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Effect of Conjugated Linoleic Acid on Tumor Cell Growth and Angiogenesis

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Effect of Conjugated Linoleic Acid on Tumor Cell Growth and ...

Cancer Pathogenesis and Therapy:A new journal,a new inspiration

“基因、进化与生理功能多样性”海内外学术研讨会暨中国生理学会第七届比较生理学学术会议

作者： david kerr Department of Clinical Pharmacology University of OxfordOxford UK

A dietary fatty acid,cis-9,trans- 11-conjugated linoleic acid(CLA) derived from dairy products and meats of ruminant animal, has been shown to be a potent antitumour agent in vitro and in *** is capable of inducing tumour cell apoptosis by up-regulation of p53,p21 and Bax in some human cancer cell ***,its precise mechanism in anti-tumour progression remains elusive. In this study,we found that a high dose of CLA(144μM) but not a low dose(36μM) decreased Akt and eNOS phosphorylation in GP2D(a human colon cancer cell line) after vascular endothelial growth factor(VEGF-50 ng/mL) *** also demonstrated that CLA at the high dose completely inhibits VEGF-induced human umbilical vein endothelial cell(HUVEC) capillary-like tube formation after 7 days co-culture with murine fibroblast *** conclusion,the CLA might play an important role on tumer cell growth and angiogenesis by inhibiting the eNOS and AKT phosphorylation in relation to nitric oxide (NO) ***,we are defining a direct effect of CLA on tumour proliferation, apoptosis and migration as well as its significant biological function in different tumour cell lines.

关键词： Cojugated linoleic acid Endothelial nitric oxide synthase Tumor cell Co-culture Angiogenesis

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Cancer Pathogenesis and Therapy 2023年第1期1卷 1-2页

作者： Yuankai Shi david James kerr Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Radcliffe Department of Medicine University of OxfordOxfordOX14DJUK

Dear readers:It is our great pleasure to introduce Cancer Pathogenesis and Therapy(CPT),a journal officially launched and supported by the Chinese Medical Association(CMA)and the only international English-language journal in the field of oncology published by the *** the Editor-in-Chief appointed by the CMA,on behalf of the editorial team,we would like to extend a warm welcome to the readership of CPT.

关键词： Medical journal Oncology Publication

GABAB受体的最新进展:从药理学到分子生物学（英文）

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Acta Pharmacologica Sinica 2000年第2期 17-29页

作者： Jennifer ONG,david IB kerr Department of Anaesthesia and Intensive Care The University of Adelaide Ade-laide South Australia 5005 Australia Department of Anaesthesia and Intensive Care The University of Adelaide Ade-laide South Australia 5005 Australia

Bicuculline-insensitive receptors for the inhibitory neurotransmitter γ-aminobutyric acid (GABA), GABAB receptors, are a distinct subclass of receptors that mediate depression of synaptic transmission and contribute to neu-ronal inhibition. When activated, these receptors reduce transmission at excitatory and inhibitory synapses, as a result of an increase in K+ conductance, or a decrease in voltage-dependent Ca2+ currents. They are also linked to G-proteins, or intracellular effector systems in a very complex manner. The recent development of highly specific and potent agonists and antagonists for these receptors has led to a much better understanding of their physiology and pharmacology, including their heterogeneity, as well as their molecular biology. Over the past year, expression and cloning studies have contributed to major advances in characterizing GABAB receptor structure, with the discovery of the amino acid sequences of GABABRla/R1b splice variants and GABABR2 receptors. These isoforms are

关键词： γ-氨基丁酸 GABA-B受体 GABABR2受体巴氯芬 GABA受体激动剂 GABA受体拮抗剂

Mantle avalanches in a Venus-like stagnant lid planet

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Earth and Planetary Physics 2024年第5期8卷 686-702页

作者： Madeleine C.kerr Dave R.Stegman Institute of Geophysics and Planetary Physics Scripps Institution of Oceanography University of California

Stagnant lid planets are characterized by a globe-encircling, conducting lid that is thick and strong, which leads to reduced global surface heat flows. Consequently, the mantles of such planets can have warmer interiors than Earth, and interestingly, a pyrolitic mantle composition under warmer conditions is predicted to have a distinctly different mantle transition zone compared to the present-day Earth(Hirose, 2002; Stixrude and Lithgow-Bertelloni, 2011; Ichikawa et al., 2014; Dannberg et al, 2022). Instead of olivine primarily transforming into its higher-pressure polymorphs such as wadsleyite and then ringwoodite, at pressures corresponding to410 km and 520 km depth in Earth, respectively, it instead transforms into a mineral assemblage of wadsleyite, majorite, and ferropericlase(WMF), and then to majorite + ferropericlase(MF), before finally transforming into bridgmanite at pressures corresponding to 660 km depth in Earth(Stixrude and Lithgow-Bertelloni, 2011; Ichikawa et al., 2014). Convective motions in stagnant lid planets are dominated by small-scale instabilities(cold drips) forming within the mobile rheological sublayer under the rigid lid. Using ASPECT and a thermodynamic model of a pyrolitic mantle composition generated by HeFESTo, we show that under certain conditions, the small drips can pond atop the WMF-MF mineral phase transition. The barrier to convective flow arises from the WMF mineral phase assemblage having an effective negative thermal expansivity(Stixrude and Lithgow-Bertelloni, 2022). Although large-scale downwellings that typically occur within mobile lid planets are able to pass through the WMF zone without difficulty(Dannberg et al., 2022; Li RP et al.,2024), the smaller and less negatively buoyant nature of downwelling drips in stagnant lid planets are more susceptible to these effects,which leads to an ephemeral layering of the mantle. Our numerical models show that in stagnant lid planets with mantle potential temperatures that exceed

关键词： Venus mantle avalanches numerical modelling phase transitions

Challenges and solutions in patient treatment strategies for stage Ⅱ colon cancer

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Gastroenterology Report 2019年第3期7卷 151-161,I0001页

作者： Susan Fotheringham Guy A.Mozolowski Eleanor M.A.Murray david J.kerr Oxford Cancer Biomarkers Limited The Magdalen CentreThe Oxford Science ParkRobert Robinson AvenueOxfordOX44GAUK The Medical School The University of SheffieldBeech Hill RoadSheffieldS102RXUK Nuffield Department of Clinical Laboratory Sciences Level 4 Academic BlockJohn Radcliffe HospitalHeadingtonOxfordOX39DUUK

Colorectal cancer remains one of the most common cancers worldwide and,despite improvements in treatment options for late-stage metastatic cancer,there are still questions surrounding how best to treat early-stage disease *** recent advances have been made in the staging of cancer and improving the risk assessment of strategies for patient treatment.A number of high-risk features have been proposed that may help to stratify stage Ⅱ cancer patients into groups that will truly benefit from adjuvant *** tests are becoming available to measure these biomarkers,utilizing both currently available and novel *** review will describe the challenges in treatment decisions for early-stage colon cancer and how personalized medicine can assist clinicians in making the best treatment choices for patients with stage Ⅱ colon cancer in particular.

关键词： Colorectal cancer treatment strategy challenge

Strategy Analytics:2010年移动行业大趋势展望

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通讯世界 2010年第1期16卷 30-31页

作者： david kerr Strategy Analytics

通信、内容及互联网行业有史以来最艰难的一年已经结束，Strategy Analytics认为，2010年，全球移动生态系统形势依然严峻，但前景堪称乐观：终端市场的复苏要比服务市场的复苏更强劲；运营商之间的整合会加剧；利润会从纯终端厂商继续... 详细信息

通信、内容及互联网行业有史以来最艰难的一年已经结束，Strategy Analytics认为，2010年，全球移动生态系统形势依然严峻，但前景堪称乐观：终端市场的复苏要比服务市场的复苏更强劲；运营商之间的整合会加剧；利润会从纯终端厂商继续流向整合终端和服务的厂商；3G会在更多的新兴市场推出，而新兴市场会继续主导手机出货量；2010年全球无线服务／应用、终端，及网络设备市场总规模将会有不到3％的小幅增长。

关键词： Strategy 移动行业服务市场终端市场展望互联网行业生态系统无线服务

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Global spatio-temporally harmonised datasets for producing high-resolution gridded population distribution datasets

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Big Earth Data 2019年第2期3卷 108-139页

作者： Christopher T.Lloyd Heather Chamberlain david kerr Greg Yetman Linda Pistolesi Forrest R.Stevens Andrea E.Gaughan Jeremiah J.Nieves Graeme Hornby Kytt MacManus Parmanand Sinha Maksym Bondarenko Alessandro Sorichetta Andrew J.Tatem WorldPop School of Geography and Environmental ScienceUniversity of SouthamptonSouthamptonUK Flowminder Foundation StockholmSweden Center for International Earth Science Information Network(CIESIN) Columbia UniversityPalisadesNYUSA Department of Geography and Geosciences University of LouisvilleLouisvilleKYUSA GeoData University of SouthamptonSouthamptonUK

Multi-temporal,globally consistent,high-resolution human population datasets provide consistent and comparable population distributions in support of mapping sub-national heterogeneities in health,wealth,and resource access,and monitoring change in these over *** production of more reliable and spatially detailed population datasets is increasingly necessary due to the importance of improving metrics at sub-national and multitemporal *** is in support of measurement and monitoring of UN Sustainable Development Goals and related *** response to these agendas,a method has been developed to assemble and harmonise a unique,open access,archive of geospatial *** are provided as global,annual time series,where pertinent at the timescale of population analyses and where data is available,for use in the construction of population distribution *** archive includes sub-national census-based population estimates,matched to a geospatial layer denoting administrative unit boundaries,and a number of co-registered gridded geospatial factors that correlate strongly with population presence and ***,we describe these harmonised datasets and their limitations,along with the production ***,we demonstrate applications of the archive by producing multi-temporal gridded population outputs for Africa and using these to derive health and development *** geospatial archive is available at https://***/10.5258/SOTON/WP00650.

关键词： Human population subnational global spatial dataset multi-temporal

Late Ordovician Mass Extinction: Earth, fire and ice

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National Science Review 2024年第1期11卷 51-65页

作者： david A.T.Harper Palaeoecosystems Group Department of Earth SciencesDurham University

The Late Ordovician Mass Extinction was the earliest of the ‘big’ five extinction events and the earliest to affect the trajectory of metazoan life. Two phases have been identified near the start of the Hirnantian period and in the middle. It was a massive taxonomic extinction, a weak phylogenetic extinction and a relatively benign ecological extinction. A rapid cooling, triggering a major ice age that reduced the temperature of surface waters, prompted a drop in sea level of some 100 m and introduced toxic bottom waters onto the shelves. These symptoms of more fundamental planetary processes have been associated with a range of factors with an underlying driver identified as volcanicity. Volcanic eruptions, and other products, may have extended back in time to at least the Sandbian and early Katian, suggesting the extinctions were more protracted and influential than hitherto documented.

关键词： Ordovician LOME paleoecology palaeobiogeography biotas

One-dimensional monotone nonautonomous dynamical systems

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Science China Mathematics 2024年第2期67卷 281-314页

作者： david Cheban Faculty of Mathematics and Computer Science Laboratory of Fundamental and Applied MathematicsMoldova State UniversityChisinau 2009Moldova

This work is devoted to the study of the dynamics of one-dimensional monotone nonautonomous(cocycle) dynamical systems. A description of the structures of their invariant sets, omega limit sets,Bohr/Levitan almost periodic and almost automorphic motions, global attractors, and pinched and minimalsets is given. An application of our general results is given to scalar differential and difference equations.

关键词： one-dimensional dynamics pinched and minimal sets global attractors monotone nonautonomous cocycle almost periodic solutions scalar differential/difference equations

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