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Constipation-predominant irritable bowel syndrome: A review of current and emerging drug therapies

World Journal of Gastroenterology 2014年第27期20卷 8898-8909页

作者： Khaled A Jadallah susan M Kullab david s sanders Department of InternalMedicine King Abdullah University Hospital Faculty of Medicine Jordan University of Science and Technology Department of Gastroenterology and Liver Unit Royal Hallamshire Hospital Sheffield South Yorkshire S102JF United Kingdom

Irritable bowel syndrome(IBs) is a highly prevalent medical condition that adversely affects patient quality of life and constitutes a significant economic burden on healthcare resources. A large proportion of patients suffer from the constipation subtype of IBs(IBs-C), most commonly afflicting older individuals and those with a lower socioeconomic status. Conventional pharmacologic and nonpharmacologic treatment options have limited efficacies and/or significant adverse events, which lead to increased long-term health care expenditures. Failure to effectively treat IBs-C patients over the past decades has largely been due to a poor understanding of disease pathophysiology, lack of a global view of the patient, and an inappropriate selection of patients and treatment endpoints in clinical trials. In recent years, however, more effective and safer drugs have been developed for the treatment of IBs-C. The advancement in the area of pharmacologic treatment is based on new knowledge of the pathophysiologic basis of IBs-C and the development of drugs with increased selectivity within pharmacologic classes with recognized efficacies. This narrative review covers the spectrum of available drugs and their mechanisms of action, as well as the efficacy and safety profiles of each as determined in relevant clinical trials that have investigated treatment options for IBs-C and chronic constipation. A brief summary of laxative-based treatment options is presented, followed by up-to-date assessments for three classes of drugs: prokinetics, prosecretory agents, and bile acid modulators.

关键词： Constipation Irritable bowel syndrome Drug therapy serotonergic agents Prokinetics 5-hydroxytryptamine type 4 agonists secretagogues Prosecretory agents Bile acid modulators

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Understanding celiac disease monitoring patterns and outcomes after diagnosis:A multinational,retrospective chart review study

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World Journal of Gastroenterology 2021年第20期27卷 2603-2614页

作者： Knut EA Lundin Ciaran P Kelly david s sanders Kristina Chen sheena Kayaniyil sisi Wang Rajvi J Wani Caitlin Barrett shakira Yoosuf Ellen s Pettersen Robert sambrook Daniel A Leffler K.G.Jebsen Coeliac Disease Research Centre University of OsloOslo 0450Norway Department of Gastroenterology Oslo University Hospital RikshospitaletOslo 0372Norway Celiac Center Beth Israel Deaconess Medical Center Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Royal Hallamshire Hospital University of SheffieldSheffield S102TNUnited Kingdom Takeda Pharmaceuticals International Co. CambridgeMA 02139United States Real World Evidence strategy and Analytics ICON plc.TorontoON L7N 3G2Canada Real World Evidence strategy and Analytics ICON plc.VancouverBC V6B 1P1Canada

BACKGROUND Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac *** To understand patterns of follow-up and management of patients with celiac disease,and to characterize symptoms and villous atrophy after *** A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac *** gastroenterology referral centers,with substantial expertise in celiac disease,participated in the United Kingdom,United states,and *** and clinical data were collected from medical *** analyses were conducted on patients with biopsyconfirmed celiac disease,diagnosed between 2008 and 2012,with at least one follow-up visit before December 31,*** demographic and clinical characteristics,biopsy/serology tests and results,symptoms,and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period(i.e.,before the study end date of December 31,2017).REsULTs A total of 300 patients were included in this study[72%female;mean age at diagnosis:38.9 years,standard deviation(sD)17.2].Patients were followed-up for a mean of 29.9 mo(sD 22.1)and there were,on average,three follow-up visits per patient during the study *** two-thirds(68.4%)of patients were recorded as having ongoing gastrointestinal symptoms and 11.0%had ongoing symptoms and enteropathy during *** 80%of patients were referred to a dietician at least once during the follow-up ***(50.0%)of the patients underwent at least one follow-up duodenal biopsy and 36.6%had continued villous *** of monitoring varied between *** were conducted more frequently in Norway and patients in the United states had a longer follow-up *** This real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology

关键词： Celiac disease Outcomes research Endoscopy Real-world General practice Villous atrophy

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是否应该保留无麸质食品处方？

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英国医学杂志中文版 2017年第7期20卷 370-372页

作者： Matthew Kurien sarah sleet david s sanders James Cave 符天旭周国鹏 Academic Unit of Gastroenterology Departments of Infection and Immunity and Cardiovascular Science University of Sheffield UK Department of Gastroenterology Royal Hallamshire Hospital Sheffield UK Coeliac UK High Wycombe UK Newbury UK 北京大学第一医院内科

Matthew Kurien及其同事撰写文章提出无麸质食品处方可改善乳糜泻患者预后，但JamesCave则抨击这一昂贵的供应系统可能使患者和医生均感到失望。正方——Matthew Kurien,sarah sleet，david sanders由于近三分之二的信托机构存在赤字，... 详细信息

Matthew Kurien及其同事撰写文章提出无麸质食品处方可改善乳糜泻患者预后，但JamesCave则抨击这一昂贵的供应系统可能使患者和医生均感到失望。正方——Matthew Kurien,sarah sleet，david sanders由于近三分之二的信托机构存在赤字，英国国家健康体系（NHs）正面临着前所未有的财政和运营压力。英国医疗保健支出占国内生产总值的比例目前低于其他西欧邻国，这更加剧了上述压力。政府通过责令医疗专业人员提高生产力、工作效率和分配制度来恢复财政平衡。

关键词：无麸质食品处方食品安全发展现状

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Microscopic enteritis:Bucharest consensus

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World Journal of Gastroenterology 2015年第9期21卷 2593-2604页

作者： Kamran Rostami david Aldulaimi Geoffrey Holmes Matt W Johnson Marie Robert Amitabh srivastava Jean-Francois Fléjou david s sanders Umberto Volta Mohammad H Derakhshan James J Going Gabriel Becheanu Carlo Catassi Mihai Danciu Luke Materacki Kamran Ghafarzadegan sauid Ishaq Mohammad Rostami-Nejad A salvador Pe?a Gabrio Bassotti Michael N Marsh Vincenzo Villanacci Department of Gastroenterology Alexandra HospitalWorcestershire B98 7UBUnited Kingdom Department of Gastroenterology Royal Derby HospitalDerby DE22 3NEUnited Kingdom Gastroenterology Unit Luton Dunstable University FT Hospital LU4 0DZUnited Kingdom Department of Pathology and Medicine Yale University School of MedicineNew HavenCT 06520United States Department of Pathology Staff PathologistBrigham and Women’s HospitalHarvard Medical School BostonBostonMA 02115United Sates Department of Pathology Serviced’Anatomie PathologiqueHopital Saint-AntoineAP-HPUniversité Pierre et Marie Curie75005 ParisFrance Department of Gastroenterology University of SheffieldSouth Yorkshire S10 2TNUnited Kingdom Department of Gastroenterology Department of Medical and Surgical SciencesUniversity of Bologna40126 BolognaItaly section of Gastroenterology Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgow G12 8QQUnited Kingdom Department of Pathology Southern General HospitalLanarkshire G51 4TFUnited Kindom Department of Pathology Carol Davila Univerity of Medicine and PharmacyBucharest 050474Romania Università Politecnica delle Marche AnconaItalyPresidente Società Italiana di GastroenterologiaEpatologia e Nutrizione PediatricaCo-DirectorCenter For Celiac Research University of Maryland school of Medicine BaltimoreMD 21201United States Grigore T Popa" University of Medicine and Pharmacy Iasi 747800Romania Laboratory Department Mashad Razavi HospitalKhorasan Razavi ***Iran Dudley group of Hospitals Birmingham City UniversityBirmingham B42 2SUUnited Kindom Gastroenterology and Liver Diseases Research Institute Shahid Beheshti University of Medical SciencesTehran ***Iran Laboratory of Immunogenetics Department of Medical Microbiology and Infection ControlVrije Universiteit medical centre (VUmc)1081 HZ AmsterdamThe Netherlands Gastroenterology section Department of MedicineUniversity of Perugia Medical School06100 PerugiaItaly Wolfson College University of OxfordOxford

Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient *** is characterised by microscopic or sub-microscopic abnormalities such as microvillus changes and enterocytic alterations in the absence of definite macroscopic changes using standard modern *** work recognises a need to characterize disorders with microscopic and submicroscopic features,currently regarded as functional or non-specific entities,to obtain further understanding of their clinical *** consensus working party reviewed statements about the aetiology,diagnosis and symptoms associated with ME and proposes an algorithm for its investigation and *** the 5th International Course in Digestive Pathology in Bucharest in November 2012,an international group of 21 interested pathologists and gastroenterologists formed a working party with a view to formulating a consensus statement on ME.A five-step agreement scale(from strong agreement to strong disagreement) was used to score 21 statements,*** was strong agreement on all statements about ME histology(95%-100%).statements concerning diagnosis achieved 85% to 100% agreement.A statement on the management of ME elicited agreement from the lowest rate(60%) up to 100%.The remaining two categories showed general agreement between experts on clinical presentation(75%-95%) and pathogenesis(80%-90%) of *** was strong agreement on the histological definition of *** agreement on management indicates a need for further investigations,better definitions and clinical trials to produce quality guidelines for *** ME consensus is a step toward greater recognition of a significant entity affecting symptomatic patients previously labelled as non-specific or functional enteropathy.

关键词： Microscopic enteritis Enteropathy Gluten Malabsorption Non-celiac gluten Bucharest consensus

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Multinuclear MR and MRI study of lithium-ion cells using a variable field magnet and a fixed frequency RF probe

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Magnetic Resonance Letters 2024年第1期4卷 10-20页

作者： Andrés Ramírez Aguilera Florin Marica Kevin J.sanders Md Al Raihan C.Adam Dyker Gillian R.Goward Bruce *** UNB MRI Centre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of Chemistry McMaster UniversityHamiltonOntarioL8S 4L8Canada Department of Chemistry University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An exploratory multinuclear magnetic resonance(MR)and magnetic resonance imaging(MRI)study was performed on lithium-ion battery cells with ^(7)Li,^(19)F,and ^(1)H measurements.A variable field superconducting magnet with a fixed frequency parallel-plate radiofrequency(RF)probe was employed in the *** magnetic field was changed to set the resonance frequency of each nucleus to the fixed RF probe frequency of 33.7 *** cartridge-like lithium-ion cells,with graphite anodes and LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC)cathodes,were *** cell was pristine,and one was charged to a cell voltage of 4.2 *** results presented demonstrate the great potential of the variable field magnet approach in multinuclear measurement of lithium-ion *** methods open the door for developing faster and simpler methods for detecting,quantifying,and interpreting MR and MRI data from lithium-ion and other batteries.

关键词： Multinuclear MR/MRI Variable field magnet Lithium-ion battery Parallel-plate rf probe

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经皮内镜下胃造瘘营养

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英国医学杂志中文版 2010年第4期13卷 219-223页

作者： Matthew Kurien Mark E McAlindon david Westaby david s sanders 张月宁(译) Department of Gastroenterology Chesterfield Royal Cherfield S44 5BL Department of Gastroenterology Royal Hallamshine Hospital Shefficld S10 2JF Department of Coasroenterology Imperial College Healtheare NFIS Trust London UK 北京佑安医院消化内科

经皮内镜下胃造瘘（Percutaneous endoscopic gastrostomy，PEG）营养于1980年被引入临床，目前被视作胃肠道功能正常但不能经口获得充足营养患者的有效肠内营养途径。若患者营养摄取不足可能超过4～6周，且肠内营养可能防止体重进一步... 详细信息

经皮内镜下胃造瘘（Percutaneous endoscopic gastrostomy，PEG）营养于1980年被引入临床，目前被视作胃肠道功能正常但不能经口获得充足营养患者的有效肠内营养途径。若患者营养摄取不足可能超过4～6周，且肠内营养可能防止体重进一步减轻、纠正营养不良、避免营养摄入不足引起的生活质量下降，此时PEG是优先考虑的方法。

关键词：经皮内镜下胃造瘘肠内营养途径 endoscopic 胃肠道功能营养摄取营养不良生活质量摄入不足

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消化道胶囊内镜——从三级医疗中心到初级保健

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英国医学杂志中文版 2006年第3期9卷 158-161页

作者： Reena sidhu david s sanders Mark E McAlindon 夏志伟（译） Royal Hallarnshire Hospital Sheffeld S10 2JF 不详

1907年,布鲁日开始应用第一台内镜来观察人的上消化道,最初是硬的直管内镜,需要全身麻醉.40年后,可屈式内镜诞生,只需要局部麻醉或轻度镇静就可以进行内镜检查.随后20年的技术进步催生了第一台肠镜的出现.1999年,又实现了一个巨大的飞跃... 详细信息

1907年,布鲁日开始应用第一台内镜来观察人的上消化道,最初是硬的直管内镜,需要全身麻醉.40年后,可屈式内镜诞生,只需要局部麻醉或轻度镇静就可以进行内镜检查.随后20年的技术进步催生了第一台肠镜的出现.1999年,又实现了一个巨大的飞跃,胶囊内镜可以全面观察整个小肠.胶囊被咽下后,在肠道的蠕动推进下经过所有肠道,胶囊内镜具有成像装置,可将肠道内的影像传输给腹部的接收装置.

关键词：胶囊内镜上消化道三级医疗中心初级保健成像装置肠道内全身麻醉内镜检查局部麻醉全面观察

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乳糜泻

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英国医学杂志中文版 2015年第4期18卷 211-217页

作者： Peter D Mooney david s sanders 乔新伟 Regional Gastrointestinal and Liver Unit Royal Hanamshire HospitalShemeld SI0 2JF UK Department of Neurology Royal Hallamshire HospitalSheffield UK 北京协和医院消化内科

乳糜泻是一种常见的自身免疫性疾病，以摄入麦胶后出现过度的免疫应答为特征，在美国和欧洲成年人的患病率为0．2％～1％。近年来的研究表明该病的患病率呈上升趋势。荟萃分析表明有7／8的乳糜泻患者未被明确诊断。本文将总结近年来有... 详细信息

乳糜泻是一种常见的自身免疫性疾病，以摄入麦胶后出现过度的免疫应答为特征，在美国和欧洲成年人的患病率为0．2％～1％。近年来的研究表明该病的患病率呈上升趋势。荟萃分析表明有7／8的乳糜泻患者未被明确诊断。本文将总结近年来有关改进和提高乳糜泻检测和诊断的相关证据，同时为临床上处理新诊断的乳糜泻患者和处理对去麦胶饮食治疗无效的患者提供依据。文中涉及的证据均来自相关的荟萃分析、系统性综述和随机对照试验。

关键词：乳糜泻患者自身免疫性疾病治疗方法

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应该在开放获取期刊上发表文章吗?

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英国医学杂志中文版 2020年第11期23卷 639-641页

作者： Matthew Kurien david s sanders James J Ashton R Mark Beattie 赵巍(译) Academic Unit of Gastroenterology Departments of Infection and Immunity and Cardiovascular ScienceUniversity of Sheffield Medical SchoolSheffieldUK Department of Gastroenterology Royal Hallamshire HospitalSheffield Department of Paediatric Gastroenterology Southampton Children's HospitalUK Department of Human Genetics and Genomic Medicine University of Southampton 中华医学会杂志社总编室

Matthew Kurien和david s sanders说,"作者付费"出版模式是让所有人都能获得生物医学研究成果的唯一公平途径,但James J Ashton和R Mark Beattie担心,这会导致证据基础因商业驱动造成偏倚。

关键词：医学研究成果出版模式开放获取期刊证据基础

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Capturing CO2 Emissions in the George C. Wallace Tunnel: A Case study

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Intelligent Control and Automation 2024年第3期15卷 83-94页

作者： Gabe Canitz Cole Ciesta Klint Green Justin sanders Jason Valencia Jeremy Willingham Daniel Fonseca Department of Mechanical Engineering The University of Alabama Tuscaloosa AL USA

This paper describes the design of a ventilation system to be paired with a carbon capture system. The ventilation system utilizes the geometry of the George C. Wallace tunnel, located in the City of Mobile, Alabama, UsA to capture and redirect emissions to a direct air capture (DAC) device to sequester 25% of the total CO2 mass generated from inside the tunnel. The total CO2 mass rate for the westbound traffic between the week-day hours of 7 a.m. and 6 p.m. has been estimated between 2,300 to 3,000 lbs./hr. By sequestering these emissions, the overall surrounding air quality was shown to be improved to a level that mirrors that from the pre-Us industrial era of 270 ppm.

关键词： CO2 Capture Tunnel Ventilation Air Flow Analysis Jet Fan sizing

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