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Injury Mortality of children and Adolescents Aged 0–19 Years—china,2010–2021

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china cDc weekly 2024年第14期6卷 294-299,I0001-I0006页

作者： Jingtao Zhou Min Zhao Hao Huang david c.schwebel Peishan Ning Zhenzhen Rao Peixia cheng Li Li Guoqing Hu Department of Epidemiology and Health Statistics Hunan Provincial Key Laboratory of Clinical EpidemiologyXiangya School of Public HealthCentral South UniversityChangsha CityHunan ProvinceChina Department of Psychology University of Alabama at BirminghamBirminghamALUSA Department of child Adolescent and Women’s HealthSchool of Public HealthCapital Medical UniversityBeijingChina National clinical Research center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha CityHunan ProvinceChina

Introduction:To examine the recent trends in child injury mortality in ***:Injury mortality data of 2010–2021 for children and adolescents aged 0–19 years were from the china Health Statistics *** mortality disparities across urban *** locations,gender,and age groups were *** percent change(APc),average annual percent change(AAPc),and their 95%confidence intervals(95%cI)were estiamted usimg Joinpoint regression ***:The age-standardized injury mortality significantly dropped from 21.87 to 9.41 per 100,000 population among children and youth aged 0–19 years during 2010–2021,with an AAPc of−6.7%(95%cI:−8.2%,−5.2%).The urban-rural disparity and gender gap in injury mortality reduced *** 2021,drowning and road traffic crashes were the top two causes of child injury deaths,explaing 31.1%and 27.9%of total injury deaths,*** accounted for 62.3%of injury deaths among infants younger than a ***,the suicide mortality rate rose from 2.16 to 3.42 per 100,000 population between 2010 and 2021 among teenagers aged 15–19 *** analyses yielded similar ***:During 2010–2021,the injury mortality decreased significantly among chinese children and adolescents,and the responding urbanrural disparities narrowed.

关键词： injury younger narrow

Incidence of Interpersonal Violence among Individuals with Drug Addiction Receiving compulsory Treatment: A Survey at Two Drug Detention centers in Hunan, china

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Biomedical and Environmental Sciences 2018年第12期31卷 883-887页

作者： WU Xiao Lin XIE Yi Yun NING Pei Shan DI Xiao Kang david c.schwebel HU Guo Qing Zhou Enlai School of Government Nankai University Jinnan District Tianjin 300050 China Department of Public Administration Central South University Changsha 410008 Hunan China Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University Changsha 410078 Hunan China Department of Social Medicine and Health Management Xiangya School of Public Health Central South University Changsha 410078 Hunan China Department of Psychology University of Alabama at Birmingham Birmingham35294 Alabama United States of America

Drug dependence is a serious global health *** assist individuals with drug addiction,china alone has established 678 compulsory Detoxification Detention centers （cDDcs） that treat over300,000i ndividuals who are re... 详细信息

关键词： A Survey at Two Drug Detention centers in Hunan china Incidence of Interpersonal Violence among Individuals with Drug Addiction Receiving compulsory Treatment

Unintentional injury mortality attributed to changes in data reporting for Americans aged 65 years and older,1999-2015

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Unintentional injury mortality attributed to changes in data...

Injury Morbidity between 2013 and 2018 in Hunan Province,china

2017年中国卫生统计学学术年会

作者： Peishan Ning david c.schwebel Haitao chu Motao Zhu Guoqing Hu Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South University Department of Psychology University of Alabama at Birmingham Division of Biostatistics School of Public HealthUniversity of Minnesota center for Injury Research and Policy The Research Institute at Nationwide Children's Hospital

Objective Underlying cause of death（UcD）statistics highly depend on data reporting *** study quantified overall and specific unintentional injury mortality attributed to changes in data reporting for Americans aged 65 years and older from 1999 to *** We used data from the *** for Disease control and Prevention WONDER online databases to develop an attribution model and to calculate injury mortality attributed to data reporting changes in cause specificity and selection of UcD from multiple cause of death（McD）.Results From 1999 through 2015,the proportion of McD cause-specific unintentional injury mortality increased from 0.74 to 0.84;proportions of UcD/McD mortality for overall and cause-specific unintentional injury rose substantially in all categories except motor vehicle *** UcD-based mortality attributed to data reporting changes increased distinctly between 1999 and 2015;the increase for overall unintentional injury,falls,motor vehicle crash,suffocation,poisoning,and fire/burn was 23.19,12.78,1.99,2.55,1.44 and 0.33 per 100,000 persons,*** change in mortality between 1999 and 2015 differed greatly between reported and expected mortality--overall unintentional injury,16%vs.-9%;falls,106%vs.62%;motor vehicle crashes,-31%vs.-40%;suffocation,-17%vs.-43%;poisoning,118%vs.47%;fire/burn,-29%vs.-39%).conclusion Data reporting changes have altered trends in overall and causespecific unintentional injury mortality for older Americans.

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Biomedical and Environmental Sciences 2022年第3期35卷 263-269页

作者： WANG Wan Hui GAO De Yue HUA Jun Jie NING Pei Shan schwebel david c HU Guo Qing Department of Epidemiology and Health Statistics Hunan Provincial Key Laboratory of Clinical EpidemiologyXiangya School of Public HealthCentral South UniversityChangsha 410083HunanChina Shanxi Bethune Hospital Taiyuan 030032ShanxiChina Department of Psychology University of Alabama at BirminghamBirminghamAlabama35294United States of America

Accurate and timely injury statistics are critical to assess the severity of public health *** statistics allow researchers,practitioners,and policymakers to determine morbidity and mortality rate disparities across s... 详细信息

关键词： Hunan problems. policy

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

coronavirus disease-2019: A tocsin to our aging, unfit, corpulent, and immunodeficient society

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Journal of Sport and Health Science 2020年第4期9卷 293-301页

作者： david c.Nieman Department of Biology College of Arts and SciencesAppalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

Acute and chronic respiratory illnesses cause widespread morbidity and mortality,and this class of illness now includes the novel coronavirus severe acute respiratory syndrome that is causing coronavirus disease-2019(cOVID-19).The world is experiencing a major demographic shift toward an older,obese,and physically inactive *** factor assessments based on pandemic data indicate that those at higher risk for severe illness from cOVID-19 include older males,and people of all ages with obesity and related comorbidities such as hypertension and type 2 *** in and of itself leads to negative changes in innate and adaptive immunity,a process termed *** causes systemic inflammation and adversely impacts immune function and host defense in a way that patterns *** primary prevention strategies to reduce the risk for cOVID-19 at both the community and individual levels include mitigation activities and the adoption of lifestyle practices consistent with good immune *** and human studies support the idea that,in contrast to high exercise workloads,regular moderate-intensity physical activity improves immunosurveillance against pathogens and reduces morbidity and mortality from viral infection and respiratory illnesses including the common cold,pneumonia,and *** odds are high that infectious disease pandemics spawned by novel pathogens will continue to inflict morbidity and mortality as the world’s population becomes older and more ***-19 is indeed a wake-up call,a tocsin,to the world that primary prevention countermeasures focused on health behaviors and hygiene demand our full attention and support.

关键词： cOVID-19 Exercise Immunology Infection Obesity