1 b and GLTlc, whereas the abundant brain form （GLTla） was detectable only at the mRNA level. EAAT5 was also strongly expressed, whereas EAAC1 and EAAT4 were absent. These patterns of expression were compared with the patterns of endogenous glutamate localization and with patterns of D-aspartate accumulation, as assessed by immunocytochemistry. The presence of multiple glutamate transporters in the testis, including unusually spliced forms, suggests that glutamate homeostasis may be critical in this organ. The apparent presence of many of these transporters in the testis and sperm may indicate a need for glutamate transport by such cells.

关键词： excitatory amino acid transporter glutamate aspartate transporter glutamate transporter 1 sperm splice variant testis transporter

Survival is negatively associated with glucocorticoids in a wild ungulate neonate

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Integrative Zoology 2021年第2期16卷 214-225页

作者： Tess Michelle GINGERY Duane Richard DIEFENBACH Catharine ElizabethPRITCHARD david charles ENSMINGER Bret Daniel WALLINGFORD Christopher Scott ROSENBERRY Pennsylvania Cooperative Fish and Wildlife Research Unit Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA U.S.Geological Survey Pennsylvania Cooperative Fish and Wildlife Research UnitPennsylvania State UniversityUniversity ParkPennsylvaniaUSA Department of Ecosystem Science and Management Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Pennsylvania Game Commission 2001 Elmerton AvenueHarrisburgPennsylvaniaUSA Department of Integrative Biology University of CaliforniaBerkeleyValley Life Sciences BuildingBerkeleyCaliforniaUSA

It is unknown how ungulate physiological responses to environmental perturbation influence overall population ***,neonatal physiological responses remain poorly studied despite the importance of neonatal survival to population ***(GC)hormones potentially facilitate critical physiological and behavioral responses to environmental ***,elevated GC concentrations over time may compromise body condition and indirectly reduce *** evaluated baseline salivary cortisol(CORT;a primary GC in mammals)concentrations in 19 wild neonatal white-tailed deer(Odocoileus virginianus)in a northern(NS)and southern(SS)area in *** ranking survival models consisting of variables hypothesized to influence neonate survival(***,sex),the probability of neonate survival was best explained by CORT concentrations,where elevated CORT concentrations were associated with reduced survival probability to 12 weeks of *** concentrations were greater in the SS where predation rates and predator densities were *** the first evaluation of baseline CORT concentrations in an ungulate neonate to our knowledge,this is also the first study to demonstrate CORT concentrations are negatively associated with ungulate survival at any life *** hormones could provide a framework in which to better understand susceptibility to mortality in neonatal white-tailed deer.

关键词： neonates salivary cortisol stress survival ungulates

Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy

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Cancer Communications 2023年第6期43卷 706-710页

作者： Jinping Liu Lan Cheng Hilana El-Mekkoussi charles-Antoine Assenmacher Michelle Y.Y.lee Danielle R.Jaffe Kaisha Garvin-Darby Ashleigh Morgan Elisabetta Manduchi Jonathan Schug Klaus H.Kaestner Department of Genetics and Center for Molecular Studies in Digestive and Liver Disease University of PennsylvaniaPhiladelphiaPAUSA Institute for Diabetes Obesity and MetabolismPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPAUSA Department of Pathobiology School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Dear Editor Combinatorial immunotherapy has provided patients with advanced hepatocellular carcinoma(HCC)the potential for long-term ***,sustained responses are seen only in a minority of patients[1].Thus,there is an unmet need for precision modeling to understand the different responses and uncover predictive biomarkers for treatment stratification.

关键词： immunotherapy hepatocellular sustained

Risk factors for carotid plaque progression after optimising the risk factor treatment: substudy results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the carotid Bifurcation Plaque Study (ANTIQUE)

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Stroke & Vascular Neurology 2022年第2期7卷 132-139页

作者： david Školoudik Petra Kešnerova Tomaš Hrbač david Netuka Jaroslav Vomačka Kateřina Langova Roman Herzig Tomaš Belšan Center for Health Research Faculty of MedicineUniversity of OstravaOstravaCzech Republic Department of Neurology University Hospital OstravaOstravaCzech Republic Department of Neurology Second Faculty of MedicineCharles UniversityPrahaCzech Republic Department of Neurology Motol University HospitalPrahaCzech Republic Department of Neurosurgery Faculty of MedicineUniversity of OstravaOstravaCzech Republic Department of Neurosurgery University Hospital OstravaOstravaCzech Republic Department of Neurosurgery Military University Hospital PraguePrahaCzech Republic Department of Radiological Assistance Faculty of Health SciencesPalacky University OlomoucOlomoucCzech Republic Deaprtment of Radiology University Hospital OlomoucOlomoucCzech Republic Department of Biophysics Faculty of MedicinePalacky University OlomoucOlomoucCzech Republic Department of Neurology University Hospital Hradec KrálovéHradec KraloveCzech Republic Department of Neurology Faculty of Medicine in Hradec KrálovéCharles UniversityHradec KrálovéCzech Republic Department of Radiology Military University Hospital PraguePrahaCzech Republic

Background and aim Carotid plaque progression contributes to increasing stroke *** study aims to identify factors influencing carotid plaque thickness progression after changing the preventive treatment to the‘treating arteries instead of risk factors’strategy,that is,change in treatment depending on the progression of *** The study participants who completed sonographic controls over the course of 3 years were enrolled to the *** sonography of cervical arteries was performed in 6-month intervals with measurement of carotid plaque *** thickness measurement error(σ)was set as 3 *** evidently stable and progressive plaques(defined as plaque thickness difference between initial and final measurements of˂σand>2σ,respectively)were included to *** and multivariate logistic regression analysis was performed to identify factors influencing plaque *** A total of 1391 patients(466 males,age 67.2±9.2 years)were enrolled in the *** plaque in at least one carotid artery was detected in 255(18.3%)*** age,male sex,greater plaque thickness,coronary heart disease,vascular surgery/stenting history and smoking were more frequently present in patients with progressive plaque(p˂0.05 in all cases).Multivariate logistic regression analysis identified only the plaque thickness(OR 1.850 for left side,95%CI 1.398 to 2.449;and OR 1.376 for right side,95%CI 1.070 to 1.770)as an independent factor influencing plaque *** Carotid plaque thickness corresponding to stenosis severity is the only independent risk factor for plaque thickness progression after optimising the prevention treatment.

关键词： prevention treatment Duplex

Externally-induced meditative states： an exploratory fMRI study of architects＇ responses to contemplative architecture

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Frontiers of Architectural Research 2017年第2期6卷 123-136页

作者： Julio Bermudez david Krizaj david L. Lipschitz charles Eiliott Bueler Jadwiga Rogowska Deborah Yurgelun-Todd Yoshio Nakamura School of Architecture and Planning The Catholic University of America 620 Michigan Ave. NE Washington DC 20064 USA Department of Ophthalmology and Visual Sciences and Department of Neurobiology & Anatomy School of Medicine University of Utah 65 Maria Capecchi Dr. Salt Lake City UT 84132 USA Utah Center for Exploring Mind-Body Interactions Pain Research Center Department of Anesthesiology University of Utah 615 Arapeen Drive Suite 200 Salt Lake City UT 84108 USA Cognitive Neuroimaging Laboratory Department of Psychiatry University of Utah 383 Colorow Drive Room 323 Salt Lake City UT 84108 USA

Built environments can induce contemplative states, but direct evidence for their impact on the brain is lacking. This exploratory work investigated brain correlates of internal states elicited by architecture designed for contemplative experience. Functional MRI and self-reports of 12 architects were assessed to study their responses to photographs of ordinary and contemplative architectures. Images of contemplative buildings：（1） induced attentive, receptive, and absorbing experiences and diminished internal dialogue; （2） involved decreased engagement of prefrontal cortex; and （3） activated the occipital lobe, precentra[ gyrus, and inferior parietal lobule. They suggest that viewing buildings designed for contemplation may evoke experiential and brain signatures that consistently differ from those induced by buildings that serve everyday functions. The depth of such externally induced states was inversely correlated with the engagement of the Default Mode Network. Our study points toward a novel avenue for investigating how contemplation can be cultivated in the human brain/mind.

关键词： ContempLation Meditation Architecture Embodiment Phenomenotogy Neuroscience