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胶质母细胞瘤的几何形态学分析:一项基于T1增强扫描的MRI研究

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国际医学放射学杂志 2017年第3期 357-357页

作者： P.b.Julián M.G.Alicia M.david A.S.Mariano L.belén A.Elena 王大伟 Laboratory of Mathematical Oncology Edificio Politécnico Institutode Matemática Aplicada a la Ciencia y la IngenieríaUniversidad de Castilla-La Mancha Avenida de Camilo José Cela

摘要背景通过MRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中... 详细信息

摘要背景通过MRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中心回顾性研究。对临床变量进行收集、肿瘤分割,测量参数包括:强化方式、坏死、体积、肿瘤最大直径、等效球径度增强宽幅及其他几个强化"边缘"的形态学参数。应用比例风险分析与Kaplan Meier生存曲线进行

关键词：胶质母细胞瘤几何形态学初等数学 MRI T1

TGF-β体外诱导产生的调节性T细胞减轻抗体介导的急性移植肾排斥

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TGF-β体外诱导产生的调节性T细胞减轻抗体介导的急性移植肾排斥

美西南航空为其波音737NG机队全面加装ADS-b系统

第十二届全国免疫学学术大会

作者：廖涛薛有求赵大强李思雯刘明宇陈敬荣 david brand 郑浩锋张燕楠郑颂国孙启全中山大学附属第三医院肾移植科中山大学附属第三医院临床免疫中心宾夕法尼亚大学赫尔希弥尔顿医学中心风湿免疫科中山大学生命科学院

背景:抗体介导的排斥(AMR)是导致移植肾失功的首要原因,亟需更为有效的防治方法;调节性T细胞(Treg)具有广泛的免疫调节功能,在移植免疫耐受中也起重要作用。目的:本研究旨在探讨初TGF-β诱导Treg(iTreg)对移植肾急性AMR的防治效果及其... 详细信息

背景:抗体介导的排斥(AMR)是导致移植肾失功的首要原因,亟需更为有效的防治方法;调节性T细胞(Treg)具有广泛的免疫调节功能,在移植免疫耐受中也起重要作用。目的:本研究旨在探讨初TGF-β诱导Treg(iTreg)对移植肾急性AMR的防治效果及其相应的机制。方法:5周balb/c小鼠的脾脏分离出初始CD4细胞,体外利用TGF-β和IL-2结合CD3/CD28抗体刺激诱导成为CD4Foxp3Treg细胞。8-10周龄雄性C3H、balb/c小鼠作为供体和受体,皮肤移植预致敏后第4天行肾移植建立急性AMR模型,未预致敏作为对照。利用该模型分为两组:1)iTreg治疗组:在皮肤移植前1天、皮肤移植当天、肾移植当天、肾移植术后第3天每次给予受体小鼠iTreg 3x10个;2)在相同时间点给予注射等量的PbS溶液。记录受体存活时间,术后第5天DSA水平;移植肾病理观察毛细血管炎、肾小管坏死、移植肾损伤、C3d和IgG沉积程度;利用流式细胞、免疫荧光、qPCR技术检测移植肾内免疫细胞浸润程度和功能。结果:初始CD4细胞在体外利用TGF-β和IL-2诱导成为的iTreg具有Treg的各种表型;利用C3H→balb/c小鼠在皮肤移植后第4天行肾移植建立的急性AMR模型满足banff标准,受体存活时间为(6.2±1.8)天,iTreg治疗后可明显延长受体存活时间,并且使得约30%小鼠在2周观察期内长期存活;iTreg治疗可以明显减轻移植肾毛细血管炎、肾小管坏死和移植肾损伤程度。进一步机制探讨发现iTreg治疗可以显著降低受体循环DSA-IgG水平,移植肾内IgG和C3d沉积;iTreg治疗可以显著减少移植肾内CD4细胞(包括Th1、Th17和Tfh),CD8IFN-γNK细胞,b细胞和浆细胞浸润;也发现在急性AMR中,移植肾内巨噬细胞所占比例最多,而且以M1型巨噬细胞为主,而iTreg治疗显著减少M1型巨噬细胞的浸润。结论:TGF-β体外诱导产生的iTreg可以通过广泛的免疫调节功能而显著减轻抗体介导的急性移植肾排斥和损伤,iTreg的安全性在很多临床研究中已经得到证实,有望应用于临床防治急性AMR和肾移植的免疫排斥的预防。

关键词：抗体介导的排斥肾移植调节性T细胞 TGF-β 巨噬细胞

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航空维修与工程 2016年第12期 26-26页

作者： Paul Seidenman david Spanovich 蓝楠

目前,美国西南航空公司正在为其波音737NG机队进行航空电子设备改装。截至2016年底,美国西南航空公司波音737NG机队的数量达到了625架,由波音737-700和波音737-800飞机组成。这一改装工作将分为三个阶段进行,第一阶段的改装工作主要是... 详细信息

目前,美国西南航空公司正在为其波音737NG机队进行航空电子设备改装。截至2016年底,美国西南航空公司波音737NG机队的数量达到了625架,由波音737-700和波音737-800飞机组成。这一改装工作将分为三个阶段进行,第一阶段的改装工作主要是为这些飞机加装广播式自动相关监视（ADS-b）发送设备,使其满足适航法规的要求。美国西南航空公司表示,

关键词：波音737-700 西南航空公司航空电子 ADS-b 广播式自动相关监视系统设备改装发送设备

Computational cytometer based on magnetically modulated coherent imaging and deep learning

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Light(Science & Applications) 2019年第1期8卷 385-399页

作者： Yibo Zhang Mengxing Ouyang Aniruddha Ray Tairan Liu Janay Kong bijie bai Donghyuk Kim Alexander Guziak Yi Luo Alborz Feizi Katherine Tsai Zhuoran Duan Xuewei Liu Danny Kim Chloe Cheung Sener Yalcin Hatice Ceylan Koydemir Omai b.Garner Dino Di Carlo Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Department of bioengineering University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Physics and Astronomy University of ToledoToledoOH 43606USA Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Yale School of Medicine New HavenCT 06510USA Department of biochemistry University of CaliforniaLos AngelesCA 90095USA Department of Pathology and Laboratory Medicine University of CaliforniaLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Detecting rare cells within blood has numerous applications in disease *** rare cell detection techniques are typically hindered by their high cost and low ***,we present a computational cytometer based on magnetically modulated lensless speckle imaging,which introduces oscillatory motion to the magneticbead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three dimensions(3D).In addition to using cell-specific antibodies to magnetically label target cells,detection specificity is further enhanced through a deep-learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network(P3D CNN),which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic *** demonstrate the performance of this technique,we built a high-throughput,compact and cost-effective prototype for detecting MCF7 cancer cells spiked in whole blood *** serial dilution experiments,we quantified the limit of detection(LoD)as 10 cells per millilitre of whole blood,which could be further improved through multiplexing parallel imaging channels within the same *** compact,cost-effective and high-throughput computational cytometer can potentially be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

关键词： rare magnetic speckle

CSCO_3 CYCLES IN SALAWUSU RIVER bASINSINCE 150KA b.P.

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Chinese Geographical Science 2001年第4期11卷 50-56页

作者： LUO Kai-li1,2, LI bao-sheng1,2, ZHU Yi-zhi2, JIN He-ling3, ZHANG david Dian4, YAN Man-cun5, LI Hou-xin1, YAO Chun-xia1, ZHANG Yu-hong1f 1. Department of Geography, South China Normal University, Guangzhou 510631, P. R. China 2. State Key Labor

AbSTRACT: This paper, with Milanggouwan stratigraphic section as a typical section of the Salawusu River basin, explores the relation between CaCO3 content distribution and climate change since 150 ka b. P. and concludes that: 1) The low-high changes of CaCO3 content in the section has a remarkable corresponding relation with the sedimentary cycles of ancient aeolian sand and overlying fluviolacustrine facies or palaeosols. 2) CaCO3 distribution in aeolian sand is relatively meagre, ranging from 0. 8% - 7. 18%, or on an average 2. 50% but relatively enriches in the fluviolacustrine faceis and palaeosols, ranging from 2. 20% - 14. 9% , or on an average 5. 74%. This implies that they have different climatic backgrounds. The former was the product of erosion, transport and deposition by wind under arid and cold climatic conditions, whereas the latter was related to its special low-lying geomorphic position between the Ordos Plateau and Loess Plateau and warm-humid climatic environment. When the climatic became warm and humid, fluviolacustrine and swamp facies developed, soil-forming action strengthened, and low-lying catchment condition was favorable to CaCO3 accumulation. 3) The basic cause responsible for the multicycle of CaCO3 migration and accumulation in the Milanggouwan section may be the multiple alterations of winter and summer monsoons over the Mu Us Desert under the influences of climatic fluctuation of glacial and interglacial periods in the Northern Hemisphere since 150ka b. P. .

关键词： Milanggouwan section 150ka b. P. CaCO3, 27 sediment-climatic cycles

Families of Dothideomycetes

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Fungal Diversity 2013年第6期63卷 1-313页

作者： Kevin D.Hyde E.b.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric boehm Saranyaphat boonmee Uwe braun Putarak Chomnunti Pedro W.Crous Dong-Qin Dai Paul Diederich Asha Dissanayake Mingkhuan Doilom Francesco Doveri Singang Hongsanan Ruvishika Jayawardena James D.Lawrey Yan-Mei Li Yong-Xiang Liu Robert Lücking Jutamart Monkai Lucia Muggia Matthew P.Nelsen Ka-Lai Pang Rungtiwa Phookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia Wu Ying Zhang begoña Aguirre-Hudson S.Aisyah Alias AndréAptroot Ali H.bahkali Jose L.bezerra D.Jayarama bhat Erio Camporesi Ekachai Chukeatirote Cécile Gueidan david L.Hawksworth Kazuyuki Hirayama Sybren De Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-Yi Liu Ausana Mapook Eric H.C.McKenzie Andrew N.Miller Peter E.Mortimer Alan J.L.Phillips Huzefa A.Raja Christian Scheuer Felix Schumm Joanne E.Taylor Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yong Wang Jian-Chu Xu Supalak Yacharoen Ji-Ye Yan Min Zhang Key Laboratory for Plant biodiversity and biogeography of East Asia(KLPb) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth Sciences Kuala Lumpur 50603SelangorMalaysia Department of botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre Drive LivingstonNJ 07039USA Institut für biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CbS-KNAW Fungal biodiversity Centre Uppsalalaan 83584CT UtrechtThe Netherlands Musée National d’histoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal Research and Development Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China The Research Institute of Resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizhou Key Laboratory of Agricultural biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria Department of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofMarine biology and Center of Excellence for the Oceans Taiwan

Dothideomycetes comprise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate *** species are saprobes,with many asexual states comprising important plant *** are also endophytes,epiphytes,fungicolous,lichenized,or lichenicolous *** occur in terrestrial,freshwater and marine habitats in almost every part of the *** accept 105 families in Dothideomycetes with the new families Anteagloniaceae,bambusicolaceae,biatriosporaceae,Lichenoconiaceae,Muyocopronaceae,Paranectriellaceae,Roussoellaceae,Salsugineaceae,Seynesiopeltidaceae and Thyridariaceae introduced in this *** family is provided with a description and notes,including asexual and asexual states,and if more than one genus is included,the type genus is also *** family is provided with at least one figure-plate,usually illustrating the type genus,a list of accepted genera,including asexual genera,and a key to these genera.A phylogenetic tree based on four gene combined analysis add support for 64 of the families and 22 orders,including the novel orders,Dyfrolomycetales,Lichenoconiales,Lichenotheliales,Monoblastiales,Natipusillales,Phaeotrichales and *** paper is expected to provide a working document on Dothideomycetes which can be modified as new data comes to *** is hoped that by illustrating types we provide stimulation and interest so that more work is carried out in this remarkable group of fungi.

关键词： Acrospermales Asterinales botryosphaeriales Capnodiales Dothideales Dyfrolomycetales Hysteriales Jahnulales Lichenoconiales Lichenotheliales Microthyriales Monoblastiales Myriangiales Mytilinidiales Natipusillales Patellariales Phaeotrichales Phylogeny Pleosporales Strigulales Taxonomy Trypetheliales Tubeufiales Type species Venturiales

A Study of the Structural, Optical and Electrical Properties of SnS Thin Films Modified by Plasma

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材料科学与工程（中英文b版） 2013年第6期3卷 352-358页

作者： Aar6n Gomez Horacio Martinez Manuela Calixto-Rodriguez david Avellaneda Pedro Guillermo Reyes Osvaldo Flores Laboratorio de Fisica Avanzada Facultad de Ciencias Universidad Autonoma del Estado de Mexico Estado de Mexico Mexico Laboratorio de Espectroscopia Instituto de Ciencias Fisicas Universidad Nacional Aut6noma de Mdxico Cuernavaca MorelosMdxico Intituto de Energia Renovable Universidad Nacional Aut6noma de Mdxico Cuernavaca Morelos M~xico Facultad de Ingenieria Meconica y Electrica Universidad Autonoma de Nuevo Leon Mexico

SnS thin films were deposited by chemical bath deposition technique and treated using glow discharge O2 plasma. The pressure discharge was 3 Torr, discharge voltage of 2.5 kV and 20 mA of discharge current. The as-deposited and treated thin films were characterized by X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis. The photoconductivity and electrical effects of SnS have been studied. The SnS thin films had an orthorhombic crystalline structure. The optical gap changed from 1.61 to 1.84 eV due to the O2 plasma treatment. The conductivity shows a marked increase with the treatment, from 2.56 × 10-6 (??cm)-1 for as-deposited film until 0.10 (??cm)-1 for the film treated at 180 min. This result is a suitable range of conductivity for the improvement of the solar cell with SnS as an absorber material.

关键词： SnS薄膜晶体结构等离子体改性电学性能光学扫描电子显微镜等离子体处理沉积技术

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抗虫棉花

江西棉花 1991年第4期13卷 42-46页

作者： Frederick J.Perlak Randy W.Deaton Toni A.Armstrong Roy L.Fuchs Steven R.Sims John T.Greenplate david A.Fischhoff 张震林江苏省农科院经济作物研究所

我们将苏云金芽孢杆菌(bacillus thuringiensis)的两个变种 *** HD-1(cryIA(b)和 HD-73(cryIA(c)的抗虫基因进行修饰后转化棉花并使其得到表达,其表达的抗虫蛋白能有效地毒杀农业生产上重要的鳞翅目害虫。在实验室中测定了这些转基因棉... 详细信息

我们将苏云金芽孢杆菌(bacillus thuringiensis)的两个变种 *** HD-1(cryIA(b)和 HD-73(cryIA(c)的抗虫基因进行修饰后转化棉花并使其得到表达,其表达的抗虫蛋白能有效地毒杀农业生产上重要的鳞翅目害虫。在实验室中测定了这些转基因棉花叶组织的总抗虫能力,试验所用的两个鳞翅目昆虫是对 b.t.k.抗虫蛋白相对敏感的甘蓝尺蠖(Trichoplusia ni,cabbage looper)和敏感性比甘蓝尺蠖低100倍的甜菜粘虫(Spodoptera exigua,beet armyworm)。在高虫口密度胁迫下用棉铃虫(Heliothis *** bollworm)对整株棉花进行抗虫试验,结果显示出蕾、铃的有效抗虫性。对棉花植株进行的免疫(?)迹分析表明,抗虫蛋白的含量为总可溶性蛋白的0.05～0.1%。我们将这些结果视为向农业生产上推广这种经过抗虫遗传改良的经济价值高、种植面广的农作物的主要一步。

关键词：棉花抗虫性育种

萨拉乌苏河流域末次间冰阶气候——以米浪沟湾剖面为例

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地质学报 2007年第4期81卷 553-562页

作者：温小浩李保生章典范小平叶建萍杜恕环郭云海陈德牛华南师范大学地理科学学院中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061 香港大学地理系贵州师范大学地理与生物科学学院中国科学院动物研究所

米浪沟湾剖面末次间冰阶层序粒度和化学元素波动韵律与由古流动砂丘砂和上覆河湖相或古土壤构成的沉积旋回颇为一致。古流动砂丘砂犹如现代流动砂丘砂,是东亚冬季风主导下干冷气候的产物;河湖相和古土壤颗粒细化,化学、生物等地球风化... 详细信息

米浪沟湾剖面末次间冰阶层序粒度和化学元素波动韵律与由古流动砂丘砂和上覆河湖相或古土壤构成的沉积旋回颇为一致。古流动砂丘砂犹如现代流动砂丘砂,是东亚冬季风主导下干冷气候的产物;河湖相和古土壤颗粒细化,化学、生物等地球风化程度增强,含较多喜暖的软体动物化石,指示其偏南夏季风主导下的温暖湿润气候。据此,末次间冰阶萨拉乌苏河流域至少经历了10次温湿（W事件）和9次冷干（C事件）气候波动,且可划分为MIS3e（58.85-48.98kabP）、MIS3d（48.98-39.55kabP）、MIS3c（39.55-34.59kabP）、MIS3b（34.59-26.47kabP）和MIS3a（26.47-23.07kabP）等5个亚段。其中,19次冷/暖波动可与格陵兰GRIP冰心δ18O冰段/间冰段相对应,5个亚段与我国古里雅冰心在波动性质和相位上都极为一致,与V23-81冷性浮游有孔虫数代表的北大西洋地区气候也具有较好的可比性。谱分析显示出21.70ka、1.05ka、0.64ka、0.50ka等显著周期,即该地千百年尺度气候主要受与北大西洋热盐环流波动引起的东亚冬、夏季风强弱有关,而万年尺度上则受控于岁差周期所导致的太阳辐射变化。

关键词：萨拉乌苏河流域米浪沟湾剖面末次间冰阶粒度和化学元素古气候